Result of FASTA (omim) for
pF1KB3424
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3424, 440 aa
1>>>pF1KB3424 440 - 440 aa - 440 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5616+/-0.000327; mu= 18.6738+/- 0.021
mean_var=98.4589+/-19.529, 0's: 0 Z-trim(117.2): 180 B-trim: 1079 in 1/52
Lambda= 0.129255
statistics sampled from 28809 (28995) to 28809 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.34), width: 16
Scan time: 7.630
The best scores are: opt bits E(85289)
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 2863 544.0 2.8e-154
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 2364 450.9 2.5e-126
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 2364 450.9 2.5e-126
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 1311 254.6 3.6e-67
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 1284 249.5 1.1e-65
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1161 226.6 9.2e-59
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1158 226.1 1.3e-58
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 1120 219.0 1.9e-56
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 1062 208.2 3.6e-53
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 1050 205.9 1.6e-52
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 1021 200.5 6.6e-51
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 927 182.8 9.8e-46
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 681 137.4 1.3e-31
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 662 133.8 1.4e-30
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 662 133.8 1.5e-30
XP_011531234 (OMIM: 615347) PREDICTED: ATPase fami ( 791) 656 132.7 3.3e-30
XP_011531233 (OMIM: 615347) PREDICTED: ATPase fami ( 837) 656 132.7 3.4e-30
XP_011531232 (OMIM: 615347) PREDICTED: ATPase fami ( 841) 656 132.7 3.5e-30
XP_011531231 (OMIM: 615347) PREDICTED: ATPase fami ( 843) 656 132.7 3.5e-30
XP_011531230 (OMIM: 615347) PREDICTED: ATPase fami ( 849) 656 132.8 3.5e-30
XP_006712094 (OMIM: 615347) PREDICTED: ATPase fami (1067) 656 132.8 4.1e-30
XP_011531227 (OMIM: 615347) PREDICTED: ATPase fami (1079) 656 132.8 4.1e-30
XP_011531226 (OMIM: 615347) PREDICTED: ATPase fami (1083) 656 132.9 4.1e-30
NP_001229267 (OMIM: 615347) ATPase family AAA doma (1453) 656 133.0 5.1e-30
NP_060022 (OMIM: 615347) ATPase family AAA domain- (1458) 656 133.0 5.1e-30
XP_006712093 (OMIM: 615347) PREDICTED: ATPase fami (1460) 656 133.0 5.1e-30
XP_011531223 (OMIM: 615347) PREDICTED: ATPase fami (1467) 656 133.0 5.1e-30
XP_005264429 (OMIM: 615347) PREDICTED: ATPase fami (1472) 656 133.0 5.2e-30
XP_016859864 (OMIM: 615347) PREDICTED: ATPase fami (1492) 656 133.0 5.2e-30
XP_011531222 (OMIM: 615347) PREDICTED: ATPase fami (1497) 656 133.0 5.2e-30
XP_011531221 (OMIM: 615347) PREDICTED: ATPase fami (1506) 656 133.0 5.2e-30
XP_011531220 (OMIM: 615347) PREDICTED: ATPase fami (1511) 656 133.0 5.3e-30
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 642 130.2 2.3e-29
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 642 130.3 2.8e-29
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 642 130.3 3e-29
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 598 121.8 4.7e-27
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 598 121.8 5e-27
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 598 121.9 6e-27
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 598 121.9 6.1e-27
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 590 120.4 1.5e-26
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 590 120.4 1.7e-26
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 590 120.4 1.7e-26
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 590 120.5 1.8e-26
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 590 120.5 1.8e-26
NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 578 118.1 7e-26
XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 579 118.4 7.5e-26
XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 118.2 7.7e-26
XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 578 118.2 7.7e-26
XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 578 118.2 7.8e-26
XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 578 118.2 8.2e-26
>>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa)
initn: 2863 init1: 2863 opt: 2863 Z-score: 2890.8 bits: 544.0 E(85289): 2.8e-154
Smith-Waterman score: 2863; 100.0% identity (100.0% similar) in 440 aa overlap (1-440:1-440)
10 20 30 40 50 60
pF1KB3 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
370 380 390 400 410 420
430 440
pF1KB3 KSKENVLYKKQEGTPEGLYL
::::::::::::::::::::
NP_002 KSKENVLYKKQEGTPEGLYL
430 440
>>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa)
initn: 2364 init1: 2364 opt: 2364 Z-score: 2388.9 bits: 450.9 E(85289): 2.5e-126
Smith-Waterman score: 2364; 100.0% identity (100.0% similar) in 367 aa overlap (74-440:1-367)
50 60 70 80 90 100
pF1KB3 DAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLR
::::::::::::::::::::::::::::::
NP_001 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
110 120 130 140 150 160
pF1KB3 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB3 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB3 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB3 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB3 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
280 290 300 310 320 330
410 420 430 440
pF1KB3 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
:::::::::::::::::::::::::::::::::::::
NP_001 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
340 350 360
>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa)
initn: 2364 init1: 2364 opt: 2364 Z-score: 2388.9 bits: 450.9 E(85289): 2.5e-126
Smith-Waterman score: 2364; 100.0% identity (100.0% similar) in 367 aa overlap (74-440:1-367)
50 60 70 80 90 100
pF1KB3 DAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLR
::::::::::::::::::::::::::::::
XP_016 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
110 120 130 140 150 160
pF1KB3 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB3 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB3 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB3 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB3 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
280 290 300 310 320 330
410 420 430 440
pF1KB3 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
:::::::::::::::::::::::::::::::::::::
XP_016 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
340 350 360
>>NP_006494 (OMIM: 602707) 26S protease regulatory subun (418 aa)
initn: 1255 init1: 1226 opt: 1311 Z-score: 1327.0 bits: 254.6 E(85289): 3.6e-67
Smith-Waterman score: 1311; 50.7% identity (83.2% similar) in 369 aa overlap (64-432:46-412)
40 50 60 70 80 90
pF1KB3 GKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQE
::.. ..: ..::.:.... : :...
NP_006 PALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFL
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB3 EERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN
. . .: ... :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :.
NP_006 HAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALH
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB3 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE
.. .:.. :: ..: . .. .. :. ::::::.: : ::..:.::::::: : :..
NP_006 KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQ
140 150 160 170 180 190
220 230 240 250 260 270
pF1KB3 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV
.:: ::.::..::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.
NP_006 IGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRL
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB3 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR
:.:.::.:.::::::::.:::.:...:..::.:: .::::::.::::. .:::::::::
NP_006 AKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNR
260 270 280 290 300 310
340 350 360 370 380 390
pF1KB3 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA
.::::::.::::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::
NP_006 ADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGA
320 330 340 350 360 370
400 410 420 430 440
pF1KB3 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
::..:: :.:..:.:: :. : .::.:. ..:. : ..
NP_006 DINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
380 390 400 410
>>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa)
initn: 1226 init1: 1226 opt: 1284 Z-score: 1300.2 bits: 249.5 E(85289): 1.1e-65
Smith-Waterman score: 1284; 52.0% identity (83.7% similar) in 350 aa overlap (83-432:35-381)
60 70 80 90 100 110
pF1KB3 TPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTL
:... : . .:: ...... :. .: .
NP_694 GILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKEEVKRIQSI---PLVIGQF
10 20 30 40 50 60
120 130 140 150 160 170
pF1KB3 EEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVT
: .:.: :::....::..:: ::: .:..::.:. :: :... .:.. :: ..: .
NP_694 LEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIM
70 80 90 100 110 120
180 190 200 210 220 230
pF1KB3 VMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGK
.. .. :. ::::::.: : ::..:.::::::: : :...:: ::.::..::::: ::
NP_694 MLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGK
130 140 150 160 170 180
240 250 260 270 280 290
pF1KB3 TLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGT
:.::::::..:.:.:.::::::..:::::.::..::..::.:.:.::.:.::::::::.:
NP_694 TMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIAT
190 200 210 220 230 240
300 310 320 330 340 350
pF1KB3 KRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIE
::.:...:..::.:: .::::::.::::. .::::::::: .::::::.::::.:::::
NP_694 KRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIE
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB3 FPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRM
:::::.. :. ::. ::.:.:...: :.: . : .:::::..:: :.:..:.:: :.
NP_694 FPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRY
310 320 330 340 350 360
420 430 440
pF1KB3 KVTNEDFKKSKENVLYKKQEGTPEGLYL
: .::.:. ..:. : ..
NP_694 IVLAKDFEKAYKTVIKKDEQEHEFYK
370 380
>>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa)
initn: 1096 init1: 1073 opt: 1161 Z-score: 1176.0 bits: 226.6 E(85289): 9.2e-59
Smith-Waterman score: 1161; 46.3% identity (74.8% similar) in 393 aa overlap (44-432:4-396)
20 30 40 50 60 70
pF1KB3 GKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLL
:. .. : .. :. : .:.. :
NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQL
10 20 30
80 90 100 110 120
pF1KB3 M----EEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGS
. ... : : : . :. : . : ... :. :: . . .: ....:.. .
NP_002 IVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 EHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGG
. :.. . .: . . :.: : : . ... .: . .::::..: :::.:. :: :::
NP_002 KFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGG
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 LDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLR
::.::.:::: .:::. ::: .: .:: ::::.:::::::::::::.:::..:. ::.:
NP_002 LDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 VVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTM
: ::::.::..:.: ..::::: .:.::::::.:.::::.::..: ...:::. :.::::
NP_002 VSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 LELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHT
::::::::::.. ..:::::::::. :: ::.:::::::::::: :.:... :..::.
NP_002 LELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB3 SRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYK
.:.:. ..: . :::..:..:::::..::::::..::.:::. . .:. :
NP_002 RKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQK
340 350 360 370 380 390
430 440
pF1KB3 KQEGTPEGLYL
.:
NP_002 DSEKNMSIKKLWK
400
>>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa)
initn: 1096 init1: 1073 opt: 1158 Z-score: 1173.1 bits: 226.1 E(85289): 1.3e-58
Smith-Waterman score: 1158; 47.7% identity (76.1% similar) in 377 aa overlap (60-432:12-388)
30 40 50 60 70 80
pF1KB3 PTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLM----EEEFIRNQEQM
:. : .:.. :. ... : : :
NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQR
10 20 30 40
90 100 110 120 130 140
pF1KB3 KPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLE
. :. : . : ... :. :: . . .: ....:.. .. :.. . .: . .
NP_001 NELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB3 PGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPL
:.: : : . ... .: . .::::..: :::.:. :: :::::.::.:::: .:::.
NP_001 PNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPV
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB3 THPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPK
::: .: .:: ::::.:::::::::::::.:::..:. ::.:: ::::.::..:.: .
NP_001 KHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGAR
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB3 LVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDV
.::::: .:.::::::.:.::::.::..: ...:::. :.::::::::::::::.. ..
NP_001 MVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNI
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB3 KVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIM
:::::::::. :: ::.:::::::::::: :.:... :..::. .:.:. ..: .
NP_001 KVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAE
290 300 310 320 330 340
390 400 410 420 430 440
pF1KB3 AKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
:::..:..:::::..::::::..::.:::. . .:. : .:
NP_001 LMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
350 360 370 380 390
>>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa)
initn: 1107 init1: 1107 opt: 1120 Z-score: 1134.2 bits: 219.0 E(85289): 1.9e-56
Smith-Waterman score: 1146; 42.8% identity (72.2% similar) in 432 aa overlap (27-431:5-432)
10 20 30 40 50
pF1KB3 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASK-------LPLVT
: . . : ...: . : : . : . :
NP_002 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMST
10 20 30
60 70 80 90 100 110
pF1KB3 PHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLE
. : .:: : :: .:. : .: .... ...: .:. :. . :. :...
NP_002 EEIIQRTRLLDSE-IK---IMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI
40 50 60 70 80 90
120 130 140 150
pF1KB3 EIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN
:..: :.. :...::. . ... ....:: . :.:: : .:
NP_002 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN
100 110 120 130 140 150
160 170 180 190 200 210
pF1KB3 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE
. . .. .: . : : .:.:.. : : :.::::::.::::. :.. ::..: : .:.
NP_002 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN
160 170 180 190 200 210
220 230 240 250 260 270
pF1KB3 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV
.::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: ::::. : .
NP_002 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL
220 230 240 250 260 270
280 290 300 310 320 330
pF1KB3 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR
:.:.::::.::::.:::::::.::...:.::.::::::::::::::. .:::: ::::
NP_002 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB3 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA
.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: ::..::
NP_002 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA
340 350 360 370 380 390
400 410 420 430 440
pF1KB3 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
. ::.:.:::..:::. ..:.::. .. .: ::.
NP_002 QCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA
400 410 420 430
>>XP_016873515 (OMIM: 186852) PREDICTED: 26S protease re (461 aa)
initn: 1062 init1: 1062 opt: 1062 Z-score: 1075.5 bits: 208.2 E(85289): 3.6e-53
Smith-Waterman score: 1088; 43.4% identity (72.2% similar) in 403 aa overlap (27-402:5-403)
10 20 30 40 50
pF1KB3 MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASK-------LPLVT
: . . : ...: . : : . : . :
XP_016 MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMST
10 20 30
60 70 80 90 100 110
pF1KB3 PHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLE
. : .:: : :: .:. : .: .... ...: .:. :. . :. :...
XP_016 EEIIQRTRLLDSE-IK---IMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVI
40 50 60 70 80 90
120 130 140 150
pF1KB3 EIID---------------DNH-----AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN
:..: :.. :...::. . ... ....:: . :.:: : .:
XP_016 ELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVN
100 110 120 130 140 150
160 170 180 190 200 210
pF1KB3 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE
. . .. .: . : : .:.:.. : : :.::::::.::::. :.. ::..: : .:.
XP_016 KDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFEN
160 170 180 190 200 210
220 230 240 250 260 270
pF1KB3 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV
.::.:::::..::::::::::::.: : ::.::::...: .:.: ..::: ::::. : .
XP_016 LGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFAL
220 230 240 250 260 270
280 290 300 310 320 330
pF1KB3 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR
:.:.::::.::::.:::::::.::...:.::.::::::::::::::. .:::: ::::
XP_016 AKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNR
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB3 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA
.. :::::.: ::.:::::::.:.:... ::.:::. .:... ::. ..: ::..::
XP_016 VDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGA
340 350 360 370 380 390
400 410 420 430 440
pF1KB3 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
. ::.:.::
XP_016 QCKAVCVEAVSGQLGWVRCFVPSCPLPGQDGGIWLVETAEGRGLSLREPGKAFRRSDLDS
400 410 420 430 440 450
>>NP_002794 (OMIM: 154365) 26S protease regulatory subun (433 aa)
initn: 1022 init1: 1022 opt: 1050 Z-score: 1063.8 bits: 205.9 E(85289): 1.6e-52
Smith-Waterman score: 1050; 47.3% identity (76.2% similar) in 336 aa overlap (106-435:92-427)
80 90 100 110 120 130
pF1KB3 EEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIID----DNHAIVSTSVGSEH
:..:. .::. : . :.... ..
NP_002 LTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKF
70 80 90 100 110 120
140 150 160 170 180 190
pF1KB3 YVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLD
:.. . : .: : : .... . . : :: ::.:.::. :. ::.:.::
NP_002 VVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCK
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB3 NQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVV
.::....: :: :: ::: . ..::.:::::.:.::::::::: :.::::.:.: :.::.
NP_002 EQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVI
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB3 GSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLE
::::.:::.:.: ..:::::..:. . ..:.::::::: :.:...::. :.::::::
NP_002 GSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLE
250 260 270 280 290 300
320 330 340 350 360 370
pF1KB3 LLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSR
:.::::::: ::..::.::::: .::::::.::::.:::::: ::: . . .::.::.
NP_002 LINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARS
310 320 330 340 350 360
380 390 400 410 420
pF1KB3 MTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVL--YK
:.. :. .. : . .::.:...:::::..:.: :: .:..:: .. ..:. :
NP_002 MSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYA
370 380 390 400 410 420
430 440
pF1KB3 KQEGTPEGLYL
: .::
NP_002 KFSATPRYMTYN
430
440 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 02:22:47 2016 done: Fri Nov 4 02:22:49 2016
Total Scan time: 7.630 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]