FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB2048, 1017 aa
  1>>>pF1KB2048 1017 - 1017 aa - 1017 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.4967+/-0.000444; mu= 5.9568+/- 0.027
 mean_var=173.9115+/-35.990, 0's: 0 Z-trim(113.8): 138  B-trim: 0 in 0/56
 Lambda= 0.097255
 statistics sampled from 23197 (23344) to 23197 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.274), width:  16
 Scan time: 14.870

The best scores are:                                      opt bits E(85289)
NP_003316 (OMIM: 600237) protein HIRA [Homo sapien (1017) 6738 959.0       0
NP_004795 (OMIM: 604333) probable cytosolic iron-s ( 339)  228 45.3 0.00068


>>NP_003316 (OMIM: 600237) protein HIRA [Homo sapiens]    (1017 aa)
 initn: 6738 init1: 6738 opt: 6738  Z-score: 5120.3  bits: 959.0 E(85289):    0
Smith-Waterman score: 6738; 99.9% identity (99.9% similar) in 1017 aa overlap (1-1017:1-1017)

               10        20        30        40        50        60
pF1KB2 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIP
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB2 KMLCQMDNHLACVNCVRWSNSGMYLPSGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_003 KMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB2 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB2 TWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB2 HAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSAKPSCPYCCC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB2 AVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB2 ELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAAT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB2 REMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 REMGSATSVAGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB2 SIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SIPLSGSLAGTMLSSHSSPQLLPLDSSTPNSFGASKPCTEPVVAASARPAGDSVNKDSMN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB2 ATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ATSTPAALSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPALTSMTPTAVERLKEQNLVK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB2 ELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ELRPRDLLESSSDSDEKVPLAKASSLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB2 SPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SPAALTAEKEAMCLSAPALALKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSR
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB2 LKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB2 HCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 HCTGSYVMALTAAATLSVWDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLS
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB2 DGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGKAYCFNPSLSTWNLVSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQA
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB2 ARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICK
              910       920       930       940       950       960

              970       980       990      1000      1010       
pF1KB2 DLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DLLGPVHYSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
              970       980       990      1000      1010       

>>NP_004795 (OMIM: 604333) probable cytosolic iron-sulfu  (339 aa)
 initn: 384 init1: 129 opt: 228  Z-score: 190.9  bits: 45.3 E(85289): 0.00068
Smith-Waterman score: 295; 27.5% identity (51.8% similar) in 309 aa overlap (78-365:24-287)

        50        60        70        80        90       100       
pF1KB2 VLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLPSGGDDKLIMVWKRATYIGPST
                                     :. .:  : : : :. : .:          
NP_004        MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIW----------
                      10        20        30        40             

       110       120        130       140       150         160    
pF1KB2 VFGSSGKLANVEQWRCVSIL-RNHSGDVMDVAWSPHDAWLASCSVDNTVVIW--NAVKFP
         :. :     ..: : :.: ..:.  :  :::::   .::: : : :. ::  :   : 
NP_004 --GTEG-----DSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDF-
                   50        60        70        80        90      

          170       180       190       200       210       220    
pF1KB2 EILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTH
       : ..::.:: . ::...: : :. .:. . :.:. ::. .: . :   .. ..  . :  
NP_004 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE-VDEEDEYECVSVLN--SHTQD
         100       110       120       130        140         150  

          230       240       250         260       270       280  
pF1KB2 VLRLSWSPDGHYLVSAHAMNNSGPTAQII--EREGWKTNMDFVGHRKAVTVVKFNPKIFK
       : .. : :. . :.::    .   :...   :.. :     . ::...:  . :.:    
NP_004 VKHVVWHPSQELLASA----SYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDP----
            160           170       180       190       200        

            290       300       310                      320       
pF1KB2 KKQKNGSSAKPSCPYCCCAVGSKDRSLSVW----------LTCL-KRP----LVVIHELF
           .:.    ::        : ::.. .:          ..:  . :    . ..  . 
NP_004 ----SGQRLA-SC--------SDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFH
              210                220       230       240       250 

       330        340       350       360       370       380      
pF1KB2 DKSIMDISWT-LNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIM
       ...:.::.:  :.:    .:. :   :.  :..:  .::                     
NP_004 SRTIYDIAWCQLTGALATACGDD---AIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC
             260       270          280       290       300        

        390       400       410       420       430       440      
pF1KB2 TEAQLSTAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLL
                                                                   
NP_004 VAWNPKEPGLLASCSDDGEVAFWKYQRPEGL                             
      310       320       330                                      




1017 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 11:59:23 2016 done: Thu Nov  3 11:59:25 2016
 Total Scan time: 14.870 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]