Result of FASTA (omim) for
pF1KB3050
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3050, 540 aa
1>>>pF1KB3050 540 - 540 aa - 540 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5173+/-0.000332; mu= 18.6846+/- 0.021
mean_var=84.9553+/-17.066, 0's: 0 Z-trim(117.0): 54 B-trim: 840 in 1/53
Lambda= 0.139149
statistics sampled from 28635 (28689) to 28635 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.336), width: 16
Scan time: 8.560
The best scores are: opt bits E(85289)
NP_001003931 (OMIM: 607726) poly [ADP-ribose] poly ( 540) 3649 742.4 8.3e-214
NP_005476 (OMIM: 607726) poly [ADP-ribose] polymer ( 533) 3609 734.3 2.1e-211
XP_016860979 (OMIM: 607726) PREDICTED: poly [ADP-r ( 533) 3609 734.3 2.1e-211
XP_005264836 (OMIM: 607726) PREDICTED: poly [ADP-r ( 533) 3609 734.3 2.1e-211
NP_005475 (OMIM: 607725) poly [ADP-ribose] polymer ( 583) 934 197.4 1e-49
NP_001036083 (OMIM: 607725) poly [ADP-ribose] poly ( 570) 931 196.8 1.5e-49
XP_005267304 (OMIM: 607725) PREDICTED: poly [ADP-r ( 500) 826 175.6 3.1e-43
XP_016876401 (OMIM: 607725) PREDICTED: poly [ADP-r ( 487) 823 175.0 4.6e-43
NP_001609 (OMIM: 173870) poly [ADP-ribose] polymer (1014) 715 153.6 2.7e-36
XP_011533234 (OMIM: 607519) PREDICTED: poly [ADP-r (1724) 272 64.8 2.4e-09
NP_006428 (OMIM: 607519) poly [ADP-ribose] polymer (1724) 272 64.8 2.4e-09
XP_011533233 (OMIM: 607519) PREDICTED: poly [ADP-r (1771) 272 64.8 2.5e-09
XP_011510780 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 162 42.3 0.0037
XP_016861281 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 162 42.3 0.0037
XP_011510781 (OMIM: 612066) PREDICTED: poly [ADP-r ( 425) 162 42.3 0.0037
NP_689828 (OMIM: 612066) poly [ADP-ribose] polymer ( 444) 162 42.3 0.0038
XP_011510779 (OMIM: 612066) PREDICTED: poly [ADP-r ( 552) 162 42.4 0.0045
XP_005247217 (OMIM: 612066) PREDICTED: poly [ADP-r ( 602) 162 42.4 0.0048
XP_011510778 (OMIM: 612066) PREDICTED: poly [ADP-r ( 628) 162 42.4 0.0049
XP_011510777 (OMIM: 612066) PREDICTED: poly [ADP-r ( 638) 162 42.4 0.005
NP_001106995 (OMIM: 612066) poly [ADP-ribose] poly ( 678) 162 42.4 0.0052
NP_001295250 (OMIM: 612066) poly [ADP-ribose] poly ( 375) 156 41.0 0.0077
NP_001295249 (OMIM: 612066) poly [ADP-ribose] poly ( 483) 156 41.1 0.0093
>>NP_001003931 (OMIM: 607726) poly [ADP-ribose] polymera (540 aa)
initn: 3649 init1: 3649 opt: 3649 Z-score: 3959.5 bits: 742.4 E(85289): 8.3e-214
Smith-Waterman score: 3649; 100.0% identity (100.0% similar) in 540 aa overlap (1-540:1-540)
10 20 30 40 50 60
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
490 500 510 520 530 540
>>NP_005476 (OMIM: 607726) poly [ADP-ribose] polymerase (533 aa)
initn: 3609 init1: 3609 opt: 3609 Z-score: 3916.2 bits: 734.3 E(85289): 2.1e-211
Smith-Waterman score: 3609; 100.0% identity (100.0% similar) in 533 aa overlap (8-540:1-533)
10 20 30 40 50 60
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB3 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB3 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB3 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
480 490 500 510 520 530
>>XP_016860979 (OMIM: 607726) PREDICTED: poly [ADP-ribos (533 aa)
initn: 3609 init1: 3609 opt: 3609 Z-score: 3916.2 bits: 734.3 E(85289): 2.1e-211
Smith-Waterman score: 3609; 100.0% identity (100.0% similar) in 533 aa overlap (8-540:1-533)
10 20 30 40 50 60
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB3 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB3 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB3 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
480 490 500 510 520 530
>>XP_005264836 (OMIM: 607726) PREDICTED: poly [ADP-ribos (533 aa)
initn: 3609 init1: 3609 opt: 3609 Z-score: 3916.2 bits: 734.3 E(85289): 2.1e-211
Smith-Waterman score: 3609; 100.0% identity (100.0% similar) in 533 aa overlap (8-540:1-533)
10 20 30 40 50 60
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCP
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKIN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPV
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEAL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB3 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB3 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARG
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB3 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
480 490 500 510 520 530
>>NP_005475 (OMIM: 607725) poly [ADP-ribose] polymerase (583 aa)
initn: 705 init1: 138 opt: 934 Z-score: 1013.4 bits: 197.4 E(85289): 1e-49
Smith-Waterman score: 935; 35.2% identity (64.9% similar) in 542 aa overlap (20-540:54-577)
10 20 30 40
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREED-PFRSTA-----EAL
: . .: : ... : :: : :..
NP_005 NNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESV
30 40 50 60 70 80
50 60 70 80 90
pF1KB3 KAIPAEKRIIRVDPTCPLSSNPG-TQVYED----YNCTLNQTNIENNNNKFYIIQLLQD-
::. . . ::: : ... : ..:: . :. :::::.. ::::.:.::::.:
NP_005 KALLLKGKAP-VDPEC--TAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDD
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB3 SNRFFTCWNRWGRVGEVGQ-SKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGK
..: :. : ::::::..:: : . :. ::. :.::: .:::::: .:..: . :::
NP_005 AQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGK
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB3 YTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCS-LDPATQKLITNIFSKEMFKNTMAL
: ..... ..:. . . ... . ..: : :: .:.:: : . . ... :
NP_005 YDMLQMDYATNTQD---EEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMME
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 MDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHS
: ..:: :::::. :: :...:. .:. ... : ..: : ..::: :::.::
NP_005 MKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHG-RALMEACNEFYTRIPHDFGLR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB3 QPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQL
:: : . . :. : ..: .:.:::. :.. :. . .. : ::::. :. :.: :.
NP_005 TPPLIRTQKELSEKIQLLEALGDIEI--AIKLVKTELQSPE---HPLDQHYRNLHCALRP
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB3 LDSGAPEYKVIQTYLEQTGS-NHR--CPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHG
:: . :.:::. ::..: . .: :: ...:...::.. :. : :: :::::
NP_005 LDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFRED--LHNRMLLWHG
380 390 400 410 420
400 410 420 430 440
pF1KB3 TNMAVVAAILTSGLRIMPH----SGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFL
. :. ..::. :::: : .: :::::::. .::::.: .. . ...: ..:
NP_005 SRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASR--LKNTGLLLL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB3 GEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVP
.:::::. ... ::. .. : :. .: . :.. . :.:. : . .. .
NP_005 SEVALGQCNELLEANPKAEGLLQGKHST--KGLGKMAPSSAHFVTLNGSTVPLGPASDTG
490 500 510 520 530 540
510 520 530 540
pF1KB3 CPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
. .. :.. .::..:. .: :.::::.:..
NP_005 ILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
550 560 570 580
>>NP_001036083 (OMIM: 607725) poly [ADP-ribose] polymera (570 aa)
initn: 705 init1: 138 opt: 931 Z-score: 1010.3 bits: 196.8 E(85289): 1.5e-49
Smith-Waterman score: 931; 35.4% identity (65.4% similar) in 537 aa overlap (22-540:46-564)
10 20 30 40
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTA---EALKAIPA
:.:: :: . . :. :..::.
NP_001 ALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDESVKALLL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB3 EKRIIRVDPTCPLSSNPG-TQVYED----YNCTLNQTNIENNNNKFYIIQLLQD-SNRFF
. . ::: : ... : ..:: . :. :::::.. ::::.:.::::.: ..: :
NP_001 KGKAP-VDPEC--TAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNF
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB3 TCWNRWGRVGEVGQ-SKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIE
. : ::::::..:: : . :. ::. :.::: .:::::: .:..: . :::: ...
NP_001 SVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQ
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB3 VQAEDEAQEAVVKVDRGPVRTVTKRVQPCS-LDPATQKLITNIFSKEMFKNTMALMDLDV
.. ..:. . . ... . ..: : :: .:.:: : . . ... : : ..
NP_001 MDYATNTQD---EEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNT
200 210 220 230 240
230 240 250 260 270 280
pF1KB3 KKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPI
:: :::::. :: :...:. .:. ... . :..: : ..::: :::.:: :: :
NP_001 KKAPLGKLTVAQIKAGYQSLKKIEDCIRAG-QHGRALMEACNEFYTRIPHDFGLRTPPLI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB3 NSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGA
. . :. : ..: .:.:::.: .. :. . .. : ::::. :. :.: :. :: .
NP_001 RTQKELSEKIQLLEALGDIEIA--IKLVKTELQSPE---HPLDQHYRNLHCALRPLDHES
310 320 330 340 350 360
350 360 370 380 390
pF1KB3 PEYKVIQTYLEQTGS-NHR--CPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAV
:.:::. ::..: . .: :: ...:...::.. :. : :: :::::. :.
NP_001 YEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFRE--DLHNRMLLWHGSRMSN
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB3 VAAILTSGLRIMPH----SGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVAL
..::. :::: : .: :::::::. .::::.: .. . ...: ..:.::::
NP_001 WVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRL--KNTGLLLLSEVAL
430 440 450 460 470
460 470 480 490 500 510
pF1KB3 GREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFS
:. ... ::. .. : : ..: . :.. . :.:. : . .. . . .
NP_001 GQCNELLEANPKAEGLLQGKHS--TKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPD
480 490 500 510 520 530
520 530 540
pF1KB3 SSTFSQSEYLIYQESQCRLRYLLEVHL
. :.. .::..:. .: :.::::.:..
NP_001 GYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
540 550 560 570
>>XP_005267304 (OMIM: 607725) PREDICTED: poly [ADP-ribos (500 aa)
initn: 659 init1: 138 opt: 826 Z-score: 897.2 bits: 175.6 E(85289): 3.1e-43
Smith-Waterman score: 827; 36.8% identity (65.0% similar) in 451 aa overlap (20-450:54-489)
10 20 30 40
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREED-PFRSTA-----EAL
: . .: : ... : :: : :..
XP_005 NNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESV
30 40 50 60 70 80
50 60 70 80 90
pF1KB3 KAIPAEKRIIRVDPTCPLSSNPGTQVYED----YNCTLNQTNIENNNNKFYIIQLLQD-S
::. . . ::: : . . . .:: . :. :::::.. ::::.:.::::.: .
XP_005 KALLLKGKAP-VDPECTAKVGKA-HVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDA
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB3 NRFFTCWNRWGRVGEVGQ-SKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKY
.: :. : ::::::..:: : . :. ::. :.::: .:::::: .:..: . ::::
XP_005 QRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKY
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB3 TLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCS-LDPATQKLITNIFSKEMFKNTMALM
..... ..:. . . ... . ..: : :: .:.:: : . . ... : :
XP_005 DMLQMDYATNTQD---EEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEM
210 220 230 240 250
220 230 240 250 260 270
pF1KB3 DLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQ
..:: :::::. :: :...:. .:. ... : ..: : ..::: :::.::
XP_005 KYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHG-RALMEACNEFYTRIPHDFGLRT
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB3 PPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLL
:: : . . :. : ..: .:.:::.: .. :. . .. : ::::. :. :.: :. :
XP_005 PPLIRTQKELSEKIQLLEALGDIEIA--IKLVKTELQSPE---HPLDQHYRNLHCALRPL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB3 DSGAPEYKVIQTYLEQTGS-NHR--CPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGT
: . :.:::. ::..: . .: :: ...:...::.. :. : :: :::::.
XP_005 DHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFRED--LHNRMLLWHGS
380 390 400 410 420 430
400 410 420 430 440
pF1KB3 NMAVVAAILTSGLRIMPH----SGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLG
:. ..::. :::: : .: :::::::. .::::.: .. . ...: ..:.
XP_005 RMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASR--LKNTGLLLLS
440 450 460 470 480
450 460 470 480 490 500
pF1KB3 EVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPC
:
XP_005 EEWEYSAIRTSK
490 500
>>XP_016876401 (OMIM: 607725) PREDICTED: poly [ADP-ribos (487 aa)
initn: 659 init1: 138 opt: 823 Z-score: 894.1 bits: 175.0 E(85289): 4.6e-43
Smith-Waterman score: 823; 36.9% identity (65.2% similar) in 445 aa overlap (22-450:46-476)
10 20 30 40
pF1KB3 MSLLFLAMAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAE--
:.:: :: . . :. . ... :
XP_016 ALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDESVKALLL
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB3 KRIIRVDPTCPLSSNPGTQVYED----YNCTLNQTNIENNNNKFYIIQLLQD-SNRFFTC
: ::: : . . . .:: . :. :::::.. ::::.:.::::.: ..: :.
XP_016 KGKAPVDPECTAKVGKA-HVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSV
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB3 WNRWGRVGEVGQ-SKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQ
: ::::::..:: : . :. ::. :.::: .:::::: .:..: . :::: .....
XP_016 WMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMD
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB3 AEDEAQEAVVKVDRGPVRTVTKRVQPCS-LDPATQKLITNIFSKEMFKNTMALMDLDVKK
..:. . . ... . ..: : :: .:.:: : . . ... : : ..::
XP_016 YATNTQD---EEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKK
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB3 MPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINS
:::::. :: :...:. .:. ... . :..: : ..::: :::.:: :: : .
XP_016 APLGKLTVAQIKAGYQSLKKIEDCIRAG-QHGRALMEACNEFYTRIPHDFGLRTPPLIRT
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB3 PELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPE
. :. : ..: .:.:::.: .. :. . .. : ::::. :. :.: :. :: . :
XP_016 QKELSEKIQLLEALGDIEIA--IKLVKTELQSPE---HPLDQHYRNLHCALRPLDHESYE
320 330 340 350 360
350 360 370 380 390
pF1KB3 YKVIQTYLEQTGS-NHR--CPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVA
.:::. ::..: . .: :: ...:...::.. :. : :: :::::. :. .
XP_016 FKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFRED--LHNRMLLWHGSRMSNWV
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB3 AILTSGLRIMPH----SGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGR
.::. :::: : .: :::::::. .::::.: .. . ...: ..:.:
XP_016 GILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASR--LKNTGLLLLSEEWEYS
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB3 EHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSS
XP_016 AIRTSK
>>NP_001609 (OMIM: 173870) poly [ADP-ribose] polymerase (1014 aa)
initn: 609 init1: 159 opt: 715 Z-score: 772.5 bits: 153.6 E(85289): 2.7e-36
Smith-Waterman score: 867; 33.8% identity (64.6% similar) in 565 aa overlap (4-540:472-1007)
10 20
pF1KB3 MSLLFLA--MAP-----KPKPWVQTEGPEKKKG
:::: ..: : .: :.. .:. :.:
NP_001 KMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEP-VEVVAPRGKSG
450 460 470 480 490 500
30 40 50 60 70
pF1KB3 -----RQAGR-EEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYED----YNCT
.. :. .:. . .. . .: . : ::: : . ..: : .. :
NP_001 AALSKKSKGQVKEEGINKSEKRMKL--TLKGGAAVDPDSGLEHS--AHVLEKGGKVFSAT
510 520 530 540 550
80 90 100 110 120 130
pF1KB3 LNQTNIENNNNKFYIIQLLQDS--NRFFTCWNRWGRVGEV-GQSKINHFTRLEDAKKDFE
:. ..: ...:..: .:::.:. ::.. . ::::: : :..:.... ::: . :
NP_001 LGLVDIVKGTNSYYKLQLLEDDKENRYWI-FRSWGRVGTVIGSNKLEQMPSKEDAIEHFM
560 570 580 590 600 610
140 150 160 170 180 190
pF1KB3 KKFREKTKNNWAERDHFVSHPGKYTLIEVQ-AEDEAQEAVVKVDRGPVRTVTKRVQPCSL
: ..::: : : .. :...: :. .:.. ..:: ::: :. .: : .: .:
NP_001 KLYEEKTGNAWHSKN-FTKYPKKFYPLEIDYGQDE--EAVKKLTVNP-GTKSKLPKP---
620 630 640 650 660
200 210 220 230 240 250
pF1KB3 DPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTD
.: :: ::. : .:..:. ...:..:::::::::.:: .. : ...:.. ..
NP_001 ---VQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSS
670 680 690 700 710 720
260 270 280 290 300 310
pF1KB3 GGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQE
.: :. ::..:::.:::.:: ..:: .:. . .::: .:: : :::.: .: . ..
NP_001 DSQILD-LSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDD
730 740 750 760 770 780
320 330 340 350 360
pF1KB3 KTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQT-GSNHRCPTLQ--HIWKVN
.. . :.: .:. :: .....: . : ..:. :...: ...: :. :.:..
NP_001 SSKD----PIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
790 800 810 820 830 840
370 380 390 400 410 420
pF1KB3 QEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPH----SGGRVGKGIYFASE
.::: .:.. ..: ::.:::::. . :.::..:::: : .: :::::::.
NP_001 REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
850 860 870 880 890 900
430 440 450 460 470 480
pF1KB3 NSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPD
::::.: . .: ..::::::: .... . ... : : :: . :.: ::
NP_001 VSKSANYC--HTSQGDPIGLILLGEVALGNMYELKHAS-HISKLPKGKHSVKGLGKTTPD
910 920 930 940 950
490 500 510 520 530 540
pF1KB3 PTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
:. . . ::: : :: : . ..... .::..:. .: :.:::....
NP_001 PSAN--ISLDG--VDVPLGTGISSG-VNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTS
960 970 980 990 1000 1010
NP_001 LW
>>XP_011533234 (OMIM: 607519) PREDICTED: poly [ADP-ribos (1724 aa)
initn: 229 init1: 82 opt: 272 Z-score: 288.7 bits: 64.8 E(85289): 2.4e-09
Smith-Waterman score: 285; 24.8% identity (55.2% similar) in 391 aa overlap (126-505:209-555)
100 110 120 130 140 150
pF1KB3 QDSNRFFTCWNRWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPG
:::.. ::. ..: :... :.::. .
XP_011 SRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPE--
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB3 KYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMAL
.: .: .:.. . . .. .:. .. :. :... . . :
XP_011 -----ATQLASEQLQALL---------LEEVMNSSTLSQEVSDLVEMIWAEALGHLEHML
240 250 260 270 280
220 230 240 250 260 270
pF1KB3 MDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHS
. :....: ...... : .. :::. . ...:... ..:: .:::. : .
XP_011 LK------PVNRISLNDVSKAEGILLLVKAALKNG-ETAEQLQKMMTEFYRLIPHK-G-T
290 300 310 320 330
280 290 300 310 320 330
pF1KB3 QPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQL
.: .: :: : :. .. :. :. : .. . : :. :.:...
XP_011 MPKEVNLG-LLAKKADLCQLIRDM--------VNVCETNLSKPNPPSLAKYRALRCKIEH
340 350 360 370 380
340 350 360 370 380 390
pF1KB3 LDSGAPEY-KVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTN
..... :. .: . :.. :. .:: :..:.. .: .: ::::: . : ::.
XP_011 VEQNTEEFLRVRKEVLQNHHSKSPVDVLQ-IFRVGRVNETTEFL--SKLGNVRPLLHGSP
390 400 410 420 430 440
400 410 420 430 440
pF1KB3 MAVVAAILTSGL---RIMPHSG------GRVGKGIYFASENSKSAGYV-IGMKCGAHHVG
. ...:: :: ... : : .:.::::.. : : : : :..
XP_011 VQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTR---
450 460 470 480 490
450 460 470 480 490 500
pF1KB3 YMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQG
... .::::. .. . :: :::.::: . ..: . : : : : . :: .
XP_011 LLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTA-SVTTDFE---DDEFVVYKTN
500 510 520 530 540 550
510 520 530 540
pF1KB3 QPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
:
XP_011 QVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQLPDAKTSSSTKAGLQ
560 570 580 590 600 610
540 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:48:56 2016 done: Sat Nov 5 04:48:57 2016
Total Scan time: 8.560 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]