Result of FASTA (ccds) for
pF1KB3334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3334, 770 aa
1>>>pF1KB3334 770 - 770 aa - 770 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7925+/-0.00113; mu= 4.5811+/- 0.068
mean_var=210.0723+/-41.158, 0's: 0 Z-trim(108.8): 49 B-trim: 0 in 0/51
Lambda= 0.088489
statistics sampled from 10408 (10445) to 10408 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.321), width: 16
Scan time: 3.800
The best scores are: opt bits E(32554)
CCDS13576.1 APP gene_id:351|Hs108|chr21 ( 770) 5160 672.3 7.8e-193
CCDS46639.1 APP gene_id:351|Hs108|chr21 ( 714) 4648 607.0 3.5e-173
CCDS56213.1 APP gene_id:351|Hs108|chr21 ( 752) 4294 561.8 1.5e-159
CCDS56212.1 APP gene_id:351|Hs108|chr21 ( 746) 2674 355.0 2.6e-97
CCDS33523.1 APP gene_id:351|Hs108|chr21 ( 751) 2674 355.0 2.6e-97
CCDS46638.1 APP gene_id:351|Hs108|chr21 ( 639) 2653 352.2 1.5e-96
CCDS56211.1 APP gene_id:351|Hs108|chr21 ( 660) 2653 352.2 1.5e-96
CCDS13577.1 APP gene_id:351|Hs108|chr21 ( 695) 2653 352.3 1.6e-96
CCDS8486.1 APLP2 gene_id:334|Hs108|chr11 ( 763) 1295 178.9 2.6e-44
CCDS44773.1 APLP2 gene_id:334|Hs108|chr11 ( 751) 985 139.3 2.1e-32
CCDS58196.1 APLP2 gene_id:334|Hs108|chr11 ( 761) 985 139.3 2.1e-32
CCDS44774.1 APLP2 gene_id:334|Hs108|chr11 ( 695) 959 136.0 2e-31
CCDS44775.1 APLP2 gene_id:334|Hs108|chr11 ( 522) 949 134.6 3.9e-31
CCDS32997.1 APLP1 gene_id:333|Hs108|chr19 ( 651) 685 101.0 6.4e-21
>>CCDS13576.1 APP gene_id:351|Hs108|chr21 (770 aa)
initn: 5160 init1: 5160 opt: 5160 Z-score: 3575.5 bits: 672.3 E(32554): 7.8e-193
Smith-Waterman score: 5160; 100.0% identity (100.0% similar) in 770 aa overlap (1-770:1-770)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
670 680 690 700 710 720
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
730 740 750 760 770
>>CCDS46639.1 APP gene_id:351|Hs108|chr21 (714 aa)
initn: 4648 init1: 4648 opt: 4648 Z-score: 3222.7 bits: 607.0 E(32554): 3.5e-173
Smith-Waterman score: 4648; 100.0% identity (100.0% similar) in 696 aa overlap (75-770:19-714)
50 60 70 80 90 100
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
::::::::::::::::::::::::::::::
CCDS46 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
10 20 30 40
110 120 130 140 150 160
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
350 360 370 380 390 400
470 480 490 500 510 520
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
410 420 430 440 450 460
530 540 550 560 570 580
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
470 480 490 500 510 520
590 600 610 620 630 640
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
530 540 550 560 570 580
650 660 670 680 690 700
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
590 600 610 620 630 640
710 720 730 740 750 760
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
650 660 670 680 690 700
770
pF1KB3 FEQMQN
::::::
CCDS46 FEQMQN
710
>>CCDS56213.1 APP gene_id:351|Hs108|chr21 (752 aa)
initn: 4294 init1: 4294 opt: 4294 Z-score: 2978.2 bits: 561.8 E(32554): 1.5e-159
Smith-Waterman score: 4993; 97.7% identity (97.7% similar) in 770 aa overlap (1-770:1-752)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
:::::::::::::::::::::::::::::::::::: ::::::
CCDS56 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
610 620 630 640
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
650 660 670 680 690 700
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
710 720 730 740 750
>>CCDS56212.1 APP gene_id:351|Hs108|chr21 (746 aa)
initn: 2640 init1: 2640 opt: 2674 Z-score: 1860.5 bits: 355.0 E(32554): 2.6e-97
Smith-Waterman score: 4872; 97.3% identity (97.5% similar) in 751 aa overlap (20-770:15-746)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
:::::::::::::::::::::::::::::::::::::::::
CCDS56 MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::.
CCDS56 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
300 310 320 330 340
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
350 360 370 380 390
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
640 650 660 670 680 690
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
700 710 720 730 740
>>CCDS33523.1 APP gene_id:351|Hs108|chr21 (751 aa)
initn: 2640 init1: 2640 opt: 2674 Z-score: 1860.5 bits: 355.0 E(32554): 2.6e-97
Smith-Waterman score: 4990; 97.4% identity (97.5% similar) in 770 aa overlap (1-770:1-751)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::.
CCDS33 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
310 320 330 340
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
650 660 670 680 690 700
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS33 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
710 720 730 740 750
>>CCDS46638.1 APP gene_id:351|Hs108|chr21 (639 aa)
initn: 2759 init1: 2650 opt: 2653 Z-score: 1846.9 bits: 352.2 E(32554): 1.5e-96
Smith-Waterman score: 3944; 89.1% identity (89.2% similar) in 696 aa overlap (75-770:19-639)
50 60 70 80 90 100
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
::::::::::::::::::::::::::::::
CCDS46 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
10 20 30 40
110 120 130 140 150 160
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
::::
CCDS46 EVVR--------------------------------------------------------
230
350 360 370 380 390 400
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
.::::::::::::::::::::::::::::::::::::::::
CCDS46 -------------------VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
240 250 260 270
410 420 430 440 450 460
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
460 470 480 490 500 510
650 660 670 680 690 700
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
520 530 540 550 560 570
710 720 730 740 750 760
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
580 590 600 610 620 630
770
pF1KB3 FEQMQN
::::::
CCDS46 FEQMQN
>>CCDS56211.1 APP gene_id:351|Hs108|chr21 (660 aa)
initn: 2650 init1: 2650 opt: 2653 Z-score: 1846.7 bits: 352.2 E(32554): 1.5e-96
Smith-Waterman score: 4234; 89.7% identity (89.8% similar) in 735 aa overlap (36-770:1-660)
10 20 30 40 50 60
pF1KB3 ALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
::::::::::::::::::::::::::::::
CCDS56 MFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
10 20 30
70 80 90 100 110 120
pF1KB3 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIS
:::::::::::::::::::::::::::::::::::::::::::
CCDS56 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR-----------------
220 230 240 250
310 320 330 340 350 360
pF1KB3 RWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLP
.:
CCDS56 ----------------------------------------------------------VP
370 380 390 400 410 420
pF1KB3 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
260 270 280 290 300 310
430 440 450 460 470 480
pF1KB3 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
320 330 340 350 360 370
490 500 510 520 530 540
pF1KB3 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
380 390 400 410 420 430
550 560 570 580 590 600
pF1KB3 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
440 450 460 470 480 490
610 620 630 640 650 660
pF1KB3 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
500 510 520 530 540 550
670 680 690 700 710 720
pF1KB3 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
560 570 580 590 600 610
730 740 750 760 770
pF1KB3 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
:::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
620 630 640 650 660
>>CCDS13577.1 APP gene_id:351|Hs108|chr21 (695 aa)
initn: 2650 init1: 2650 opt: 2653 Z-score: 1846.4 bits: 352.3 E(32554): 1.6e-96
Smith-Waterman score: 4456; 90.1% identity (90.3% similar) in 770 aa overlap (1-770:1-695)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
250 260 270 280
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
CCDS13 ------------------------------------------------------------
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
290 300 310 320 330 340
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
410 420 430 440 450 460
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
470 480 490 500 510 520
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
530 540 550 560 570 580
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
590 600 610 620 630 640
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
650 660 670 680 690
>>CCDS8486.1 APLP2 gene_id:334|Hs108|chr11 (763 aa)
initn: 2195 init1: 925 opt: 1295 Z-score: 908.9 bits: 178.9 E(32554): 2.6e-44
Smith-Waterman score: 2497; 50.5% identity (74.1% similar) in 798 aa overlap (5-769:15-762)
10 20 30 40
pF1KB3 MLPGLALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLN
: ::::.. :: :: . .::: .::::::::::.::
CCDS84 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB3 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
CCDS84 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
::::.. :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.: ..
CCDS84 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
130 140 150 160 170
170 180 190 200 210 220
pF1KB3 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
.:..::::::::.:.:.:.:.:::: .. .:.. . :::. . . :: : .
CCDS84 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
180 190 200 210 220 230
230 240 250 260 270
pF1KB3 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
.. :. :. .:. .: ::::.:.:.:: :. . :. : : ..
CCDS84 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB3 TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEY
: . . . . :. :::..: ::::::.. :::::...:::. :.:::::::::::..:.:
CCDS84 TMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDY
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB3 CMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKE
::::: . . : :. ::: . :: :.:: .:.::::.::::::
CCDS84 CMAVCKAMI----------P----PTPLPT------NDVDVYFETSADDNEHARFQKAKE
360 370 380 390
400 410 420 430 440 450
pF1KB3 RLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVET
.:: .::.::..: .:::::: ::::::::.....::::: :..::.:::.:.::::::
CCDS84 QLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVET
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB3 HMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVR
:.::::::::::::.:::::..:::. ::::..... :..:::::.::: ::..:..::
CCDS84 HLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB3 MVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDV
:::.::::..:::::::.:: :: ::::::::.:: ::.:::.:.:::::...
CCDS84 AVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR------
520 530 540 550 560
580 590 600 610 620 630
pF1KB3 LANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE
:.: : . :..:: . :. :..: : ... :.: : :: :::
CCDS84 -ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENE
570 580 590 600 610
640 650 660 670 680 690
pF1KB3 -VEPVDARPAADRGLTTRPGSGLTNIKTEEI-SEVKMDAEFRHDSGYEVHHQKLVFFAED
..: .: . . . .:: . . . : :. :.: .. : .: ....: ::
CCDS84 DTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV--KEMIFNAER
620 630 640 650 660 670
700 710 720 730
pF1KB3 VGS-----------------NKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVE
::. ...:.:::.: .:.:::::::.::::.:.:: .: ::.::
CCDS84 VGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVE
680 690 700 710 720 730
740 750 760 770
pF1KB3 VDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
:: .:::::::.:::..::::::::..::::
CCDS84 VDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
740 750 760
>>CCDS44773.1 APLP2 gene_id:334|Hs108|chr11 (751 aa)
initn: 2195 init1: 925 opt: 985 Z-score: 695.1 bits: 139.3 E(32554): 2.1e-32
Smith-Waterman score: 2498; 50.9% identity (75.1% similar) in 784 aa overlap (5-769:15-750)
10 20 30 40
pF1KB3 MLPGLALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLN
: ::::.. :: :: . .::: .::::::::::.::
CCDS44 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB3 MHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGR
::.:.:.:::. ::.:::.:..::: .::::::.:::::::::.:::: :.:.:::.: .
CCDS44 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB3 KQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKS
::::.. :: :..:::::::::.::::.::.:.:.:::.:::.: :::::.::.: ..
CCDS44 KQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQG
130 140 150 160 170
170 180 190 200 210 220
pF1KB3 TNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSE
.:..::::::::.:.:.:.:.:::: .. .:.. . :::. . . :: : .
CCDS44 MTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYK
180 190 200 210 220 230
230 240 250 260 270
pF1KB3 DKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEE------ATERTTSIATTT
.. :. :. .:. .: ::::.:.:.:: :. . :. : : ..
CCDS44 SEFPTEADLEDFTEAAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB3 TTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEY
: . . . . :. :::..: ::::::.. :::::...:::. :.:::::::::::..:.:
CCDS44 TMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDY
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB3 CMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKE
::::: . . : :. ::: . :: :.:: .:.::::.::::::
CCDS44 CMAVCKAMI----------P----PTPLPT------NDVDVYFETSADDNEHARFQKAKE
360 370 380 390
400 410 420 430 440 450
pF1KB3 RLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVET
.:: .::.::..: .:::::: ::::::::.....::::: :..::.:::.:.::::::
CCDS44 QLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVET
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB3 HMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVR
:.::::::::::::.:::::..:::. ::::..... :..:::::.::: ::..:..::
CCDS44 HLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL
460 470 480 490 500 510
520 530 540 550 560 570
pF1KB3 MVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDV
:::.::::..:::::::.:: :: ::::::::.:: ::.:::.:.:::::...
CCDS44 AVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR------
520 530 540 550 560
580 590 600 610 620 630
pF1KB3 LANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE
:.: : . :..:: . :. :..: : ... :.: : :: :::
CCDS44 -ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENE
570 580 590 600 610
640 650 660 670 680 690
pF1KB3 VEPVDARPA----ADRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFF
: . . :.. . . .. :. .: .:: : . .. .: : ..... .
CCDS44 GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPL
620 630 640 650 660 670
700 710 720 730 740 750
pF1KB3 AEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSK
:: . ...:.:::.: .:.:::::::.::::.:.:: .: ::.:::: .:::::::.:
CCDS44 REDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNK
680 690 700 710 720 730
760 770
pF1KB3 MQQNGYENPTYKFFEQMQN
::..::::::::..::::
CCDS44 MQNHGYENPTYKYLEQMQI
740 750
770 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 12:55:03 2016 done: Thu Nov 3 12:55:04 2016
Total Scan time: 3.800 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]