Result of FASTA (omim) for
pF1KB3674
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3674, 515 aa
1>>>pF1KB3674 515 - 515 aa - 515 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.5701+/-0.000503; mu= -20.8222+/- 0.031
mean_var=730.8111+/-161.451, 0's: 0 Z-trim(121.4): 899 B-trim: 2258 in 1/56
Lambda= 0.047443
statistics sampled from 36762 (38036) to 36762 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.446), width: 16
Scan time: 10.280
The best scores are: opt bits E(85289)
NP_057315 (OMIM: 609476) serine/threonine-protein ( 527) 3544 258.2 4.3e-68
XP_005258045 (OMIM: 609476) PREDICTED: serine/thre ( 498) 2560 190.8 7.8e-48
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 948 80.8 1.7e-14
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 948 80.8 1.7e-14
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 948 80.8 1.7e-14
XP_006721620 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 78.5 8.4e-14
XP_006721622 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 78.5 8.4e-14
XP_006721621 (OMIM: 602521) PREDICTED: mitogen-act ( 822) 915 78.5 8.4e-14
NP_620407 (OMIM: 176948) mitogen-activated protein ( 360) 865 74.7 5.3e-13
NP_002736 (OMIM: 176948) mitogen-activated protein ( 360) 865 74.7 5.3e-13
NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357) 847 73.4 1.2e-12
NP_002737 (OMIM: 601795) mitogen-activated protein ( 379) 847 73.5 1.3e-12
NP_002742 (OMIM: 602898) mitogen-activated protein ( 364) 821 71.7 4.3e-12
NP_620581 (OMIM: 600289) mitogen-activated protein ( 360) 810 70.9 7.2e-12
NP_001306 (OMIM: 600289) mitogen-activated protein ( 360) 785 69.2 2.4e-11
XP_011512612 (OMIM: 600289) PREDICTED: mitogen-act ( 401) 777 68.7 3.7e-11
NP_002960 (OMIM: 602399) mitogen-activated protein ( 367) 758 67.3 8.6e-11
XP_016865788 (OMIM: 600289) PREDICTED: mitogen-act ( 328) 752 66.9 1.1e-10
NP_002745 (OMIM: 602899) mitogen-activated protein ( 365) 743 66.3 1.7e-10
XP_016865790 (OMIM: 600289) PREDICTED: mitogen-act ( 301) 735 65.7 2.2e-10
NP_620582 (OMIM: 600289) mitogen-activated protein ( 297) 732 65.5 2.6e-10
XP_016865793 (OMIM: 600289) PREDICTED: mitogen-act ( 258) 725 64.9 3.3e-10
XP_016865789 (OMIM: 600289) PREDICTED: mitogen-act ( 328) 727 65.2 3.5e-10
NP_620583 (OMIM: 600289) mitogen-activated protein ( 307) 725 65.0 3.7e-10
XP_016863923 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863925 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863927 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863926 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863924 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863928 (OMIM: 602897) PREDICTED: mitogen-act ( 384) 721 64.8 5.1e-10
XP_016863921 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 721 64.9 5.4e-10
NP_002744 (OMIM: 602897) mitogen-activated protein ( 422) 721 64.9 5.4e-10
XP_016863919 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 721 64.9 5.4e-10
XP_005263192 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 721 64.9 5.4e-10
XP_016863918 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 721 64.9 5.4e-10
XP_016863920 (OMIM: 602897) PREDICTED: mitogen-act ( 422) 721 64.9 5.4e-10
XP_016863912 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_006714331 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_011530422 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_016863914 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_016863915 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_016863913 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
NP_620446 (OMIM: 602897) mitogen-activated protein ( 426) 721 64.9 5.5e-10
XP_011530423 (OMIM: 602897) PREDICTED: mitogen-act ( 426) 721 64.9 5.5e-10
XP_016863909 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
XP_011530419 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
XP_011530420 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
XP_005263186 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
XP_005263187 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
XP_016863908 (OMIM: 602897) PREDICTED: mitogen-act ( 464) 721 64.9 5.8e-10
>>NP_057315 (OMIM: 609476) serine/threonine-protein kina (527 aa)
initn: 3544 init1: 3544 opt: 3544 Z-score: 1343.5 bits: 258.2 E(85289): 4.3e-68
Smith-Waterman score: 3544; 100.0% identity (100.0% similar) in 515 aa overlap (1-515:13-527)
10 20 30 40
pF1KB3 MAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB3 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB3 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB3 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB3 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB3 SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB3 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
430 440 450 460 470 480
470 480 490 500 510
pF1KB3 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
:::::::::::::::::::::::::::::::::::::::::::::::
NP_057 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
490 500 510 520
>>XP_005258045 (OMIM: 609476) PREDICTED: serine/threonin (498 aa)
initn: 3336 init1: 2560 opt: 2560 Z-score: 979.8 bits: 190.8 E(85289): 7.8e-48
Smith-Waterman score: 3282; 94.4% identity (94.4% similar) in 515 aa overlap (1-515:13-498)
10 20 30 40
pF1KB3 MAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB3 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB3 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB3 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB3 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB3 SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
::::::::::::::::::::::: ::::::::
XP_005 SLEAMRTACEGAKAHILRGPHKQ-----------------------------SKRISAKD
370 380 390
410 420 430 440 450 460
pF1KB3 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
400 410 420 430 440 450
470 480 490 500 510
pF1KB3 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
460 470 480 490
>>NP_620603 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 928 init1: 361 opt: 948 Z-score: 381.0 bits: 80.8 E(85289): 1.7e-14
Smith-Waterman score: 968; 41.7% identity (66.4% similar) in 434 aa overlap (89-510:16-426)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
NP_620 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
NP_620 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220 230
pF1KB3 LCFFKHDNVLSALDILQPPHIDY--FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLY
: :::::... :::.: . : :. .::: .::.::::.:: : :::. .::. :::
NP_620 LKHFKHDNIIAIKDILRPT-VPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLY
110 120 130 140 150 160
240 250 260 270 280 290
pF1KB3 QILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MTQEVVT
:.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::. :.:
NP_620 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB3 QYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE
..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .:::::
NP_620 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB3 AMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDAL
..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::: ::
NP_620 VIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARISAAAAL
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB3 AHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIH
::.: .:: : :: : :: .:... . ...:: :
NP_620 RHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERIKEAIV
350 360 370 380
480 490 500 510
pF1KB3 QFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
: . ...: : . ..:. : . : .:: ::
NP_620 AEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCP
390 400 410 420 430 440
NP_620 GPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAP
450 460 470 480 490 500
>>NP_620602 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 928 init1: 361 opt: 948 Z-score: 381.0 bits: 80.8 E(85289): 1.7e-14
Smith-Waterman score: 968; 41.7% identity (66.4% similar) in 434 aa overlap (89-510:16-426)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
NP_620 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
NP_620 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220 230
pF1KB3 LCFFKHDNVLSALDILQPPHIDY--FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLY
: :::::... :::.: . : :. .::: .::.::::.:: : :::. .::. :::
NP_620 LKHFKHDNIIAIKDILRPT-VPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLY
110 120 130 140 150 160
240 250 260 270 280 290
pF1KB3 QILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MTQEVVT
:.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::. :.:
NP_620 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB3 QYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE
..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .:::::
NP_620 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB3 AMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDAL
..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::: ::
NP_620 VIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARISAAAAL
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB3 AHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIH
::.: .:: : :: : :: .:... . ...:: :
NP_620 RHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERIKEAIV
350 360 370 380
480 490 500 510
pF1KB3 QFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
: . ...: : . ..:. : . : .:: ::
NP_620 AEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCP
390 400 410 420 430 440
NP_620 GPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAP
450 460 470 480 490 500
>>NP_002740 (OMIM: 602521) mitogen-activated protein kin (816 aa)
initn: 928 init1: 361 opt: 948 Z-score: 381.0 bits: 80.8 E(85289): 1.7e-14
Smith-Waterman score: 968; 41.7% identity (66.4% similar) in 434 aa overlap (89-510:16-426)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
NP_002 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
NP_002 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220 230
pF1KB3 LCFFKHDNVLSALDILQPPHIDY--FEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLY
: :::::... :::.: . : :. .::: .::.::::.:: : :::. .::. :::
NP_002 LKHFKHDNIIAIKDILRPT-VPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLY
110 120 130 140 150 160
240 250 260 270 280 290
pF1KB3 QILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MTQEVVT
:.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::. :.:
NP_002 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB3 QYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE
..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .:::::
NP_002 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB3 AMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDAL
..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::: ::
NP_002 VIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARISAAAAL
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB3 AHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIH
::.: .:: : :: : :: .:... . ...:: :
NP_002 RHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERIKEAIV
350 360 370 380
480 490 500 510
pF1KB3 QFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
: . ...: : . ..:. : . : .:: ::
NP_002 AEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCP
390 400 410 420 430 440
NP_002 GPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAP
450 460 470 480 490 500
>>XP_006721620 (OMIM: 602521) PREDICTED: mitogen-activat (822 aa)
initn: 916 init1: 349 opt: 915 Z-score: 368.8 bits: 78.5 E(85289): 8.4e-14
Smith-Waterman score: 949; 41.2% identity (65.4% similar) in 439 aa overlap (89-510:16-432)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
XP_006 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
XP_006 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220
pF1KB3 LCFFKHDNVLSALDILQP--PH-----IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHV
: :::::... :::.: :. . : ::: .::.::::.:: : :::. .::
XP_006 LKHFKHDNIIAIKDILRPTVPYGEFKSVPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 KVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MT
. ::::.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::
XP_006 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMT
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 QEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLG
. :.:..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .::
XP_006 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLG
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB3 TPSLEAMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS
::: ..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::
XP_006 TPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARIS
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB3 AKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQV
: :: ::.: .:: : :: : :: .:... . ...
XP_006 AAAALRHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERI
350 360 370 380
470 480 490 500 510
pF1KB3 KEIIHQFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
:: : : . ...: : . ..:. : . : .:: ::
XP_006 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
390 400 410 420 430 440
XP_006 PPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSA
450 460 470 480 490 500
>>XP_006721622 (OMIM: 602521) PREDICTED: mitogen-activat (822 aa)
initn: 916 init1: 349 opt: 915 Z-score: 368.8 bits: 78.5 E(85289): 8.4e-14
Smith-Waterman score: 949; 41.2% identity (65.4% similar) in 439 aa overlap (89-510:16-432)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
XP_006 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
XP_006 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220
pF1KB3 LCFFKHDNVLSALDILQP--PH-----IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHV
: :::::... :::.: :. . : ::: .::.::::.:: : :::. .::
XP_006 LKHFKHDNIIAIKDILRPTVPYGEFKSVPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 KVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MT
. ::::.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::
XP_006 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMT
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 QEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLG
. :.:..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .::
XP_006 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLG
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB3 TPSLEAMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS
::: ..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::
XP_006 TPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARIS
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB3 AKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQV
: :: ::.: .:: : :: : :: .:... . ...
XP_006 AAAALRHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERI
350 360 370 380
470 480 490 500 510
pF1KB3 KEIIHQFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
:: : : . ...: : . ..:. : . : .:: ::
XP_006 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
390 400 410 420 430 440
XP_006 PPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSA
450 460 470 480 490 500
>>XP_006721621 (OMIM: 602521) PREDICTED: mitogen-activat (822 aa)
initn: 916 init1: 349 opt: 915 Z-score: 368.8 bits: 78.5 E(85289): 8.4e-14
Smith-Waterman score: 949; 41.2% identity (65.4% similar) in 439 aa overlap (89-510:16-432)
60 70 80 90 100 110
pF1KB3 AAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSH
. :::. : ::.. :..:: : . .:
XP_006 MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSF
10 20 30 40
120 130 140 150 160 170
pF1KB3 HPQQQLDIEPD--RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKM
.. : . . :: ::.::: :. :..::.::.::.:. ... ::..::::.
XP_006 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI
50 60 70 80 90 100
180 190 200 210 220
pF1KB3 LCFFKHDNVLSALDILQP--PH-----IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHV
: :::::... :::.: :. . : ::: .::.::::.:: : :::. .::
XP_006 LKHFKHDNIIAIKDILRPTVPYGEFKSVPYGVPGYVVLDLMESDLHQIIHSSQPLTLEHV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 KVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRH---MT
. ::::.::::::.::: ..:::.::.::::: :: ::: :::.:: . ..: ::
XP_006 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMT
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 QEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLG
. :.:..:::::.... ..:..:::.:::::::.:.:.:: :: ... ..::.:: .::
XP_006 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLG
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB3 TPSLEAMRTA-CEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS
::: ..... : ..:.: : .:: .: :. : ..:. :: ::: :.:: :::
XP_006 TPSPAVIQAVGAERVRAYIQSLPPRQP-VP-WETVYPGADRQALSLLGRMLRFEPSARIS
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB3 AKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQV
: :: ::.: .:: : :: : :: .:... . ...
XP_006 AAAALRHPFLA----KYHD----------------PDDEPDCAPPFDFAFDREALTRERI
350 360 370 380
470 480 490 500 510
pF1KB3 KEIIHQFILE---QQKGNRVPLCINPQSAAFKSFISST-VAQPSEMPPSPLVWE
:: : : . ...: : . ..:. : . : .:: ::
XP_006 KEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPA
390 400 410 420 430 440
XP_006 PPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSA
450 460 470 480 490 500
>>NP_620407 (OMIM: 176948) mitogen-activated protein kin (360 aa)
initn: 813 init1: 291 opt: 865 Z-score: 354.4 bits: 74.7 E(85289): 5.3e-13
Smith-Waterman score: 865; 45.2% identity (75.9% similar) in 303 aa overlap (122-417:17-315)
100 110 120 130 140
pF1KB3 GPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRP----IGYGAFGVVWSVTDPR
: .:. : :: ::.:.: :. :
NP_620 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNV
10 20 30 40
150 160 170 180 190 200
pF1KB3 DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVT
. :::.::. . :.. . :.:..::.:.: :.:.:... ::.. : :. ....:.:
NP_620 NKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQ
50 60 70 80 90 100
210 220 230 240 250 260
pF1KB3 ELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLK
.::..::.:.. . : ::.::. :::::::::::.:::..::::.::.:::.:..: ::
NP_620 DLMETDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK
110 120 130 140 150 160
270 280 290 300 310 320
pF1KB3 ICDFGLARVEELDESR--HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGR
::::::::: . :... .:. :.:..::::::...:. :...:::::::::.::.:.
NP_620 ICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
170 180 190 200 210 220
330 340 350 360 370 380
pF1KB3 RILFQAQSPIQQLDLITDLLGTPSLEAMRTACE-GAKAHILRGPHKQPSLPVLYTLSSQA
: .: .. ..::. : .::.:: : . . :. ..: :::. ..: : .:
NP_620 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-KVP-WNRLFPNA
230 240 250 260 270 280
390 400 410 420 430 440
pF1KB3 THEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFE
.:. :: .::.:.: ::: ...:::::::..
NP_620 DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEK
290 300 310 320 330 340
450 460 470 480 490 500
pF1KB3 PVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQP
NP_620 LKELIFEETARFQPGYRS
350 360
>>NP_002736 (OMIM: 176948) mitogen-activated protein kin (360 aa)
initn: 813 init1: 291 opt: 865 Z-score: 354.4 bits: 74.7 E(85289): 5.3e-13
Smith-Waterman score: 865; 45.2% identity (75.9% similar) in 303 aa overlap (122-417:17-315)
100 110 120 130 140
pF1KB3 GPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRP----IGYGAFGVVWSVTDPR
: .:. : :: ::.:.: :. :
NP_002 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNV
10 20 30 40
150 160 170 180 190 200
pF1KB3 DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVT
. :::.::. . :.. . :.:..::.:.: :.:.:... ::.. : :. ....:.:
NP_002 NKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQ
50 60 70 80 90 100
210 220 230 240 250 260
pF1KB3 ELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLK
.::..::.:.. . : ::.::. :::::::::::.:::..::::.::.:::.:..: ::
NP_002 DLMETDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK
110 120 130 140 150 160
270 280 290 300 310 320
pF1KB3 ICDFGLARVEELDESR--HMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGR
::::::::: . :... .:. :.:..::::::...:. :...:::::::::.::.:.
NP_002 ICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN
170 180 190 200 210 220
330 340 350 360 370 380
pF1KB3 RILFQAQSPIQQLDLITDLLGTPSLEAMRTACE-GAKAHILRGPHKQPSLPVLYTLSSQA
: .: .. ..::. : .::.:: : . . :. ..: :::. ..: : .:
NP_002 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-KVP-WNRLFPNA
230 240 250 260 270 280
390 400 410 420 430 440
pF1KB3 THEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFE
.:. :: .::.:.: ::: ...:::::::..
NP_002 DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEK
290 300 310 320 330 340
450 460 470 480 490 500
pF1KB3 PVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQP
NP_002 LKELIFEETARFQPGYRS
350 360
515 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:36:33 2016 done: Thu Nov 3 13:36:34 2016
Total Scan time: 10.280 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]