Result of FASTA (omim) for
pF1KB0069
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0069, 2580 aa
1>>>pF1KB0069 2580 - 2580 aa - 2580 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.0710+/-0.000915; mu= -16.3502+/- 0.056
mean_var=860.0639+/-184.241, 0's: 0 Z-trim(113.6): 950 B-trim: 1215 in 1/55
Lambda= 0.043733
statistics sampled from 22037 (22991) to 22037 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.543), E-opt: 0.2 (0.27), width: 16
Scan time: 22.610
The best scores are: opt bits E(85289)
NP_001273663 (OMIM: 117143,616051) centromere-asso (2580) 16150 1037.9 0
XP_011529849 (OMIM: 117143,616051) PREDICTED: cent (2605) 12722 821.6 0
XP_011529850 (OMIM: 117143,616051) PREDICTED: cent (2604) 12703 820.4 0
XP_011529846 (OMIM: 117143,616051) PREDICTED: cent (2676) 12125 784.0 0
NP_001804 (OMIM: 117143,616051) centromere-associa (2701) 8697 567.7 7.6e-160
XP_011529847 (OMIM: 117143,616051) PREDICTED: cent (2648) 7499 492.1 4.2e-137
XP_016863148 (OMIM: 117143,616051) PREDICTED: cent (2551) 7474 490.5 1.2e-136
XP_011529851 (OMIM: 117143,616051) PREDICTED: cent (2553) 6290 415.8 3.8e-114
XP_011529848 (OMIM: 117143,616051) PREDICTED: cent (2633) 5809 385.5 5.3e-105
NP_001092763 (OMIM: 609184) chromosome-associated (1234) 1018 82.8 3.2e-14
NP_036442 (OMIM: 300521,300923) chromosome-associa (1232) 994 81.3 9.1e-14
XP_016870391 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_016870390 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_011517150 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_011517152 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_016870389 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_011517151 (OMIM: 611253) PREDICTED: kinesin-lik (1427) 987 80.9 1.4e-13
XP_016870392 (OMIM: 611253) PREDICTED: kinesin-lik (1401) 986 80.9 1.4e-13
NP_060046 (OMIM: 611253) kinesin-like protein KIF2 (1401) 986 80.9 1.4e-13
XP_016870393 (OMIM: 611253) PREDICTED: kinesin-lik (1401) 986 80.9 1.4e-13
XP_016864485 (OMIM: 604683) PREDICTED: kinesin-lik ( 697) 967 79.3 2e-13
NP_008985 (OMIM: 604683) kinesin-like protein KIF3 ( 699) 967 79.3 2e-13
XP_016864484 (OMIM: 604683) PREDICTED: kinesin-lik ( 700) 965 79.2 2.2e-13
NP_001287721 (OMIM: 604683) kinesin-like protein K ( 702) 965 79.2 2.2e-13
XP_016870394 (OMIM: 611253) PREDICTED: kinesin-lik (1361) 968 79.7 3e-13
XP_006714589 (OMIM: 604683) PREDICTED: kinesin-lik ( 724) 955 78.6 3.5e-13
NP_001287720 (OMIM: 604683) kinesin-like protein K ( 726) 955 78.6 3.5e-13
XP_011517158 (OMIM: 611253) PREDICTED: kinesin-lik (1162) 954 78.8 5e-13
XP_016870395 (OMIM: 611253) PREDICTED: kinesin-lik (1355) 954 78.8 5.6e-13
NP_004512 (OMIM: 602809) kinesin-1 heavy chain [Ho ( 963) 935 77.5 1e-12
NP_004789 (OMIM: 603754) kinesin-like protein KIF3 ( 747) 931 77.1 1e-12
NP_001258857 (OMIM: 611253) kinesin-like protein K (1304) 934 77.5 1.3e-12
XP_016870397 (OMIM: 611253) PREDICTED: kinesin-lik (1304) 934 77.5 1.3e-12
NP_004513 (OMIM: 604593,615282) kinesin heavy chai ( 957) 929 77.1 1.3e-12
XP_016859551 (OMIM: 604593,615282) PREDICTED: kine ( 957) 929 77.1 1.3e-12
XP_005246008 (OMIM: 605037) PREDICTED: kinesin-lik ( 984) 924 76.8 1.7e-12
XP_005246007 (OMIM: 605037) PREDICTED: kinesin-lik ( 985) 924 76.8 1.7e-12
XP_011540147 (OMIM: 605037) PREDICTED: kinesin-lik ( 992) 924 76.8 1.7e-12
XP_011540146 (OMIM: 605037) PREDICTED: kinesin-lik ( 997) 924 76.8 1.7e-12
XP_011540145 (OMIM: 605037) PREDICTED: kinesin-lik (1017) 924 76.8 1.7e-12
NP_001116291 (OMIM: 605037) kinesin-like protein K (1028) 924 76.8 1.7e-12
NP_065867 (OMIM: 605037) kinesin-like protein KIF1 (1029) 924 76.8 1.7e-12
XP_011540144 (OMIM: 605037) PREDICTED: kinesin-lik (1031) 924 76.8 1.7e-12
XP_011540143 (OMIM: 605037) PREDICTED: kinesin-lik (1038) 924 76.8 1.7e-12
XP_011540142 (OMIM: 605037) PREDICTED: kinesin-lik (1042) 924 76.8 1.7e-12
XP_011540141 (OMIM: 605037) PREDICTED: kinesin-lik (1043) 924 76.8 1.7e-12
XP_011540140 (OMIM: 605037) PREDICTED: kinesin-lik (1062) 924 76.8 1.8e-12
XP_011540139 (OMIM: 605037) PREDICTED: kinesin-lik (1063) 924 76.8 1.8e-12
XP_011517156 (OMIM: 611253) PREDICTED: kinesin-lik (1296) 908 75.9 4e-12
XP_016870396 (OMIM: 611253) PREDICTED: kinesin-lik (1335) 906 75.8 4.5e-12
>>NP_001273663 (OMIM: 117143,616051) centromere-associat (2580 aa)
initn: 16150 init1: 16150 opt: 16150 Z-score: 5532.3 bits: 1037.9 E(85289): 0
Smith-Waterman score: 16150; 100.0% identity (100.0% similar) in 2580 aa overlap (1-2580:1-2580)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
NP_001 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 ERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB0 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB0 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB0 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB0 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB0 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB0 HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB0 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB0 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB0 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB0 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB0 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB0 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB0 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KB0 KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KB0 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KB0 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KB0 KISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIK
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KB0 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQR
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KB0 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KB0 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KB0 IEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEK
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KB0 LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKE
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KB0 SKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLK
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KB0 MKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDP
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KB0 QPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLS
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KB0 NEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPK
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KB0 SCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
2530 2540 2550 2560 2570 2580
>>XP_011529849 (OMIM: 117143,616051) PREDICTED: centrome (2605 aa)
initn: 12679 init1: 12679 opt: 12722 Z-score: 4363.4 bits: 821.6 E(85289): 0
Smith-Waterman score: 16090; 99.0% identity (99.0% similar) in 2605 aa overlap (1-2580:1-2605)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_011 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVK
1930 1940 1950 1960 1970 1980
1960 1970 1980 1990 2000 2010
pF1KB0 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
1990 2000 2010 2020 2030 2040
2020 2030 2040 2050 2060 2070
pF1KB0 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
2050 2060 2070 2080 2090 2100
2080 2090 2100 2110 2120 2130
pF1KB0 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
2110 2120 2130 2140 2150 2160
2140 2150 2160 2170 2180 2190
pF1KB0 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
2170 2180 2190 2200 2210 2220
2200 2210 2220 2230 2240 2250
pF1KB0 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
2230 2240 2250 2260 2270 2280
2260 2270 2280 2290 2300 2310
pF1KB0 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
2290 2300 2310 2320 2330 2340
2320 2330 2340 2350 2360 2370
pF1KB0 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
2350 2360 2370 2380 2390 2400
2380 2390 2400 2410 2420 2430
pF1KB0 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
2410 2420 2430 2440 2450 2460
2440 2450 2460 2470 2480 2490
pF1KB0 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
2470 2480 2490 2500 2510 2520
2500 2510 2520 2530 2540 2550
pF1KB0 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
2530 2540 2550 2560 2570 2580
2560 2570 2580
pF1KB0 AESVDSQPGPWHASSGKDVPECKTQ
:::::::::::::::::::::::::
XP_011 AESVDSQPGPWHASSGKDVPECKTQ
2590 2600
>>XP_011529850 (OMIM: 117143,616051) PREDICTED: centrome (2604 aa)
initn: 8568 init1: 8568 opt: 12703 Z-score: 4356.9 bits: 820.4 E(85289): 0
Smith-Waterman score: 16071; 99.0% identity (99.0% similar) in 2605 aa overlap (1-2580:1-2604)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_011 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940 1950
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK-DRQNHQVK
1930 1940 1950 1960 1970
1960 1970 1980 1990 2000 2010
pF1KB0 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
1980 1990 2000 2010 2020 2030
2020 2030 2040 2050 2060 2070
pF1KB0 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
2040 2050 2060 2070 2080 2090
2080 2090 2100 2110 2120 2130
pF1KB0 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
2100 2110 2120 2130 2140 2150
2140 2150 2160 2170 2180 2190
pF1KB0 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
2160 2170 2180 2190 2200 2210
2200 2210 2220 2230 2240 2250
pF1KB0 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
2220 2230 2240 2250 2260 2270
2260 2270 2280 2290 2300 2310
pF1KB0 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
2280 2290 2300 2310 2320 2330
2320 2330 2340 2350 2360 2370
pF1KB0 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
2340 2350 2360 2370 2380 2390
2380 2390 2400 2410 2420 2430
pF1KB0 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
2400 2410 2420 2430 2440 2450
2440 2450 2460 2470 2480 2490
pF1KB0 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
2460 2470 2480 2490 2500 2510
2500 2510 2520 2530 2540 2550
pF1KB0 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
2520 2530 2540 2550 2560 2570
2560 2570 2580
pF1KB0 AESVDSQPGPWHASSGKDVPECKTQ
:::::::::::::::::::::::::
XP_011 AESVDSQPGPWHASSGKDVPECKTQ
2580 2590 2600
>>XP_011529846 (OMIM: 117143,616051) PREDICTED: centrome (2676 aa)
initn: 16130 init1: 12038 opt: 12125 Z-score: 4159.7 bits: 784.0 E(85289): 0
Smith-Waterman score: 15480; 96.2% identity (96.3% similar) in 2612 aa overlap (1-2516:1-2612)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 ERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKTKKDQENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB0 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB0 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB0 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB0 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB0 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB0 HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB0 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB0 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB0 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB0 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB0 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KB0 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KB0 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDAL
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KB0 KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KB0 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KB0 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE
1870 1880 1890 1900 1910 1920
1930 1940
pF1KB0 KISEKTIQISDIQKDLDKSKDELQKK----------------------------------
::::::::::::::::::::::::::
XP_011 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQ
1930 1940 1950 1960 1970 1980
pF1KB0 ------------------------------------------------------------
XP_011 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM
1990 2000 2010 2020 2030 2040
1950 1960 1970 1980 1990 2000
pF1KB0 --QDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE
2050 2060 2070 2080 2090 2100
2010 2020 2030 2040 2050 2060
pF1KB0 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE
2110 2120 2130 2140 2150 2160
2070 2080 2090 2100 2110 2120
pF1KB0 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD
2170 2180 2190 2200 2210 2220
2130 2140 2150 2160 2170 2180
pF1KB0 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN
2230 2240 2250 2260 2270 2280
2190 2200 2210 2220 2230 2240
pF1KB0 RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD
2290 2300 2310 2320 2330 2340
2250 2260 2270 2280 2290 2300
pF1KB0 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV
2350 2360 2370 2380 2390 2400
2310 2320 2330 2340 2350 2360
pF1KB0 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT
2410 2420 2430 2440 2450 2460
2370 2380 2390 2400 2410 2420
pF1KB0 KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALIL
2470 2480 2490 2500 2510 2520
2430 2440 2450 2460 2470 2480
pF1KB0 KSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENS
2530 2540 2550 2560 2570 2580
2490 2500 2510 2520 2530 2540
pF1KB0 PKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSS
::::::::::::::::::::::::::::::::
XP_011 PKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSS
2590 2600 2610 2620 2630 2640
2550 2560 2570 2580
pF1KB0 LGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
XP_011 LGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKTQ
2650 2660 2670
>>NP_001804 (OMIM: 117143,616051) centromere-associated (2701 aa)
initn: 12659 init1: 8567 opt: 8697 Z-score: 2990.7 bits: 567.7 E(85289): 7.6e-160
Smith-Waterman score: 15420; 95.3% identity (95.4% similar) in 2637 aa overlap (1-2516:1-2637)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
NP_001 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
NP_001 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
1690 1700 1710 1720 1730 1740
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
1750 1760 1770 1780 1790 1800
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1810 1820 1830 1840 1850 1860
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1870 1880 1890 1900 1910 1920
1900 1910 1920 1930 1940
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
1930 1940 1950 1960 1970 1980
pF1KB0 ------------------------------------------------------------
NP_001 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
1990 2000 2010 2020 2030 2040
1950 1960 1970
pF1KB0 ---------------------------QDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
.::::::::::::::::::::::::::::::::
NP_001 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
2050 2060 2070 2080 2090 2100
1980 1990 2000 2010 2020 2030
pF1KB0 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
2110 2120 2130 2140 2150 2160
2040 2050 2060 2070 2080 2090
pF1KB0 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
2170 2180 2190 2200 2210 2220
2100 2110 2120 2130 2140 2150
pF1KB0 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
2230 2240 2250 2260 2270 2280
2160 2170 2180 2190 2200 2210
pF1KB0 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
2290 2300 2310 2320 2330 2340
2220 2230 2240 2250 2260 2270
pF1KB0 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
2350 2360 2370 2380 2390 2400
2280 2290 2300 2310 2320 2330
pF1KB0 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
2410 2420 2430 2440 2450 2460
2340 2350 2360 2370 2380 2390
pF1KB0 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
2470 2480 2490 2500 2510 2520
2400 2410 2420 2430 2440 2450
pF1KB0 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
2530 2540 2550 2560 2570 2580
2460 2470 2480 2490 2500 2510
pF1KB0 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
2590 2600 2610 2620 2630 2640
2520 2530 2540 2550 2560 2570
pF1KB0 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
NP_001 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
2650 2660 2670 2680 2690 2700
>>XP_011529847 (OMIM: 117143,616051) PREDICTED: centrome (2648 aa)
initn: 11340 init1: 7248 opt: 7499 Z-score: 2582.3 bits: 492.1 E(85289): 4.2e-137
Smith-Waterman score: 15352; 93.5% identity (93.5% similar) in 2690 aa overlap (1-2569:1-2637)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_011 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
:::::::::::::::::::::::::::::::::::::
XP_011 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL-----------------------
1690 1700 1710
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::
XP_011 ------------------------------KIQEELRIAHMHLKEQQETIDKLRGIVSEK
1720 1730 1740
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1750 1760 1770 1780 1790 1800
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1810 1820 1830 1840 1850 1860
1900 1910 1920 1930 1940
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
1870 1880 1890 1900 1910 1920
pF1KB0 ------------------------------------------------------------
XP_011 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
1930 1940 1950 1960 1970 1980
1950 1960 1970
pF1KB0 ---------------------------QDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
.::::::::::::::::::::::::::::::::
XP_011 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
1990 2000 2010 2020 2030 2040
1980 1990 2000 2010 2020 2030
pF1KB0 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
2050 2060 2070 2080 2090 2100
2040 2050 2060 2070 2080 2090
pF1KB0 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
2110 2120 2130 2140 2150 2160
2100 2110 2120 2130 2140 2150
pF1KB0 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
2170 2180 2190 2200 2210 2220
2160 2170 2180 2190 2200 2210
pF1KB0 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
2230 2240 2250 2260 2270 2280
2220 2230 2240 2250 2260 2270
pF1KB0 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
2290 2300 2310 2320 2330 2340
2280 2290 2300 2310 2320 2330
pF1KB0 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
2350 2360 2370 2380 2390 2400
2340 2350 2360 2370 2380 2390
pF1KB0 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
2410 2420 2430 2440 2450 2460
2400 2410 2420 2430 2440 2450
pF1KB0 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
2470 2480 2490 2500 2510 2520
2460 2470 2480 2490 2500 2510
pF1KB0 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
2530 2540 2550 2560 2570 2580
2520 2530 2540 2550 2560 2570
pF1KB0 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
2590 2600 2610 2620 2630 2640
2580
pF1KB0 Q
XP_011 Q
>>XP_016863148 (OMIM: 117143,616051) PREDICTED: centrome (2551 aa)
initn: 8147 init1: 7249 opt: 7474 Z-score: 2574.0 bits: 490.5 E(85289): 1.2e-136
Smith-Waterman score: 15620; 96.9% identity (96.9% similar) in 2605 aa overlap (1-2580:1-2551)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_016 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_016 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
:::::::::::::::::::::::::::::::::::::
XP_016 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL-----------------------
1690 1700 1710
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::
XP_016 ------------------------------KIQEELRIAHMHLKEQQETIDKLRGIVSEK
1720 1730 1740
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1750 1760 1770 1780 1790 1800
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1810 1820 1830 1840 1850 1860
1900 1910 1920 1930 1940 1950
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKQDRQNHQVK
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_016 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK-DRQNHQVK
1870 1880 1890 1900 1910 1920
1960 1970 1980 1990 2000 2010
pF1KB0 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSM
1930 1940 1950 1960 1970 1980
2020 2030 2040 2050 2060 2070
pF1KB0 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM
1990 2000 2010 2020 2030 2040
2080 2090 2100 2110 2120 2130
pF1KB0 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKT
2050 2060 2070 2080 2090 2100
2140 2150 2160 2170 2180 2190
pF1KB0 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE
2110 2120 2130 2140 2150 2160
2200 2210 2220 2230 2240 2250
pF1KB0 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT
2170 2180 2190 2200 2210 2220
2260 2270 2280 2290 2300 2310
pF1KB0 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTK
2230 2240 2250 2260 2270 2280
2320 2330 2340 2350 2360 2370
pF1KB0 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVI
2290 2300 2310 2320 2330 2340
2380 2390 2400 2410 2420 2430
pF1KB0 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI
2350 2360 2370 2380 2390 2400
2440 2450 2460 2470 2480 2490
pF1KB0 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTAS
2410 2420 2430 2440 2450 2460
2500 2510 2520 2530 2540 2550
pF1KB0 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAG
2470 2480 2490 2500 2510 2520
2560 2570 2580
pF1KB0 AESVDSQPGPWHASSGKDVPECKTQ
:::::::::::::::::::::::::
XP_016 AESVDSQPGPWHASSGKDVPECKTQ
2530 2540 2550
>>XP_011529851 (OMIM: 117143,616051) PREDICTED: centrome (2553 aa)
initn: 10105 init1: 5511 opt: 6290 Z-score: 2170.3 bits: 415.8 E(85289): 3.8e-114
Smith-Waterman score: 14671; 90.0% identity (90.0% similar) in 2701 aa overlap (1-2580:1-2553)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_011 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
:::::::::::::::::::::::::::::::
XP_011 AKEKDDLQRLQEVLQSESDQLKENIKEIVAK-----------------------------
1450 1460 1470
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
XP_011 ------------------------------------------------------------
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
:
XP_011 -----------------------------------------------------------M
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1480 1490 1500 1510 1520 1530
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
1540 1550 1560 1570 1580 1590
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
1600 1610 1620 1630 1640 1650
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1660 1670 1680 1690 1700 1710
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1720 1730 1740 1750 1760 1770
1900 1910 1920 1930 1940
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
1780 1790 1800 1810 1820 1830
pF1KB0 ------------------------------------------------------------
XP_011 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
1840 1850 1860 1870 1880 1890
1950 1960 1970
pF1KB0 ---------------------------QDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
.::::::::::::::::::::::::::::::::
XP_011 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
1900 1910 1920 1930 1940 1950
1980 1990 2000 2010 2020 2030
pF1KB0 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
1960 1970 1980 1990 2000 2010
2040 2050 2060 2070 2080 2090
pF1KB0 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
2020 2030 2040 2050 2060 2070
2100 2110 2120 2130 2140 2150
pF1KB0 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
2080 2090 2100 2110 2120 2130
2160 2170 2180 2190 2200 2210
pF1KB0 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
2140 2150 2160 2170 2180 2190
2220 2230 2240 2250 2260 2270
pF1KB0 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
2200 2210 2220 2230 2240 2250
2280 2290 2300 2310 2320 2330
pF1KB0 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
2260 2270 2280 2290 2300 2310
2340 2350 2360 2370 2380 2390
pF1KB0 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
2320 2330 2340 2350 2360 2370
2400 2410 2420 2430 2440 2450
pF1KB0 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
2380 2390 2400 2410 2420 2430
2460 2470 2480 2490 2500 2510
pF1KB0 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
2440 2450 2460 2470 2480 2490
2520 2530 2540 2550 2560 2570
pF1KB0 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
2500 2510 2520 2530 2540 2550
2580
pF1KB0 Q
:
XP_011 Q
>>XP_011529848 (OMIM: 117143,616051) PREDICTED: centrome (2633 aa)
initn: 13035 init1: 5463 opt: 5809 Z-score: 2006.1 bits: 385.5 E(85289): 5.3e-105
Smith-Waterman score: 14862; 92.8% identity (92.8% similar) in 2637 aa overlap (1-2516:1-2569)
10 20 30 40 50 60
pF1KB0 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 VTWCLGKINKMKNSNYADQSNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL
490 500 510 520 530 540
550 560 570
pF1KB0 ERKTKKDQE-------------------------NELSSKVELLREKEDQIKKLQEYIDS
::::::::: ::::::::::::::::::::::::::
XP_011 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB0 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB0 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB0 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB0 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB0 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB0 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB0 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK---------
970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KB0 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT
:
XP_011 -----------------------------------------------------------T
1060 1070 1080 1090 1100 1110
pF1KB0 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ
1020 1030 1040 1050 1060 1070
1120 1130 1140 1150 1160 1170
pF1KB0 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK
1080 1090 1100 1110 1120 1130
1180 1190 1200 1210 1220 1230
pF1KB0 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE
1140 1150 1160 1170 1180 1190
1240 1250 1260 1270 1280 1290
pF1KB0 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS
1200 1210 1220 1230 1240 1250
1300 1310 1320 1330 1340 1350
pF1KB0 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ
1260 1270 1280 1290 1300 1310
1360 1370 1380 1390 1400 1410
pF1KB0 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV
1320 1330 1340 1350 1360 1370
1420 1430 1440 1450 1460 1470
pF1KB0 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL
1380 1390 1400 1410 1420 1430
1480 1490 1500 1510 1520 1530
pF1KB0 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK
1440 1450 1460 1470 1480 1490
1540 1550 1560 1570 1580 1590
pF1KB0 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM
1500 1510 1520 1530 1540 1550
1600 1610 1620 1630 1640 1650
pF1KB0 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE
1560 1570 1580 1590 1600 1610
1660 1670 1680 1690 1700 1710
pF1KB0 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL
1620 1630 1640 1650 1660 1670
1720 1730 1740 1750 1760 1770
pF1KB0 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK
1680 1690 1700 1710 1720 1730
1780 1790 1800 1810 1820 1830
pF1KB0 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS
1740 1750 1760 1770 1780 1790
1840 1850 1860 1870 1880 1890
pF1KB0 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL
1800 1810 1820 1830 1840 1850
1900 1910 1920 1930 1940
pF1KB0 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL
1860 1870 1880 1890 1900 1910
pF1KB0 ------------------------------------------------------------
XP_011 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE
1920 1930 1940 1950 1960 1970
1950 1960 1970
pF1KB0 ---------------------------QDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
.::::::::::::::::::::::::::::::::
XP_011 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI
1980 1990 2000 2010 2020 2030
1980 1990 2000 2010 2020 2030
pF1KB0 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQ
2040 2050 2060 2070 2080 2090
2040 2050 2060 2070 2080 2090
pF1KB0 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD
2100 2110 2120 2130 2140 2150
2100 2110 2120 2130 2140 2150
pF1KB0 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF
2160 2170 2180 2190 2200 2210
2160 2170 2180 2190 2200 2210
pF1KB0 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNE
2220 2230 2240 2250 2260 2270
2220 2230 2240 2250 2260 2270
pF1KB0 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK
2280 2290 2300 2310 2320 2330
2280 2290 2300 2310 2320 2330
pF1KB0 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL
2340 2350 2360 2370 2380 2390
2340 2350 2360 2370 2380 2390
pF1KB0 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD
2400 2410 2420 2430 2440 2450
2400 2410 2420 2430 2440 2450
pF1KB0 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL
2460 2470 2480 2490 2500 2510
2460 2470 2480 2490 2500 2510
pF1KB0 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESP
2520 2530 2540 2550 2560 2570
2520 2530 2540 2550 2560 2570
pF1KB0 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
XP_011 KSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQPGPWHASSGKDVPECKT
2580 2590 2600 2610 2620 2630
>>NP_001092763 (OMIM: 609184) chromosome-associated kine (1234 aa)
initn: 934 init1: 313 opt: 1018 Z-score: 376.3 bits: 82.8 E(85289): 3.2e-14
Smith-Waterman score: 1115; 27.7% identity (62.5% similar) in 1055 aa overlap (7-1010:10-1043)
10 20 30 40 50
pF1KB0 MAEEGAVAVCVRVRPLNSREESLG-ETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGN
: : .: ::: .: : : . . ...:. .: :::..: ::
NP_001 MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTD--KSFTYDFVFDPC
10 20 30 40 50
60 70 80 90 100
pF1KB0 ETTKNVYEEIAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGS-------EDHLGVIPRA
..:... .::.: . ..:::.:..:::::.:::::.: :. : .:.:::.
NP_001 TEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRV
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB0 IHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTE
:. .:..: : : :: :.:::.::::: : :::: ... . :::: .... .. :::
NP_001 IQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB0 EVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVS
..: .. ... . .:..:: . : ::..:::::.:: . .:.:.:.. .:: : . :
NP_001 KTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSD-KNC--SFR-S
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB0 HLNLVDLAGSERAAQTGAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLT
.:.::::::::: .: : : ::::: ::::.:. ::.::. :.: . :.:. :::::::
NP_001 KLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLT
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB0 RILQNSLGGNAKTRIICTITPV--SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKR
:.::.:::::..: .: ..:. ...:::..:..:. :. .:: : :: .. : :..
NP_001 RLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVN-IDPHTAELNH
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB0 YRKEIMDLKKQLEEV---SLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTS
......:. : .. .: .: ...: .:.:... : . .::: :.: : .
NP_001 LKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVE-ENEK---LSRCLSKA
360 370 380 390 400
410 420 430 440 450
pF1KB0 SSLTLQQELKAKRKRRVTWCLG-KINKMKN--SNYADQSNIPTNITTKTHKLSI----NL
.. : :. . ..:. :. :...... . : ... .. . : .. ::
NP_001 AGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNL
410 420 430 440 450 460
460 470 480 490 500 510
pF1KB0 LREI----DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLD
. : ::.: . ....... ...: .: :. ... . .. .:.... :..
NP_001 QQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSR-SSDAFTTQHALHQAQMSKEVVE
470 480 490 500 510 520
520 530 540 550 560 570
pF1KB0 YEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQENELSSKVELLREKEDQIKKLQ---
.. . :: . :. . :: .... .. . . . .: ..: .:::. ...::
NP_001 LNNALALKEALVRKMTQ-ND-NQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAK
530 540 550 560 570 580
580 590 600 610 620
pF1KB0 EYIDSQKLENIKMDLSYSLES-IEDPKQM--KQTLF-----DAETVALDAKRESAFLRSE
. ... :: . . : ::. : : :. .:. . ..: .. ..: .....
NP_001 KNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQ
590 600 610 620 630 640
630 640 650 660 670
pF1KB0 NLELKEKMKELATTYKQ--MENDIQLYQSQLEAKKKMQ--VDLEKELQSAFNEITKLTSL
..: ..::: : ..: ...: .. : . . .:.. . ::...:. . . . :
NP_001 RVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEE
650 660 670 680 690 700
680 690 700 710 720 730
pF1KB0 IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI
. . : : :. . ..:: .:: ... .:. : : . : .:.. . : .:. ....
NP_001 A-AAANKRLKDALQKQREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVS-TEEAKRHL
710 720 730 740 750 760
740 750 760 770 780 790
pF1KB0 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY-KSTDQEFQNF
.: :. .:.... .: . :::: .. .. : .:. .... .: : ...
NP_001 NDLLEDRKILAQDVVQLKEK---KESR-ENPPPKLRKCTFSLSEVHGQVLESEDCITKQI
770 780 790 800 810 820
800 810 820 830 840 850
pF1KB0 KTLHMDFEQKYKMVLEENERM-NQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE
..:. ..: . .. . .... . : . :. . ... : :.: :: . .
NP_001 ESLETEMELRSAQIADLQQKLLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIH
830 840 850 860 870 880
860 870 880 890 900 910
pF1KB0 VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK--DDLKQLQE
: . : ..: : . . .. : . . . : .:: : ... ::: ..::::
NP_001 VTKLENSLRQSKASCADMQKMLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQE
890 900 910 920 930 940
920 930 940 950 960
pF1KB0 SLQIERDQLKS------DIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS--EEV
: . :.. :: .. .:.. . . :..:.. :. .: . . .:.:. . .
NP_001 SQMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVA
950 960 970 980 990 1000
970 980 990 1000 1010 1020
pF1KB0 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE
::. :. ..: . : . . : . .. : . . :..:
NP_001 SRQKHLPNDTLLSPDSSFEYIPPKPKPSRVKEKFLEQ-SMDIEDLKYCSEHSVNEHEDGD
1010 1020 1030 1040 1050
1030 1040 1050 1060 1070 1080
pF1KB0 KNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK
NP_001 GDGDSDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKC
1060 1070 1080 1090 1100 1110
2580 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:31:03 2016 done: Sat Nov 5 02:31:07 2016
Total Scan time: 22.610 Total Display time: 1.580
Function used was FASTA [36.3.4 Apr, 2011]