Result of FASTA (omim) for
pF1KB3683
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3683, 1174 aa
1>>>pF1KB3683 1174 - 1174 aa - 1174 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6084+/-0.000493; mu= 20.4511+/- 0.031
mean_var=64.4669+/-13.154, 0's: 0 Z-trim(108.2): 32 B-trim: 33 in 1/51
Lambda= 0.159737
statistics sampled from 16274 (16287) to 16274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.532), E-opt: 0.2 (0.191), width: 16
Scan time: 14.510
The best scores are: opt bits E(85289)
NP_000929 (OMIM: 180661) DNA-directed RNA polymera (1174) 7858 1820.7 0
NP_001290198 (OMIM: 180661) DNA-directed RNA polym (1167) 7808 1809.1 0
NP_001290197 (OMIM: 180661) DNA-directed RNA polym (1099) 7299 1691.8 0
NP_001154180 (OMIM: 607694,614366,614381) DNA-dire (1075) 1625 384.2 2.3e-105
NP_060552 (OMIM: 607694,614366,614381) DNA-directe (1133) 1625 384.2 2.4e-105
XP_016875110 (OMIM: 607694,614366,614381) PREDICTE (1024) 1099 263.0 6.9e-69
NP_001269705 (OMIM: 602000) DNA-directed RNA polym ( 924) 416 105.6 1.5e-21
NP_001269703 (OMIM: 602000) DNA-directed RNA polym ( 952) 416 105.6 1.5e-21
NP_001269708 (OMIM: 602000) DNA-directed RNA polym ( 996) 416 105.6 1.6e-21
NP_001269706 (OMIM: 602000) DNA-directed RNA polym ( 996) 416 105.6 1.6e-21
NP_001131076 (OMIM: 602000) DNA-directed RNA polym (1079) 416 105.6 1.7e-21
NP_061887 (OMIM: 602000) DNA-directed RNA polymera (1135) 416 105.6 1.8e-21
NP_001269701 (OMIM: 602000) DNA-directed RNA polym (1173) 416 105.6 1.9e-21
>>NP_000929 (OMIM: 180661) DNA-directed RNA polymerase I (1174 aa)
initn: 7858 init1: 7858 opt: 7858 Z-score: 9774.9 bits: 1820.7 E(85289): 0
Smith-Waterman score: 7858; 100.0% identity (100.0% similar) in 1174 aa overlap (1-1174:1-1174)
10 20 30 40 50 60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
1090 1100 1110 1120 1130 1140
1150 1160 1170
pF1KB3 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
::::::::::::::::::::::::::::::::::
NP_000 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
1150 1160 1170
>>NP_001290198 (OMIM: 180661) DNA-directed RNA polymeras (1167 aa)
initn: 7808 init1: 7808 opt: 7808 Z-score: 9712.7 bits: 1809.1 E(85289): 0
Smith-Waterman score: 7808; 100.0% identity (100.0% similar) in 1167 aa overlap (8-1174:1-1167)
10 20 30 40 50 60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB3 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB3 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB3 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB3 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB3 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB3 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB3 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB3 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
780 790 800 810 820 830
850 860 870 880 890 900
pF1KB3 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
840 850 860 870 880 890
910 920 930 940 950 960
pF1KB3 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KB3 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB3 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KB3 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
1080 1090 1100 1110 1120 1130
1150 1160 1170
pF1KB3 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
::::::::::::::::::::::::::::::::::
NP_001 RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
1140 1150 1160
>>NP_001290197 (OMIM: 180661) DNA-directed RNA polymeras (1099 aa)
initn: 7299 init1: 7299 opt: 7299 Z-score: 9079.2 bits: 1691.8 E(85289): 0
Smith-Waterman score: 7299; 100.0% identity (100.0% similar) in 1093 aa overlap (82-1174:7-1099)
60 70 80 90 100 110
pF1KB3 QMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
::::::::::::::::::::::::::::::
NP_001 MLDCNQPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
10 20 30
120 130 140 150 160 170
pF1KB3 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB3 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRP
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB3 TSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYD
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB3 FEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHV
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
280 290 300 310 320 330
420 430 440 450 460 470
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
340 350 360 370 380 390
480 490 500 510 520 530
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
400 410 420 430 440 450
540 550 560 570 580 590
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLR
460 470 480 490 500 510
600 610 620 630 640 650
pF1KB3 RQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNY
520 530 540 550 560 570
660 670 680 690 700 710
pF1KB3 SWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASII
580 590 600 610 620 630
720 730 740 750 760 770
pF1KB3 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRE
640 650 660 670 680 690
780 790 800 810 820 830
pF1KB3 LPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEK
700 710 720 730 740 750
840 850 860 870 880 890
pF1KB3 PTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRD
760 770 780 790 800 810
900 910 920 930 940 950
pF1KB3 CSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQ
820 830 840 850 860 870
960 970 980 990 1000 1010
pF1KB3 EDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKI
880 890 900 910 920 930
1020 1030 1040 1050 1060 1070
pF1KB3 SNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILN
940 950 960 970 980 990
1080 1090 1100 1110 1120 1130
pF1KB3 RQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTR
1000 1010 1020 1030 1040 1050
1140 1150 1160 1170
pF1KB3 THTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
:::::::::::::::::::::::::::::::::::::::::::
NP_001 THTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
1060 1070 1080 1090
>>NP_001154180 (OMIM: 607694,614366,614381) DNA-directed (1075 aa)
initn: 2121 init1: 802 opt: 1625 Z-score: 2012.6 bits: 384.2 E(85289): 2.3e-105
Smith-Waterman score: 2618; 39.4% identity (69.2% similar) in 1109 aa overlap (82-1171:13-1068)
60 70 80 90 100 110
pF1KB3 QMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPN
: . ::. .::.. : : .. :. :.
NP_001 MKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPH
10 20 30 40
120 130 140 150 160 170
pF1KB3 EARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDL
: :::..:::::. ::: : .: ... .. ::..::::::. :.:.: : ..
NP_001 ECRLRDMTYSAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEF
50 60 70 80 90
180 190 200 210 220 230
pF1KB3 CELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSR
.:::::::::::::..: :::.. ::... : . : : : : : . : :..::
NP_001 AKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB3 PTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIY
..: .. : :. .....::.:.:.:.: ::..:.. :
NP_001 ------TNMAVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG-
160 170 180 190
300 310 320 330 340
pF1KB3 DFEDPEMMEMVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQ
. ..: :::.: : : ::..::.. . : :. .:. :.:.:
NP_001 --TEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLA
200 210 220 230 240 250
350 360 370 380 390 400
pF1KB3 KEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLF
. .: :: :..: : . . ::.:..:: : ..::::.::::::.::: ::..::
NP_001 STILTHVPVKEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLF
260 270 280 290 300 310
410 420 430 440 450 460
pF1KB3 RGMFKNLLKEVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQA
. .::.. .:.. :.. : .:. .:.. .. :..:. ...::::. :. ..
NP_001 EDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMD
320 330 340 350 360 370
470 480 490 500 510 520
pF1KB3 RAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGL
: ::.:::.::.. :.:. . :..: . . :.. ::.:. . :::.::..::::.: ::
NP_001 RQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGL
380 390 400 410 420 430
530 540 550 560 570 580
pF1KB3 VKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDP
:::::::..:.. . .::... . ..:... . .. .. .:.:: .:. .:
NP_001 VKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDH
440 450 460 470 480 490
590 600 610 620 630 640
pF1KB3 EQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHI
..:.::.: .:: : ::. .. .: . : .:.::.::: .::.::: . ..:.
NP_001 KKLVNTFRLMRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHM
500 510 520 530 540 550
650 660 670 680 690 700
pF1KB3 DQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHP
..: . : :. .:.. ..:::.:. ::. .:. ... :: ::.:
NP_001 EELAQG-YRNF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT-------THLEIEP
560 570 580 590 600
710 720 730 740 750 760
pF1KB3 SMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVT
.:::::..::.: :::::::::: ::::::::. : . :.::: ..: :::::.:
NP_001 FTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVK
610 620 630 640 650 660
770 780 790 800 810
pF1KB3 TRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQ
:...: ..:..:::: :. ::. ::.::. ::....:....:::: : . :.. : ..
NP_001 TKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKR
670 680 690 700 710 720
820 830 840 850 860 870
pF1KB3 ESKKGFDQE--EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE
... ::. ... ::. :: : :: ::. .:: .: . .:...:. .:
NP_001 YTNQTFDKVMGPMLDAATRKPIW--RHEI---LDADGICSPGEKVENKQVLVNKS--MPT
730 740 750 760 770
880 890 900 910 920 930
pF1KB3 -NEDELESTN--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIG
.. ::..: .. .: . . . ...::.. : : . :. .:..: :.::
NP_001 VTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIG
780 790 800 810 820 830
940 950 960 970 980 990
pF1KB3 DKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSAN
:::.:::::::.::. :::::: :: ::::.:::..:::::.:.::: : ::...
NP_001 DKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVL
840 850 860 870 880 890
1000 1010 1020 1030 1040 1050
pF1KB3 KGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLK
:.. .: :. . .:. . . : .::. :.. . .:.::. . . :..::.:::.::
NP_001 DGRFHYGTAFGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLK
900 910 920 930 940 950
1060 1070 1080 1090 1100 1110
pF1KB3 HMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASD
::: ::.:.::::: .:.::: ::::::::::.::::::: :..::...: :::. .::
NP_001 HMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSD
960 970 980 990 1000 1010
1120 1130 1140 1150 1160 1170
pF1KB3 PYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMM
..: ::. ::... .. :. :... ..: .:.:::::::::::.::.: ::.
NP_001 AFEVDVCGQCGLLG------YSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLK
1020 1030 1040 1050 1060
pF1KB3 SV
NP_001 LSKYNE
1070
>>NP_060552 (OMIM: 607694,614366,614381) DNA-directed RN (1133 aa)
initn: 2189 init1: 802 opt: 1625 Z-score: 2012.2 bits: 384.2 E(85289): 2.4e-105
Smith-Waterman score: 2692; 38.6% identity (68.6% similar) in 1167 aa overlap (24-1171:24-1126)
10 20 30 40 50 60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
: : .. ... ::::.:..:::. ::.. ...:..
NP_060 MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
. .:. : . ::. .::.. : : .. :. :.: :::..::
NP_060 ANEKVTSDAD-----------PMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTY
70 80 90 100
130 140 150 160 170 180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
:::. ::: : .: ... .. ::..::::::. :.:.: : .. .:::::::
NP_060 SAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLD
110 120 130 140 150 160
190 200 210 220 230
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSRPTSTIWVSM
::::::..: :::.. ::... : . : : : : : . : :..:: ..:
NP_060 PGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR------TNM
170 180 190 200 210
240 250 260 270 280 290
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMME
.. : :. .....::.:.:.:.: ::..:.. : . ..:
NP_060 AVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG---TEEHVMA
220 230 240 250 260
300 310 320 330 340 350
pF1KB3 MVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQKEMLPHVGV
:::.: : : ::..::.. . : :. .:. :.:.: . .: :: :
NP_060 AFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPV
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB3 SDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLK
..: : . . ::.:..:: : ..::::.::::::.::: ::..::. .::.. .
NP_060 KEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNS
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB3 EVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
:.. :.. : .:. .:.. .. :..:. ...::::. :. .. : ::.:::.
NP_060 EMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMDRQGVTQVLS
390 400 410 420 430 440
480 490 500 510 520 530
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
::.. :.:. . :..: . . :.. ::.:. . :::.::..::::.: :::::::::..
NP_060 RLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTH
450 460 470 480 490 500
540 550 560 570 580
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDPEQLMNTLRK
:.. . .::... . ..:... . .. .. .:.:: .:. .: ..:.::.:
NP_060 ITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRL
510 520 530 540 550 560
590 600 610 620 630 640
pF1KB3 LRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYN
.:: : ::. .. .: . : .:.::.::: .::.::: . ..:...: . :
NP_060 MRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQG-YR
570 580 590 600 610
650 660 670 680 690 700
pF1KB3 NYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCAS
:. .:.. ..:::.:. ::. .:. ... :: ::.: .:::::.
NP_060 NF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT-------THLEIEPFTLLGVCAG
620 630 640 650 660 670
710 720 730 740 750 760
pF1KB3 IIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRF
.::.: :::::::::: ::::::::. : . :.::: ..: :::::.: :...: ..:
NP_060 LIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF
680 690 700 710 720 730
770 780 790 800 810 820
pF1KB3 RELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQE
..:::: :. ::. ::.::. ::....:....:::: : . :.. : .. ... ::.
NP_060 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKV
740 750 760 770 780 790
830 840 850 860 870 880
pF1KB3 --EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE-NEDELEST
... ::. :: : :: ::. .:: .: . .:...:. .: .. ::..
NP_060 MGPMLDAATRKPI--WRHEI---LDADGICSPGEKVENKQVLVNKS--MPTVTQIPLEGS
800 810 820 830 840
890 900 910 920 930 940
pF1KB3 N--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQ
: .. .: . . . ...::.. : : . :. .:..: :.:::::.:::::
NP_060 NVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQ
850 860 870 880 890 900
950 960 970 980 990 1000
pF1KB3 KGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATP
::.::. :::::: :: ::::.:::..:::::.:.::: : ::... :.. .:
NP_060 KGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTA
910 920 930 940 950 960
1010 1020 1030 1040 1050 1060
pF1KB3 FNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHS
:. . .:. . . : .::. :.. . .:.::. . . :..::.:::.::::: ::.:.
NP_060 FGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHA
970 980 990 1000 1010 1020
1070 1080 1090 1100 1110 1120
pF1KB3 RARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNL
::::: .:.::: ::::::::::.::::::: :..::...: :::. .:: ..: ::.
NP_060 RARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQ
1030 1040 1050 1060 1070 1080
1130 1140 1150 1160 1170
pF1KB3 CGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
::... .. :. :... ..: .:.:::::::::::.::.: ::.
NP_060 CGLLG------YSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE
1090 1100 1110 1120 1130
>>XP_016875110 (OMIM: 607694,614366,614381) PREDICTED: D (1024 aa)
initn: 1770 init1: 519 opt: 1099 Z-score: 1357.8 bits: 263.0 E(85289): 6.9e-69
Smith-Waterman score: 2166; 36.2% identity (66.2% similar) in 1057 aa overlap (24-1061:24-1022)
10 20 30 40 50 60
pF1KB3 MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
: : .. ... ::::.:..:::. ::.. ...:..
XP_016 MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
. .:. : . ::. .::.. : : .. :. :.: :::..::
XP_016 ANEKVTSDAD-----------PMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTY
70 80 90 100
130 140 150 160 170 180
pF1KB3 SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
:::. ::: : .: ... .. ::..::::::. :.:.: : .. .:::::::
XP_016 SAPITVDIEYT---RGSQRII--RNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLD
110 120 130 140 150 160
190 200 210 220 230
pF1KB3 PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCL-ENSSRPTSTIWVSM
::::::..: :::.. ::... : . : : : : : . : :..:: ..:
XP_016 PGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRKGAVGASVTSSTHEKKSR------TNM
170 180 190 200 210
240 250 260 270 280 290
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMME
.. : :. .....::.:.:.:.: ::..:.. : . ..:
XP_016 AVKQG----------RFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG---TEEHVMA
220 230 240 250 260
300 310 320 330 340 350
pF1KB3 MVKPSLDEAFVIQ--EQNVALNFIGSRGAKP----GVTKEKRIKYAKEVLQKEMLPHVGV
:::.: : : ::..::.. . : :. .:. :.:.: . .: :: :
XP_016 AFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPV
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB3 SDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLK
..: : . . ::.:..:: : ..::::.::::::.::: ::..::. .::.. .
XP_016 KEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNS
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB3 EVRIYAQKFI--DRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLN
:.. :.. : .:. .:.. .. :..:. ...::::. :. .. : ::.:::.
XP_016 EMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWS-LKRFKMDRQGVTQVLS
390 400 410 420 430 440
480 490 500 510 520 530
pF1KB3 RLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAY
::.. :.:. . :..: . . :.. ::.:. . :::.::..::::.: :::::::::..
XP_016 RLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTH
450 460 470 480 490 500
540 550 560 570 580
pF1KB3 ISVGSQPSPILEFLEEWSMENLEEISPAAIA--DATKIFVNGCWVGIHKDPEQLMNTLRK
:.. . .::... . ..:... . .. .. .:.:: .:. .: ..:.::.:
XP_016 ITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVNTFRL
510 520 530 540 550 560
590 600 610 620 630 640
pF1KB3 LRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYN
.:: : ::. .. .: . : .:.::.::: .::.::: . ..:...: . :
XP_016 MRRA-GYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQG-YR
570 580 590 600 610
650 660 670 680 690 700
pF1KB3 NYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCAS
:. .:.. ..:::.:. ::. .: : :. . . :: ::.: .:::::.
XP_016 NF--EDFLHESLVEYLDVNEENDCNIA-----LYEHTIN--KDTTHLEIEPFTLLGVCAG
620 630 640 650 660 670
710 720 730 740 750 760
pF1KB3 IIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRF
.::.: :::::::::: ::::::::. : . :.::: ..: :::::.: :...: ..:
XP_016 LIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEF
680 690 700 710 720 730
770 780 790 800 810 820
pF1KB3 RELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYK---EQESKKGFDQE
..:::: :. ::. ::.::. ::....:....:::: : . :.. : .. ... ::.
XP_016 EKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKV
740 750 760 770 780 790
830 840 850 860 870 880
pF1KB3 --EVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPE-NEDELEST
... ::. :: : :: ::. .:: .: . .:...:. .: .. ::..
XP_016 MGPMLDAATRKPI--WRHEI---LDADGICSPGEKVENKQVLVNKS--MPTVTQIPLEGS
800 810 820 830 840
890 900 910 920 930 940
pF1KB3 N--RRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQ
: .. .: . . . ...::.. : : . :. .:..: :.:::::.:::::
XP_016 NVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQ
850 860 870 880 890 900
950 960 970 980 990 1000
pF1KB3 KGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATP
::.::. :::::: :: ::::.:::..:::::.:.::: : ::... :.. .:
XP_016 KGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTA
910 920 930 940 950 960
1010 1020 1030 1040 1050 1060
pF1KB3 FNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHS
:. . .:. . . : .::. :.. . .:.:: : . .. ..:: . :.
XP_016 FGGS-KVKDVCEDLVRHGYNYLGKDYVTSGITGNKAHFWPGVDQKVQNHRINLVDLREHN
970 980 990 1000 1010 1020
1070 1080 1090 1100 1110 1120
pF1KB3 RARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNL
XP_016 LY
>>NP_001269705 (OMIM: 602000) DNA-directed RNA polymeras (924 aa)
initn: 1126 init1: 368 opt: 416 Z-score: 507.9 bits: 105.6 E(85289): 1.5e-21
Smith-Waterman score: 1271; 30.7% identity (57.4% similar) in 952 aa overlap (267-1171:36-921)
240 250 260 270 280 290
pF1KB3 VSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPE
.:. ....:: :: .:....: ::
NP_001 EEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDS
10 20 30 40 50 60
300 310 320 330 340 350
pF1KB3 MM-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPH
.. .:.. ..:. :.: .::..: .: .: . : : : ..
NP_001 FLRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---
70 80 90 100 110 120
360 370 380 390 400 410
pF1KB3 VGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKN
. . .:.: :.: :...:. : :. :. : :... : :. .... ...
NP_001 ICIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEG
130 140 150 160 170 180
420 430 440 450 460
pF1KB3 LLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-
: ..: .: .. . ... ::.. :. .: .:::: .. .
NP_001 WLVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQD
190 200 210 220 230
470 480 490 500 510 520
pF1KB3 AGVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAV
.:. : ..:.: :::.: .. : : .:. :.: ::..::..::.:.
NP_001 SGLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPC
240 250 260 270 280 290
530 540 550 560 570
pF1KB3 GLVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHK
::...: :. .. . : .: . .. .. . .. ....: :: . :
NP_001 GLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDK
300 310 320 330 340 350
580 590 600 610 620
pF1KB3 D-PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVE
: . ..::. ::.. :.... .. .. . ..: :. ::.
NP_001 DLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV----
360 370 380 390 400 410
630 640 650 660 670 680
pF1KB3 KQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAY
:.: : :. : : :.:. . .:. :.. .
NP_001 -QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------F
420 430 440
690 700 710 720 730 740
pF1KB3 CSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAH
.. :: :. : .:.: :..::: :::::::: :: ::::.:: . ... : :. .
NP_001 AGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLY
450 460 470 480 490 500
750 760 770 780 790 800
pF1KB3 VLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSV
: ::.::: ..: . . : : :.:::. :::::..::..:.:... .::: ..
NP_001 RLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGS
510 520 530 540 550 560
810 820 830 840 850 860
pF1KB3 FYRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVI
:.: .:. : :. :: :: . .::::::: :.... :
NP_001 VYKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPY
570 580 590 600 610
870 880 890 900 910 920
pF1KB3 IGKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIR
. : . :: : .:..: .::.. : :. : .: :
NP_001 YSYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCIT
620 630 640 650
930 940 950 960 970 980
pF1KB3 VRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLI
.: : : ::::::::::::: . . :::::: :..:::..:::..::::::: ::
NP_001 MRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLI
660 670 680 690 700 710
990 1000 1010 1020 1030
pF1KB3 ECLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITS
: . :: .: .: ::::: .. .. ....:. ::.. :.: ::.:..: .. .
NP_001 ESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEA
720 730 740 750 760 770
1040 1050 1060 1070 1080 1090
pF1KB3 QIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGA
.:::: .:::::.:::.::.. :. : . .. ::. ::. .::.:::::::: .:::.
NP_001 DIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGT
780 790 800 810 820 830
1100 1110 1120 1130 1140
pF1KB3 AQFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLV
. .:..:::. :: .::: :: . . . :.. :.: : . :. :
NP_001 SFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTV
840 850 860 870 880 890
1150 1160 1170
pF1KB3 RMPYACKLLFQELMSMSIAPRMMSV
.::. . . :: .:.: ..
NP_001 SVPYVFRYFVAELAAMNIKVKLDVV
900 910 920
>>NP_001269703 (OMIM: 602000) DNA-directed RNA polymeras (952 aa)
initn: 1158 init1: 368 opt: 416 Z-score: 507.6 bits: 105.6 E(85289): 1.5e-21
Smith-Waterman score: 1115; 38.5% identity (62.5% similar) in 538 aa overlap (654-1171:441-949)
630 640 650 660 670 680
pF1KB3 PLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQ
:.: : : : : :.:. . .:. :..
NP_001 EVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNL-ALGKEELIGTMEQIFMNVAIFEDEV-
420 430 440 450 460
690 700 710 720 730 740
pF1KB3 EKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVR
. .. :: :. : .:.: :..::: :::::::: :: ::::.:: . ... :
NP_001 -----FAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDR
470 480 490 500 510 520
750 760 770 780 790 800
pF1KB3 MDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDR
:. . : ::.::: ..: . . : : :.:::. :::::..::..:.:... .:
NP_001 SDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWER
530 540 550 560 570 580
810 820 830 840 850 860
pF1KB3 GFFRSVFYRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRV
:: .. :.: .:. : :. :: :: . .::::::: :...
NP_001 GFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKL
590 600 610 620 630
870 880 890 900 910
pF1KB3 SGDDVIIGKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---Y
. : . : . :: : .:..: .::.. : :. : .
NP_001 QYGDPYYSYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKF
640 650 660 670 680
920 930 940 950 960 970
pF1KB3 KFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRM
: : .: : : ::::::::::::: . . :::::: :..:::..:::..::::
NP_001 KCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRM
690 700 710 720 730 740
980 990 1000 1010 1020 1030
pF1KB3 TIGHLIECLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFT
::: ::: . :: .: .: ::::: .. .. ....:. ::.. :.: ::.:..
NP_001 TIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGIS
750 760 770 780 790 800
1040 1050 1060 1070 1080 1090
pF1KB3 GRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDC
: .. ..:::: .:::::.:::.::.. :. : . .. ::. ::. .::.::::::::
NP_001 GLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDA
810 820 830 840 850 860
1100 1110 1120 1130 1140
pF1KB3 QIAHGAAQFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNK
.:::.. .:..:::. :: .::: :: . . . :.. :.: : .
NP_001 LLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRS
870 880 890 900 910 920
1150 1160 1170
pF1KB3 TQISLVRMPYACKLLFQELMSMSIAPRMMSV
:. : .::. . . :: .:.: ..
NP_001 DTIDTVSVPYVFRYFVAELAAMNIKVKLDVV
930 940 950
>--
initn: 158 init1: 122 opt: 229 Z-score: 274.7 bits: 62.5 E(85289): 1.5e-08
Smith-Waterman score: 229; 23.3% identity (51.6% similar) in 382 aa overlap (39-406:38-387)
10 20 30 40 50 60
pF1KB3 QYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQ
:.: ...::. .. .. :. ::...
NP_001 RNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 AEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERD-GAPSPMMPNEARLRNLTYSAPLYVD
. .. : . . .: :: . . ..: : : : :: . : .:
NP_001 FKDERISFTILDA----------VISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTAD
70 80 90 100 110
130 140 150 160 170 180
pF1KB3 ITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII
:. .: .: .. : :.: .:::..: : : .: . : : .: . ::::::
NP_001 INWAV--NG---ISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFII
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 NGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSMLAR
:: ::: .. . . ... : .. :. : :... .. . . .:
NP_001 NGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHYLEN
180 190 200 210 220 230
250 260 270 280 290
pF1KB3 GGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEMM--
: .. .. : :. .:. ....:: :: .:....: :: ..
NP_001 G-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRN
240 250 260 270 280
300 310 320 330 340 350
pF1KB3 ---EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
.:.. ..:. :.: .::..: .: .: . : : : .. . .
NP_001 SVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---ICIH
290 300 310 320 330
360 370 380 390 400 410
pF1KB3 DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
.:.: :.: :...:. : :. :. : :... : :. ....:
NP_001 LKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKGSLPLMELP
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB3 VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
NP_001 TDHTVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTME
400 410 420 430 440 450
>>NP_001269708 (OMIM: 602000) DNA-directed RNA polymeras (996 aa)
initn: 1185 init1: 368 opt: 416 Z-score: 507.3 bits: 105.6 E(85289): 1.6e-21
Smith-Waterman score: 1328; 29.8% identity (56.2% similar) in 1071 aa overlap (155-1171:1-993)
130 140 150 160 170 180
pF1KB3 YVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGY
:..: : : .: . : : .: . :::
NP_001 MVKSKLCNLRNLPPQALIEHHEEAEEMGGY
10 20 30
190 200 210 220 230
pF1KB3 FIINGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSM
::::: ::: .. . . ... : .. :. : :... .. . . .
NP_001 FIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHY
40 50 60 70 80
240 250 260 270 280 290
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEM
: : .. .. : :. .:. ....:: :: .:....: :: .
NP_001 LENG-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSF
90 100 110 120 130
300 310 320 330 340 350
pF1KB3 M-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHV
. .:.. ..:. :.: .::..: .: .: . : : : .. .
NP_001 LRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---I
140 150 160 170 180 190
360 370 380 390 400 410
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
. .:.: :.: :...:. : :. :. : :... : :. .... ...
NP_001 CIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGW
200 210 220 230 240 250
420 430 440 450 460
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-A
: ..: .: .. . ... ::.. :. .: .:::: .. . .
NP_001 LVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDS
260 270 280 290 300 310
470 480 490 500 510 520
pF1KB3 GVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAVG
:. : ..:.: :::.: .. : : .:. :.: ::..::..::.:. :
NP_001 GLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCG
320 330 340 350 360 370
530 540 550 560 570
pF1KB3 LVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHKD
:...: :. .. . : .: . .. .. . .. ....: :: . ::
NP_001 LMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKD
380 390 400 410 420 430
580 590 600 610 620 630
pF1KB3 -PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEK
. ..::. ::.. :.... .. .. . ..: :. ::.
NP_001 LAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV-----
440 450 460 470 480
640 650 660 670 680 690
pF1KB3 QKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYC
:.: : :. : : :.:. . .:. :.. .
NP_001 QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------FA
490 500 510
700 710 720 730 740 750
pF1KB3 STYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
.. :: :. : .:.: :..::: :::::::: :: ::::.:: . ... : :. .
NP_001 GVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYR
520 530 540 550 560 570
760 770 780 790 800 810
pF1KB3 LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVF
: ::.::: ..: . . : : :.:::. :::::..::..:.:... .::: ..
NP_001 LQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSV
580 590 600 610 620 630
820 830 840 850 860
pF1KB3 YRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVII
:.: .:. : :. :: :: . .::::::: :.... :
NP_001 YKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPYY
640 650 660 670 680
870 880 890 900 910 920
pF1KB3 GKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIRV
. : . :: : .:..: .::.. : :. : .: : .
NP_001 SYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCITM
690 700 710 720 730
930 940 950 960 970 980
pF1KB3 RSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIE
: : : ::::::::::::: . . :::::: :..:::..:::..::::::: :::
NP_001 RVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIE
740 750 760 770 780 790
990 1000 1010 1020 1030 1040
pF1KB3 CLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQ
. :: .: .: ::::: .. .. ....:. ::.. :.: ::.:..: .. ..
NP_001 SMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEAD
800 810 820 830 840 850
1050 1060 1070 1080 1090 1100
pF1KB3 IFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAA
:::: .:::::.:::.::.. :. : . .. ::. ::. .::.:::::::: .:::..
NP_001 IFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTS
860 870 880 890 900 910
1110 1120 1130 1140 1150
pF1KB3 QFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLVR
.:..:::. :: .::: :: . . . :.. :.: : . :. :
NP_001 FLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVS
920 930 940 950 960 970
1160 1170
pF1KB3 MPYACKLLFQELMSMSIAPRMMSV
.::. . . :: .:.: ..
NP_001 VPYVFRYFVAELAAMNIKVKLDVV
980 990
>>NP_001269706 (OMIM: 602000) DNA-directed RNA polymeras (996 aa)
initn: 1185 init1: 368 opt: 416 Z-score: 507.3 bits: 105.6 E(85289): 1.6e-21
Smith-Waterman score: 1328; 29.8% identity (56.2% similar) in 1071 aa overlap (155-1171:1-993)
130 140 150 160 170 180
pF1KB3 YVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGY
:..: : : .: . : : .: . :::
NP_001 MVKSKLCNLRNLPPQALIEHHEEAEEMGGY
10 20 30
190 200 210 220 230
pF1KB3 FIINGSEKV--LIAQEKMATNTVYVFAKKDSK---YAYTGECRSCLENSSRPTSTIWVSM
::::: ::: .. . . ... : .. :. : :... .. . . .
NP_001 FIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVN-MNLHY
40 50 60 70 80
240 250 260 270 280 290
pF1KB3 LARGGQGAKKSAIGQRIVATLPYIKQE--VPIIIVFRALGFVSDRDILEHIIYDFEDPEM
: : .. .. : :. .:. ....:: :: .:....: :: .
NP_001 LENG-----------TVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSF
90 100 110 120 130
300 310 320 330 340 350
pF1KB3 M-----EMVKPSLDEAFVIQEQNVALNFIGS-RGAKPGVTKEKRIKYAKEVLQKEMLPHV
. .:.. ..:. :.: .::..: .: .: . : : : .. .
NP_001 LRNSVSQMLRIVMEEGCSTQKQ--VLNYLGECFRVKLNVPDWYPNEQAAEFLFNQC---I
140 150 160 170 180 190
360 370 380 390 400 410
pF1KB3 GVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNL
. .:.: :.: :...:. : :. :. : :... : :. .... ...
NP_001 CIHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGW
200 210 220 230 240 250
420 430 440 450 460
pF1KB3 LKEVRIYAQKFIDRGKDFNLELAIKTRIISDGL------KYSLATGNWGDQKKAHQAR-A
: ..: .: .. . ... ::.. :. .: .:::: .. . .
NP_001 LVSIKIAFDKKAQK-TSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDS
260 270 280 290 300 310
470 480 490 500 510 520
pF1KB3 GVSQVLNRLTFASTLSHLRRLNSPIGRD-GKLAKP--RQLHNTLWGMVCPAETPEGHAVG
:. : ..:.: :::.: .. : : .:. :.: ::..::..::.:. :
NP_001 GLCVVADKLNFIRYLSHFRCVHR--GADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCG
320 330 340 350 360 370
530 540 550 560 570
pF1KB3 LVKNL-ALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVG-IHKD
:...: :. .. . : .: . .. .. . .. ....: :: . ::
NP_001 LMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDGVMVGWVDKD
380 390 400 410 420 430
580 590 600 610 620 630
pF1KB3 -PEQLMNTLRK---LRRQ-----MDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEK
. ..::. ::.. :.... .. .. . ..: :. ::.
NP_001 LAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPG-LFLFTTPCRLVRPV-----
440 450 460 470 480
640 650 660 670 680 690
pF1KB3 QKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYC
:.: : :. : : :.:. . .:. :.. .
NP_001 QNLALGKE------------------------ELIGTMEQIFMNVAIFEDEV------FA
490 500 510
700 710 720 730 740 750
pF1KB3 STYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHV
.. :: :. : .:.: :..::: :::::::: :: ::::.:: . ... : :. .
NP_001 GVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYR
520 530 540 550 560 570
760 770 780 790 800 810
pF1KB3 LYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVF
: ::.::: ..: . . : : :.:::. :::::..::..:.:... .::: ..
NP_001 LQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSV
580 590 600 610 620 630
820 830 840 850 860
pF1KB3 YRS--YKEQESKKGFDQEEVFE-KPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVII
:.: .:. : :. :: :: . .::::::: :.... :
NP_001 YKSEFIDLSEKIKQGDSSLVFGIKPGDPR-------VLQKLDDDGLPFIGAKLQYGDPYY
640 650 660 670 680
870 880 890 900 910 920
pF1KB3 GKTVTLPENEDELESTNRRY-TKRDCSTFLRTSETGIVDQVMVTLNQEG---YKFCKIRV
. : . :: : .:..: .::.. : :. : .: : .
NP_001 SYL-----NLNTGESFVMYYKSKENC----------VVDNIKVCSNDTGSGKFKCVCITM
690 700 710 720 730
930 940 950 960 970 980
pF1KB3 RSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIE
: : : ::::::::::::: . . :::::: :..:::..:::..::::::: :::
NP_001 RVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIE
740 750 760 770 780 790
990 1000 1010 1020 1030 1040
pF1KB3 CLQGKVSANKGEIGDATPF---NDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQ
. :: .: .: ::::: .. .. ....:. ::.. :.: ::.:..: .. ..
NP_001 SMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEAD
800 810 820 830 840 850
1050 1060 1070 1080 1090 1100
pF1KB3 IFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAA
:::: .:::::.:::.::.. :. : . .. ::. ::. .::.:::::::: .:::..
NP_001 IFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTS
860 870 880 890 900 910
1110 1120 1130 1140 1150
pF1KB3 QFLRERLFEASDPYQVHVCNLCGIM----------AIANTRTHTYECRGCRNKTQISLVR
.:..:::. :: .::: :: . . . :.. :.: : . :. :
NP_001 FLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVS
920 930 940 950 960 970
1160 1170
pF1KB3 MPYACKLLFQELMSMSIAPRMMSV
.::. . . :: .:.: ..
NP_001 VPYVFRYFVAELAAMNIKVKLDVV
980 990
1174 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:40:44 2016 done: Thu Nov 3 13:40:46 2016
Total Scan time: 14.510 Total Display time: 0.540
Function used was FASTA [36.3.4 Apr, 2011]