Result of FASTA (omim) for
pF1KB3039
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3039, 1124 aa
1>>>pF1KB3039 1124 - 1124 aa - 1124 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.1452+/-0.000815; mu= -31.6264+/- 0.048
mean_var=1002.2790+/-218.644, 0's: 0 Z-trim(114.3): 801 B-trim: 0 in 0/55
Lambda= 0.040512
statistics sampled from 23210 (24010) to 23210 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.602), E-opt: 0.2 (0.282), width: 16
Scan time: 10.440
The best scores are: opt bits E(85289)
NP_000450 (OMIM: 600195,600221) angiopoietin-1 rec (1124) 7699 468.1 1.3e-130
XP_005251618 (OMIM: 600195,600221) PREDICTED: angi (1123) 7671 466.5 4e-130
NP_001277006 (OMIM: 600195,600221) angiopoietin-1 (1081) 5451 336.7 4.5e-91
NP_001277007 (OMIM: 600195,600221) angiopoietin-1 ( 976) 5434 335.7 8.4e-91
XP_005251620 (OMIM: 600195,600221) PREDICTED: angi (1080) 5423 335.1 1.4e-90
XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-pr ( 783) 1949 131.9 1.5e-29
NP_001240286 (OMIM: 600222) tyrosine-protein kinas (1093) 1949 132.0 1.9e-29
XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-pr (1095) 1949 132.0 1.9e-29
NP_005415 (OMIM: 600222) tyrosine-protein kinase r (1138) 1949 132.1 1.9e-29
XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-pr ( 830) 1415 100.7 3.9e-20
NP_075254 (OMIM: 100800,109800,114500,134934,14600 ( 694) 851 67.6 2.9e-10
NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806) 851 67.7 3.2e-10
XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807) 851 67.7 3.2e-10
NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808) 851 67.7 3.2e-10
XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810) 851 67.7 3.2e-10
XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807) 849 67.6 3.4e-10
XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808) 849 67.6 3.4e-10
XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809) 849 67.6 3.5e-10
XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809) 849 67.6 3.5e-10
XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810) 849 67.6 3.5e-10
XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811) 849 67.6 3.5e-10
NP_001138387 (OMIM: 101200,101400,101600,123150,12 ( 707) 843 67.2 4e-10
NP_001307583 (OMIM: 101200,101400,101600,123150,12 ( 593) 832 66.5 5.6e-10
XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498) 829 66.2 5.6e-10
NP_001138391 (OMIM: 101200,101400,101600,123150,12 ( 680) 832 66.5 6.1e-10
XP_016871414 (OMIM: 101200,101400,101600,123150,12 ( 689) 832 66.5 6.2e-10
NP_001138390 (OMIM: 101200,101400,101600,123150,12 ( 704) 832 66.5 6.3e-10
NP_001138389 (OMIM: 101200,101400,101600,123150,12 ( 705) 832 66.5 6.3e-10
NP_001138388 (OMIM: 101200,101400,101600,123150,12 ( 706) 832 66.5 6.3e-10
NP_001138386 (OMIM: 101200,101400,101600,123150,12 ( 709) 832 66.5 6.3e-10
XP_016871413 (OMIM: 101200,101400,101600,123150,12 ( 725) 832 66.6 6.4e-10
XP_006717775 (OMIM: 101200,101400,101600,123150,12 ( 726) 832 66.6 6.4e-10
NP_075418 (OMIM: 101200,101400,101600,123150,12350 ( 732) 832 66.6 6.4e-10
XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508) 826 66.0 6.5e-10
XP_016871412 (OMIM: 101200,101400,101600,123150,12 ( 749) 832 66.6 6.5e-10
XP_016871411 (OMIM: 101200,101400,101600,123150,12 ( 750) 832 66.6 6.5e-10
XP_006717774 (OMIM: 101200,101400,101600,123150,12 ( 752) 832 66.6 6.6e-10
NP_001138385 (OMIM: 101200,101400,101600,123150,12 ( 769) 832 66.6 6.6e-10
XP_016871410 (OMIM: 101200,101400,101600,123150,12 ( 804) 832 66.6 6.8e-10
XP_016871409 (OMIM: 101200,101400,101600,123150,12 ( 805) 832 66.6 6.8e-10
XP_006717773 (OMIM: 101200,101400,101600,123150,12 ( 807) 832 66.6 6.9e-10
NP_001307587 (OMIM: 101200,101400,101600,123150,12 ( 819) 832 66.6 6.9e-10
NP_000132 (OMIM: 101200,101400,101600,123150,12350 ( 821) 832 66.6 6.9e-10
NP_075259 (OMIM: 101200,101400,101600,123150,12350 ( 822) 832 66.6 6.9e-10
XP_006717771 (OMIM: 101200,101400,101600,123150,12 ( 839) 832 66.6 7e-10
XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729) 829 66.4 7.2e-10
NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731) 829 66.4 7.3e-10
NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733) 829 66.4 7.3e-10
NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733) 829 66.4 7.3e-10
XP_011532767 (OMIM: 134935) PREDICTED: fibroblast ( 696) 828 66.3 7.3e-10
>>NP_000450 (OMIM: 600195,600221) angiopoietin-1 recepto (1124 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 2465.9 bits: 468.1 E(85289): 1.3e-130
Smith-Waterman score: 7699; 100.0% identity (100.0% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1090 1100 1110 1120
>>XP_005251618 (OMIM: 600195,600221) PREDICTED: angiopoi (1123 aa)
initn: 5600 init1: 5429 opt: 7671 Z-score: 2457.1 bits: 466.5 E(85289): 4e-130
Smith-Waterman score: 7671; 99.8% identity (99.8% similar) in 1124 aa overlap (1-1124:1-1123)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAQAFQN-REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
790 800 810 820 830
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
840 850 860 870 880 890
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1080 1090 1100 1110 1120
>>NP_001277006 (OMIM: 600195,600221) angiopoietin-1 rece (1081 aa)
initn: 5235 init1: 5235 opt: 5451 Z-score: 1756.0 bits: 336.7 E(85289): 4.5e-91
Smith-Waterman score: 7239; 96.2% identity (96.2% similar) in 1124 aa overlap (1-1124:1-1081)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
:::::::::::::::::
NP_001 -------------------------------------------GIPRMTPKIVDLPDHIE
310
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
740 750 760 770 780 790
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
800 810 820 830 840 850
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
980 990 1000 1010 1020 1030
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1040 1050 1060 1070 1080
>>NP_001277007 (OMIM: 600195,600221) angiopoietin-1 rece (976 aa)
initn: 4269 init1: 2976 opt: 5434 Z-score: 1751.2 bits: 335.7 E(85289): 8.4e-91
Smith-Waterman score: 6423; 95.6% identity (95.6% similar) in 1003 aa overlap (122-1124:18-976)
100 110 120 130 140 150
pF1KB3 KASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEE
::::::::::::::::::::::::::::::
NP_001 MDSLASLVLCGVSLLLSASFLPATLTMTVDKGDNVNISFKKVLIKEE
10 20 30 40
160 170 180 190 200 210
pF1KB3 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
50 60 70 80 90 100
220 230 240 250 260 270
pF1KB3 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
110 120 130 140 150 160
280 290 300 310 320 330
pF1KB3 EGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLC
:::::::::::::::::::::::::::::
NP_001 EGCKSYVFCLPDPYGCSCATGWKGLQCNE-------------------------------
170 180 190
340 350 360 370 380 390
pF1KB3 SPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------GIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
200 210 220 230 240
400 410 420 430 440 450
pF1KB3 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
250 260 270 280 290 300
460 470 480 490 500 510
pF1KB3 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
310 320 330 340 350 360
520 530 540 550 560 570
pF1KB3 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
370 380 390 400 410 420
580 590 600 610 620 630
pF1KB3 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
430 440 450 460 470 480
640 650 660 670 680 690
pF1KB3 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
490 500 510 520 530 540
700 710 720 730 740 750
pF1KB3 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
550 560 570 580 590 600
760 770 780 790 800 810
pF1KB3 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNP
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_001 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-REEPAVQFNSGTLALNRKVKNNP
610 620 630 640 650 660
820 830 840 850 860 870
pF1KB3 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
670 680 690 700 710 720
880 890 900 910 920 930
pF1KB3 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
730 740 750 760 770 780
940 950 960 970 980 990
pF1KB3 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
790 800 810 820 830 840
1000 1010 1020 1030 1040 1050
pF1KB3 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
850 860 870 880 890 900
1060 1070 1080 1090 1100 1110
pF1KB3 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
910 920 930 940 950 960
1120
pF1KB3 TYAGIDCSAEEAA
:::::::::::::
NP_001 TYAGIDCSAEEAA
970
>>XP_005251620 (OMIM: 600195,600221) PREDICTED: angiopoi (1080 aa)
initn: 5057 init1: 2965 opt: 5423 Z-score: 1747.2 bits: 335.1 E(85289): 1.4e-90
Smith-Waterman score: 7211; 96.0% identity (96.0% similar) in 1124 aa overlap (1-1124:1-1080)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
:: ::::::::::::::
XP_005 -------------------------------------------GIQRMTPKIVDLPDHIE
310
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAQAFQN-REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
740 750 760 770 780 790
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
800 810 820 830 840 850
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
980 990 1000 1010 1020 1030
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1040 1050 1060 1070 1080
>>XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-protei (783 aa)
initn: 2188 init1: 1843 opt: 1949 Z-score: 651.5 bits: 131.9 E(85289): 1.5e-29
Smith-Waterman score: 2348; 51.0% identity (72.4% similar) in 775 aa overlap (370-1123:17-783)
340 350 360 370 380 390
pF1KB3 CEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFN
: :.: :.:. . : :::::::
XP_006 MASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAI
10 20 30 40
400 410 420 430 440 450
pF1KB3 HTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHN
. ..: : . :.. ::: : : :.: .:. . :...::: : :: :: .. : ..
XP_006 VEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQS
50 60 70 80 90 100
460 470 480 490 500 510
pF1KB3 FAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQ
.. . :::::.. .: :.: . :. : : .: ::: :.:.: : . ::
XP_006 RQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQ
110 120 130 140 150 160
520 530 540 550 560 570
pF1KB3 LVRRGEGGEGHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--D
: : :::::: :: .:: . : .: .. .. : ..:. :. :. :
XP_006 LSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGD
170 180 190 200 210 220
580 590 600 610 620 630
pF1KB3 DFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTA
: ... . . ..:.. : :. ::..: : .: . ... . : : .
XP_006 GFLLRLWDGTRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV
230 240 250 260 270 280
640 650 660 670 680
pF1KB3 WTLSDILPPQPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDV
: :: :.... . .. : ..: : : ::. ... .: : : .::
XP_006 -LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDV
290 300 310 320 330 340
690 700 710 720 730
pF1KB3 KIKNATITQYQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------A
. : : ..::. : : . : ...:. :: . : . ....: :
XP_006 DRPEETSTI--IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAA
350 360 370 380 390
740 750 760 770 780 790
pF1KB3 DLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNS
. : ..:..:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.:
XP_006 EEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSS
400 410 420 430 440 450
800 810 820 830 840 850
pF1KB3 GTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK
:::.:.:. : .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:
XP_006 GTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLK
460 470 480 490 500 510
860 870 880 890 900 910
pF1KB3 EYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR
::::..::::::::::::::::::::::::::::..:::::.::::::.:::::::::::
XP_006 EYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR
520 530 540 550 560 570
920 930 940 950 960 970
pF1KB3 VLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA
::::::::: ..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..
XP_006 VLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLAS
580 590 600 610 620 630
980 990 1000 1010 1020 1030
pF1KB3 KIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP
::::::::::.::::::::::::::::::::::::::::.:::::.::::::::::::::
XP_006 KIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTP
640 650 660 670 680 690
1040 1050 1060 1070 1080 1090
pF1KB3 YCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE
::::::::::::::::::.:.: :::::::.:::::::..::::: :::: ..:.::::
XP_006 YCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA
700 710 720 730 740 750
1100 1110 1120
pF1KB3 RKTYVNTTLYEKFTYAGIDCSAEEAA
::.::: .:.:.::::::: .::::
XP_006 RKAYVNMSLFENFTYAGIDATAEEA
760 770 780
>>NP_001240286 (OMIM: 600222) tyrosine-protein kinase re (1093 aa)
initn: 3040 init1: 1843 opt: 1949 Z-score: 649.8 bits: 132.0 E(85289): 1.9e-29
Smith-Waterman score: 3298; 47.5% identity (71.5% similar) in 1102 aa overlap (46-1123:9-1093)
20 30 40 50 60 70
pF1KB3 LSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRDFEALMNQHQDPLEVT
...: : :. . .: . . . ::..
NP_001 MWAGAGRGSDAWGP--PLLLEKDDRIVRTPPGPPLRL-
10 20 30
80 90 100 110 120 130
pF1KB3 QDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVD
.:. ...:. . : : . :.. : : . .. :. .. : .:: .: ::.
NP_001 ---ARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 KGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDI-LEVHLPHAQPQDAGVYSARY
:::.. .: . :. :.. .:::..... ::. : . ..::..:: ..:.::: :
NP_001 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 IGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEK
. .. . ::: ::::: : : .::: :.. : .:...::::. :::.::::: : ::.
NP_001 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 ACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKL
::. ::..:.:.: : ::.. .:::::::::::..::.: ::.::: :: .: ::.:
NP_001 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPI-CKA
.:.:.:: ::::.::.: ::.:..::. :. :.:... ...: : . : : :
NP_001 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD--RI-PQILNMASELEFNLETMPRINCAA
280 290 300 310 320
380 390 400 410 420 430
pF1KB3 SGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGM
.: :.:. . : ::::::: . ..: : . :.. ::: : : :.: .:.
NP_001 AGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQ
330 340 350 360 370 380
440 450 460 470 480 490
pF1KB3 VEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAW
. :...::: : :: :: .. : .. .. . :::::.. .: :.: . :
NP_001 DSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDW
390 400 410 420 430 440
500 510 520 530 540
pF1KB3 QHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTT---ASIGLPPPRG
. : : .: ::: :.:.: : . ::: : :::::: :: .:: . : .:
NP_001 STIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEG
450 460 470 480 490 500
550 560 570 580 590 600
pF1KB3 LNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNL
.. .. : ..:. :. :. : : ... . . ..:.. : :. ::..:
NP_001 WHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTA-LLTGL
510 520 530 540 550 560
610 620 630 640 650 660
pF1KB3 HPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT---I
: .: . ... . : : . : :: :.... . .. : ..:
NP_001 TPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEA
570 580 590 600 610 620
670 680 690 700 710
pF1KB3 LDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQLKGLEPETAYQVDIFAE-NNIG
: : ::. ... .: : : .:: . : : ..::. : : . : ...:
NP_001 LPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--IRGLNASTRYLFRMRASIQGLG
630 640 650 660 670 680
720 730 740 750 760 770
pF1KB3 S-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQL
. :: . : . ....: :. : ..:..:..::.. ::::.: :.: .. .
NP_001 DWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCI
690 700 710 720 730 740
780 790 800 810 820 830
pF1KB3 KRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIG
.:. ..:: . ..:. :: .::.::::.:.:. : .:.: ::::.:.:: :.:.::
NP_001 RRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIG
750 760 770 780 790 800
840 850 860 870 880 890
pF1KB3 EGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGA
:::::::..: ::::::.:.:::: .:::::..:::::::::::::::::::::::::::
NP_001 EGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGA
810 820 830 840 850 860
900 910 920 930 940 950
pF1KB3 CEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARG
:..:::::.::::::.:::::::::::::::::::: ..:::::::.:::.::.:.: :
NP_001 CKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANG
870 880 890 900 910 920
960 970 980 990 1000 1010
pF1KB3 MDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLN
:.:::.::::::::::::.::::: ..::::::::::.::::::::::::::::::::::
NP_001 MQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLN
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KB3 YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLM
::::::.:::::.::::::::::::::::::::::::::::::::.:.: :::::::.::
NP_001 YSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELM
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120
pF1KB3 RQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
:::::..::::: :::: ..:.:::: ::.::: .:.:.::::::: .::::
NP_001 RQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
1050 1060 1070 1080 1090
>>XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-protei (1095 aa)
initn: 2888 init1: 1843 opt: 1949 Z-score: 649.8 bits: 132.0 E(85289): 1.9e-29
Smith-Waterman score: 3020; 44.9% identity (68.0% similar) in 1143 aa overlap (14-1123:13-1095)
10 20 30 40 50
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
:.:.. : .:.:: :. .: :.. . :::... .: :
XP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
:. . .: . . . ::. ..:. ...:. . : : . :.. : : . ..
XP_005 --PLLLEKDDRIVRTPPGPPLR----LARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
XP_005 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
120 130 140 150 160 170
180 190 200 210 220
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
XP_005 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
..::.: ::.: ::.
XP_005 GSGWRGSQCQE-----------------------DRI-----------------------
300
350 360 370 380 390 400
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
XP_005 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
310 320 330 340 350 360
410 420 430 440 450 460
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
XP_005 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
370 380 390 400 410 420
470 480 490 500 510 520
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
XP_005 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
430 440 450 460 470 480
530 540 550 560 570 580
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
: :: .:: . : .: .. .. : ..:. :. :. : : ...
XP_005 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
490 500 510 520 530 540
590 600 610 620 630 640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
XP_005 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
550 560 570 580 590 600
650 660 670 680 690
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
:.... . .. : ..: : : ::. ... .: : : .:: . : :
XP_005 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETST-
610 620 630 640 650 660
700 710 720 730 740
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
..::. : : . : ...:. :: . : . ....: :. : ..:.
XP_005 -IIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
670 680 690 700 710
750 760 770 780 790 800
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKV
.:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:.
XP_005 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
720 730 740 750 760 770
810 820 830 840 850 860
pF1KB3 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
: .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
XP_005 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
780 790 800 810 820 830
870 880 890 900 910 920
pF1KB3 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
:::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
XP_005 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
840 850 860 870 880 890
930 940 950 960 970 980
pF1KB3 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
XP_005 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
900 910 920 930 940 950
990 1000 1010 1020 1030 1040
pF1KB3 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
:.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
XP_005 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
960 970 980 990 1000 1010
1050 1060 1070 1080 1090 1100
pF1KB3 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
:::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
XP_005 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
1020 1030 1040 1050 1060 1070
1110 1120
pF1KB3 YEKFTYAGIDCSAEEAA
.:.::::::: .::::
XP_005 FENFTYAGIDATAEEA
1080 1090
>>NP_005415 (OMIM: 600222) tyrosine-protein kinase recep (1138 aa)
initn: 3040 init1: 1843 opt: 1949 Z-score: 649.6 bits: 132.1 E(85289): 1.9e-29
Smith-Waterman score: 3334; 46.9% identity (71.0% similar) in 1143 aa overlap (14-1123:13-1138)
10 20 30 40 50
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
:.:.. : .:.:: :. .: :.. . :::... .: :
NP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
:. . .: . . . ::. ..:. ...:. . : : . :.. : : . ..
NP_005 --PLLLEKDDRIVRTPPGPPLR----LARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
NP_005 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
120 130 140 150 160 170
180 190 200 210 220
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_005 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
NP_005 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
..::.: ::.::: :: .: ::.:.:.:.:: ::::.::.: ::.:..::. :.
NP_005 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
NP_005 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
NP_005 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
420 430 440 450 460
470 480 490 500 510 520
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
NP_005 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
: :: .:: . : .: .. .. : ..:. :. :. : : ...
NP_005 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
NP_005 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
590 600 610 620 630 640
650 660 670 680 690
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
:.... . .. : ..: : : ::. ... .: : : .:: . : :
NP_005 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETST-
650 660 670 680 690 700
700 710 720 730 740
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
..::. : : . : ...:. :: . : . ....: :. : ..:.
NP_005 -IIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
710 720 730 740 750 760
750 760 770 780 790 800
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKV
.:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:.
NP_005 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
770 780 790 800 810 820
810 820 830 840 850 860
pF1KB3 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
: .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
NP_005 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
830 840 850 860 870 880
870 880 890 900 910 920
pF1KB3 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
:::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
NP_005 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
890 900 910 920 930 940
930 940 950 960 970 980
pF1KB3 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
NP_005 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
950 960 970 980 990 1000
990 1000 1010 1020 1030 1040
pF1KB3 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
:.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
NP_005 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
1010 1020 1030 1040 1050 1060
1050 1060 1070 1080 1090 1100
pF1KB3 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
:::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
NP_005 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
1070 1080 1090 1100 1110 1120
1110 1120
pF1KB3 YEKFTYAGIDCSAEEAA
.:.::::::: .::::
NP_005 FENFTYAGIDATAEEA
1130
>>XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-protei (830 aa)
initn: 1276 init1: 822 opt: 1415 Z-score: 482.5 bits: 100.7 E(85289): 3.9e-20
Smith-Waterman score: 1508; 33.5% identity (61.5% similar) in 806 aa overlap (14-787:13-801)
10 20 30 40 50
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
:.:.. : .:.:: :. .: :.. . :::... .: :
XP_016 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
:. . .: . . . ::... :. ...:. . : : . :.. : : . ..
XP_016 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
XP_016 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
120 130 140 150 160 170
180 190 200 210 220
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_016 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
XP_016 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
..::.: ::.::: :: .: ::.:.:.:.:: ::::.::.: ::.:..::. :.
XP_016 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
XP_016 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
XP_016 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
420 430 440 450 460
470 480 490 500 510 520
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
XP_016 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
: :: .:: . : .: .. .. : ..:. :. :. : : ...
XP_016 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
XP_016 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
590 600 610 620 630 640
650 660 670 680 690
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
:.... . .. : ..: : : ::. ... .: : : .:: . : :
XP_016 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
650 660 670 680 690 700
700 710 720 730 740
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
..::. : : . : ...:. :: . : . ....: :. : ..:.
XP_016 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
710 720 730 740 750 760
750 760 770 780 790 800
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVK
.:..::.. ::::.: :.: .. ..:. ..:: . ..:.
XP_016 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSAFLGSGASLCLHTSLADVL
770 780 790 800 810 820
810 820 830 840 850 860
pF1KB3 NNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD
XP_016 SPAVATCQ
830
1124 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:33:48 2016 done: Thu Nov 3 20:33:50 2016
Total Scan time: 10.440 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]