Result of FASTA (omim) for
pF1KB4430
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4430, 567 aa
1>>>pF1KB4430 567 - 567 aa - 567 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.7186+/-0.000686; mu= -6.9195+/- 0.040
mean_var=614.9596+/-144.787, 0's: 0 Z-trim(112.6): 191 B-trim: 961 in 1/51
Lambda= 0.051719
statistics sampled from 21483 (21606) to 21483 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.607), E-opt: 0.2 (0.253), width: 16
Scan time: 9.690
The best scores are: opt bits E(85289)
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 3879 306.0 2.1e-82
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 3665 290.0 1.4e-77
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 3665 290.0 1.4e-77
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 3632 287.5 7.2e-77
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 3632 287.5 7.2e-77
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 935 86.1 2.4e-16
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 935 86.3 2.7e-16
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 935 86.3 2.7e-16
XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 919 85.1 6.1e-16
NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 919 85.1 6.1e-16
XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 919 85.1 6.2e-16
XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 919 85.1 6.2e-16
XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 919 85.1 6.3e-16
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 818 77.4 1e-13
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 818 77.4 1e-13
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 818 77.5 1.1e-13
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 808 76.7 1.7e-13
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 808 76.8 1.9e-13
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 788 75.1 4.4e-13
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 789 75.3 4.8e-13
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 788 75.2 4.9e-13
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 789 75.4 5.1e-13
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 763 73.3 1.8e-12
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 763 73.4 1.9e-12
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 746 72.0 4.2e-12
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 728 70.8 1.2e-11
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 728 70.8 1.2e-11
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 728 70.8 1.2e-11
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 728 70.8 1.2e-11
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 728 70.8 1.2e-11
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 728 70.8 1.2e-11
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 728 70.8 1.2e-11
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 728 70.8 1.2e-11
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 728 70.8 1.2e-11
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 727 70.7 1.3e-11
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 727 70.7 1.3e-11
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 727 70.7 1.3e-11
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 717 70.0 2.1e-11
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 717 70.0 2.1e-11
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 717 70.0 2.1e-11
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 715 69.9 2.4e-11
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 715 69.9 2.4e-11
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 715 69.9 2.4e-11
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 668 66.2 2.4e-10
XP_011509989 (OMIM: 178600,265450,600799) PREDICTE (1037) 622 63.4 4.3e-09
>>NP_003233 (OMIM: 133239,190182,610168,614331) TGF-beta (567 aa)
initn: 3879 init1: 3879 opt: 3879 Z-score: 1600.3 bits: 306.0 E(85289): 2.1e-82
Smith-Waterman score: 3879; 100.0% identity (100.0% similar) in 567 aa overlap (1-567:1-567)
10 20 30 40 50 60
pF1KB4 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
490 500 510 520 530 540
550 560
pF1KB4 LEHLDRLSGRSCSEEKIPEDGSLNTTK
:::::::::::::::::::::::::::
NP_003 LEHLDRLSGRSCSEEKIPEDGSLNTTK
550 560
>>XP_011532345 (OMIM: 133239,190182,610168,614331) PREDI (576 aa)
initn: 3660 init1: 3660 opt: 3665 Z-score: 1513.9 bits: 290.0 E(85289): 1.4e-77
Smith-Waterman score: 3665; 99.1% identity (99.4% similar) in 541 aa overlap (27-567:36-576)
10 20 30 40 50
pF1KB4 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDV
: . .::::::::::::::::::::::::
XP_011 GVLTLKTTLEDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB4 RFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB4 ASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB4 GVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNIN
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB4 HNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSD
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB4 INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLAR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB4 GIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB4 GQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB4 KVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE
490 500 510 520 530 540
540 550 560
pF1KB4 RFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:::::::::::::::::::::::::::::::
XP_011 RFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
550 560 570
>>NP_001020018 (OMIM: 133239,190182,610168,614331) TGF-b (592 aa)
initn: 3660 init1: 3660 opt: 3665 Z-score: 1513.8 bits: 290.0 E(85289): 1.4e-77
Smith-Waterman score: 3818; 95.6% identity (95.8% similar) in 592 aa overlap (1-567:1-592)
10 20 30
pF1KB4 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKS-------------------------VNND
::::::::::::::::::::::::::::::: .:::
NP_001 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINND
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB4 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB4 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB4 SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB4 CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB4 VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB4 YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB4 CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB4 EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE
490 500 510 520 530 540
520 530 540 550 560
pF1KB4 TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
550 560 570 580 590
>>XP_011532347 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 3632 init1: 3632 opt: 3632 Z-score: 1501.0 bits: 287.5 E(85289): 7.2e-77
Smith-Waterman score: 3632; 100.0% identity (100.0% similar) in 532 aa overlap (36-567:1-532)
10 20 30 40 50 60
pF1KB4 LRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
::::::::::::::::::::::::::::::
XP_011 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
10 20 30
70 80 90 100 110 120
pF1KB4 SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKE
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB4 KKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIII
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB4 FYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB4 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB4 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB4 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB4 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB4 SMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLD
460 470 480 490 500 510
550 560
pF1KB4 RLSGRSCSEEKIPEDGSLNTTK
::::::::::::::::::::::
XP_011 RLSGRSCSEEKIPEDGSLNTTK
520 530
>>XP_016862595 (OMIM: 133239,190182,610168,614331) PREDI (532 aa)
initn: 3632 init1: 3632 opt: 3632 Z-score: 1501.0 bits: 287.5 E(85289): 7.2e-77
Smith-Waterman score: 3632; 100.0% identity (100.0% similar) in 532 aa overlap (36-567:1-532)
10 20 30 40 50 60
pF1KB4 LRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
::::::::::::::::::::::::::::::
XP_016 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
10 20 30
70 80 90 100 110 120
pF1KB4 SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKE
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB4 KKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIII
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB4 FYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB4 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB4 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB4 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB4 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB4 SMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLD
460 470 480 490 500 510
550 560
pF1KB4 RLSGRSCSEEKIPEDGSLNTTK
::::::::::::::::::::::
XP_016 RLSGRSCSEEKIPEDGSLNTTK
520 530
>>NP_001265509 (OMIM: 102581) activin receptor type-2A i (405 aa)
initn: 893 init1: 352 opt: 935 Z-score: 414.6 bits: 86.1 E(85289): 2.4e-16
Smith-Waterman score: 935; 45.4% identity (75.2% similar) in 306 aa overlap (241-544:81-377)
220 230 240 250 260 270
pF1KB4 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
: :..: . ..:::. :.::.: .
NP_001 WVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLN-----
60 70 80 90 100
280 290 300 310 320 330
pF1KB4 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK
: ::::::: .. ::..: ...: ..::::::::. ::.: : . . ::::::: :
NP_001 -EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEK
110 120 130 140 150 160
340 350 360 370 380
pF1KB4 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIV-HRDLKSSNILVKN
:.:...: .:.::..: ... ..:::.:.:: : . : . :::.::.:.:.::
NP_001 GSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKN
170 180 190 200 210 220
390 400 410 420 430 440
pF1KB4 DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYS
.:: :. ::::.:... :. : . ::::: :::::::::. .:.. ..: . :.:.
NP_001 NLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMYA
230 240 250 260 270 280
450 460 470 480 490 500
pF1KB4 MALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQ
:.:::::..:::.:. : : .: :: .. .:: .:.:.. :.. . :: . ..: .:
NP_001 MGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA
290 300 310 320 330 340
510 520 530 540 550 560
pF1KB4 GIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:. :.:::. :::::: ::::.: ::.::......:
NP_001 GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPK
350 360 370 380 390 400
NP_001 ESSL
>>NP_001607 (OMIM: 102581) activin receptor type-2A isof (513 aa)
initn: 866 init1: 352 opt: 935 Z-score: 413.6 bits: 86.3 E(85289): 2.7e-16
Smith-Waterman score: 975; 34.7% identity (62.9% similar) in 518 aa overlap (37-544:13-485)
10 20 30 40 50 60
pF1KB4 RGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAV---KFPQLCKFCDVRFSTCDN
... ..::. . : : : .. . .
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRT
10 20 30 40
70 80 90 100 110 120
pF1KB4 QKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIM
... . : . .: .. : :.:.. . .: : : . : :. : .. :.
NP_001 NQTGVEPCYGDK--DKRRH-CFATWKNISGSI--EIVKQGCWLD--DINCYDRTD--CV-
50 60 70 80 90
130 140 150 160 170
pF1KB4 KEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGV
::: :..: : : .. ::... . :.....: : ... ::.: . .
NP_001 -EKKDSPEVYF-CCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB4 AISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHN
: :: :. :: .. : . . .: : .
NP_001 AGIVICAFWVYRHHK----------------MAYPP-VLVPTQDPGPPPPSPLLG-----
160 170 180
240 250 260 270 280 290
pF1KB4 TELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN
: :..: . ..:::. :.::.: . : ::::::: .. ::..: ...: .
NP_001 --LKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB4 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGI
.::::::::. ::.: : . . ::::::: ::.:...: .:.::..: ... ..:::.
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB4 AHLHSDHTPCGRPKMPIV-HRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSG
:.:: : . : . :::.::.:.:.::.:: :. ::::.:... :. : . :
NP_001 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THG
310 320 330 340 350
420 430 440 450 460 470
pF1KB4 QVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGS
:::: :::::::::. .:.. ..: . :.:.:.:::::..:::.:. : : .: ::
NP_001 QVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEE
360 370 380 390 400 410
480 490 500 510 520 530
pF1KB4 KVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE
.. .:: .:.:.. :.. . :: . ..: .: :. :.:::. :::::: ::::.: ::.:
NP_001 EIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGE
420 430 440 450 460 470
540 550 560
pF1KB4 RFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:......:
NP_001 RITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
480 490 500 510
>>NP_001265508 (OMIM: 102581) activin receptor type-2A i (513 aa)
initn: 866 init1: 352 opt: 935 Z-score: 413.6 bits: 86.3 E(85289): 2.7e-16
Smith-Waterman score: 975; 34.7% identity (62.9% similar) in 518 aa overlap (37-544:13-485)
10 20 30 40 50 60
pF1KB4 RGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAV---KFPQLCKFCDVRFSTCDN
... ..::. . : : : .. . .
NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRT
10 20 30 40
70 80 90 100 110 120
pF1KB4 QKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIM
... . : . .: .. : :.:.. . .: : : . : :. : .. :.
NP_001 NQTGVEPCYGDK--DKRRH-CFATWKNISGSI--EIVKQGCWLD--DINCYDRTD--CV-
50 60 70 80 90
130 140 150 160 170
pF1KB4 KEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGV
::: :..: : : .. ::... . :.....: : ... ::.: . .
NP_001 -EKKDSPEVYF-CCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB4 AISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHN
: :: :. :: .. : . . .: : .
NP_001 AGIVICAFWVYRHHK----------------MAYPP-VLVPTQDPGPPPPSPLLG-----
160 170 180
240 250 260 270 280 290
pF1KB4 TELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN
: :..: . ..:::. :.::.: . : ::::::: .. ::..: ...: .
NP_001 --LKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPG
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB4 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGI
.::::::::. ::.: : . . ::::::: ::.:...: .:.::..: ... ..:::.
NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB4 AHLHSDHTPCGRPKMPIV-HRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSG
:.:: : . : . :::.::.:.:.::.:: :. ::::.:... :. : . :
NP_001 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THG
310 320 330 340 350
420 430 440 450 460 470
pF1KB4 QVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGS
:::: :::::::::. .:.. ..: . :.:.:.:::::..:::.:. : : .: ::
NP_001 QVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEE
360 370 380 390 400 410
480 490 500 510 520 530
pF1KB4 KVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE
.. .:: .:.:.. :.. . :: . ..: .: :. :.:::. :::::: ::::.: ::.:
NP_001 EIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGE
420 430 440 450 460 470
540 550 560
pF1KB4 RFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:......:
NP_001 RITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
480 490 500 510
>>XP_016863005 (OMIM: 602730,613751) PREDICTED: activin (511 aa)
initn: 837 init1: 584 opt: 919 Z-score: 407.1 bits: 85.1 E(85289): 6.1e-16
Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (69-539:40-478)
40 50 60 70 80 90
pF1KB4 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI
.: : :: :. : : ::...
XP_016 INNLSPVGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG--
10 20 30 40 50 60
100 110 120 130 140 150
pF1KB4 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S
:.: : . : :: : .:. :.. : ...: : : .. ::. . .
XP_016 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG
70 80 90 100 110 120
160 170 180 190 200 210
pF1KB4 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM
: . : ... : . :::: :... :.. :. :: .:. .
XP_016 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------
130 140 150 160
220 230 240 250 260 270
pF1KB4 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
: : :: : .. : :..: . ..:::. :.::.: ..
XP_016 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF---
170 180 190 200 210
280 290 300 310 320 330
pF1KB4 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK
::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: :
XP_016 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK
220 230 240 250 260
340 350 360 370 380
pF1KB4 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK
:.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.:
XP_016 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK
270 280 290 300 310 320
390 400 410 420 430 440
pF1KB4 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY
.::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.:
XP_016 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY
330 340 350 360 370 380
450 460 470 480 490 500
pF1KB4 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH
.:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.:
XP_016 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH
390 400 410 420 430 440
510 520 530 540 550 560
pF1KB4 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:. ..: :. :::::: ::::.: :: :: :
XP_016 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP
450 460 470 480 490 500
XP_016 KESSI
510
>>NP_001097 (OMIM: 602730,613751) activin receptor type- (512 aa)
initn: 837 init1: 584 opt: 919 Z-score: 407.1 bits: 85.1 E(85289): 6.1e-16
Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (69-539:41-479)
40 50 60 70 80 90
pF1KB4 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI
.: : :: :. : : ::...
NP_001 LWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG--
20 30 40 50 60
100 110 120 130 140 150
pF1KB4 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S
:.: : . : :: : .:. :.. : ...: : : .. ::. . .
NP_001 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG
70 80 90 100 110 120
160 170 180 190 200 210
pF1KB4 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM
: . : ... : . :::: :... :.. :. :: .:. .
NP_001 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------
130 140 150 160
220 230 240 250 260 270
pF1KB4 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
: : :: : .. : :..: . ..:::. :.::.: ..
NP_001 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF---
170 180 190 200 210
280 290 300 310 320 330
pF1KB4 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK
::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: :
NP_001 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK
220 230 240 250 260 270
340 350 360 370 380
pF1KB4 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK
:.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.:
NP_001 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB4 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY
.::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.:
NP_001 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY
340 350 360 370 380
450 460 470 480 490 500
pF1KB4 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH
.:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.:
NP_001 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH
390 400 410 420 430 440
510 520 530 540 550 560
pF1KB4 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
:. ..: :. :::::: ::::.: :: :: :
NP_001 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP
450 460 470 480 490 500
NP_001 KESSI
510
567 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:00:39 2016 done: Thu Nov 3 15:00:40 2016
Total Scan time: 9.690 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]