Result of FASTA (omim) for
pF1KB3244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3244, 2162 aa
1>>>pF1KB3244 2162 - 2162 aa - 2162 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4512+/-0.000527; mu= 5.2020+/- 0.032
mean_var=227.3942+/-47.073, 0's: 0 Z-trim(115.3): 45 B-trim: 0 in 0/54
Lambda= 0.085052
statistics sampled from 25597 (25633) to 25597 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.301), width: 16
Scan time: 19.400
The best scores are: opt bits E(85289)
NP_001293008 (OMIM: 114010,616457) CAD protein iso (2162) 14382 1779.9 0
XP_006712164 (OMIM: 114010,616457) PREDICTED: CAD (2179) 12026 1490.8 0
NP_004332 (OMIM: 114010,616457) CAD protein isofor (2225) 10262 1274.4 0
XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD (2242) 7906 985.3 0
NP_001116106 (OMIM: 237300,608307,615371) carbamoy (1049) 2170 281.2 4.2e-74
XP_011508945 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508946 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508943 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
XP_011508944 (OMIM: 237300,608307,615371) PREDICTE (1500) 2170 281.3 5.6e-74
NP_001866 (OMIM: 237300,608307,615371) carbamoyl-p (1500) 2170 281.3 5.6e-74
NP_001116105 (OMIM: 237300,608307,615371) carbamoy (1506) 2170 281.3 5.6e-74
XP_011508942 (OMIM: 237300,608307,615371) PREDICTE (1511) 2170 281.3 5.6e-74
NP_000522 (OMIM: 300461,311250) ornithine carbamoy ( 354) 333 55.5 1.3e-06
XP_016885045 (OMIM: 300461,311250) PREDICTED: orni ( 311) 272 48.0 0.0002
>>NP_001293008 (OMIM: 114010,616457) CAD protein isoform (2162 aa)
initn: 14382 init1: 14382 opt: 14382 Z-score: 9545.2 bits: 1779.9 E(85289): 0
Smith-Waterman score: 14382; 100.0% identity (100.0% similar) in 2162 aa overlap (1-2162:1-2162)
10 20 30 40 50 60
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB3 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB3 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB3 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB3 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB3 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB3 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB3 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB3 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB3 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB3 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KB3 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KB3 PAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSLVG
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KB3 QHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFAAA
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KB3 MARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRPVI
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KB3 NAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSLRY
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KB3 VAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEACFG
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KB3 QFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATVLG
2110 2120 2130 2140 2150 2160
pF1KB3 RF
::
NP_001 RF
>>XP_006712164 (OMIM: 114010,616457) PREDICTED: CAD prot (2179 aa)
initn: 12018 init1: 12018 opt: 12026 Z-score: 7982.8 bits: 1490.8 E(85289): 0
Smith-Waterman score: 14338; 99.2% identity (99.2% similar) in 2179 aa overlap (1-2162:1-2179)
10 20 30 40 50 60
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EYEVVRDAYGNCVTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNSVT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRI
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNM
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB3 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGVKV
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB3 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYK
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB3 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB3 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB3 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAM
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB3 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNETF
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB3 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEILL
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB3 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVIDCF
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB3 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFHLP
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB3 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPP
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KB3 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDPGL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840
pF1KB3 PA-----------------EEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGT
:: :::::::::::::::::::::::::::::::::::::::::
XP_006 PAVFLRPGAGIPRGSRAWAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGT
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KB3 PGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMA
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KB3 SMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHP
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KB3 QPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRT
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KB3 VHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTR
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KB3 IQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQ
2110 2120 2130 2140 2150 2160
2150 2160
pF1KB3 AENGMYIRMALLATVLGRF
:::::::::::::::::::
XP_006 AENGMYIRMALLATVLGRF
2170
>>NP_004332 (OMIM: 114010,616457) CAD protein isoform 1 (2225 aa)
initn: 10262 init1: 10262 opt: 10262 Z-score: 6812.8 bits: 1274.4 E(85289): 0
Smith-Waterman score: 14055; 97.1% identity (97.1% similar) in 2194 aa overlap (32-2162:32-2225)
10 20 30 40 50 60
pF1KB3 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
::::::::::::::::::::::::::::::
NP_004 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
550 560 570 580 590 600
610
pF1KB3 YEVVRDAYGNCVT-----------------------------------------------
:::::::::::::
NP_004 YEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGI
610 620 630 640 650 660
620 630 640 650
pF1KB3 ----------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
::::::::::::::::::::::::::::::::::::::::::::
NP_004 VGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KB3 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
730 740 750 760 770 780
720 730 740 750 760 770
pF1KB3 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
790 800 810 820 830 840
780 790 800 810 820 830
pF1KB3 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
850 860 870 880 890 900
840 850 860 870 880 890
pF1KB3 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
910 920 930 940 950 960
900 910 920 930 940 950
pF1KB3 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KB3 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KB3 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KB3 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
1150 1160 1170 1180 1190 1200
1140 1150 1160 1170 1180 1190
pF1KB3 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
1210 1220 1230 1240 1250 1260
1200 1210 1220 1230 1240 1250
pF1KB3 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
1270 1280 1290 1300 1310 1320
1260 1270 1280 1290 1300 1310
pF1KB3 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
1330 1340 1350 1360 1370 1380
1320 1330 1340 1350 1360 1370
pF1KB3 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
1390 1400 1410 1420 1430 1440
1380 1390 1400 1410 1420 1430
pF1KB3 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
1450 1460 1470 1480 1490 1500
1440 1450 1460 1470 1480 1490
pF1KB3 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
1510 1520 1530 1540 1550 1560
1500 1510 1520 1530 1540 1550
pF1KB3 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
1570 1580 1590 1600 1610 1620
1560 1570 1580 1590 1600 1610
pF1KB3 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
1630 1640 1650 1660 1670 1680
1620 1630 1640 1650 1660 1670
pF1KB3 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
1690 1700 1710 1720 1730 1740
1680 1690 1700 1710 1720 1730
pF1KB3 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
1750 1760 1770 1780 1790 1800
1740 1750 1760 1770 1780 1790
pF1KB3 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
1810 1820 1830 1840 1850 1860
1800 1810 1820 1830 1840 1850
pF1KB3 GLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHSL
1870 1880 1890 1900 1910 1920
1860 1870 1880 1890 1900 1910
pF1KB3 VGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSFA
1930 1940 1950 1960 1970 1980
1920 1930 1940 1950 1960 1970
pF1KB3 AAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRRP
1990 2000 2010 2020 2030 2040
1980 1990 2000 2010 2020 2030
pF1KB3 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVSL
2050 2060 2070 2080 2090 2100
2040 2050 2060 2070 2080 2090
pF1KB3 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEAC
2110 2120 2130 2140 2150 2160
2100 2110 2120 2130 2140 2150
pF1KB3 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLATV
2170 2180 2190 2200 2210 2220
2160
pF1KB3 LGRF
::::
NP_004 LGRF
>>XP_005264612 (OMIM: 114010,616457) PREDICTED: CAD prot (2242 aa)
initn: 7898 init1: 7898 opt: 7906 Z-score: 5250.4 bits: 985.3 E(85289): 0
Smith-Waterman score: 14011; 96.4% identity (96.4% similar) in 2211 aa overlap (32-2162:32-2242)
10 20 30 40 50 60
pF1KB3 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
::::::::::::::::::::::::::::::
XP_005 AALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVDT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEAT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQTA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEIE
550 560 570 580 590 600
610
pF1KB3 YEVVRDAYGNCVT-----------------------------------------------
:::::::::::::
XP_005 YEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLGI
610 620 630 640 650 660
620 630 640 650
pF1KB3 ----------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRNS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KB3 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALR
730 740 750 760 770 780
720 730 740 750 760 770
pF1KB3 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMK
790 800 810 820 830 840
780 790 800 810 820 830
pF1KB3 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVK
850 860 870 880 890 900
840 850 860 870 880 890
pF1KB3 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQ
910 920 930 940 950 960
900 910 920 930 940 950
pF1KB3 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPN
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KB3 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTV
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KB3 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVA
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KB3 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNL
1150 1160 1170 1180 1190 1200
1140 1150 1160 1170 1180 1190
pF1KB3 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVGV
1210 1220 1230 1240 1250 1260
1200 1210 1220 1230 1240 1250
pF1KB3 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGS
1270 1280 1290 1300 1310 1320
1260 1270 1280 1290 1300 1310
pF1KB3 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSIL
1330 1340 1350 1360 1370 1380
1320 1330 1340 1350 1360 1370
pF1KB3 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALG
1390 1400 1410 1420 1430 1440
1380 1390 1400 1410 1420 1430
pF1KB3 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVC
1450 1460 1470 1480 1490 1500
1440 1450 1460 1470 1480 1490
pF1KB3 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLNE
1510 1520 1530 1540 1550 1560
1500 1510 1520 1530 1540 1550
pF1KB3 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEEI
1570 1580 1590 1600 1610 1620
1560 1570 1580 1590 1600 1610
pF1KB3 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVID
1630 1640 1650 1660 1670 1680
1620 1630 1640 1650 1660 1670
pF1KB3 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIFH
1690 1700 1710 1720 1730 1740
1680 1690 1700 1710 1720 1730
pF1KB3 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVLV
1750 1760 1770 1780 1790 1800
1740 1750 1760 1770 1780 1790
pF1KB3 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASDP
1810 1820 1830 1840 1850 1860
1800 1810 1820 1830 1840
pF1KB3 GLPA-----------------EEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNL
:::: :::::::::::::::::::::::::::::::::::::::
XP_005 GLPAVFLRPGAGIPRGSRAWAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNL
1870 1880 1890 1900 1910 1920
1850 1860 1870 1880 1890 1900
pF1KB3 GTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTPGLLHPQTSPLLHSLVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKV
1930 1940 1950 1960 1970 1980
1910 1920 1930 1940 1950 1960
pF1KB3 MASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASMFYEVSTRTSSSFAAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLR
1990 2000 2010 2020 2030 2040
1970 1980 1990 2000 2010 2020
pF1KB3 HPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHG
2050 2060 2070 2080 2090 2100
2030 2040 2050 2060 2070 2080
pF1KB3 RTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVHSLACLLTQYRVSLRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYM
2110 2120 2130 2140 2150 2160
2090 2100 2110 2120 2130 2140
pF1KB3 TRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TRIQKERFGSTQEYEACFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYF
2170 2180 2190 2200 2210 2220
2150 2160
pF1KB3 RQAENGMYIRMALLATVLGRF
:::::::::::::::::::::
XP_005 RQAENGMYIRMALLATVLGRF
2230 2240
>>NP_001116106 (OMIM: 237300,608307,615371) carbamoyl-ph (1049 aa)
initn: 2868 init1: 1545 opt: 2170 Z-score: 1451.4 bits: 281.2 E(85289): 4.2e-74
Smith-Waterman score: 3069; 48.8% identity (73.2% similar) in 1037 aa overlap (423-1377:1-1026)
400 410 420 430 440
pF1KB3 PRKVLILGSGGLSIGQAGEFDYSGSQAIKALKEENIQTLLINPNIATVQTSQ-GL--ADK
.::::..:.:.:::::.:::.. :: ::
NP_001 MKEENVKTVLMNPNIASVQTNEVGLKQADT
10 20 30
450 460 470 480 490 500
pF1KB3 VYFLPITPHYVTQVIRNERPDGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETI
::::::::..::.::. :.:::..: .:::::::::::: : ::: .:::.:::: ::.:
NP_001 VYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESI
40 50 60 70 80 90
510 520 530 540 550 560
pF1KB3 ELTEDRRAFAARMAEIGEHVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFAS
::::. :. .. ::.:..::: :..:.:.: ::. .::::..:.:.::::::::.
NP_001 MATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICP
100 110 120 130 140 150
570 580 590 600 610
pF1KB3 NREELSALVAPAFAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVT---------------
::: : : . ::: :.:.::.::. ::::::::::::: ::::
NP_001 NRETLMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTG
160 170 180 190 200 210
620
pF1KB3 ------------------------------------------------YYIIEVNARLSR
: ::::::::::
NP_001 DSVVVAPAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSR
220 230 240 250 260 270
630 640 650 660 670 680
pF1KB3 SSALASKATGYPLAYVAAKLALGIPLPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKF
::::::::::::::..:::.::::::::..: :.: :.: ::::.:: :.:::::::..:
NP_001 SSALASKATGYPLAFIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRF
280 290 300 310 320 330
690 700 710 720 730
pF1KB3 LRVSTKIGSCMKSVGEVMGIGRSFEEAFQKALRMVDENCVGFDHTVKPVS-------DM-
.:..::: ::::::::.:::.:::.::::::: . :: . :.. :.
NP_001 HGTSSRIGSSMKSVGEVMAIGRTFEESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLR
340 350 360 370 380
740 750 760 770 780 790
pF1KB3 -ELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLP
:: :.. ::...: :. ..:.:.. .:: ::.:::..:. :. . :. .. .
NP_001 KELSEPSSTRIYAIAKAIDDNMSLDEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMT
390 400 410 420 430 440
800 810 820 830 840 850
pF1KB3 PDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYL
. :..:: .:::::::. . :: .:.:: . .: : ::::::.:::.:. :::::.
NP_001 EETLKRAKEIGFSDKQISKCLGLTEAQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYV
450 460 470 480 490 500
860 870 880 890 900 910
pF1KB3 TYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETV
:: : ::..: ..::: : :.::::::::::::. :. ::..: ::..:: :::::
NP_001 TYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETV
510 520 530 540 550 560
920 930 940 950 960 970
pF1KB3 STDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSP
:::.: ::.:::.:.:.: ..:::. : : :.:.:::.:::.:. :... ...::::
NP_001 STDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSP
570 580 590 600 610 620
980 990 1000 1010 1020 1030
pF1KB3 EAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMN
:: ::.: :: .:: . ..: :. .. :. : .: ..: :::..::::::::.:::
NP_001 LQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMN
630 640 650 660 670 680
1040 1050 1060 1070 1080 1090
pF1KB3 VAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAG
:.... ....:: :. ::.:::::..::.. :.:...:::..:: : . :::::::.::
NP_001 VVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAG
690 700 710 720 730 740
1100 1110 1120 1130 1140 1150
pF1KB3 VHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRV
::::::::. : : :. ..:..: .. ... . ..::::.:...: ... :::::.:.
NP_001 VHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRA
750 760 770 780 790 800
1160 1170 1180 1190 1200 1210
pF1KB3 SRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMT------GSGVVGVKVPQFSFSRLAG
::::::::::::::.. .::.:..::.:. : : . :..:.:.::. ::
NP_001 SRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRD
810 820 830 840 850 860
1220 1230 1240 1250 1260 1270
pF1KB3 ADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVR
:: .: ::.:::::: :::. :.::::::::::::.:.::. : . . . ..: ...
NP_001 ADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAE
870 880 890 900 910 920
1280 1290 1300 1310 1320 1330
pF1KB3 LLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVI
:.. :..:.:. .:.:. . ..: .: : : .: :. : :: . . . ...:::
NP_001 QLHNEGFKLFATEATSDWLNANNVPATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVI
930 940 950 960 970 980
1340 1350 1360 1370 1380 1390
pF1KB3 NLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHV
:: . ..:: .: :: :.: ..::. ... ::::.::.
NP_001 NLPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFH
990 1000 1010 1020 1030
1400 1410 1420 1430 1440 1450
pF1KB3 DCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMVCAMPNTRPPIIDA
NP_001 YRQYSAGKAA
1040
>>XP_011508945 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa)
initn: 3922 init1: 1545 opt: 2170 Z-score: 1449.1 bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)
10 20 30 40 50
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
:.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
: : : .::.:: :..::.::.:..:.: . .:: ::..: .:::.. .:..
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
::::: ::: .:..:..:::. .: .: . :.::: . :. ::: : .:.. :. .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
170 180 190 200 210
180 190 200 210 220 230
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.:: .....
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
..: .:.::: :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
:.. ..::: : :::.:.:: .::::.:.: :::.:::::: :: : : ::: :. .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
:.. : . .: : :.. . . :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
400 410 420 430 440
420 430 440 450 460 470
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
::.::.::::..:.:.:::::.:::.. :: :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
.:::::::::::: : ::: .:::.:::: ::.: ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
510 520 530 540 550 560
540 550 560 570 580 590
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
..:.:.: ::. .::::..:.:.::::::::. ::: : : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
570 580 590 600 610 620
600 610
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
::::::::::::: ::::
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
630 640 650 660 670 680
620 630 640 650
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
: ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
690 700 710 720 730 740
660 670 680 690 700 710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
:::..: :.: :.: ::::.:: :.:::::::..: .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
750 760 770 780 790 800
720 730 740 750 760
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
:.::::::: . :: . :.. :. :: :.. ::...: :. ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
810 820 830 840 850 860
770 780 790 800 810 820
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
.. .:: ::.:::..:. :. . :. .. . . :..:: .:::::::. . ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
870 880 890 900 910 920
830 840 850 860 870 880
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
.:.:: . .: : ::::::.:::.:. :::::.:: : ::..: ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
930 940 950 960 970 980
890 900 910 920 930 940
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
: : :.:.:::.:::.:. :... ...:::: :: ::.: :: .:: . ..:
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
1050 1060 1070 1080 1090 1100
1010 1020 1030 1040 1050 1060
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
:. .. :. : .: ..: :::..::::::::.::::.... ....:: :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
1110 1120 1130 1140 1150 1160
1070 1080 1090 1100 1110 1120
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
..::.. :.:...:::..:: : . :::::::.::::::::::. : : :. ..:..:
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
1170 1180 1190 1200 1210 1220
1130 1140 1150 1160 1170 1180
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
.. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
1230 1240 1250 1260 1270 1280
1190 1200 1210 1220 1230
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
:.:. : : . :..:.:.::. :: :: .: ::.:::::: :::. :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
1290 1300 1310 1320 1330 1340
1240 1250 1260 1270 1280 1290
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
.::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..:
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
1350 1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
.: : : .: :. : :: . . . ...::::: . ..:: .: ::
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
:.: ..::. ... ::::.::.
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
1460 1470 1480 1490 1500
>>XP_011508946 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa)
initn: 3922 init1: 1545 opt: 2170 Z-score: 1449.1 bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)
10 20 30 40 50
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
:.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
: : : .::.:: :..::.::.:..:.: . .:: ::..: .:::.. .:..
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
::::: ::: .:..:..:::. .: .: . :.::: . :. ::: : .:.. :. .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
170 180 190 200 210
180 190 200 210 220 230
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.:: .....
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
..: .:.::: :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
:.. ..::: : :::.:.:: .::::.:.: :::.:::::: :: : : ::: :. .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
:.. : . .: : :.. . . :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
400 410 420 430 440
420 430 440 450 460 470
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
::.::.::::..:.:.:::::.:::.. :: :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
.:::::::::::: : ::: .:::.:::: ::.: ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
510 520 530 540 550 560
540 550 560 570 580 590
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
..:.:.: ::. .::::..:.:.::::::::. ::: : : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
570 580 590 600 610 620
600 610
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
::::::::::::: ::::
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
630 640 650 660 670 680
620 630 640 650
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
: ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
690 700 710 720 730 740
660 670 680 690 700 710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
:::..: :.: :.: ::::.:: :.:::::::..: .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
750 760 770 780 790 800
720 730 740 750 760
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
:.::::::: . :: . :.. :. :: :.. ::...: :. ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
810 820 830 840 850 860
770 780 790 800 810 820
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
.. .:: ::.:::..:. :. . :. .. . . :..:: .:::::::. . ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
870 880 890 900 910 920
830 840 850 860 870 880
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
.:.:: . .: : ::::::.:::.:. :::::.:: : ::..: ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
930 940 950 960 970 980
890 900 910 920 930 940
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
: : :.:.:::.:::.:. :... ...:::: :: ::.: :: .:: . ..:
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
1050 1060 1070 1080 1090 1100
1010 1020 1030 1040 1050 1060
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
:. .. :. : .: ..: :::..::::::::.::::.... ....:: :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
1110 1120 1130 1140 1150 1160
1070 1080 1090 1100 1110 1120
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
..::.. :.:...:::..:: : . :::::::.::::::::::. : : :. ..:..:
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
1170 1180 1190 1200 1210 1220
1130 1140 1150 1160 1170 1180
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
.. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
1230 1240 1250 1260 1270 1280
1190 1200 1210 1220 1230
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
:.:. : : . :..:.:.::. :: :: .: ::.:::::: :::. :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
1290 1300 1310 1320 1330 1340
1240 1250 1260 1270 1280 1290
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
.::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..:
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
1350 1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
.: : : .: :. : :: . . . ...::::: . ..:: .: ::
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
:.: ..::. ... ::::.::.
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
1460 1470 1480 1490 1500
>>XP_011508943 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa)
initn: 3922 init1: 1545 opt: 2170 Z-score: 1449.1 bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)
10 20 30 40 50
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
:.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
: : : .::.:: :..::.::.:..:.: . .:: ::..: .:::.. .:..
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
::::: ::: .:..:..:::. .: .: . :.::: . :. ::: : .:.. :. .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
170 180 190 200 210
180 190 200 210 220 230
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.:: .....
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
..: .:.::: :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
:.. ..::: : :::.:.:: .::::.:.: :::.:::::: :: : : ::: :. .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
:.. : . .: : :.. . . :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
400 410 420 430 440
420 430 440 450 460 470
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
::.::.::::..:.:.:::::.:::.. :: :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
.:::::::::::: : ::: .:::.:::: ::.: ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
510 520 530 540 550 560
540 550 560 570 580 590
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
..:.:.: ::. .::::..:.:.::::::::. ::: : : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
570 580 590 600 610 620
600 610
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
::::::::::::: ::::
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
630 640 650 660 670 680
620 630 640 650
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
: ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
690 700 710 720 730 740
660 670 680 690 700 710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
:::..: :.: :.: ::::.:: :.:::::::..: .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
750 760 770 780 790 800
720 730 740 750 760
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
:.::::::: . :: . :.. :. :: :.. ::...: :. ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
810 820 830 840 850 860
770 780 790 800 810 820
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
.. .:: ::.:::..:. :. . :. .. . . :..:: .:::::::. . ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
870 880 890 900 910 920
830 840 850 860 870 880
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
.:.:: . .: : ::::::.:::.:. :::::.:: : ::..: ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
930 940 950 960 970 980
890 900 910 920 930 940
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
: : :.:.:::.:::.:. :... ...:::: :: ::.: :: .:: . ..:
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
1050 1060 1070 1080 1090 1100
1010 1020 1030 1040 1050 1060
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
:. .. :. : .: ..: :::..::::::::.::::.... ....:: :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
1110 1120 1130 1140 1150 1160
1070 1080 1090 1100 1110 1120
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
..::.. :.:...:::..:: : . :::::::.::::::::::. : : :. ..:..:
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
1170 1180 1190 1200 1210 1220
1130 1140 1150 1160 1170 1180
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
.. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
1230 1240 1250 1260 1270 1280
1190 1200 1210 1220 1230
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
:.:. : : . :..:.:.::. :: :: .: ::.:::::: :::. :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
1290 1300 1310 1320 1330 1340
1240 1250 1260 1270 1280 1290
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
.::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..:
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
1350 1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
.: : : .: :. : :: . . . ...::::: . ..:: .: ::
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
:.: ..::. ... ::::.::.
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
1460 1470 1480 1490 1500
>>XP_011508944 (OMIM: 237300,608307,615371) PREDICTED: c (1500 aa)
initn: 3922 init1: 1545 opt: 2170 Z-score: 1449.1 bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)
10 20 30 40 50
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
:.::. :::::.:::.::.:::... :.::
XP_011 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
: : : .::.:: :..::.::.:..:.: . .:: ::..: .:::.. .:..
XP_011 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
::::: ::: .:..:..:::. .: .: . :.::: . :. ::: : .:.. :. .
XP_011 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
170 180 190 200 210
180 190 200 210 220 230
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.:: .....
XP_011 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
..: .:.::: :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
XP_011 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
:.. ..::: : :::.:.:: .::::.:.: :::.:::::: :: : : ::: :. .
XP_011 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
:.. : . .: : :.. . . :::::::::::::::::::::::
XP_011 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
400 410 420 430 440
420 430 440 450 460 470
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
::.::.::::..:.:.:::::.:::.. :: :: ::::::::..::.::. :.:::..:
XP_011 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
.:::::::::::: : ::: .:::.:::: ::.: ::::. :. .. ::.:..::: :
XP_011 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
510 520 530 540 550 560
540 550 560 570 580 590
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
..:.:.: ::. .::::..:.:.::::::::. ::: : : . ::: :.:.::.::.
XP_011 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
570 580 590 600 610 620
600 610
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
::::::::::::: ::::
XP_011 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
630 640 650 660 670 680
620 630 640 650
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
: ::::::::::::::::::::::::..:::.:::::
XP_011 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
690 700 710 720 730 740
660 670 680 690 700 710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
:::..: :.: :.: ::::.:: :.:::::::..: .:..::: ::::::::.:::.::
XP_011 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
750 760 770 780 790 800
720 730 740 750 760
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
:.::::::: . :: . :.. :. :: :.. ::...: :. ..:.:
XP_011 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
810 820 830 840 850 860
770 780 790 800 810 820
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
.. .:: ::.:::..:. :. . :. .. . . :..:: .:::::::. . ::
XP_011 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
870 880 890 900 910 920
830 840 850 860 870 880
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
.:.:: . .: : ::::::.:::.:. :::::.:: : ::..: ..::: : :.
XP_011 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
930 940 950 960 970 980
890 900 910 920 930 940
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
XP_011 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
: : :.:.:::.:::.:. :... ...:::: :: ::.: :: .:: . ..:
XP_011 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
1050 1060 1070 1080 1090 1100
1010 1020 1030 1040 1050 1060
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
:. .. :. : .: ..: :::..::::::::.::::.... ....:: :. ::.:::::
XP_011 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
1110 1120 1130 1140 1150 1160
1070 1080 1090 1100 1110 1120
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
..::.. :.:...:::..:: : . :::::::.::::::::::. : : :. ..:..:
XP_011 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
1170 1180 1190 1200 1210 1220
1130 1140 1150 1160 1170 1180
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
.. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
XP_011 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
1230 1240 1250 1260 1270 1280
1190 1200 1210 1220 1230
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
:.:. : : . :..:.:.::. :: :: .: ::.:::::: :::. :
XP_011 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
1290 1300 1310 1320 1330 1340
1240 1250 1260 1270 1280 1290
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
.::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..:
XP_011 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
1350 1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
.: : : .: :. : :: . . . ...::::: . ..:: .: ::
XP_011 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
:.: ..::. ... ::::.::.
XP_011 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
1460 1470 1480 1490 1500
>>NP_001866 (OMIM: 237300,608307,615371) carbamoyl-phosp (1500 aa)
initn: 3922 init1: 1545 opt: 2170 Z-score: 1449.1 bits: 281.3 E(85289): 5.6e-74
Smith-Waterman score: 4311; 48.5% identity (73.5% similar) in 1432 aa overlap (29-1377:73-1477)
10 20 30 40 50
pF1KB3 MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIG
:.::. :::::.:::.::.:::... :.::
NP_001 AQTAHIVLEDGTKMKGYSFGHPSSVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB3 NYGIPPDE-MDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQ
: : : .::.:: :..::.::.:..:.: . .:: ::..: .:::.. .:..
NP_001 NGGAPDTTALDELGLSKYLESNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIY
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB3 GVDTRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPR
::::: ::: .:..:..:::. .: .: . :.::: . :. ::: : .:.. :. .
NP_001 GVDTRMLTKIIRDKGTMLGKIEFEG-QP--VDFVDPNKQNLIAEVSTKDVKVYGKGNPTK
170 180 190 200 210
180 190 200 210 220 230
pF1KB3 ILALDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLS
..:.:::.: : :: : .::::: .:::.: . ..::.:.....:::.:: .....
NP_001 VVAVDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVR
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB3 RVLSEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGF
..: .:.::: :. . .:: ::::::: ..:::.::: : . . . :.:.::::.
NP_001 KILESDRKEPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGY
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB3 AVETDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETV
:.. ..::: : :::.:.:: .::::.:.: :::.:::::: :: : : ::: :. .
NP_001 ALD-NTLPAGWKPLFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLI
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB3 KEATAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGS
:.. : . .: : :.. . . :::::::::::::::::::::::
NP_001 KKGKATT---------ITSVLPKPALVASRVEVS---KVLILGSGGLSIGQAGEFDYSGS
400 410 420 430 440
420 430 440 450 460 470
pF1KB3 QAIKALKEENIQTLLINPNIATVQTSQ-GL--ADKVYFLPITPHYVTQVIRNERPDGVLL
::.::.::::..:.:.:::::.:::.. :: :: ::::::::..::.::. :.:::..:
NP_001 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITPQFVTEVIKAEQPDGLIL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KB3 TFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEA
.:::::::::::: : ::: .:::.:::: ::.: ::::. :. .. ::.:..::: :
NP_001 GMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDRQLFSDKLNEINEKIAPSFA
510 520 530 540 550 560
540 550 560 570 580 590
pF1KB3 ANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSL
..:.:.: ::. .::::..:.:.::::::::. ::: : : . ::: :.:.::.::.
NP_001 VESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMDLSTKAFAMTNQILVEKSV
570 580 590 600 610 620
600 610
pF1KB3 KGWKEIEYEVVRDAYGNCVT----------------------------------------
::::::::::::: ::::
NP_001 TGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQTLSNAEFQMLRRTSIN
630 640 650 660 670 680
620 630 640 650
pF1KB3 -----------------------YYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIP
: ::::::::::::::::::::::::..:::.:::::
NP_001 VVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLAFIAAKIALGIP
690 700 710 720 730 740
660 670 680 690 700 710
pF1KB3 LPELRNSVTGGTAA-FEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFE
:::..: :.: :.: ::::.:: :.:::::::..: .:..::: ::::::::.:::.::
NP_001 LPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMAIGRTFE
750 760 770 780 790 800
720 730 740 750 760
pF1KB3 EAFQKALRMVDENCVGFDHTVKPVS-------DM--ELETPTDKRIFVVAAALWAGYSVD
:.::::::: . :: . :.. :. :: :.. ::...: :. ..:.:
NP_001 ESFQKALRMCHPSIEGFTPRL-PMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSLD
810 820 830 840 850 860
770 780 790 800 810 820
pF1KB3 RLYELTRIDRWFLHRMKRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTE
.. .:: ::.:::..:. :. . :. .. . . :..:: .:::::::. . ::
NP_001 EIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTE
870 880 890 900 910 920
830 840 850 860 870 880
pF1KB3 LAVRKLRQELGICPAVKQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYR
.:.:: . .: : ::::::.:::.:. :::::.:: : ::..: ..::: : :.
NP_001 AQTRELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYH
930 940 950 960 970 980
890 900 910 920 930 940
pF1KB3 IGSSVEFDWCAVGCIQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYE
::::::::::::. :. ::..: ::..:: ::::::::.: ::.:::.:.:.: ..:::.
NP_001 IGSSVEFDWCAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYH
990 1000 1010 1020 1030 1040
950 960 970 980 990 1000
pF1KB3 LENPEGVILSMGGQLPNNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQ
: : :.:.:::.:::.:. :... ...:::: :: ::.: :: .:: . ..:
NP_001 QEACGGCIISVGGQIPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAP
1050 1060 1070 1080 1090 1100
1010 1020 1030 1040 1050 1060
pF1KB3 WRELSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVV
:. .. :. : .: ..: :::..::::::::.::::.... ....:: :. ::.:::::
NP_001 WKAVNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVV
1110 1120 1130 1140 1150 1160
1070 1080 1090 1100 1110 1120
pF1KB3 ISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKA
..::.. :.:...:::..:: : . :::::::.::::::::::. : : :. ..:..:
NP_001 LTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKD
1170 1180 1190 1200 1210 1220
1130 1140 1150 1160 1170 1180
pF1KB3 IVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMG
.. ... . ..::::.:...: ... :::::.:.::::::::::::::.. .::.:..:
NP_001 ATRKIAKAFAISGPFNVQFLVKGNDVLVIECNLRASRSFPFVSKTLGVDFIDVATKVMIG
1230 1240 1250 1260 1270 1280
1190 1200 1210 1220 1230
pF1KB3 EEVEPVGLMT------GSGVVGVKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEA
:.:. : : . :..:.:.::. :: :: .: ::.:::::: :::. :
NP_001 ENVDEKHLPTLDHPIIPADYVAIKAPMFSWPRLRDADPILRCEMASTGEVACFGEGIHTA
1290 1300 1310 1320 1330 1340
1240 1250 1260 1270 1280 1290
pF1KB3 YLKAMLSTGFKIPKKNILLTIGSYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVK
.::::::::::::.:.::. : . . . ..: ... :.. :..:.:. .:.:. . ..:
NP_001 FLKAMLSTGFKIPQKGILIGI-QQSFRPRFLGVAEQLHNEGFKLFATEATSDWLNANNVP
1350 1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KB3 VTAVDWHFEEAVDGECPPQRSILEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRL
.: : : .: :. : :: . . . ...::::: . ..:: .: ::
NP_001 ATPVAWPSQE---GQNPSLSSIRKLIRDGSIDLVINLPNNN------TKFVHDNYVIRRT
1410 1420 1430 1440 1450
1360 1370 1380 1390 1400 1410
pF1KB3 AADFSVPLIIDIKCTKLFVEALGQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPG
:.: ..::. ... ::::.::.
NP_001 AVDSGIPLLTNFQVTKLFAEAVQKSRKVDSKSLFHYRQYSAGKAA
1460 1470 1480 1490 1500
2162 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:51:54 2016 done: Thu Nov 3 20:51:57 2016
Total Scan time: 19.400 Total Display time: 1.260
Function used was FASTA [36.3.4 Apr, 2011]