FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB3456, 359 aa 1>>>pF1KB3456 359 - 359 aa - 359 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9749+/-0.000384; mu= 17.4931+/- 0.024 mean_var=56.5884+/-11.639, 0's: 0 Z-trim(110.7): 13 B-trim: 847 in 1/50 Lambda= 0.170495 statistics sampled from 19051 (19054) to 19051 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.223), width: 16 Scan time: 6.200 The best scores are: opt bits E(85289) NP_005054 (OMIM: 604031) acyl-CoA desaturase [Homo ( 359) 2466 615.0 7.9e-176 NP_001032671 (OMIM: 608370) stearoyl-CoA desaturas ( 330) 1382 348.4 1.4e-95 NP_079182 (OMIM: 608370) stearoyl-CoA desaturase 5 ( 256) 731 188.2 1.7e-47 >>NP_005054 (OMIM: 604031) acyl-CoA desaturase [Homo sap (359 aa) initn: 2466 init1: 2466 opt: 2466 Z-score: 3277.7 bits: 615.0 E(85289): 7.9e-176 Smith-Waterman score: 2466; 99.7% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KB3 MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB3 DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB3 RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB3 HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLLMCFILPTLVPWYFWGE :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_005 HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB3 TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY 250 260 270 280 290 300 310 320 330 340 350 pF1KB3 HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG 310 320 330 340 350 >>NP_001032671 (OMIM: 608370) stearoyl-CoA desaturase 5 (330 aa) initn: 1401 init1: 1381 opt: 1382 Z-score: 1837.2 bits: 348.4 E(85289): 1.4e-95 Smith-Waterman score: 1382; 61.0% identity (82.9% similar) in 315 aa overlap (49-355:15-329) 20 30 40 50 60 70 pF1KB3 TITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSP--------KVE : :..: ... : .: . . NP_001 MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQN 10 20 30 40 80 90 100 110 120 130 pF1KB3 YVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKA ::::..:::::::::.:...::: : : ::. : ....:::.:::::::::::::.: NP_001 IVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRA 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB3 RLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKH .::::.:: .::.::::::..::.::::::::.::: :::::.::::::::.:::.:::: NP_001 KLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKH 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB3 PAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLLMCFILPTLVPWYFWGETFQNSVFVAT : ::: ::..:: :. .: .::.::: ...::::..:::::::.:::.. :: :.:. NP_001 RDVIEKGRKLDVTDLLADPVVRIQRKYYKISVVLMCFVVPTLVPWYIWGESLWNSYFLAS 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB3 FLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSA .:::.. :: .::::::::..: :::::.::::.: ::.:::.:::::::::.::.:::: NP_001 ILRYTISLNISWLVNSAAHMYGNRPYDKHISPRQNPLVALGAIGEGFHNYHHTFPFDYSA 230 240 250 260 270 280 320 330 340 350 pF1KB3 SEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG ::. ..: ::.::: : :::: :::...: : :: ::::.. NP_001 SEFGLNFNPTTWFIDFMCWLGLATDRKRATKPMIEARKARTGDSSA 290 300 310 320 330 >>NP_079182 (OMIM: 608370) stearoyl-CoA desaturase 5 iso (256 aa) initn: 730 init1: 730 opt: 731 Z-score: 973.5 bits: 188.2 E(85289): 1.7e-47 Smith-Waterman score: 731; 58.9% identity (80.0% similar) in 175 aa overlap (49-215:15-189) 20 30 40 50 60 70 pF1KB3 TITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSP--------KVE : :..: ... : .: . . NP_079 MPGPATDAGKIPFCDAKEEIRAGLESSEGGGGPERPGARGQRQN 10 20 30 40 80 90 100 110 120 130 pF1KB3 YVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKA ::::..:::::::::.:...::: : : ::. : ....:::.:::::::::::::.: NP_079 IVWRNVVLMSLLHLGAVYSLVLIPKAKPLTLLWAYFCFLLAALGVTAGAHRLWSHRSYRA 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB3 RLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKH .::::.:: .::.::::::..::.::::::::.::: :::::.::::::::.:::.:::: NP_079 KLPLRIFLAVANSMAFQNDIFEWSRDHRAHHKYSETDADPHNARRGFFFSHIGWLFVRKH 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB3 PAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLLMCFILPTLVPWYFWGETFQNSVFVAT : ::: ::..:: :. .: .:: NP_079 RDVIEKGRKLDVTDLLADPVVRIQRNTQHIQKEGRALNQEAACEMLREWHQGHILKVTLP 170 180 190 200 210 220 359 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 05:07:01 2016 done: Sat Nov 5 05:07:02 2016 Total Scan time: 6.200 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]