Result of FASTA (omim) for
pF1KB1325
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB1325, 754 aa
1>>>pF1KB1325 754 - 754 aa - 754 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3226+/-0.000374; mu= 20.0029+/- 0.023
mean_var=71.4919+/-14.276, 0's: 0 Z-trim(112.3): 31 B-trim: 163 in 1/55
Lambda= 0.151686
statistics sampled from 21108 (21139) to 21108 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.248), width: 16
Scan time: 11.390
The best scores are: opt bits E(85289)
NP_001106819 (OMIM: 145500,600423,613870) endothel ( 754) 5113 1128.8 0
XP_006710461 (OMIM: 145500,600423,613870) PREDICTE ( 753) 5106 1127.2 0
XP_011539175 (OMIM: 145500,600423,613870) PREDICTE ( 753) 5106 1127.2 0
XP_016856000 (OMIM: 145500,600423,613870) PREDICTE ( 753) 5106 1127.2 0
NP_001106820 (OMIM: 145500,600423,613870) endothel ( 767) 5106 1127.3 0
NP_001388 (OMIM: 145500,600423,613870) endothelin- ( 770) 5106 1127.3 0
XP_011539174 (OMIM: 145500,600423,613870) PREDICTE ( 778) 5106 1127.3 0
NP_001106818 (OMIM: 145500,600423,613870) endothel ( 758) 4940 1090.9 0
NP_001093591 (OMIM: 610145) endothelin-converting ( 765) 3371 747.6 4.5e-215
NP_001032401 (OMIM: 610145) endothelin-converting ( 736) 3296 731.1 3.8e-210
NP_055508 (OMIM: 610145) endothelin-converting enz ( 883) 3293 730.5 6.9e-210
NP_001093590 (OMIM: 610145) endothelin-converting ( 811) 3292 730.3 7.5e-210
NP_001277716 (OMIM: 605896,615065) endothelin-conv ( 773) 1812 406.4 2.3e-112
NP_004817 (OMIM: 605896,615065) endothelin-convert ( 775) 1803 404.4 8.9e-112
NP_000435 (OMIM: 300550,307800) phosphate-regulati ( 749) 1379 311.6 7.4e-84
NP_009218 (OMIM: 120520,614692,617017,617018) nepr ( 750) 1270 287.8 1.1e-76
NP_009219 (OMIM: 120520,614692,617017,617018) nepr ( 750) 1270 287.8 1.1e-76
XP_011511157 (OMIM: 120520,614692,617017,617018) P ( 750) 1270 287.8 1.1e-76
XP_006713709 (OMIM: 120520,614692,617017,617018) P ( 750) 1270 287.8 1.1e-76
XP_011511158 (OMIM: 120520,614692,617017,617018) P ( 750) 1270 287.8 1.1e-76
XP_011511159 (OMIM: 120520,614692,617017,617018) P ( 750) 1270 287.8 1.1e-76
NP_000893 (OMIM: 120520,614692,617017,617018) nepr ( 750) 1270 287.8 1.1e-76
XP_006713710 (OMIM: 120520,614692,617017,617018) P ( 750) 1270 287.8 1.1e-76
NP_009220 (OMIM: 120520,614692,617017,617018) nepr ( 750) 1270 287.8 1.1e-76
NP_000411 (OMIM: 110900,613883) kell blood group g ( 732) 1253 284.1 1.5e-75
XP_005250050 (OMIM: 110900,613883) PREDICTED: kell ( 744) 1253 284.1 1.5e-75
XP_016885068 (OMIM: 300550,307800) PREDICTED: phos ( 497) 1246 282.4 3.1e-75
XP_011543835 (OMIM: 300550,307800) PREDICTED: phos ( 497) 1246 282.4 3.1e-75
NP_001269683 (OMIM: 300550,307800) phosphate-regul ( 695) 1219 276.6 2.4e-73
XP_011543838 (OMIM: 300550,307800) PREDICTED: phos ( 380) 1052 239.9 1.5e-62
XP_005250051 (OMIM: 110900,613883) PREDICTED: kell ( 423) 666 155.5 4.4e-37
>>NP_001106819 (OMIM: 145500,600423,613870) endothelin-c (754 aa)
initn: 5113 init1: 5113 opt: 5113 Z-score: 6042.6 bits: 1128.8 E(85289): 0
Smith-Waterman score: 5113; 100.0% identity (100.0% similar) in 754 aa overlap (1-754:1-754)
10 20 30 40 50 60
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB1 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB1 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB1 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB1 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB1 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB1 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB1 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB1 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB1 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB1 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB1 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
670 680 690 700 710 720
730 740 750
pF1KB1 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::
NP_001 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750
>>XP_006710461 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.3 bits: 1127.2 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:1-753)
10 20 30 40 50 60
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
10 20 30 40 50
70 80 90 100 110 120
pF1KB1 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB1 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB1 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB1 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB1 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB1 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB1 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB1 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB1 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB1 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB1 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
660 670 680 690 700 710
730 740 750
pF1KB1 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::
XP_006 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>XP_011539175 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.3 bits: 1127.2 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:1-753)
10 20 30 40 50 60
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
10 20 30 40 50
70 80 90 100 110 120
pF1KB1 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB1 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB1 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB1 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB1 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB1 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB1 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB1 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB1 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB1 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB1 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
660 670 680 690 700 710
730 740 750
pF1KB1 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::
XP_011 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>XP_016856000 (OMIM: 145500,600423,613870) PREDICTED: e (753 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.3 bits: 1127.2 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:1-753)
10 20 30 40 50 60
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
10 20 30 40 50
70 80 90 100 110 120
pF1KB1 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB1 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB1 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB1 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALAN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB1 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB1 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB1 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB1 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB1 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB1 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB1 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR
660 670 680 690 700 710
730 740 750
pF1KB1 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::
XP_016 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
720 730 740 750
>>NP_001106820 (OMIM: 145500,600423,613870) endothelin-c (767 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.2 bits: 1127.3 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:15-767)
10 20 30 40
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAART
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAART
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB1 QVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCH
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB1 DFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB1 ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB1 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQ
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB1 MQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB1 SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB1 TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLK
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB1 WMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWR
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB1 VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB1 VVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRH
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB1 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS
670 680 690 700 710 720
710 720 730 740 750
pF1KB1 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750 760
>>NP_001388 (OMIM: 145500,600423,613870) endothelin-conv (770 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.2 bits: 1127.3 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:18-770)
10 20 30 40
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
:::::::::::::::::::::::::::::::::::::::::::
NP_001 MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB1 ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB1 PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB1 YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB1 VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB1 RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB1 INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB1 MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB1 TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
490 500 510 520 530 540
530 540 550 560 570 580
pF1KB1 SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
550 560 570 580 590 600
590 600 610 620 630 640
pF1KB1 IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KB1 GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
670 680 690 700 710 720
710 720 730 740 750
pF1KB1 ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750 760 770
>>XP_011539174 (OMIM: 145500,600423,613870) PREDICTED: e (778 aa)
initn: 5106 init1: 5106 opt: 5106 Z-score: 6034.1 bits: 1127.3 E(85289): 0
Smith-Waterman score: 5106; 100.0% identity (100.0% similar) in 753 aa overlap (2-754:26-778)
10 20 30
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSP
:::::::::::::::::::::::::::::::::::
XP_011 MCMRIIRNAGYKCKFHCPHPRGSNSMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB1 RSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSIL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB1 SSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB1 EAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB1 TSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB1 GGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB1 NTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB1 ADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIK
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB1 KAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFE
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB1 NAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB1 PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB1 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQ
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB1 VWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750 760 770
>>NP_001106818 (OMIM: 145500,600423,613870) endothelin-c (758 aa)
initn: 4940 init1: 4940 opt: 4940 Z-score: 5838.0 bits: 1090.9 E(85289): 0
Smith-Waterman score: 4940; 99.7% identity (99.9% similar) in 729 aa overlap (26-754:30-758)
10 20 30 40 50
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVL
: .::::::::::::::::::::::::::::
NP_001 MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB1 VVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB1 WIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB1 ELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB1 IQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFET
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB1 ALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB1 EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRW
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB1 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB1 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB1 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHA
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB1 FDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADN
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB1 GGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPH
670 680 690 700 710 720
720 730 740 750
pF1KB1 SPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::::::::::::::::::::::::::::::::::
NP_001 SPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
730 740 750
>>NP_001093591 (OMIM: 610145) endothelin-converting enzy (765 aa)
initn: 2722 init1: 2563 opt: 3371 Z-score: 3982.3 bits: 747.6 E(85289): 4.5e-215
Smith-Waterman score: 3371; 63.2% identity (86.2% similar) in 756 aa overlap (2-754:14-765)
10 20 30 40
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQ
: :::::: .:: .. :: : :....:.:. .. .. ..:::
NP_001 MNVALQELGAGSNMVEYKRATLRDEDAPETPVEGGASPDAMEVGFQ--KGTRQLLGSRTQ
10 20 30 40 50
50 60 70 80 90 100
pF1KB1 VEKRLVVLVVLLAAGLVACLAALGIQYQTRSPS--VCLSEACVSVTSSILSSMDPTVDPC
.: :. .:::: :..::.:::.::. :.:: .::.:::. :...:: :.: :.::
NP_001 LELVLAGASLLLAALLLGCLVALGVQYH-RDPSHSTCLTEACIRVAGKILESLDRGVSPC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB1 HDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST-ASVSEAERKAQVY
.::....:::::. ::.:::.:::.::..::..::::.::::::.: : ::::.:.: .
NP_001 EDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRF
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB1 YRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYV
: .:.. ::::: :.:: .:::..::::::::: .:::...:..:.. ::..:::.::.
NP_001 YLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB1 SADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIR
:::::.::::::::::::: :::::::::.: ::::::.::.:: .:: :::: . :
NP_001 SADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG-RPTSTR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB1 PQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEI
::::.:..: :::::.::..::::: ::::.. .:::.:::...:: ::. .. :.:.
NP_001 EQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLEL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB1 NESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVM
..:::.::: .::.:.: ::: :. .::::.:::::.::.: ::.::..:.::..:..
NP_001 SDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETL
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB1 YGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLST
:::::.:.:::. :.:.:.. :::::: .:::::: ..:: :: .: ::. ::::.:.
NP_001 YGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ
420 430 440 450 460 470
470 480 490 500 510 520
pF1KB1 LKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFS
: ::::.::..:::::::::.:::.:.::..::::: :.. : : .:.: . ..:::
NP_001 LVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFS
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB1 WRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGI
.: :::::: :.:::::::: ::::: ::::::::::::::::::.:. :::::::::
NP_001 AKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGI
540 550 560 570 580 590
590 600 610 620 630 640
pF1KB1 GVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNG
:::.:::::::::::::::::.:::::::.: :. ::. .: :: :::..:.:::: .::
NP_001 GVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNG
600 610 620 630 640 650
650 660 670 680 690 700
pF1KB1 RHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPE
:.:::::::::::::::: ::. :..:.: :..::..::::.::::.:::::::::::::
NP_001 RQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPE
660 670 680 690 700 710
710 720 730 740 750
pF1KB1 SSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
::::::.::::::.::::.:.::::..: .:: :: :::::: . ::::
NP_001 SSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
720 730 740 750 760
>>NP_001032401 (OMIM: 610145) endothelin-converting enzy (736 aa)
initn: 2646 init1: 2563 opt: 3296 Z-score: 3893.8 bits: 731.1 E(85289): 3.8e-210
Smith-Waterman score: 3296; 63.8% identity (86.8% similar) in 730 aa overlap (28-754:11-736)
10 20 30 40 50 60
pF1KB1 MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLL
: .:.:. .. .. ..:::.: :. .::
NP_001 MNVALQELGAGSNVGFQ--KGTRQLLGSRTQLELVLAGASLLL
10 20 30 40
70 80 90 100 110
pF1KB1 AAGLVACLAALGIQYQTRSPS--VCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWI
:: :..::.:::.::. :.:: .::.:::. :...:: :.: :.::.::....:::::
NP_001 AALLLGCLVALGVQYH-RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB1 KANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST-ASVSEAERKAQVYYRACMNETRIEE
. ::.:::.:::.::..::..::::.::::::.: : ::::.:.: .: .:.. ::::
NP_001 RRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEE
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB1 LRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVI
: :.:: .:::..::::::::: .:::...:..:.. ::..:::.::.:::::.::::::
NP_001 LGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVI
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB1 QVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETA
::::::: :::::::::.: ::::::.::.:: .:: :::: . : ::::.:..:
NP_001 QVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG-RPTSTREQMQQVLELEIQ
230 240 250 260 270
300 310 320 330 340 350
pF1KB1 LANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKE
:::::.::..::::: ::::.. .:::.:::...:: ::. .. :.:...:::.::: .
NP_001 LANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMD
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB1 YLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWK
::.:.: ::: :. .::::.:::::.::.: ::.::..:.::..:..:::::.:.:::.
NP_001 YLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQ
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB1 FCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSA
:.:.:.. :::::: .:::::: ..:: :: .: ::. ::::.:. : ::::.::..:
NP_001 TCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KB1 KEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAP
::::::::.:::.:.::..::::: :.. : : .:.: . ..::: .: :::::: :
NP_001 KEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPP
460 470 480 490 500 510
540 550 560 570 580 590
pF1KB1 NRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAF
.:::::::: ::::: ::::::::::::::::::.:. ::::::::::::.::::::::
NP_001 SRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAF
520 530 540 550 560 570
600 610 620 630 640 650
pF1KB1 DDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNG
:::::::::.:::::::.: :. ::. .: :: :::..:.:::: .:::.::::::::::
NP_001 DDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNG
580 590 600 610 620 630
660 670 680 690 700 710
pF1KB1 GLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHS
:::::: ::. :..:.: :..::..::::.::::.:::::::::::::::::::.:::::
NP_001 GLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHS
640 650 660 670 680 690
720 730 740 750
pF1KB1 PSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
:.::::.:.::::..: .:: :: :::::: . ::::
NP_001 PARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
700 710 720 730
754 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 11:49:58 2016 done: Thu Nov 3 11:50:00 2016
Total Scan time: 11.390 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]