Result of FASTA (omim) for
pF1KB3410
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3410, 763 aa
1>>>pF1KB3410 763 - 763 aa - 763 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0845+/-0.000466; mu= 12.6968+/- 0.029
mean_var=162.3707+/-33.801, 0's: 0 Z-trim(114.1): 92 B-trim: 499 in 3/55
Lambda= 0.100652
statistics sampled from 23652 (23746) to 23652 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.278), width: 16
Scan time: 12.130
The best scores are: opt bits E(85289)
NP_001275649 (OMIM: 601511) signal transducer and ( 763) 5109 755.0 2.6e-217
XP_005257681 (OMIM: 601511) PREDICTED: signal tran ( 761) 3017 451.3 7.1e-126
NP_001275647 (OMIM: 601511) signal transducer and ( 794) 3017 451.3 7.4e-126
NP_003143 (OMIM: 601511) signal transducer and act ( 794) 3017 451.3 7.4e-126
XP_005257683 (OMIM: 245590,604260) PREDICTED: sign ( 497) 2862 428.6 3.1e-119
NP_036580 (OMIM: 245590,604260) signal transducer ( 787) 2862 428.8 4.4e-119
XP_016880466 (OMIM: 245590,604260) PREDICTED: sign ( 693) 2287 345.2 5.4e-94
NP_001275648 (OMIM: 601511) signal transducer and ( 764) 2160 326.8 2.1e-88
NP_001171551 (OMIM: 601512) signal transducer and ( 737) 761 123.6 2.9e-27
NP_001171552 (OMIM: 601512) signal transducer and ( 737) 761 123.6 2.9e-27
NP_001171549 (OMIM: 601512) signal transducer and ( 847) 761 123.7 3.2e-27
NP_003144 (OMIM: 601512) signal transducer and act ( 847) 761 123.7 3.2e-27
NP_001171550 (OMIM: 601512) signal transducer and ( 847) 761 123.7 3.2e-27
XP_006719638 (OMIM: 601512) PREDICTED: signal tran ( 847) 761 123.7 3.2e-27
XP_011537006 (OMIM: 601512) PREDICTED: signal tran ( 865) 573 96.4 5.3e-19
XP_011537005 (OMIM: 601512) PREDICTED: signal tran ( 865) 573 96.4 5.3e-19
XP_011537007 (OMIM: 601512) PREDICTED: signal tran ( 865) 573 96.4 5.3e-19
XP_011537008 (OMIM: 601512) PREDICTED: signal tran ( 865) 573 96.4 5.3e-19
XP_011537009 (OMIM: 601512) PREDICTED: signal tran ( 865) 573 96.4 5.3e-19
XP_011537010 (OMIM: 601512) PREDICTED: signal tran ( 755) 487 83.9 2.8e-15
XP_011537011 (OMIM: 601512) PREDICTED: signal tran ( 755) 487 83.9 2.8e-15
XP_011510007 (OMIM: 600558,612253) PREDICTED: sign ( 748) 429 75.4 9.5e-13
NP_001230764 (OMIM: 600558,612253) signal transduc ( 748) 429 75.4 9.5e-13
XP_006712782 (OMIM: 600558,612253) PREDICTED: sign ( 748) 429 75.4 9.5e-13
NP_003142 (OMIM: 600558,612253) signal transducer ( 748) 429 75.4 9.5e-13
XP_005257674 (OMIM: 102582,147060,615952) PREDICTE ( 770) 406 72.1 9.8e-12
NP_644805 (OMIM: 102582,147060,615952) signal tran ( 770) 406 72.1 9.8e-12
XP_011523447 (OMIM: 102582,147060,615952) PREDICTE ( 770) 406 72.1 9.8e-12
XP_016880464 (OMIM: 102582,147060,615952) PREDICTE ( 769) 399 71.1 2e-11
XP_005257673 (OMIM: 102582,147060,615952) PREDICTE ( 769) 399 71.1 2e-11
NP_003141 (OMIM: 102582,147060,615952) signal tran ( 769) 399 71.1 2e-11
NP_998827 (OMIM: 102582,147060,615952) signal tran ( 722) 395 70.5 2.8e-11
XP_016880461 (OMIM: 102582,147060,615952) PREDICTE ( 722) 395 70.5 2.8e-11
XP_011523448 (OMIM: 102582,147060,615952) PREDICTE ( 722) 395 70.5 2.8e-11
NP_009330 (OMIM: 600555,613796,614162,614892) sign ( 750) 394 70.4 3.2e-11
XP_006712781 (OMIM: 600555,613796,614162,614892) P ( 750) 394 70.4 3.2e-11
XP_016860272 (OMIM: 600555,613796,614162,614892) P ( 752) 394 70.4 3.2e-11
XP_016880463 (OMIM: 102582,147060,615952) PREDICTE ( 721) 389 69.6 5.2e-11
XP_016880462 (OMIM: 102582,147060,615952) PREDICTE ( 721) 389 69.6 5.2e-11
XP_016880465 (OMIM: 102582,147060,615952) PREDICTE ( 721) 389 69.6 5.2e-11
NP_644671 (OMIM: 600555,613796,614162,614892) sign ( 712) 382 68.6 1e-10
XP_016875393 (OMIM: 600556,616636) PREDICTED: sign ( 607) 345 63.2 3.8e-09
XP_011537002 (OMIM: 600556,616636) PREDICTED: sign ( 615) 345 63.2 3.9e-09
NP_938146 (OMIM: 600556,616636) signal transducer ( 847) 345 63.3 4.9e-09
NP_005410 (OMIM: 600556,616636) signal transducer ( 851) 345 63.3 4.9e-09
XP_011537000 (OMIM: 600556,616636) PREDICTED: sign ( 855) 345 63.3 4.9e-09
XP_011536999 (OMIM: 600556,616636) PREDICTED: sign ( 859) 345 63.3 4.9e-09
XP_016860273 (OMIM: 600558,612253) PREDICTED: sign ( 500) 299 56.4 3.4e-07
XP_011537001 (OMIM: 600556,616636) PREDICTED: sign ( 592) 204 42.7 0.0055
>>NP_001275649 (OMIM: 601511) signal transducer and acti (763 aa)
initn: 5109 init1: 5109 opt: 5109 Z-score: 4022.5 bits: 755.0 E(85289): 2.6e-217
Smith-Waterman score: 5109; 100.0% identity (100.0% similar) in 763 aa overlap (1-763:1-763)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKGRVPFAVPDKVLWPQLCEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKGRVPFAVPDKVLWPQLCEAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 NMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 DGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGE
670 680 690 700 710 720
730 740 750 760
pF1KB3 FDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
:::::::::::::::::::::::::::::::::::::::::::
NP_001 FDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
730 740 750 760
>>XP_005257681 (OMIM: 601511) PREDICTED: signal transduc (761 aa)
initn: 4376 init1: 3017 opt: 3017 Z-score: 2380.8 bits: 451.3 E(85289): 7.1e-126
Smith-Waterman score: 4336; 89.7% identity (91.4% similar) in 746 aa overlap (1-713:1-741)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
::::::::::::::::::::::::::::::::::::::::
XP_005 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
470 480 490 500
pF1KB3 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB3 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
:::::::::::::::::::::::::::: .. : .:.. .. : .:
XP_005 GDLSYLIYVFPDRPKDEVFSKYYTPVLALTM--Y---SIRMENSTWMRPWMWPGTWRNSY
670 680 690 700 710
690 700 710 720 730 740
pF1KB3 MDQAP--SPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSR
:: .:: : .. :. :.:
XP_005 ADQWTVLTPASRPLPVFSPLPEAPSHECLNPTLLFGNNMQCEAVVL
720 730 740 750 760
>>NP_001275647 (OMIM: 601511) signal transducer and acti (794 aa)
initn: 5095 init1: 3017 opt: 3017 Z-score: 2380.6 bits: 451.3 E(85289): 7.4e-126
Smith-Waterman score: 5037; 96.1% identity (96.1% similar) in 794 aa overlap (1-763:1-794)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
::::::::::::::::::::::::::::::::::::::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
470 480 490 500
pF1KB3 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB3 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
670 680 690 700 710 720
690 700 710 720 730 740
pF1KB3 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
730 740 750 760 770 780
750 760
pF1KB3 PPAGLFTSARGSLS
::::::::::::::
NP_001 PPAGLFTSARGSLS
790
>>NP_003143 (OMIM: 601511) signal transducer and activat (794 aa)
initn: 5095 init1: 3017 opt: 3017 Z-score: 2380.6 bits: 451.3 E(85289): 7.4e-126
Smith-Waterman score: 5037; 96.1% identity (96.1% similar) in 794 aa overlap (1-763:1-794)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
::::::::::::::::::::::::::::::::::::::::
NP_003 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
430 440 450 460 470 480
470 480 490 500
pF1KB3 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB3 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
670 680 690 700 710 720
690 700 710 720 730 740
pF1KB3 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
730 740 750 760 770 780
750 760
pF1KB3 PPAGLFTSARGSLS
::::::::::::::
NP_003 PPAGLFTSARGSLS
790
>>XP_005257683 (OMIM: 245590,604260) PREDICTED: signal t (497 aa)
initn: 2862 init1: 2862 opt: 2862 Z-score: 2261.5 bits: 428.6 E(85289): 3.1e-119
Smith-Waterman score: 2862; 94.8% identity (98.3% similar) in 460 aa overlap (1-460:1-460)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
XP_005 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
XP_005 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
XP_005 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKGRVPFAVPDKVLWPQLCEAL
::::::.::::::::::::::.:::::::::.::::::::
XP_005 LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 NMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFW
XP_005 TVLWDNAFAEPNIGFDC
490
>>NP_036580 (OMIM: 245590,604260) signal transducer and (787 aa)
initn: 4654 init1: 2862 opt: 2862 Z-score: 2259.0 bits: 428.8 E(85289): 4.4e-119
Smith-Waterman score: 4589; 90.0% identity (93.1% similar) in 779 aa overlap (1-743:1-779)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
:: :::::::::.::.:::.::::::::::::::.:::::: ::..::::::. .::::
NP_036 MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::.::::::.:::::::::::::::::
NP_036 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
::::: ::::: :.::::::::::::::::::::::::::::::::::::::::::::::
NP_036 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::. ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::. ::::::::::::::::::::::::::::
NP_036 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
370 380 390 400 410 420
430 440 450 460
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
::::::.::::::::::::::.:::::::::.::::::::
NP_036 LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
430 440 450 460 470 480
470 480 490 500
pF1KB3 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
::::::::::::::::::::::::: :::::::::::::::::: :::::::::::::::
NP_036 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::: :: .::: ::::::::::::::::
NP_036 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB3 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG
:::.::::::::::::::.::::::: ::::::::::::::::::::::::::::
NP_036 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KB3 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSL
.::::::::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
NP_036 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
730 740 750 760 770 780
750 760
pF1KB3 DSRLSPPAGLFTSARGSLS
NP_036 WIPHAQS
>>XP_016880466 (OMIM: 245590,604260) PREDICTED: signal t (693 aa)
initn: 4079 init1: 2287 opt: 2287 Z-score: 1808.4 bits: 345.2 E(85289): 5.4e-94
Smith-Waterman score: 4014; 90.5% identity (92.7% similar) in 683 aa overlap (97-743:3-685)
70 80 90 100 110 120
pF1KB3 ELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNC
::::::.::::::::::::::::::::::
XP_016 MNTYDRCPMELVRCIRHILYNEQRLVREANNG
10 20 30
130 140 150 160 170 180
pF1KB3 SSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQF
::::: :.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQF
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB3 AQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTI
. ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTI
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB3 ILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIP
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB3 GPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNP
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB3 PQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKR
::::::::::::::::::::::::. ::::::::::::::::::::::::::::::::::
XP_016 PQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKR
280 290 300 310 320 330
430 440 450 460
pF1KB3 ADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------------
.::::::::::::::.:::::::::.::::::::
XP_016 SDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDN
340 350 360 370 380 390
470 480 490 500 510
pF1KB3 -----GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLE
400 410 420 430 440 450
520 530 540 550 560 570
pF1KB3 DYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDL
::::::::::::::::::: :::::::::::::::::: :::::::::::::::::::::
XP_016 DYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDL
460 470 480 490 500 510
580 590 600 610 620 630
pF1KB3 LINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYL
::::::::::::::::::::::::::::: :: .::: :::::::::::::::::::.::
XP_016 LINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYL
520 530 540 550 560 570
640 650 660 670 680 690
pF1KB3 IYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYM
::::::::::::.::::::: ::::::::::::::::::::::::::::.:::::
XP_016 IYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYM
580 590 600 610 620 630
700 710 720 730 740 750
pF1KB3 DQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSP
:::::::::::: ::::::::: ::: ::.:::..::::::.::::: :::::
XP_016 DQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQ
640 650 660 670 680 690
760
pF1KB3 PAGLFTSARGSLS
XP_016 S
>>NP_001275648 (OMIM: 601511) signal transducer and acti (764 aa)
initn: 4238 init1: 2160 opt: 2160 Z-score: 1708.2 bits: 326.8 E(85289): 2.1e-88
Smith-Waterman score: 4760; 92.3% identity (92.3% similar) in 794 aa overlap (1-763:1-764)
10 20 30 40 50 60
pF1KB3 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
:::::::::::::::::::::::::::::::::::
NP_001 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQ-------------------------
70 80 90
130 140 150 160 170 180
pF1KB3 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----CSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB3 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB3 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
340 350 360 370 380 390
430 440 450 460
pF1KB3 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK--------------------
::::::::::::::::::::::::::::::::::::::::
NP_001 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
400 410 420 430 440 450
470 480 490 500
pF1KB3 -----------GRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
460 470 480 490 500 510
510 520 530 540 550 560
pF1KB3 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
520 530 540 550 560 570
570 580 590 600 610 620
pF1KB3 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
580 590 600 610 620 630
630 640 650 660 670 680
pF1KB3 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
640 650 660 670 680 690
690 700 710 720 730 740
pF1KB3 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
700 710 720 730 740 750
750 760
pF1KB3 PPAGLFTSARGSLS
::::::::::::::
NP_001 PPAGLFTSARGSLS
760
>>NP_001171551 (OMIM: 601512) signal transducer and acti (737 aa)
initn: 1166 init1: 583 opt: 761 Z-score: 610.5 bits: 123.6 E(85289): 2.9e-27
Smith-Waterman score: 1239; 39.0% identity (64.4% similar) in 615 aa overlap (177-735:15-610)
150 160 170 180 190 200
pF1KB3 TFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQ
:: :.... . .: . . .: :: :::.
NP_001 MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLRE-ALQK
10 20 30 40
210 220 230 240 250 260
pF1KB3 K----QVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLA
::::.. .. :. .. :: :.: :. ....: : :::.::::
NP_001 GAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTGELEAAKALVLKRIQI-WKRQQQLA
50 60 70 80 90 100
270 280 290 300 310 320
pF1KB3 GNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVE-EMLAEVNATIT
:::.: : :: :: ::.:..: : .:.. : : .: . : ... .
NP_001 GNGAPFEESLAPLQERCESLVDIYSQLQQEVGAA---------GGELEPKTRASLTGRLD
110 120 130 140 150
330 340 350 360 370 380
pF1KB3 DIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGK-LNVHMNPPQVKATIISEQQAK
... .:::: :..:::::::::::::: : ::.:.: . :.. .:: :.: ...:.::.
NP_001 EVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQAR
160 170 180 190 200 210
390 400 410 420 430
pF1KB3 --SLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEE
:. .. .. : .:::.:: .: . :: :.:. ::.::: .:.:.::::::
NP_001 ELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEE
220 230 240 250 260 270
440 450 460
pF1KB3 KFTVLFESQFSVGSNELVFQVKG-------------------------------RVPFAV
: .::: ..:..: ..: .:... ::::.:
NP_001 KCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVV
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 PDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQF
..: : ..::.::.:: ::: .:::: :...:::::.::..: .: .. :::::::
NP_001 AERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQF
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 NRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLR
:.: : : ..:::::::::... :. . .:.: :.::..:: . .::.:.::::::::
NP_001 NKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLR
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB3 FSDSEIGGITIAWKF----DSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRP
:::::::::::: . ::. . :..::...:.:::::.::. ::. : ..: .:
NP_001 FSDSEIGGITIAHVIRGQDGSPQ--IENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKP
460 470 480 490 500 510
650 660 670 680 690
pF1KB3 KDEVFSKYYTPV-LAKAVDGYVKPQIKQVV--------PEF----VNASADAGGSSATYM
:::.: ..: : ..: ::: ::..: ::. . : : : . . :
NP_001 KDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSM
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB3 DQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSP
.. .: . :: .:: . . .: .. .:...: .:
NP_001 SMQLGPDMVPQ----VYPPHSHSIPPYQG-LSPEESVNVLSAFQEPHLQMPPSLGQMSLP
580 590 600 610 620
760
pF1KB3 PAGLFTSARGSLS
NP_001 FDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLL
630 640 650 660 670 680
>>NP_001171552 (OMIM: 601512) signal transducer and acti (737 aa)
initn: 1166 init1: 583 opt: 761 Z-score: 610.5 bits: 123.6 E(85289): 2.9e-27
Smith-Waterman score: 1239; 39.0% identity (64.4% similar) in 615 aa overlap (177-735:15-610)
150 160 170 180 190 200
pF1KB3 TFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQ
:: :.... . .: . . .: :: :::.
NP_001 MEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLRE-ALQK
10 20 30 40
210 220 230 240 250 260
pF1KB3 K----QVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLA
::::.. .. :. .. :: :.: :. ....: : :::.::::
NP_001 GAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTGELEAAKALVLKRIQI-WKRQQQLA
50 60 70 80 90 100
270 280 290 300 310 320
pF1KB3 GNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVE-EMLAEVNATIT
:::.: : :: :: ::.:..: : .:.. : : .: . : ... .
NP_001 GNGAPFEESLAPLQERCESLVDIYSQLQQEVGAA---------GGELEPKTRASLTGRLD
110 120 130 140 150
330 340 350 360 370 380
pF1KB3 DIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGK-LNVHMNPPQVKATIISEQQAK
... .:::: :..:::::::::::::: : ::.:.: . :.. .:: :.: ...:.::.
NP_001 EVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQAR
160 170 180 190 200 210
390 400 410 420 430
pF1KB3 --SLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEE
:. .. .. : .:::.:: .: . :: :.:. ::.::: .:.:.::::::
NP_001 ELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEE
220 230 240 250 260 270
440 450 460
pF1KB3 KFTVLFESQFSVGSNELVFQVKG-------------------------------RVPFAV
: .::: ..:..: ..: .:... ::::.:
NP_001 KCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVV
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 PDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQF
..: : ..::.::.:: ::: .:::: :...:::::.::..: .: .. :::::::
NP_001 AERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQF
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 NRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLR
:.: : : ..:::::::::... :. . .:.: :.::..:: . .::.:.::::::::
NP_001 NKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLR
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB3 FSDSEIGGITIAWKF----DSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRP
:::::::::::: . ::. . :..::...:.:::::.::. ::. : ..: .:
NP_001 FSDSEIGGITIAHVIRGQDGSPQ--IENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKP
460 470 480 490 500 510
650 660 670 680 690
pF1KB3 KDEVFSKYYTPV-LAKAVDGYVKPQIKQVV--------PEF----VNASADAGGSSATYM
:::.: ..: : ..: ::: ::..: ::. . : : : . . :
NP_001 KDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSM
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB3 DQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSP
.. .: . :: .:: . . .: .. .:...: .:
NP_001 SMQLGPDMVPQ----VYPPHSHSIPPYQG-LSPEESVNVLSAFQEPHLQMPPSLGQMSLP
580 590 600 610 620
760
pF1KB3 PAGLFTSARGSLS
NP_001 FDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLL
630 640 650 660 670 680
763 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:13:00 2016 done: Thu Nov 3 13:13:02 2016
Total Scan time: 12.130 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]