Result of FASTA (omim) for
pF1KB0015
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0015, 1591 aa
1>>>pF1KB0015 1591 - 1591 aa - 1591 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4571+/-0.00057; mu= 7.9587+/- 0.035
mean_var=209.4571+/-43.260, 0's: 0 Z-trim(112.8): 257 B-trim: 126 in 1/49
Lambda= 0.088619
statistics sampled from 21612 (21920) to 21612 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.6), E-opt: 0.2 (0.257), width: 16
Scan time: 15.880
The best scores are: opt bits E(85289)
NP_006368 (OMIM: 605836) protein unc-13 homolog B (1591) 10679 1380.4 0
XP_011515987 (OMIM: 605836) PREDICTED: protein unc (1590) 10661 1378.1 0
NP_001317582 (OMIM: 605836) protein unc-13 homolog (1610) 9488 1228.1 0
XP_016869680 (OMIM: 605836) PREDICTED: protein unc (1221) 8017 1040.0 0
XP_011515985 (OMIM: 605836) PREDICTED: protein unc (1971) 8018 1040.3 0
XP_011526113 (OMIM: 609894) PREDICTED: protein unc (1680) 6941 902.5 0
XP_011515988 (OMIM: 605836) PREDICTED: protein unc (1240) 6826 887.7 0
XP_011515983 (OMIM: 605836) PREDICTED: protein unc (1990) 6827 888.0 0
XP_011515984 (OMIM: 605836) PREDICTED: protein unc (1989) 6809 885.7 0
XP_016869681 (OMIM: 605836) PREDICTED: protein unc (1195) 6627 862.2 0
NP_001316848 (OMIM: 614568) protein unc-13 homolog (2212) 6146 801.0 0
XP_016877712 (OMIM: 614568) PREDICTED: protein unc (2212) 6146 801.0 0
NP_001074003 (OMIM: 614568) protein unc-13 homolog (2214) 6137 799.8 0
XP_005254451 (OMIM: 614568) PREDICTED: protein unc (2214) 6137 799.8 0
XP_016877711 (OMIM: 614568) PREDICTED: protein unc (2214) 6137 799.8 0
XP_016877710 (OMIM: 614568) PREDICTED: protein unc (2214) 6137 799.8 0
XP_016877709 (OMIM: 614568) PREDICTED: protein unc (2214) 6137 799.8 0
XP_016877714 (OMIM: 614568) PREDICTED: protein unc (1180) 6073 791.4 0
XP_011526112 (OMIM: 609894) PREDICTED: protein unc (1693) 5483 716.1 6.2e-205
NP_001073890 (OMIM: 609894) protein unc-13 homolog (1703) 5483 716.1 6.2e-205
XP_016881991 (OMIM: 609894) PREDICTED: protein unc (1702) 5481 715.8 7.5e-205
NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 250 46.7 0.00072
XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 250 46.7 0.00075
XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl- ( 749) 250 46.8 0.00085
NP_001122074 (OMIM: 603962) RAS guanyl-releasing p ( 762) 250 46.8 0.00086
NP_005730 (OMIM: 603962) RAS guanyl-releasing prot ( 797) 250 46.8 0.00089
NP_001139678 (OMIM: 607320) RAS guanyl-releasing p ( 484) 242 45.6 0.0012
NP_001139679 (OMIM: 607320) RAS guanyl-releasing p ( 576) 242 45.6 0.0014
NP_001139675 (OMIM: 607320) RAS guanyl-releasing p ( 581) 242 45.7 0.0014
NP_001139676 (OMIM: 607320) RAS guanyl-releasing p ( 604) 242 45.7 0.0015
XP_005264303 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 243 45.8 0.0015
XP_016859252 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 243 45.8 0.0015
XP_016859251 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 243 45.8 0.0015
NP_056191 (OMIM: 609531) ras guanyl-releasing prot ( 689) 243 45.8 0.0015
XP_011531048 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
XP_016859249 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
XP_011531050 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
NP_733772 (OMIM: 609531) ras guanyl-releasing prot ( 690) 243 45.8 0.0015
XP_016859250 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
XP_011531049 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
XP_016859248 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 243 45.8 0.0015
NP_001132960 (OMIM: 609531) ras guanyl-releasing p ( 690) 243 45.8 0.0015
NP_001139677 (OMIM: 607320) RAS guanyl-releasing p ( 639) 242 45.7 0.0015
NP_001139674 (OMIM: 607320) RAS guanyl-releasing p ( 659) 242 45.7 0.0016
NP_733749 (OMIM: 607320) RAS guanyl-releasing prot ( 673) 242 45.7 0.0016
NP_001186028 (OMIM: 604009) BAI1-associated protei (1124) 226 43.8 0.0097
NP_001186027 (OMIM: 604009) BAI1-associated protei (1129) 226 43.8 0.0097
XP_011521032 (OMIM: 604009) PREDICTED: BAI1-associ (1149) 226 43.9 0.0098
NP_001186026 (OMIM: 604009) BAI1-associated protei (1152) 226 43.9 0.0098
NP_001273393 (OMIM: 604009) BAI1-associated protei (1169) 226 43.9 0.0099
>>NP_006368 (OMIM: 605836) protein unc-13 homolog B isof (1591 aa)
initn: 10679 init1: 10679 opt: 10679 Z-score: 7390.8 bits: 1380.4 E(85289): 0
Smith-Waterman score: 10679; 99.9% identity (99.9% similar) in 1591 aa overlap (1-1591:1-1591)
10 20 30 40 50 60
pF1KB0 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB0 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB0 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB0 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB0 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB0 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB0 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB0 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB0 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB0 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB0 NEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_006 NEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT
1510 1520 1530 1540 1550 1560
1570 1580 1590
pF1KB0 ILRILSQRSNDEVAREFVKLKSESRSTEEGS
:::::::::::::::::::::::::::::::
NP_006 ILRILSQRSNDEVAREFVKLKSESRSTEEGS
1570 1580 1590
>>XP_011515987 (OMIM: 605836) PREDICTED: protein unc-13 (1590 aa)
initn: 6474 init1: 6429 opt: 10661 Z-score: 7378.3 bits: 1378.1 E(85289): 0
Smith-Waterman score: 10661; 99.9% identity (99.9% similar) in 1591 aa overlap (1-1591:1-1590)
10 20 30 40 50 60
pF1KB0 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQL-QELPPEEQGP
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KB0 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB0 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KB0 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KB0 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KB0 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KB0 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KB0 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KB0 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KB0 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KB0 NEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT
1500 1510 1520 1530 1540 1550
1570 1580 1590
pF1KB0 ILRILSQRSNDEVAREFVKLKSESRSTEEGS
:::::::::::::::::::::::::::::::
XP_011 ILRILSQRSNDEVAREFVKLKSESRSTEEGS
1560 1570 1580 1590
>>NP_001317582 (OMIM: 605836) protein unc-13 homolog B i (1610 aa)
initn: 9481 init1: 9481 opt: 9488 Z-score: 6567.8 bits: 1228.1 E(85289): 0
Smith-Waterman score: 10631; 98.8% identity (98.8% similar) in 1610 aa overlap (1-1591:1-1610)
10 20 30 40 50 60
pF1KB0 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB0 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB0 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB0 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB0 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB0 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB0 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB0 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420
pF1KB0 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQ-------------------GSGVDDPVG
:::::::::::::::::::::::::::::::: :::::::::
NP_001 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDPVG
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KB0 EVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTK
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KB0 SKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGS
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_001 SKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGS
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590
pF1KB0 CACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1570 1580 1590 1600 1610
>>XP_016869680 (OMIM: 605836) PREDICTED: protein unc-13 (1221 aa)
initn: 8017 init1: 8017 opt: 8017 Z-score: 5553.0 bits: 1040.0 E(85289): 0
Smith-Waterman score: 8017; 99.8% identity (99.9% similar) in 1203 aa overlap (389-1591:19-1221)
360 370 380 390 400 410
pF1KB0 SFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
.:::::::::::::::::::::::::::::
XP_016 MVLIFFFNFLNPYFGCSSKIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
10 20 30 40
420 430 440 450 460 470
pF1KB0 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
50 60 70 80 90 100
480 490 500 510 520 530
pF1KB0 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
110 120 130 140 150 160
540 550 560 570 580 590
pF1KB0 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
170 180 190 200 210 220
600 610 620 630 640 650
pF1KB0 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
230 240 250 260 270 280
660 670 680 690 700 710
pF1KB0 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
290 300 310 320 330 340
720 730 740 750 760 770
pF1KB0 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
350 360 370 380 390 400
780 790 800 810 820 830
pF1KB0 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
410 420 430 440 450 460
840 850 860 870 880 890
pF1KB0 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
470 480 490 500 510 520
900 910 920 930 940 950
pF1KB0 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
530 540 550 560 570 580
960 970 980 990 1000 1010
pF1KB0 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
590 600 610 620 630 640
1020 1030 1040 1050 1060 1070
pF1KB0 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
650 660 670 680 690 700
1080 1090 1100 1110 1120 1130
pF1KB0 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
710 720 730 740 750 760
1140 1150 1160 1170 1180 1190
pF1KB0 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
770 780 790 800 810 820
1200 1210 1220 1230 1240 1250
pF1KB0 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
830 840 850 860 870 880
1260 1270 1280 1290 1300 1310
pF1KB0 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
890 900 910 920 930 940
1320 1330 1340 1350 1360 1370
pF1KB0 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
950 960 970 980 990 1000
1380 1390 1400 1410 1420 1430
pF1KB0 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEH
1010 1020 1030 1040 1050 1060
1440 1450 1460 1470 1480 1490
pF1KB0 KVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFL
1070 1080 1090 1100 1110 1120
1500 1510 1520 1530 1540 1550
pF1KB0 LGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETG
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_016 LGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETG
1130 1140 1150 1160 1170 1180
1560 1570 1580 1590
pF1KB0 LTILRILSQRSNDEVAREFVKLKSESRSTEEGS
:::::::::::::::::::::::::::::::::
XP_016 LTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1190 1200 1210 1220
>>XP_011515985 (OMIM: 605836) PREDICTED: protein unc-13 (1971 aa)
initn: 8018 init1: 8018 opt: 8018 Z-score: 5550.9 bits: 1040.3 E(85289): 0
Smith-Waterman score: 8018; 99.8% identity (99.9% similar) in 1203 aa overlap (389-1591:769-1971)
360 370 380 390 400 410
pF1KB0 SFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
.:::::::::::::::::::::::::::::
XP_011 RQKKLLHELVQKANRLSVEDIHSEEKRGALQIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
740 750 760 770 780 790
420 430 440 450 460 470
pF1KB0 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
800 810 820 830 840 850
480 490 500 510 520 530
pF1KB0 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
860 870 880 890 900 910
540 550 560 570 580 590
pF1KB0 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
920 930 940 950 960 970
600 610 620 630 640 650
pF1KB0 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
980 990 1000 1010 1020 1030
660 670 680 690 700 710
pF1KB0 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
1040 1050 1060 1070 1080 1090
720 730 740 750 760 770
pF1KB0 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
1100 1110 1120 1130 1140 1150
780 790 800 810 820 830
pF1KB0 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
1160 1170 1180 1190 1200 1210
840 850 860 870 880 890
pF1KB0 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
1220 1230 1240 1250 1260 1270
900 910 920 930 940 950
pF1KB0 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
1280 1290 1300 1310 1320 1330
960 970 980 990 1000 1010
pF1KB0 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
1340 1350 1360 1370 1380 1390
1020 1030 1040 1050 1060 1070
pF1KB0 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
1400 1410 1420 1430 1440 1450
1080 1090 1100 1110 1120 1130
pF1KB0 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
1460 1470 1480 1490 1500 1510
1140 1150 1160 1170 1180 1190
pF1KB0 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
1520 1530 1540 1550 1560 1570
1200 1210 1220 1230 1240 1250
pF1KB0 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
1580 1590 1600 1610 1620 1630
1260 1270 1280 1290 1300 1310
pF1KB0 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
1640 1650 1660 1670 1680 1690
1320 1330 1340 1350 1360 1370
pF1KB0 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
1700 1710 1720 1730 1740 1750
1380 1390 1400 1410 1420 1430
pF1KB0 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEH
1760 1770 1780 1790 1800 1810
1440 1450 1460 1470 1480 1490
pF1KB0 KVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFL
1820 1830 1840 1850 1860 1870
1500 1510 1520 1530 1540 1550
pF1KB0 LGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETG
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 LGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETG
1880 1890 1900 1910 1920 1930
1560 1570 1580 1590
pF1KB0 LTILRILSQRSNDEVAREFVKLKSESRSTEEGS
:::::::::::::::::::::::::::::::::
XP_011 LTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1940 1950 1960 1970
>>XP_011526113 (OMIM: 609894) PREDICTED: protein unc-13 (1680 aa)
initn: 7394 init1: 3154 opt: 6941 Z-score: 4807.6 bits: 902.5 E(85289): 0
Smith-Waterman score: 7953; 74.3% identity (87.9% similar) in 1640 aa overlap (45-1590:45-1674)
20 30 40 50 60 70
pF1KB0 GSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGLSVEVWNKGLIWDTM
:::::::::.::::::.:::::::::::::
XP_011 GAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTM
20 30 40 50 60 70
80 90 100 110 120 130
pF1KB0 VGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHKILLDTRFELPFDIP
:::::: :.:::::.::::::: ::.....: :.:::::..:: :.::::::::::.:::
XP_011 VGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHRILLDTRFELPLDIP
80 90 100 110 120 130
140 150 160 170 180
pF1KB0 EEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCS----F-------EDPDSA
:::::::. : ::.::. ..::: :.: : ::::. . :: : .:::::
XP_011 EEEARYWAKKLEQLNAMRDQDEYSFQDE-QDKPLPVPSNQCCNWNYFGWGEQHNDDPDSA
140 150 160 170 180 190
190 200 210 220 230 240
pF1KB0 VDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSY
:::::::::::::::.::::.:.:::::::::. : : : .::.: .:::.::
XP_011 VDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSV--RPPPL-----GSRESYSDSMHSY
200 210 220 230 240
250 260 270 280 290
pF1KB0 DLDYPERRAISPTSSSRYGSSCNVSQGSSQLSEL---DQYHEQD---DDHRETDSIHSCH
. .. : .:.:::.::::.:: ..::::::::: :.. : .:.:. :: ::::
XP_011 E-EFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSDMEDERDRDSYHSCH
250 260 270 280 290 300
300 310 320
pF1KB0 SSHSLSRDGQ-------------AGFGEQEK---------------PLEVTGQAEKE--A
:: : .:. : :.:. : .. . :..: :
XP_011 SSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEVPDDLGSYAQREDVA
310 320 330 340 350 360
330 340 350
pF1KB0 ACEPKEMK-----------ED----ATTHPP-----------PDLVLQKDHF---LGPQ-
. :::..: :: : :. : :: : ... :.
XP_011 VAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKVPAAEQIPEAEPPKD
370 380 390 400 410 420
360 370 380 390 400 410
pF1KB0 -ESF-PEEN-----ASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGL
::: :.:. ... ...:.:.:.:: .:::.:::: .:. : :. ::.:::
XP_011 EESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGL
430 440 450 460 470 480
420 430 440 450 460
pF1KB0 YGIDSMPDLRRKKPLPLVSDL--SLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQAL
::::::.:..::.:::::: :::::::::::::.:. ..:..::::.::::::::::
XP_011 IIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALAS-STLNNEELKNHVYKKTLQAL
490 500 510 520 530 540
470 480 490 500 510 520
pF1KB0 IYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCL
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_011 IYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCL
550 560 570 580 590 600
530 540 550 560 570 580
pF1KB0 QRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVK
::::::: :::::::::::::..::::::::::::::::.:...:.:.:.::.::::.::
XP_011 QRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKTAHTQQMKAVK
610 620 630 640 650 660
590 600 610 620 630 640
pF1KB0 QSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWE
::::::::::::::.::::::::::::::::::::::::::.:::::::::.::::::::
XP_011 QSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWE
670 680 690 700 710 720
650 660 670 680 690 700
pF1KB0 EKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYN
:.::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_011 ENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYN
730 740 750 760 770 780
710 720 730 740 750 760
pF1KB0 LEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEA
:.::::::::::::::.:::::::::::::::::::::::::::..::.:..: :.::.:
XP_011 LDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDA
790 800 810 820 830 840
770 780 790 800 810 820
pF1KB0 RGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANI
.::::::::.::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_011 KGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANI
850 860 870 880 890 900
830 840 850 860 870 880
pF1KB0 NAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQ
::::::::::::::::::::::::::::::::::::::::::::: :::::::.::::::
XP_011 NAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQ
910 920 930 940 950 960
890 900 910 920 930 940
pF1KB0 DLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::.::::.::
XP_011 DLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYSREYQ
970 980 990 1000 1010 1020
950 960 970 980 990 1000
pF1KB0 L----KQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSA
: :. ::::::::.::::: ::::::::::::::::::: ::::::::::::.::
XP_011 TDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISA
1030 1040 1050 1060 1070 1080
1010 1020 1030 1040 1050 1060
pF1KB0 EVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAW
::::.:::::::::.:::.: .:::::::::::::::::.:::: .::... .:::::::
XP_011 EVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTELPAFKDRVPEYPAW
1090 1100 1110 1120 1130 1140
1070 1080 1090 1100 1110 1120
pF1KB0 FEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIR
:: ::.:::::::.:: .::.::::::::::::::::::::::::::::.:::::::::.
XP_011 FEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIK
1150 1160 1170 1180 1190 1200
1130 1140 1150 1160 1170 1180
pF1KB0 KLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEK--LPCILMNNVQQLRV
:::::::.:..::::::::::..::.:::::.:::: .::.::: .:::::::.:::::
XP_011 KLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEKVPCILMNNTQQLRV
1210 1220 1230 1240 1250 1260
1190 1200 1210 1220 1230 1240
pF1KB0 QLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILG
::::::::::::::: ::.: :::::::::.:::::: ::..::: .:.:::.::.:::.
XP_011 QLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQPHIEECVKQMGDILS
1270 1280 1290 1300 1310 1320
1250 1260 1270 1280 1290 1300
pF1KB0 QVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMN
::.::::. .: .:.:::::.::.:.::.::.:::::: .::::::::::::::..:::
XP_011 QVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMN
1330 1340 1350 1360 1370 1380
1310 1320 1330 1340 1350 1360
pF1KB0 TMERMIVLPPLTDQT--GTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALD
:::. :::::::::: :::.::.:::::..::::::::::::...::::::::..::::
XP_011 TMEKTIVLPPLTDQTMIGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALD
1390 1400 1410 1420 1430 1440
1370 1380 1390 1400 1410 1420
pF1KB0 TIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPV
:::::::::: :::::::::::::::::::::::::.:: ::::::..:..:: ::.:::
XP_011 TIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPV
1450 1460 1470 1480 1490 1500
1430 1440 1450 1460 1470 1480
pF1KB0 GEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTT
::::..:.::::::::::::::::::::::::::.:.::::.::...::. :::::::.:
XP_011 GEVSVHVELFTHPGTGEHKVTVKVVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFAT
1510 1520 1530 1540 1550 1560
1490 1500 1510 1520 1530 1540
pF1KB0 KSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAKG
:::.:.:::::::.:.: :. . ::: ::::.::::: ::::::..::::. ::... .:
XP_011 KSKNNSWAPKYNESFQFTLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRG
1570 1580 1590 1600 1610 1620
1550 1560 1570 1580 1590
pF1KB0 SCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
: ::: ::::.::::.::::.:::::::::::::.:::::::..::.:::
XP_011 SAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP
1630 1640 1650 1660 1670 1680
>>XP_011515988 (OMIM: 605836) PREDICTED: protein unc-13 (1240 aa)
initn: 6819 init1: 6819 opt: 6826 Z-score: 4730.0 bits: 887.7 E(85289): 0
Smith-Waterman score: 7969; 98.3% identity (98.4% similar) in 1222 aa overlap (389-1591:19-1240)
360 370 380 390 400 410
pF1KB0 SFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
.:::::::::::::::::::::::::::::
XP_011 MVLIFFFNFLNPYFGCSSKIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
10 20 30 40
420 430 440 450 460 470
pF1KB0 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
50 60 70 80 90 100
480 490 500 510 520 530
pF1KB0 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
110 120 130 140 150 160
540 550 560 570 580 590
pF1KB0 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
170 180 190 200 210 220
600 610 620 630 640 650
pF1KB0 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
230 240 250 260 270 280
660 670 680 690 700 710
pF1KB0 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
290 300 310 320 330 340
720 730 740 750 760 770
pF1KB0 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
350 360 370 380 390 400
780 790 800 810 820 830
pF1KB0 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
410 420 430 440 450 460
840 850 860 870 880 890
pF1KB0 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
470 480 490 500 510 520
900 910 920 930 940 950
pF1KB0 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
530 540 550 560 570 580
960 970 980 990 1000 1010
pF1KB0 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
590 600 610 620 630 640
1020 1030 1040 1050 1060 1070
pF1KB0 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
650 660 670 680 690 700
1080 1090 1100 1110 1120 1130
pF1KB0 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
710 720 730 740 750 760
1140 1150 1160 1170 1180 1190
pF1KB0 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
770 780 790 800 810 820
1200 1210 1220 1230 1240 1250
pF1KB0 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
830 840 850 860 870 880
1260 1270 1280 1290 1300 1310
pF1KB0 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
890 900 910 920 930 940
1320 1330 1340 1350 1360 1370
pF1KB0 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
950 960 970 980 990 1000
1380 1390 1400 1410
pF1KB0 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQ-------------------GSGVDDP
:::::::::::::::::::::::::::::::::: :::::::
XP_011 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDP
1010 1020 1030 1040 1050 1060
1420 1430 1440 1450 1460 1470
pF1KB0 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
1070 1080 1090 1100 1110 1120
1480 1490 1500 1510 1520 1530
pF1KB0 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAK
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_011 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK
1130 1140 1150 1160 1170 1180
1540 1550 1560 1570 1580 1590
pF1KB0 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1190 1200 1210 1220 1230 1240
>>XP_011515983 (OMIM: 605836) PREDICTED: protein unc-13 (1990 aa)
initn: 6820 init1: 6820 opt: 6827 Z-score: 4727.9 bits: 888.0 E(85289): 0
Smith-Waterman score: 7970; 98.3% identity (98.4% similar) in 1222 aa overlap (389-1591:769-1990)
360 370 380 390 400 410
pF1KB0 SFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
.:::::::::::::::::::::::::::::
XP_011 RQKKLLHELVQKANRLSVEDIHSEEKRGALQIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
740 750 760 770 780 790
420 430 440 450 460 470
pF1KB0 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
800 810 820 830 840 850
480 490 500 510 520 530
pF1KB0 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
860 870 880 890 900 910
540 550 560 570 580 590
pF1KB0 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
920 930 940 950 960 970
600 610 620 630 640 650
pF1KB0 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
980 990 1000 1010 1020 1030
660 670 680 690 700 710
pF1KB0 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
1040 1050 1060 1070 1080 1090
720 730 740 750 760 770
pF1KB0 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
1100 1110 1120 1130 1140 1150
780 790 800 810 820 830
pF1KB0 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
1160 1170 1180 1190 1200 1210
840 850 860 870 880 890
pF1KB0 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
1220 1230 1240 1250 1260 1270
900 910 920 930 940 950
pF1KB0 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
1280 1290 1300 1310 1320 1330
960 970 980 990 1000 1010
pF1KB0 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
1340 1350 1360 1370 1380 1390
1020 1030 1040 1050 1060 1070
pF1KB0 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
1400 1410 1420 1430 1440 1450
1080 1090 1100 1110 1120 1130
pF1KB0 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
1460 1470 1480 1490 1500 1510
1140 1150 1160 1170 1180 1190
pF1KB0 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
1520 1530 1540 1550 1560 1570
1200 1210 1220 1230 1240 1250
pF1KB0 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
1580 1590 1600 1610 1620 1630
1260 1270 1280 1290 1300 1310
pF1KB0 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
1640 1650 1660 1670 1680 1690
1320 1330 1340 1350 1360 1370
pF1KB0 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
1700 1710 1720 1730 1740 1750
1380 1390 1400 1410
pF1KB0 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQ-------------------GSGVDDP
:::::::::::::::::::::::::::::::::: :::::::
XP_011 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDP
1760 1770 1780 1790 1800 1810
1420 1430 1440 1450 1460 1470
pF1KB0 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
1820 1830 1840 1850 1860 1870
1480 1490 1500 1510 1520 1530
pF1KB0 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAK
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_011 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK
1880 1890 1900 1910 1920 1930
1540 1550 1560 1570 1580 1590
pF1KB0 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1940 1950 1960 1970 1980 1990
>>XP_011515984 (OMIM: 605836) PREDICTED: protein unc-13 (1989 aa)
initn: 4997 init1: 3766 opt: 6809 Z-score: 4715.5 bits: 885.7 E(85289): 0
Smith-Waterman score: 7952; 98.2% identity (98.3% similar) in 1222 aa overlap (389-1591:769-1989)
360 370 380 390 400 410
pF1KB0 SFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
.:::::::::::::::::::::::::::::
XP_011 RQKKLLHELVQKANRLSVEDIHSEEKRGALQIPDDGDPSLPQWLPEGPAGGLYGIDSMPD
740 750 760 770 780 790
420 430 440 450 460 470
pF1KB0 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPH
800 810 820 830 840 850
480 490 500 510 520 530
pF1KB0 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKH
860 870 880 890 900 910
540 550 560 570 580 590
pF1KB0 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKW
920 930 940 950 960 970
600 610 620 630 640 650
pF1KB0 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNS
980 990 1000 1010 1020 1030
660 670 680 690 700 710
pF1KB0 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAV
1040 1050 1060 1070 1080 1090
720 730 740 750 760 770
pF1KB0 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYF
1100 1110 1120 1130 1140 1150
780 790 800 810 820 830
pF1KB0 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTAS
1160 1170 1180 1190 1200 1210
840 850 860 870 880 890
pF1KB0 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLT
1220 1230 1240 1250 1260 1270
900 910 920 930 940 950
pF1KB0 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 SITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQL-QELPPEEQ
1280 1290 1300 1310 1320 1330
960 970 980 990 1000 1010
pF1KB0 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYA
1340 1350 1360 1370 1380 1390
1020 1030 1040 1050 1060 1070
pF1KB0 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENED
1400 1410 1420 1430 1440 1450
1080 1090 1100 1110 1120 1130
pF1KB0 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYM
1460 1470 1480 1490 1500 1510
1140 1150 1160 1170 1180 1190
pF1KB0 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDL
1520 1530 1540 1550 1560 1570
1200 1210 1220 1230 1240 1250
pF1KB0 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASA
1580 1590 1600 1610 1620 1630
1260 1270 1280 1290 1300 1310
pF1KB0 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTG
1640 1650 1660 1670 1680 1690
1320 1330 1340 1350 1360 1370
pF1KB0 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFL
1700 1710 1720 1730 1740 1750
1380 1390 1400 1410
pF1KB0 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQ-------------------GSGVDDP
:::::::::::::::::::::::::::::::::: :::::::
XP_011 EKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDP
1760 1770 1780 1790 1800 1810
1420 1430 1440 1450 1460 1470
pF1KB0 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT
1820 1830 1840 1850 1860 1870
1480 1490 1500 1510 1520 1530
pF1KB0 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYYFAREDRVLGLAVMPLRDVTAK
:::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_011 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK
1880 1890 1900 1910 1920 1930
1540 1550 1560 1570 1580 1590
pF1KB0 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS
1940 1950 1960 1970 1980
>>XP_016869681 (OMIM: 605836) PREDICTED: protein unc-13 (1195 aa)
initn: 6620 init1: 6620 opt: 6627 Z-score: 4592.7 bits: 862.2 E(85289): 0
Smith-Waterman score: 7770; 98.3% identity (98.3% similar) in 1195 aa overlap (416-1591:1-1195)
390 400 410 420 430 440
pF1KB0 QLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDLSLVQSRKAGITSAM
::::::::::::::::::::::::::::::
XP_016 MPDLRRKKPLPLVSDLSLVQSRKAGITSAM
10 20 30
450 460 470 480 490 500
pF1KB0 ATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQG
40 50 60 70 80 90
510 520 530 540 550 560
pF1KB0 MRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEI
100 110 120 130 140 150
570 580 590 600 610 620
pF1KB0 FEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYV
160 170 180 190 200 210
630 640 650 660 670 680
pF1KB0 TVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRES
220 230 240 250 260 270
690 700 710 720 730 740
pF1KB0 DDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTC
280 290 300 310 320 330
750 760 770 780 790 800
pF1KB0 LHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHF
340 350 360 370 380 390
810 820 830 840 850 860
pF1KB0 ACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH
400 410 420 430 440 450
870 880 890 900 910 920
pF1KB0 NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVK
460 470 480 490 500 510
930 940 950 960 970 980
pF1KB0 ACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNS
520 530 540 550 560 570
990 1000 1010 1020 1030 1040
pF1KB0 YTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN
580 590 600 610 620 630
1050 1060 1070 1080 1090 1100
pF1KB0 EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALF
640 650 660 670 680 690
1110 1120 1130 1140 1150 1160
pF1KB0 SCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCT
700 710 720 730 740 750
1170 1180 1190 1200 1210 1220
pF1KB0 KEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNS
760 770 780 790 800 810
1230 1240 1250 1260 1270 1280
pF1KB0 FQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCE
820 830 840 850 860 870
1290 1300 1310 1320 1330 1340
pF1KB0 KTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETR
880 890 900 910 920 930
1350 1360 1370 1380 1390 1400
pF1KB0 NLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTF
940 950 960 970 980 990
1410 1420 1430 1440
pF1KB0 VRSQTTQ-------------------GSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVA
::::::: ::::::::::::::::::::::::::::::::::
XP_016 VRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVA
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KB0 ANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPE
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550 1560
pF1KB0 SYELQICVKDYYFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILS
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILS
1120 1130 1140 1150 1160 1170
1570 1580 1590
pF1KB0 QRSNDEVAREFVKLKSESRSTEEGS
:::::::::::::::::::::::::
XP_016 QRSNDEVAREFVKLKSESRSTEEGS
1180 1190
1591 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 20:23:41 2016 done: Sat Nov 5 20:23:43 2016
Total Scan time: 15.880 Total Display time: 0.880
Function used was FASTA [36.3.4 Apr, 2011]