Result of FASTA (omim) for
pF1KB3737
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3737, 417 aa
1>>>pF1KB3737 417 - 417 aa - 417 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6663+/-0.000288; mu= 21.1884+/- 0.018
mean_var=73.2603+/-14.628, 0's: 0 Z-trim(118.6): 28 B-trim: 152 in 1/55
Lambda= 0.149844
statistics sampled from 31599 (31629) to 31599 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.371), width: 16
Scan time: 7.680
The best scores are: opt bits E(85289)
NP_003540 (OMIM: 604038) hyaluronidase-3 isoform 1 ( 417) 3047 667.7 1.5e-191
NP_001186958 (OMIM: 604038) hyaluronidase-3 isofor ( 417) 3047 667.7 1.5e-191
NP_001186959 (OMIM: 604038) hyaluronidase-3 isofor ( 387) 2158 475.5 1e-133
NP_001186960 (OMIM: 604038) hyaluronidase-3 isofor ( 168) 1223 273.0 3.9e-73
XP_005265582 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1084 243.4 9e-64
NP_149348 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1084 243.4 9e-64
XP_005265581 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1084 243.4 9e-64
NP_003764 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1084 243.4 9e-64
NP_149349 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1056 237.3 5.7e-62
NP_695013 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1056 237.3 5.7e-62
XP_011531969 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1056 237.3 5.7e-62
XP_011531970 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1056 237.3 5.7e-62
XP_011531971 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1056 237.3 5.7e-62
XP_016867400 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 948 214.0 6.5e-55
XP_011514292 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 948 214.0 6.5e-55
NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sap ( 481) 948 214.0 6.5e-55
NP_001167515 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 920 208.0 4.5e-53
NP_001167517 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 920 208.0 4.5e-53
NP_694859 (OMIM: 600930) hyaluronidase PH-20 isofo ( 509) 920 208.0 4.5e-53
NP_001167516 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 920 208.0 4.5e-53
NP_003108 (OMIM: 600930) hyaluronidase PH-20 isofo ( 511) 920 208.0 4.5e-53
NP_695014 (OMIM: 601492,607071) hyaluronidase-1 is ( 405) 795 180.9 5.2e-45
NP_001186961 (OMIM: 604038) hyaluronidase-3 isofor ( 138) 716 163.3 3.4e-40
XP_011514293 (OMIM: 604510) PREDICTED: hyaluronida ( 451) 704 161.2 4.7e-39
NP_695015 (OMIM: 601492,607071) hyaluronidase-1 is ( 253) 626 144.1 3.7e-34
NP_695017 (OMIM: 601492,607071) hyaluronidase-1 is ( 176) 369 88.4 1.5e-17
>>NP_003540 (OMIM: 604038) hyaluronidase-3 isoform 1 pre (417 aa)
initn: 3047 init1: 3047 opt: 3047 Z-score: 3560.0 bits: 667.7 E(85289): 1.5e-191
Smith-Waterman score: 3047; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417)
10 20 30 40 50 60
pF1KB3 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQR
310 320 330 340 350 360
370 380 390 400 410
pF1KB3 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
370 380 390 400 410
>>NP_001186958 (OMIM: 604038) hyaluronidase-3 isoform 1 (417 aa)
initn: 3047 init1: 3047 opt: 3047 Z-score: 3560.0 bits: 667.7 E(85289): 1.5e-191
Smith-Waterman score: 3047; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417)
10 20 30 40 50 60
pF1KB3 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQR
310 320 330 340 350 360
370 380 390 400 410
pF1KB3 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
370 380 390 400 410
>>NP_001186959 (OMIM: 604038) hyaluronidase-3 isoform 2 (387 aa)
initn: 2182 init1: 2158 opt: 2158 Z-score: 2521.8 bits: 475.5 E(85289): 1e-133
Smith-Waterman score: 2793; 92.8% identity (92.8% similar) in 417 aa overlap (1-417:1-387)
10 20 30 40 50 60
pF1KB3 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTQLGPALVLGVALCLGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSLRPGF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFEQAARAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAASSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFLSQ--
250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMACSHQR
::::::::::::::::::::::::::::::::
NP_001 ----------------------------EECWHLHDYLVDTLGPYVINVTRAAMACSHQR
300 310 320 330
370 380 390 400 410
pF1KB3 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWGWAGPTCQEPRPGPKEAV
340 350 360 370 380
>>NP_001186960 (OMIM: 604038) hyaluronidase-3 isoform 3 (168 aa)
initn: 1223 init1: 1223 opt: 1223 Z-score: 1433.9 bits: 273.0 E(85289): 3.9e-73
Smith-Waterman score: 1223; 100.0% identity (100.0% similar) in 167 aa overlap (251-417:2-168)
230 240 250 260 270 280
pF1KB3 HAATLARNTQLHWLWAASSALFPSIYLPPRLPPAHHQAFVRHRLEEAFRVALVGHRHPLP
::::::::::::::::::::::::::::::
NP_001 MLPPAHHQAFVRHRLEEAFRVALVGHRHPLP
10 20 30
290 300 310 320 330 340
pF1KB3 VLAYVRLTHRRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLAYVRLTHRRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVD
40 50 60 70 80 90
350 360 370 380 390 400
pF1KB3 TLGPYVINVTRAAMACSHQRCHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGPYVINVTRAAMACSHQRCHGHGRCARRDPGQMEAFLHLWPDGSLGDWKSFSCHCYWG
100 110 120 130 140 150
410
pF1KB3 WAGPTCQEPRPGPKEAV
:::::::::::::::::
NP_001 WAGPTCQEPRPGPKEAV
160
>>XP_005265582 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa)
initn: 1085 init1: 359 opt: 1084 Z-score: 1265.9 bits: 243.4 E(85289): 9e-64
Smith-Waterman score: 1126; 42.2% identity (64.6% similar) in 438 aa overlap (6-407:6-439)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALCLGCGQPL-PQVPE----RPFSVLWNVPSAHCEARFGVHLPLNAL
::...:...: .. .. : : .: ::: : :.::. : :. : : :::.
XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 GIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHS
. :. .. : .::.::::...::::: : : . .::.:: . : : . ...:
XP_005 DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 LRPGF-AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFE
.: :: ::.:::.: :.:. :: . .:. : . . :: :.. . .: ::
XP_005 IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 QAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASN---YTGRCHAATLARNTQL
::. .: .::: ..:.::. ::::: .: : : :....: ::::: . .::: ::
XP_005 FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYN--HDYVQNWESYTGRCPDVEVARNDQL
190 200 210 220 230
240 250 260 270 280
pF1KB3 HWLWAASSALFPSIYLPPRLPPAHH-QAFVRHRLEEAFRVALVGH-RHPLPVLAYVRLTH
:::: :.:::::.:: : ..: . :: :..::.::: . : : ::: ...: :.
XP_005 AWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 RRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINV
: ::. ::...:: :::::::::.:::: . ..: : : .:.:::. : :::.::
XP_005 SRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNV
300 310 320 330 340 350
350 360 370 380 390
pF1KB3 TRAAMACSHQRCHGHGRCARRDPGQMEAFLHL------------------WPDGSLGDWK
. :.. ::. .:::::::.::.:. .:::: : : :. :
XP_005 SWATQYCSRAQCHGHGRCVRRNPSA-STFLHLSTNSFRLVPGHAPGEPQLRPVGELS-WA
360 370 380 390 400 410
400 410
pF1KB3 S-------FSCHCYWGWAGPTCQEPRPGPKEAV
. : :.:: ::.: ::
XP_005 DIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
420 430 440 450 460 470
>>NP_149348 (OMIM: 603551) hyaluronidase-2 precursor [Ho (473 aa)
initn: 1085 init1: 359 opt: 1084 Z-score: 1265.9 bits: 243.4 E(85289): 9e-64
Smith-Waterman score: 1126; 42.2% identity (64.6% similar) in 438 aa overlap (6-407:6-439)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALCLGCGQPL-PQVPE----RPFSVLWNVPSAHCEARFGVHLPLNAL
::...:...: .. .. : : .: ::: : :.::. : :. : : :::.
NP_149 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 GIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHS
. :. .. : .::.::::...::::: : : . .::.:: . : : . ...:
NP_149 DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 LRPGF-AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFE
.: :: ::.:::.: :.:. :: . .:. : . . :: :.. . .: ::
NP_149 IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 QAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASN---YTGRCHAATLARNTQL
::. .: .::: ..:.::. ::::: .: : : :....: ::::: . .::: ::
NP_149 FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYN--HDYVQNWESYTGRCPDVEVARNDQL
190 200 210 220 230
240 250 260 270 280
pF1KB3 HWLWAASSALFPSIYLPPRLPPAHH-QAFVRHRLEEAFRVALVGH-RHPLPVLAYVRLTH
:::: :.:::::.:: : ..: . :: :..::.::: . : : ::: ...: :.
NP_149 AWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 RRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINV
: ::. ::...:: :::::::::.:::: . ..: : : .:.:::. : :::.::
NP_149 SRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNV
300 310 320 330 340 350
350 360 370 380 390
pF1KB3 TRAAMACSHQRCHGHGRCARRDPGQMEAFLHL------------------WPDGSLGDWK
. :.. ::. .:::::::.::.:. .:::: : : :. :
NP_149 SWATQYCSRAQCHGHGRCVRRNPSA-STFLHLSTNSFRLVPGHAPGEPQLRPVGELS-WA
360 370 380 390 400 410
400 410
pF1KB3 S-------FSCHCYWGWAGPTCQEPRPGPKEAV
. : :.:: ::.: ::
NP_149 DIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
420 430 440 450 460 470
>>XP_005265581 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa)
initn: 1085 init1: 359 opt: 1084 Z-score: 1265.9 bits: 243.4 E(85289): 9e-64
Smith-Waterman score: 1126; 42.2% identity (64.6% similar) in 438 aa overlap (6-407:6-439)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALCLGCGQPL-PQVPE----RPFSVLWNVPSAHCEARFGVHLPLNAL
::...:...: .. .. : : .: ::: : :.::. : :. : : :::.
XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 GIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHS
. :. .. : .::.::::...::::: : : . .::.:: . : : . ...:
XP_005 DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 LRPGF-AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFE
.: :: ::.:::.: :.:. :: . .:. : . . :: :.. . .: ::
XP_005 IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 QAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASN---YTGRCHAATLARNTQL
::. .: .::: ..:.::. ::::: .: : : :....: ::::: . .::: ::
XP_005 FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYN--HDYVQNWESYTGRCPDVEVARNDQL
190 200 210 220 230
240 250 260 270 280
pF1KB3 HWLWAASSALFPSIYLPPRLPPAHH-QAFVRHRLEEAFRVALVGH-RHPLPVLAYVRLTH
:::: :.:::::.:: : ..: . :: :..::.::: . : : ::: ...: :.
XP_005 AWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 RRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINV
: ::. ::...:: :::::::::.:::: . ..: : : .:.:::. : :::.::
XP_005 SRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNV
300 310 320 330 340 350
350 360 370 380 390
pF1KB3 TRAAMACSHQRCHGHGRCARRDPGQMEAFLHL------------------WPDGSLGDWK
. :.. ::. .:::::::.::.:. .:::: : : :. :
XP_005 SWATQYCSRAQCHGHGRCVRRNPSA-STFLHLSTNSFRLVPGHAPGEPQLRPVGELS-WA
360 370 380 390 400 410
400 410
pF1KB3 S-------FSCHCYWGWAGPTCQEPRPGPKEAV
. : :.:: ::.: ::
XP_005 DIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
420 430 440 450 460 470
>>NP_003764 (OMIM: 603551) hyaluronidase-2 precursor [Ho (473 aa)
initn: 1085 init1: 359 opt: 1084 Z-score: 1265.9 bits: 243.4 E(85289): 9e-64
Smith-Waterman score: 1126; 42.2% identity (64.6% similar) in 438 aa overlap (6-407:6-439)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALCLGCGQPL-PQVPE----RPFSVLWNVPSAHCEARFGVHLPLNAL
::...:...: .. .. : : .: ::: : :.::. : :. : : :::.
NP_003 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 GIIANRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHS
. :. .. : .::.::::...::::: : : . .::.:: . : : . ...:
NP_003 DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 LRPGF-AGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYKAYTGFE
.: :: ::.:::.: :.:. :: . .:. : . . :: :.. . .: ::
NP_003 IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB3 QAARALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASN---YTGRCHAATLARNTQL
::. .: .::: ..:.::. ::::: .: : : :....: ::::: . .::: ::
NP_003 FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYN--HDYVQNWESYTGRCPDVEVARNDQL
190 200 210 220 230
240 250 260 270 280
pF1KB3 HWLWAASSALFPSIYLPPRLPPAHH-QAFVRHRLEEAFRVALVGH-RHPLPVLAYVRLTH
:::: :.:::::.:: : ..: . :: :..::.::: . : : ::: ...: :.
NP_003 AWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 RRSGRFLSQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINV
: ::. ::...:: :::::::::.:::: . ..: : : .:.:::. : :::.::
NP_003 SRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNV
300 310 320 330 340 350
350 360 370 380 390
pF1KB3 TRAAMACSHQRCHGHGRCARRDPGQMEAFLHL------------------WPDGSLGDWK
. :.. ::. .:::::::.::.:. .:::: : : :. :
NP_003 SWATQYCSRAQCHGHGRCVRRNPSA-STFLHLSTNSFRLVPGHAPGEPQLRPVGELS-WA
360 370 380 390 400 410
400 410
pF1KB3 S-------FSCHCYWGWAGPTCQEPRPGPKEAV
. : :.:: ::.: ::
NP_003 DIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
420 430 440 450 460 470
>>NP_149349 (OMIM: 601492,607071) hyaluronidase-1 isofor (435 aa)
initn: 621 init1: 574 opt: 1056 Z-score: 1233.6 bits: 237.3 E(85289): 5.7e-62
Smith-Waterman score: 1093; 41.7% identity (63.9% similar) in 432 aa overlap (1-407:1-430)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALC-LGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIA
:...: : .: ..: .. : : .:.:::...::. . : : :: . .... ..:
NP_149 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 NRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSL-RP
: :: :.: .:::::..::: :::. : : ::.:: : ::: . .: .. :
NP_149 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 GFAGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYK-AYTGFEQAA
:.: ::.::: : : :: :: . :. : : .: :: : :. : :. ::
NP_149 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDW-PAPQVEAVAQDQFQGAA
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 RALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAA
:: : ::....::::.:::::: .: : : . .. ::::.: .. :.: :: :::.
NP_149 RAWMAGTLQLGRALRPRGLWGFYGFPDCYN-YDFLSPNYTGQCPSGIRAQNDQLGWLWGQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 SSALFPSIYLPPRLP-PAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFL
: ::.::::.: : .. : .:.::. ::::::... :::: ::.. . ...::
NP_149 SRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 SQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMAC
:.: .:.: ::: :::::::: . . ..: : ...:. ::::...::: .:. :
NP_149 PLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLC
300 310 320 330 340 350
360 370 380 390
pF1KB3 SHQRCHGHGRCARRD--PGQM-----EAF-LHLWPDG---------SLGDWKS----FSC
:. : :::::.:: : . .: ..: : : :: : . :.:
NP_149 SQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKC
360 370 380 390 400 410
400 410
pF1KB3 HCYWGWAGPTCQEPRPGPKEAV
.:: :: .: :.
NP_149 RCYPGWQAPWCERKSMW
420 430
>>NP_695013 (OMIM: 601492,607071) hyaluronidase-1 isofor (435 aa)
initn: 621 init1: 574 opt: 1056 Z-score: 1233.6 bits: 237.3 E(85289): 5.7e-62
Smith-Waterman score: 1093; 41.7% identity (63.9% similar) in 432 aa overlap (1-407:1-430)
10 20 30 40 50
pF1KB3 MTTQLGPALVLGVALC-LGCGQPLPQVPERPFSVLWNVPSAHCEARFGVHLPLNALGIIA
:...: : .: ..: .. : : .:.:::...::. . : : :: . .... ..:
NP_695 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB3 NRGQHFHGQNMTIFYKNQLGLYPYFGPRGTAHNGGIPQALPLDRHLALAAYQIHHSL-RP
: :: :.: .:::::..::: :::. : : ::.:: : ::: . .: .. :
NP_695 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 GFAGPAVLDWEEWCPLWAGNWGRRRAYQAASWAWAQQVFPDLDPQEQLYK-AYTGFEQAA
:.: ::.::: : : :: :: . :. : : .: :: : :. : :. ::
NP_695 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDW-PAPQVEAVAQDQFQGAA
130 140 150 160 170
180 190 200 210 220 230
pF1KB3 RALMEDTLRVAQALRPHGLWGFYHYPACGNGWHSMASNYTGRCHAATLARNTQLHWLWAA
:: : ::....::::.:::::: .: : : . .. ::::.: .. :.: :: :::.
NP_695 RAWMAGTLQLGRALRPRGLWGFYGFPDCYN-YDFLSPNYTGQCPSGIRAQNDQLGWLWGQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB3 SSALFPSIYLPPRLP-PAHHQAFVRHRLEEAFRVALVGHRHPLPVLAYVRLTHRRSGRFL
: ::.::::.: : .. : .:.::. ::::::... :::: ::.. . ...::
NP_695 SRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB3 SQDDLVQSIGVSAALGAAGVVLWGDLSLSSSEEECWHLHDYLVDTLGPYVINVTRAAMAC
:.: .:.: ::: :::::::: . . ..: : ...:. ::::...::: .:. :
NP_695 PLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLC
300 310 320 330 340 350
360 370 380 390
pF1KB3 SHQRCHGHGRCARRD--PGQM-----EAF-LHLWPDG---------SLGDWKS----FSC
:. : :::::.:: : . .: ..: : : :: : . :.:
NP_695 SQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKC
360 370 380 390 400 410
400 410
pF1KB3 HCYWGWAGPTCQEPRPGPKEAV
.:: :: .: :.
NP_695 RCYPGWQAPWCERKSMW
420 430
417 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:20:37 2016 done: Sat Nov 5 05:20:38 2016
Total Scan time: 7.680 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]