FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA2014, 1027 aa 1>>>pF1KA2014 1027 - 1027 aa - 1027 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9722+/-0.000455; mu= -0.0307+/- 0.029 mean_var=459.1704+/-92.926, 0's: 0 Z-trim(122.4): 89 B-trim: 151 in 1/61 Lambda= 0.059853 statistics sampled from 40407 (40503) to 40407 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.475), width: 16 Scan time: 15.450 The best scores are: opt bits E(85289) NP_783863 (OMIM: 616288) formin-like protein 3 iso (1027) 6765 599.5 3.1e-170 XP_005269275 (OMIM: 616288) PREDICTED: formin-like (1028) 6559 581.7 6.9e-165 XP_011537271 (OMIM: 616288) PREDICTED: formin-like (1046) 6475 574.5 1.1e-162 XP_011537273 (OMIM: 616288) PREDICTED: formin-like (1000) 6271 556.8 2.1e-157 XP_011537270 (OMIM: 616288) PREDICTED: formin-like (1047) 6269 556.7 2.4e-157 XP_011537276 (OMIM: 616288) PREDICTED: formin-like (1003) 6263 556.1 3.4e-157 XP_011537272 (OMIM: 616288) PREDICTED: formin-like (1046) 6245 554.6 1e-156 XP_011537275 (OMIM: 616288) PREDICTED: formin-like ( 925) 5530 492.8 3.6e-138 NP_944489 (OMIM: 616288) formin-like protein 3 iso ( 976) 5401 481.7 8.4e-135 XP_011537274 (OMIM: 616288) PREDICTED: formin-like ( 996) 5195 463.9 1.9e-129 XP_011508836 (OMIM: 616285) PREDICTED: formin-like (1076) 2478 229.3 8.6e-59 XP_005246322 (OMIM: 616285) PREDICTED: formin-like (1084) 2478 229.3 8.6e-59 XP_005246320 (OMIM: 616285) PREDICTED: formin-like (1087) 2478 229.4 8.7e-59 XP_011508835 (OMIM: 616285) PREDICTED: formin-like (1091) 2478 229.4 8.7e-59 NP_443137 (OMIM: 616285) formin-like protein 2 [Ho (1092) 2478 229.4 8.7e-59 XP_011508834 (OMIM: 616285) PREDICTED: formin-like (1093) 2478 229.4 8.7e-59 XP_011508833 (OMIM: 616285) PREDICTED: formin-like (1094) 2478 229.4 8.7e-59 XP_011508832 (OMIM: 616285) PREDICTED: formin-like (1099) 2478 229.4 8.7e-59 XP_011508838 (OMIM: 616285) PREDICTED: formin-like ( 860) 2345 217.8 2.1e-55 XP_011508837 (OMIM: 616285) PREDICTED: formin-like (1048) 2345 217.8 2.4e-55 XP_006722133 (OMIM: 604656) PREDICTED: formin-like (1104) 1870 176.9 5.6e-43 XP_006722129 (OMIM: 604656) PREDICTED: formin-like (1110) 1870 176.9 5.6e-43 NP_005883 (OMIM: 604656) formin-like protein 1 [Ho (1100) 1838 174.1 3.8e-42 XP_011523484 (OMIM: 604656) PREDICTED: formin-like (1106) 1838 174.1 3.8e-42 XP_011523482 (OMIM: 604656) PREDICTED: formin-like (1133) 1830 173.4 6.2e-42 XP_006722128 (OMIM: 604656) PREDICTED: formin-like (1148) 1830 173.4 6.3e-42 XP_006722127 (OMIM: 604656) PREDICTED: formin-like (1154) 1830 173.4 6.3e-42 XP_006722126 (OMIM: 604656) PREDICTED: formin-like (1158) 1830 173.4 6.3e-42 XP_011523481 (OMIM: 604656) PREDICTED: formin-like (1164) 1830 173.4 6.3e-42 XP_006722125 (OMIM: 604656) PREDICTED: formin-like (1164) 1830 173.4 6.3e-42 XP_006722132 (OMIM: 604656) PREDICTED: formin-like (1076) 1547 149.0 1.4e-34 NP_056160 (OMIM: 606627) disheveled-associated act (1067) 977 99.7 8.9e-20 NP_001188356 (OMIM: 606627) disheveled-associated (1068) 868 90.3 6.1e-17 XP_006715103 (OMIM: 606627) PREDICTED: disheveled- (1167) 868 90.4 6.4e-17 NP_001257449 (OMIM: 606626) disheveled-associated (1068) 864 90.0 7.7e-17 XP_006715108 (OMIM: 606627) PREDICTED: disheveled- (1077) 862 89.8 8.7e-17 XP_006715109 (OMIM: 606627) PREDICTED: disheveled- (1077) 862 89.8 8.7e-17 XP_006715106 (OMIM: 606627) PREDICTED: disheveled- (1077) 862 89.8 8.7e-17 XP_006715105 (OMIM: 606627) PREDICTED: disheveled- (1077) 862 89.8 8.7e-17 XP_016866119 (OMIM: 606627) PREDICTED: disheveled- (1100) 862 89.8 8.8e-17 XP_006715102 (OMIM: 606627) PREDICTED: disheveled- (1176) 862 89.8 9.2e-17 XP_005267487 (OMIM: 606626) PREDICTED: disheveled- (1078) 835 87.5 4.4e-16 NP_055807 (OMIM: 606626) disheveled-associated act (1078) 835 87.5 4.4e-16 XP_005267488 (OMIM: 606626) PREDICTED: disheveled- (1078) 835 87.5 4.4e-16 NP_112194 (OMIM: 609129,614567) protein diaphanous ( 849) 681 74.1 3.8e-12 XP_006719939 (OMIM: 609129,614567) PREDICTED: prot ( 930) 681 74.1 4e-12 NP_001245298 (OMIM: 609129,614567) protein diaphan (1112) 681 74.2 4.5e-12 NP_001245297 (OMIM: 609129,614567) protein diaphan (1123) 681 74.2 4.5e-12 XP_011533560 (OMIM: 609129,614567) PREDICTED: prot (1136) 681 74.2 4.6e-12 NP_001245296 (OMIM: 609129,614567) protein diaphan (1147) 681 74.2 4.6e-12 >>NP_783863 (OMIM: 616288) formin-like protein 3 isoform (1027 aa) initn: 6765 init1: 6765 opt: 6765 Z-score: 3177.4 bits: 599.5 E(85289): 3.1e-170 Smith-Waterman score: 6765; 100.0% identity (100.0% similar) in 1027 aa overlap (1-1027:1-1027) 10 20 30 40 50 60 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA2 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA2 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA2 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA2 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA2 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA2 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA2 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA2 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA2 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA2 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA2 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA2 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA2 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA2 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA2 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA2 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 970 980 990 1000 1010 1020 pF1KA2 PRAPGPH ::::::: NP_783 PRAPGPH >>XP_005269275 (OMIM: 616288) PREDICTED: formin-like pro (1028 aa) initn: 6682 init1: 6559 opt: 6559 Z-score: 3081.2 bits: 581.7 E(85289): 6.9e-165 Smith-Waterman score: 6559; 98.8% identity (99.4% similar) in 1014 aa overlap (1-1014:1-1014) 10 20 30 40 50 60 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA2 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA2 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA2 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA2 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA2 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA2 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA2 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA2 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA2 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA2 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA2 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA2 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA2 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA2 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA2 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA2 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP :::::::::::::::::::::::::::::::::::::: :. :...: :.. XP_005 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDA 970 980 990 1000 1010 1020 pF1KA2 PRAPGPH XP_005 AHHDESNC >>XP_011537271 (OMIM: 616288) PREDICTED: formin-like pro (1046 aa) initn: 6469 init1: 6469 opt: 6475 Z-score: 3041.9 bits: 574.5 E(85289): 1.1e-162 Smith-Waterman score: 6475; 98.1% identity (98.5% similar) in 1010 aa overlap (18-1027:45-1046) 10 20 30 40 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNL : .: :. .: : .: ::::: XP_011 LKEGPQCSKGKWCRWHLSARQLCEGPKGCGPYILWPSAFP---PASSGDR-----SSMNL 20 30 40 50 60 50 60 70 80 90 100 pF1KA2 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA2 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA2 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA2 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA2 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA2 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA2 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA2 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA2 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA2 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA2 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA2 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA2 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA2 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA2 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA2 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVV 970 980 990 1000 1010 1020 1010 1020 pF1KA2 RHQARSAAPPSGPPRAPGPH :::::::::::::::::::: XP_011 RHQARSAAPPSGPPRAPGPH 1030 1040 >>XP_011537273 (OMIM: 616288) PREDICTED: formin-like pro (1000 aa) initn: 6391 init1: 6268 opt: 6271 Z-score: 2947.0 bits: 556.8 E(85289): 2.1e-157 Smith-Waterman score: 6271; 98.1% identity (99.0% similar) in 983 aa overlap (34-1014:4-986) 10 20 30 40 50 60 pF1KA2 LESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERF--ALVLSSMNLPPDKARLLRQYDNE :. .: : .:::::::::::::::::::: XP_011 MFALKMKFCRAKTLSSMNLPPDKARLLRQYDNE 10 20 30 70 80 90 100 110 120 pF1KA2 KKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNH 40 50 60 70 80 90 130 140 150 160 170 180 pF1KA2 IGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPP 100 110 120 130 140 150 190 200 210 220 230 240 pF1KA2 SALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KA2 NLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH 220 230 240 250 260 270 310 320 330 340 350 360 pF1KA2 RFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRH 280 290 300 310 320 330 370 380 390 400 410 420 pF1KA2 TESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMM 340 350 360 370 380 390 430 440 450 460 470 480 pF1KA2 RVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KA2 DSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAP 460 470 480 490 500 510 550 560 570 580 590 600 pF1KA2 PLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KA2 DLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEI 580 590 600 610 620 630 670 680 690 700 710 720 pF1KA2 CRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 640 650 660 670 680 690 730 740 750 760 770 780 pF1KA2 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 700 710 720 730 740 750 790 800 810 820 830 840 pF1KA2 RGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSL 760 770 780 790 800 810 850 860 870 880 890 900 pF1KA2 ENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRY 820 830 840 850 860 870 910 920 930 940 950 960 pF1KA2 FGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQ 880 890 900 910 920 930 970 980 990 1000 1010 1020 pF1KA2 RNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGPP ::::::::::::::::::::::::::::::::::::: :. :...: :.. XP_011 RNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAA 940 950 960 970 980 990 pF1KA2 RAPGPH XP_011 HHDESNC 1000 >>XP_011537270 (OMIM: 616288) PREDICTED: formin-like pro (1047 aa) initn: 6386 init1: 6263 opt: 6269 Z-score: 2945.8 bits: 556.7 E(85289): 2.4e-157 Smith-Waterman score: 6269; 96.9% identity (97.9% similar) in 997 aa overlap (18-1014:45-1033) 10 20 30 40 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNL : .: :. .: : .: ::::: XP_011 LKEGPQCSKGKWCRWHLSARQLCEGPKGCGPYILWPSAFP---PASSGDR-----SSMNL 20 30 40 50 60 50 60 70 80 90 100 pF1KA2 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA2 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA2 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA2 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA2 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA2 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA2 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA2 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA2 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA2 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA2 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA2 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA2 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA2 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA2 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA2 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVV ::::::::::::::::::::::::::::::::::::::::::::::::::: :. :... XP_011 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTA 970 980 990 1000 1010 1020 1010 1020 pF1KA2 RHQARSAAPPSGPPRAPGPH : :.. XP_011 RTAKRGSRFFCDAAHHDESNC 1030 1040 >>XP_011537276 (OMIM: 616288) PREDICTED: formin-like pro (1003 aa) initn: 6386 init1: 6263 opt: 6263 Z-score: 2943.2 bits: 556.1 E(85289): 3.4e-157 Smith-Waterman score: 6263; 98.8% identity (99.4% similar) in 972 aa overlap (43-1014:18-989) 20 30 40 50 60 70 pF1KA2 EPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQER :::::::::::::::::::::::::::::: XP_011 MHTVHVPRDEDAKNWAESSMNLPPDKARLLRQYDNEKKWDLICDQER 10 20 30 40 80 90 100 110 120 130 pF1KA2 FQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDE 50 60 70 80 90 100 140 150 160 170 180 190 pF1KA2 NKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSL 110 120 130 140 150 160 200 210 220 230 240 250 pF1KA2 ARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVN 170 180 190 200 210 220 260 270 280 290 300 310 pF1KA2 EIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRN 230 240 250 260 270 280 320 330 340 350 360 370 pF1KA2 EDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQ 290 300 310 320 330 340 380 390 400 410 420 430 pF1KA2 AYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQ 350 360 370 380 390 400 440 450 460 470 480 490 pF1KA2 REKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 410 420 430 440 450 460 500 510 520 530 540 550 pF1KA2 ELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVL 470 480 490 500 510 520 560 570 580 590 600 610 pF1KA2 TVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKT 530 540 550 560 570 580 620 630 640 650 660 670 pF1KA2 KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQT 590 600 610 620 630 640 680 690 700 710 720 730 pF1KA2 LPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAF 650 660 670 680 690 700 740 750 760 770 780 790 pF1KA2 LGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQS 710 720 730 740 750 760 800 810 820 830 840 850 pF1KA2 LDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELG 770 780 790 800 810 820 860 870 880 890 900 910 pF1KA2 RGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPS 830 840 850 860 870 880 920 930 940 950 960 970 pF1KA2 VFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIA 890 900 910 920 930 940 980 990 1000 1010 1020 pF1KA2 ELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGPPRAPGPH :::::::::::::::::::::::::: :. :...: :.. XP_011 ELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC 950 960 970 980 990 1000 >>XP_011537272 (OMIM: 616288) PREDICTED: formin-like pro (1046 aa) initn: 6366 init1: 4158 opt: 6245 Z-score: 2934.6 bits: 554.6 E(85289): 1e-156 Smith-Waterman score: 6251; 96.8% identity (97.8% similar) in 997 aa overlap (18-1014:45-1032) 10 20 30 40 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNL : .: :. .: : .: ::::: XP_011 LKEGPQCSKGKWCRWHLSARQLCEGPKGCGPYILWPSAFP---PASSGDR-----SSMNL 20 30 40 50 60 50 60 70 80 90 100 pF1KA2 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA2 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA2 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA2 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA2 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA2 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLGLEEFLQ-SRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA2 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA2 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA2 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA2 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA2 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA2 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 730 740 750 760 770 780 770 780 790 800 810 820 pF1KA2 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW 790 800 810 820 830 840 830 840 850 860 870 880 pF1KA2 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD 850 860 870 880 890 900 890 900 910 920 930 940 pF1KA2 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KA2 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVV ::::::::::::::::::::::::::::::::::::::::::::::::::: :. :... XP_011 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTA 970 980 990 1000 1010 1020 1010 1020 pF1KA2 RHQARSAAPPSGPPRAPGPH : :.. XP_011 RTAKRGSRFFCDAAHHDESNC 1030 1040 >>XP_011537275 (OMIM: 616288) PREDICTED: formin-like pro (925 aa) initn: 5650 init1: 5527 opt: 5530 Z-score: 2601.6 bits: 492.8 E(85289): 3.6e-138 Smith-Waterman score: 5530; 98.5% identity (99.3% similar) in 864 aa overlap (151-1014:48-911) 130 140 150 160 170 180 pF1KA2 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP .::::::::::::::::::::::::::::: XP_011 DLHGGRGQEGGEGLFLRGVYPEVRMIREESLFDFEGLESGDDGAFDKLRSWSRSIEDLQP 20 30 40 50 60 70 190 200 210 220 230 240 pF1KA2 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 80 90 100 110 120 130 250 260 270 280 290 300 pF1KA2 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 140 150 160 170 180 190 310 320 330 340 350 360 pF1KA2 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 200 210 220 230 240 250 370 380 390 400 410 420 pF1KA2 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 260 270 280 290 300 310 430 440 450 460 470 480 pF1KA2 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 320 330 340 350 360 370 490 500 510 520 530 540 pF1KA2 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 380 390 400 410 420 430 550 560 570 580 590 600 pF1KA2 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 440 450 460 470 480 490 610 620 630 640 650 660 pF1KA2 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 500 510 520 530 540 550 670 680 690 700 710 720 pF1KA2 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 560 570 580 590 600 610 730 740 750 760 770 780 pF1KA2 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 620 630 640 650 660 670 790 800 810 820 830 840 pF1KA2 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 680 690 700 710 720 730 850 860 870 880 890 900 pF1KA2 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 740 750 760 770 780 790 910 920 930 940 950 960 pF1KA2 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 800 810 820 830 840 850 970 980 990 1000 1010 1020 pF1KA2 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP :::::::::::::::::::::::::::::::::::::: :. :...: :.. XP_011 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDA 860 870 880 890 900 910 pF1KA2 PRAPGPH XP_011 AHHDESNC 920 >>NP_944489 (OMIM: 616288) formin-like protein 3 isoform (976 aa) initn: 5400 init1: 5400 opt: 5401 Z-score: 2541.1 bits: 481.7 E(85289): 8.4e-135 Smith-Waterman score: 6317; 95.0% identity (95.0% similar) in 1027 aa overlap (1-1027:1-976) 10 20 30 40 50 60 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA2 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA2 HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP ::::::::::::::::::::::::::::::: NP_944 HIGWVREFLNDENKGLDVLVDYLSFAQCSVM----------------------------- 130 140 150 190 200 210 220 230 240 pF1KA2 PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG :::::::::::::::::::::::::::::::::::::: NP_944 ----------------------YSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG 160 170 180 250 260 270 280 290 300 pF1KA2 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL 190 200 210 220 230 240 310 320 330 340 350 360 pF1KA2 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 250 260 270 280 290 300 370 380 390 400 410 420 pF1KA2 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM 310 320 330 340 350 360 430 440 450 460 470 480 pF1KA2 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES 370 380 390 400 410 420 490 500 510 520 530 540 pF1KA2 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA 430 440 450 460 470 480 550 560 570 580 590 600 pF1KA2 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED 490 500 510 520 530 540 610 620 630 640 650 660 pF1KA2 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE 550 560 570 580 590 600 670 680 690 700 710 720 pF1KA2 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV 610 620 630 640 650 660 730 740 750 760 770 780 pF1KA2 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS 670 680 690 700 710 720 790 800 810 820 830 840 pF1KA2 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 730 740 750 760 770 780 850 860 870 880 890 900 pF1KA2 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR 790 800 810 820 830 840 910 920 930 940 950 960 pF1KA2 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS 850 860 870 880 890 900 970 980 990 1000 1010 1020 pF1KA2 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_944 QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGP 910 920 930 940 950 960 pF1KA2 PRAPGPH ::::::: NP_944 PRAPGPH 970 >>XP_011537274 (OMIM: 616288) PREDICTED: formin-like pro (996 aa) initn: 6040 init1: 5191 opt: 5195 Z-score: 2444.8 bits: 463.9 E(85289): 1.9e-129 Smith-Waterman score: 5821; 91.8% identity (92.8% similar) in 997 aa overlap (18-1014:45-982) 10 20 30 40 pF1KA2 MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNL : .: :. .: : .: ::::: XP_011 LKEGPQCSKGKWCRWHLSARQLCEGPKGCGPYILWPSAFP---PASSGDR-----SSMNL 20 30 40 50 60 50 60 70 80 90 100 pF1KA2 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQEST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA2 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDK :::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVM---------------- 130 140 150 160 170 170 180 190 200 210 220 pF1KA2 LRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC ::::::::::::::::::::::::: XP_011 -----------------------------------YSTLPGRRALKNSRLVSQKDDVHVC 180 190 230 240 250 260 270 280 pF1KA2 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIIL 200 210 220 230 240 250 290 300 310 320 330 340 pF1KA2 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEF 260 270 280 290 300 310 350 360 370 380 390 400 pF1KA2 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSH 320 330 340 350 360 370 410 420 430 440 450 460 pF1KA2 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQR 380 390 400 410 420 430 470 480 490 500 510 520 pF1KA2 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLP 440 450 460 470 480 490 530 540 550 560 570 580 pF1KA2 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGT 500 510 520 530 540 550 590 600 610 620 630 640 pF1KA2 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNL 560 570 580 590 600 610 650 660 670 680 690 700 pF1KA2 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 620 630 640 650 660 670 710 720 730 740 750 760 pF1KA2 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQML 680 690 700 710 720 730 770 780 790 800 810 820 pF1KA2 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFW 740 750 760 770 780 790 830 840 850 860 870 880 pF1KA2 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRD 800 810 820 830 840 850 890 900 910 920 930 940 pF1KA2 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQL 860 870 880 890 900 910 950 960 970 980 990 1000 pF1KA2 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVV ::::::::::::::::::::::::::::::::::::::::::::::::::: :. :... XP_011 AQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTA 920 930 940 950 960 970 1010 1020 pF1KA2 RHQARSAAPPSGPPRAPGPH : :.. XP_011 RTAKRGSRFFCDAAHHDESNC 980 990 1027 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:16:41 2016 done: Thu Nov 3 20:16:43 2016 Total Scan time: 15.450 Total Display time: 0.490 Function used was FASTA [36.3.4 Apr, 2011]