Result of FASTA (omim) for
pF1KB3445
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3445, 202 aa
1>>>pF1KB3445 202 - 202 aa - 202 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6853+/-0.000332; mu= 16.8112+/- 0.020
mean_var=59.3355+/-11.935, 0's: 0 Z-trim(116.0): 31 B-trim: 40 in 1/53
Lambda= 0.166501
statistics sampled from 26787 (26819) to 26787 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.314), width: 16
Scan time: 5.050
The best scores are: opt bits E(85289)
XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 202) 1468 360.4 1.1e-99
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 977 242.7 5.8e-64
XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 455) 977 242.7 6.6e-64
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 861 214.8 1.4e-55
XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 442) 861 214.9 1.6e-55
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 810 202.4 4e-52
XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 227) 556 141.4 1.1e-33
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 525 134.1 2.6e-31
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 525 134.1 2.8e-31
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 435 112.5 9e-25
XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 524) 435 112.6 1.1e-24
XP_006724353 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 317) 400 104.0 2.6e-22
XP_016884393 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 457) 400 104.1 3.5e-22
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 384 100.0 2.6e-21
NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 378 98.6 7.1e-21
NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 363 95.0 8.1e-20
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 342 89.9 2.7e-18
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 338 89.0 5.2e-18
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 338 89.0 5.6e-18
XP_011528294 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 200) 338 89.0 5.6e-18
XP_011528292 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 338 89.0 5.7e-18
XP_011528293 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 338 89.0 5.7e-18
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 285 76.3 4.2e-14
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 280 75.0 8.4e-14
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 280 75.1 9.9e-14
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 280 75.1 9.9e-14
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 262 70.7 1.7e-12
XP_011519075 (OMIM: 605257,605258) PREDICTED: sing ( 145) 260 70.2 1.9e-12
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 247 67.1 1.7e-11
NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 213 58.8 3.6e-09
XP_016884132 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 101) 213 58.8 3.6e-09
>>XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (202 aa)
initn: 1468 init1: 1468 opt: 1468 Z-score: 1910.7 bits: 360.4 E(85289): 1.1e-99
Smith-Waterman score: 1468; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
130 140 150 160 170 180
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
::::::::::::::::::::::
XP_005 KPWKGLQTNFRLLKRRLREILQ
190 200
>>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa)
initn: 977 init1: 977 opt: 977 Z-score: 1269.3 bits: 242.7 E(85289): 5.8e-64
Smith-Waterman score: 1080; 77.3% identity (84.8% similar) in 198 aa overlap (5-202:201-386)
10 20 30
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: ::. .:
NP_689 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW
180 190 200 210 220 230
40 50 60 70 80 90
pF1KB3 LCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSP
::. ... . .: .. ::::. .::::::::::::::::::::::::
NP_689 LCFTMEVTKHHSAVFRKRGVFRN------------QVDPETHCHAERCFLSWFCDDILSP
240 250 260 270
100 110 120 130 140 150
pF1KB3 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
280 290 300 310 320 330
160 170 180 190 200
pF1KB3 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
340 350 360 370 380
>--
initn: 949 init1: 949 opt: 949 Z-score: 1233.0 bits: 236.0 E(85289): 6.1e-62
Smith-Waterman score: 949; 66.0% identity (81.5% similar) in 200 aa overlap (1-200:1-200)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
::::::::::: . . ::: ::::::: . : : ...::..::.:: :. .:..::
NP_689 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
:.: ::.::: .::: :. : :.. : : . :: :::: :.::. ::.::: .. .::
NP_689 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPF
130 140 150 160 170 180
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. :.: :.::
NP_689 MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH
190 200 210 220 230 240
>>XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (455 aa)
initn: 977 init1: 977 opt: 977 Z-score: 1268.3 bits: 242.7 E(85289): 6.6e-64
Smith-Waterman score: 1080; 77.3% identity (84.8% similar) in 198 aa overlap (5-202:270-455)
10 20 30
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: ::. .:
XP_016 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW
240 250 260 270 280 290
40 50 60 70 80 90
pF1KB3 LCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSP
::. ... . .: .. ::::. .::::::::::::::::::::::::
XP_016 LCFTMEVTKHHSAVFRKRGVFRN------------QVDPETHCHAERCFLSWFCDDILSP
300 310 320 330 340
100 110 120 130 140 150
pF1KB3 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
350 360 370 380 390 400
160 170 180 190 200
pF1KB3 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
410 420 430 440 450
>--
initn: 962 init1: 812 opt: 812 Z-score: 1054.1 bits: 203.1 E(85289): 5.6e-52
Smith-Waterman score: 812; 70.6% identity (83.4% similar) in 163 aa overlap (1-163:1-163)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
::::::::::: . . ::: ::::::: . : : ...::..::.:: :. .:..::
XP_016 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
:.: ::.::: .::: :. : :.. : : . :: :::: :.
XP_016 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
130 140 150 160 170 180
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
XP_016 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
190 200 210 220 230 240
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 1518 init1: 847 opt: 861 Z-score: 1118.9 bits: 214.8 E(85289): 1.4e-55
Smith-Waterman score: 985; 70.2% identity (81.3% similar) in 198 aa overlap (5-202:188-373)
10 20 30
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: :::. .:
NP_660 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
160 170 180 190 200 210
40 50 60 70 80 90
pF1KB3 LCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSP
::. ... . .: . : ::::. .::::::::::::::::::::::::
NP_660 LCFTMEVVKHHSPVSWKRGVFRN------------QVDPETHCHAERCFLSWFCDDILSP
220 230 240 250 260
100 110 120 130 140 150
pF1KB3 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
::::::::::::::::::::::::::::::::::::::::: ::::::::::: ::::::
NP_660 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEG
270 280 290 300 310 320
160 170 180 190 200
pF1KB3 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
:::.::::::: ::.::::.:::::::::::. :: .: .:.:::.
NP_660 ASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
330 340 350 360 370
>--
initn: 701 init1: 524 opt: 708 Z-score: 920.3 bits: 178.1 E(85289): 1.6e-44
Smith-Waterman score: 708; 51.5% identity (72.5% similar) in 200 aa overlap (1-200:1-187)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::: :
NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
. :: : ::: ::::::: . : ...::..::.:::.:....::::
NP_660 SQ----------PE-H-HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
:.: ::.::: .::: :.:. ::...:: ::: :: :::: ..:. ::.:::::. .::
NP_660 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPF
110 120 130 140 150 160
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. .:.: :.::
NP_660 MPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKH
170 180 190 200 210 220
>>XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (442 aa)
initn: 1499 init1: 847 opt: 861 Z-score: 1117.9 bits: 214.9 E(85289): 1.6e-55
Smith-Waterman score: 985; 70.2% identity (81.3% similar) in 198 aa overlap (5-202:257-442)
10 20 30
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: :::. .:
XP_011 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
230 240 250 260 270 280
40 50 60 70 80 90
pF1KB3 LCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSP
::. ... . .: . : ::::. .::::::::::::::::::::::::
XP_011 LCFTMEVVKHHSPVSWKRGVFRN------------QVDPETHCHAERCFLSWFCDDILSP
290 300 310 320 330
100 110 120 130 140 150
pF1KB3 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
::::::::::::::::::::::::::::::::::::::::: ::::::::::: ::::::
XP_011 NTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEG
340 350 360 370 380 390
160 170 180 190 200
pF1KB3 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
:::.::::::: ::.::::.:::::::::::. :: .: .:.:::.
XP_011 ASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
400 410 420 430 440
>--
initn: 677 init1: 377 opt: 561 Z-score: 728.4 bits: 142.8 E(85289): 7.8e-34
Smith-Waterman score: 561; 53.1% identity (71.9% similar) in 160 aa overlap (1-160:1-147)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::: :
XP_011 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
. :: : ::: ::::::: . : ...::..::.:::.:....::::
XP_011 SQ----------PE-H-HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
:.: ::.::: .::: :.:. ::...:: ::: :: ::::
XP_011 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMK
110 120 130 140 150 160
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
XP_011 DGWICNAMAGGVPGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWEN
170 180 190 200 210 220
>--
initn: 165 init1: 150 opt: 151 Z-score: 196.2 bits: 44.3 E(85289): 0.00035
Smith-Waterman score: 151; 38.0% identity (74.0% similar) in 50 aa overlap (151-200:207-256)
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
: .. ... . ..:. ::.:::::. .::
XP_011 GGVPGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPF
180 190 200 210 220 230
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. .:.: :.::
XP_011 MPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKH
240 250 260 270 280 290
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 799 init1: 799 opt: 810 Z-score: 1056.8 bits: 202.4 E(85289): 4e-52
Smith-Waterman score: 952; 70.4% identity (80.3% similar) in 203 aa overlap (1-202:1-190)
10 20 30 40 50
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGPV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.
NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRN--
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 LPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEF
.:: :::::::::::::::::::::::.:.:::::::::::.::::::::
NP_055 ----------QVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEF
60 70 80 90 100
120 130 140 150 160 170
pF1KB3 LARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEP
:::::::::::::::: :: ::::: ::::::..:.:: :.:: ::.::::.:.::
NP_055 LARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEP
110 120 130 140 150 160
180 190 200
pF1KB3 FKPWKGLQTNFRLLKRRLREILQ
:::::::.:::::::::::: ::
NP_055 FKPWKGLKTNFRLLKRRLRESLQ
170 180 190
>>XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (227 aa)
initn: 685 init1: 530 opt: 556 Z-score: 726.0 bits: 141.4 E(85289): 1.1e-33
Smith-Waterman score: 714; 51.5% identity (72.8% similar) in 202 aa overlap (1-202:1-189)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::: :
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
. :: : ::: ::::::: . : ...::..::.:::.:....::::
XP_016 SQ----------PE-H-HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
60 70 80 90 100
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
:.: ::.::: .::: :.:. ::...:: ::: :: :::: ..:. ::.:::::. .::
XP_016 AEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPF
110 120 130 140 150 160
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. .:.: :.:::.
XP_016 MPWYKFDDNYAFLHRTLKEILRATSIHLRGRPPHSLGSPTWLLPSPWHNRICHKTGRKWA
170 180 190 200 210 220
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 928 init1: 522 opt: 525 Z-score: 683.0 bits: 134.1 E(85289): 2.6e-31
Smith-Waterman score: 906; 61.9% identity (79.2% similar) in 202 aa overlap (1-202:1-190)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
: : ::: ::::::: . : ...::..::.:::.:....::::
NP_001 FKPQY------------HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
70 80 90 100
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
..: ::.::: .::: :.:. ::...:: ::: :: :::: :..:. ::.::::.. . :
NP_001 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQF
110 120 130 140 150 160
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. .:.: :.:::.
NP_001 MPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTW
170 180 190 200 210 220
>--
initn: 402 init1: 178 opt: 361 Z-score: 470.1 bits: 94.7 E(85289): 1.9e-19
Smith-Waterman score: 390; 39.9% identity (61.1% similar) in 193 aa overlap (12-202:193-353)
10 20 30 40
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKI
: ::: ::.:.:.. : :.:::::.
NP_001 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVE-
170 180 190 200 210 220
50 60 70 80 90 100
pF1KB3 KRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVT
: :.:.. :: ...: ....:.. :.: :.::
NP_001 -R------LDNGTW---VL---MDQH----------------MGFLCNE-LDPAQIYRVT
230 240 250
110 120 130 140 150
pF1KB3 WYTSWSPCPE--CAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKI
:. ::::: ::::: :: ....: : ::.::. : .: :.:.: : . ::.:.:
NP_001 WFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARI-YDYDPLYKEALQMLRDAGAQVSI
260 270 280 290 300 310
160 170 180 190 200
pF1KB3 MGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
: : .: :: .::: . ::.:: ::. . . :. ::: :::
NP_001 MTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
320 330 340 350
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 928 init1: 522 opt: 525 Z-score: 682.6 bits: 134.1 E(85289): 2.8e-31
Smith-Waterman score: 906; 61.9% identity (79.2% similar) in 202 aa overlap (1-202:1-190)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFL
: : ::: ::::::: . : ...::..::.:::.:....::::
NP_004 FKPQY------------HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
70 80 90 100
130 140 150 160 170 180
pF1KB3 ARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPF
..: ::.::: .::: :.:. ::...:: ::: :: :::: :..:. ::.::::.. . :
NP_004 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQF
110 120 130 140 150 160
190 200
pF1KB3 KPWKGLQTNFRLLKRRLREILQ
:: .. :. .:.: :.:::.
NP_004 MPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTW
170 180 190 200 210 220
>--
initn: 425 init1: 178 opt: 413 Z-score: 537.2 bits: 107.2 E(85289): 3.5e-23
Smith-Waterman score: 413; 40.9% identity (60.6% similar) in 198 aa overlap (12-202:193-378)
10 20 30 40
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKI
: ::: ::.:.:.. : :.:::::.
NP_004 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVE-
170 180 190 200 210 220
50 60 70 80 90
pF1KB3 KRGRSNLLWDTGVFRGPVLPKRQSNHRQEVDPETHC-----HAERCFLSWFCDDILSPNT
: :.:.. :: .. . . . : ::: ::. . :.:
NP_004 -R------LDNGTW---VLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQ
230 240 250 260 270
100 110 120 130 140 150
pF1KB3 NYEVTWYTSWSPCPE--CAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEG
:.:::. ::::: ::::: :: ....: : ::.::. : .: :.:.: : . :
NP_004 IYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARI-YDYDPLYKEALQMLRDAG
280 290 300 310 320 330
160 170 180 190 200
pF1KB3 ASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
:.:.:: : .: :: .::: . ::.:: ::. . . :. ::: :::
NP_004 AQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
340 350 360 370 380
>>NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme APO (384 aa)
initn: 557 init1: 254 opt: 435 Z-score: 565.7 bits: 112.5 E(85289): 9e-25
Smith-Waterman score: 587; 48.8% identity (66.7% similar) in 207 aa overlap (1-202:1-194)
10 20 30 40 50 60
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::
NP_068 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPPLDAKIFRG---
10 20 30 40 50
70 80 90 100 110
pF1KB3 PKRQSNHRQEVDPETHCHAERCFLSWFCD-DILSPNTNYEVTWYTSWSPCPECAGEVAEF
.: : . : : :. :: : . .:::::: ::::: .:. ..: :
NP_068 ---------QVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATF
60 70 80 90 100
120 130 140 150 160 170
pF1KB3 LARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQ--EG--ASVKIMGYKDFVSCWKNFVYS
::. .:.::::.::: :::: ::::.: :: : .: :..:::.: .: ::..::::
NP_068 LAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYS
110 120 130 140 150 160
180 190 200
pF1KB3 DDEPFKPWKGLQTNFRLLKRRLREILQ
. : :.::..: . ::. : :::.
NP_068 QRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERM
170 180 190 200 210 220
>--
initn: 468 init1: 192 opt: 415 Z-score: 539.8 bits: 107.7 E(85289): 2.5e-23
Smith-Waterman score: 415; 41.2% identity (65.8% similar) in 187 aa overlap (16-202:201-380)
10 20 30 40
pF1KB3 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGR
:: ::.::: . :: :.:::::. ..
NP_068 LFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHND
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB3 SNLLWDTGVFRGPVLPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTS
. .: . :: . :. :.. : :: :::. . :. . .:.:: .::
NP_068 TWVLLNQ--RRGFLC--NQAPHKHGFLEGRH--AELCFLDVIPFWKLDLDQDYRVTCFTS
240 250 260 270 280
110 120 130 140 150 160
pF1KB3 WSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDF
:::: :: :.:.:......:.: :::::. : . :::: .:.. ::...:: :..:
NP_068 WSPCFSCAQEMAKFISKNKHVSLCIFTARI-YDDQGRCQEGLRTLAEAGAKISIMTYSEF
290 300 310 320 330 340
170 180 190 200
pF1KB3 VSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
:: .:: . ::.:: ::. . . :. ::: :::
NP_068 KHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
350 360 370 380
202 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 23:42:07 2016 done: Fri Nov 4 23:42:07 2016
Total Scan time: 5.050 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]