Result of FASTA (omim) for
pF1KA1793
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1793, 1154 aa
1>>>pF1KA1793 1154 - 1154 aa - 1154 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.2285+/-0.000611; mu= -17.8240+/- 0.038
mean_var=668.7496+/-134.217, 0's: 0 Z-trim(119.9): 329 B-trim: 0 in 0/57
Lambda= 0.049596
statistics sampled from 34168 (34523) to 34168 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.405), width: 16
Scan time: 18.870
The best scores are: opt bits E(85289)
NP_073579 (OMIM: 611902) coiled-coil domain-contai (1154) 7420 547.5 1.8e-154
XP_016868022 (OMIM: 611902) PREDICTED: coiled-coil (1157) 7185 530.7 2e-149
XP_005250591 (OMIM: 611902) PREDICTED: coiled-coil (1207) 7185 530.7 2.1e-149
XP_016868021 (OMIM: 611902) PREDICTED: coiled-coil (1195) 5939 441.5 1.4e-122
XP_005250595 (OMIM: 611902) PREDICTED: coiled-coil (1007) 5913 439.6 4.6e-122
XP_016868023 (OMIM: 611902) PREDICTED: coiled-coil ( 995) 4667 350.4 3.1e-95
XP_011514789 (OMIM: 611902) PREDICTED: coiled-coil (1197) 4587 344.8 1.9e-93
XP_011514785 (OMIM: 611902) PREDICTED: coiled-coil (1231) 4587 344.8 1.9e-93
XP_011514787 (OMIM: 611902) PREDICTED: coiled-coil (1230) 4576 344.0 3.3e-93
XP_011514790 (OMIM: 611902) PREDICTED: coiled-coil (1194) 4532 340.9 2.9e-92
XP_011514786 (OMIM: 611902) PREDICTED: coiled-coil (1231) 4532 340.9 2.9e-92
XP_011514791 (OMIM: 611902) PREDICTED: coiled-coil (1031) 4527 340.4 3.3e-92
XP_011514792 (OMIM: 611902) PREDICTED: coiled-coil ( 772) 4336 326.7 3.5e-88
XP_016868024 (OMIM: 611902) PREDICTED: coiled-coil ( 618) 3413 260.5 2.3e-68
XP_011514788 (OMIM: 611902) PREDICTED: coiled-coil (1219) 3341 255.7 1.3e-66
XP_016868025 (OMIM: 611902) PREDICTED: coiled-coil ( 606) 2167 171.4 1.6e-41
NP_001188301 (OMIM: 611902) coiled-coil domain-con ( 434) 1353 113.0 4.2e-24
XP_016884293 (OMIM: 153640,153650,155100,160775,60 (1960) 491 51.9 4.5e-05
XP_016884292 (OMIM: 153640,153650,155100,160775,60 (1960) 491 51.9 4.5e-05
XP_016884294 (OMIM: 153640,153650,155100,160775,60 (1960) 491 51.9 4.5e-05
NP_002464 (OMIM: 153640,153650,155100,160775,60020 (1960) 491 51.9 4.5e-05
XP_011528499 (OMIM: 153640,153650,155100,160775,60 (1960) 491 51.9 4.5e-05
XP_016884295 (OMIM: 153640,153650,155100,160775,60 (1960) 491 51.9 4.5e-05
XP_016862659 (OMIM: 602701) PREDICTED: sarcolemmal ( 359) 427 46.6 0.00032
NP_001298107 (OMIM: 602701) sarcolemmal membrane-a ( 359) 427 46.6 0.00032
XP_011532408 (OMIM: 602701) PREDICTED: sarcolemmal ( 362) 425 46.5 0.00036
NP_001291351 (OMIM: 602701) sarcolemmal membrane-a ( 362) 425 46.5 0.00036
XP_016862649 (OMIM: 602701) PREDICTED: sarcolemmal ( 787) 432 47.3 0.00044
XP_016862647 (OMIM: 602701) PREDICTED: sarcolemmal ( 789) 432 47.3 0.00044
XP_016862643 (OMIM: 602701) PREDICTED: sarcolemmal ( 804) 432 47.3 0.00045
XP_016862641 (OMIM: 602701) PREDICTED: sarcolemmal ( 808) 432 47.3 0.00045
XP_016862640 (OMIM: 602701) PREDICTED: sarcolemmal ( 810) 432 47.3 0.00045
XP_005265521 (OMIM: 602701) PREDICTED: sarcolemmal ( 821) 432 47.3 0.00045
XP_016862639 (OMIM: 602701) PREDICTED: sarcolemmal ( 825) 432 47.3 0.00045
XP_016862638 (OMIM: 602701) PREDICTED: sarcolemmal ( 825) 432 47.3 0.00045
XP_016862637 (OMIM: 602701) PREDICTED: sarcolemmal ( 827) 432 47.3 0.00045
XP_016862635 (OMIM: 602701) PREDICTED: sarcolemmal ( 842) 432 47.4 0.00046
XP_005265515 (OMIM: 602701) PREDICTED: sarcolemmal ( 844) 432 47.4 0.00046
XP_005265528 (OMIM: 602701) PREDICTED: sarcolemmal ( 790) 430 47.2 0.00049
NP_001291350 (OMIM: 602701) sarcolemmal membrane-a ( 790) 430 47.2 0.00049
XP_005265527 (OMIM: 602701) PREDICTED: sarcolemmal ( 792) 430 47.2 0.00049
XP_016862642 (OMIM: 602701) PREDICTED: sarcolemmal ( 807) 430 47.2 0.00049
XP_005265524 (OMIM: 602701) PREDICTED: sarcolemmal ( 809) 430 47.2 0.00049
XP_011532405 (OMIM: 602701) PREDICTED: sarcolemmal ( 809) 430 47.2 0.00049
XP_005265523 (OMIM: 602701) PREDICTED: sarcolemmal ( 811) 430 47.2 0.00049
NP_009090 (OMIM: 602701) sarcolemmal membrane-asso ( 811) 430 47.2 0.00049
XP_005265522 (OMIM: 602701) PREDICTED: sarcolemmal ( 813) 430 47.2 0.0005
XP_005265519 (OMIM: 602701) PREDICTED: sarcolemmal ( 826) 430 47.2 0.0005
XP_016862636 (OMIM: 602701) PREDICTED: sarcolemmal ( 828) 430 47.2 0.0005
XP_005265518 (OMIM: 602701) PREDICTED: sarcolemmal ( 828) 430 47.2 0.0005
>>NP_073579 (OMIM: 611902) coiled-coil domain-containing (1154 aa)
initn: 7420 init1: 7420 opt: 7420 Z-score: 2894.4 bits: 547.5 E(85289): 1.8e-154
Smith-Waterman score: 7420; 100.0% identity (100.0% similar) in 1154 aa overlap (1-1154:1-1154)
10 20 30 40 50 60
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 LYYKASQRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LYYKASQRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVV
1090 1100 1110 1120 1130 1140
1150
pF1KA1 ISALLWCWWAETSS
::::::::::::::
NP_073 ISALLWCWWAETSS
1150
>>XP_016868022 (OMIM: 611902) PREDICTED: coiled-coil dom (1157 aa)
initn: 7697 init1: 7180 opt: 7185 Z-score: 2803.5 bits: 530.7 E(85289): 2e-149
Smith-Waterman score: 7185; 98.1% identity (99.0% similar) in 1148 aa overlap (1-1146:1-1141)
10 20 30 40 50 60
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACER
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCC
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 LYYKASQRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_016 LYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130
pF1KA1 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSL--PLVGL
:::::::::::::::::::::::::::::::::::::::::. .:.: :.: :
XP_016 NEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKN-------MFGLWKPMVFL
1090 1100 1110 1120 1130
1140 1150
pF1KA1 VVISALLWCWWAETSS
.. .. :.
XP_016 AIAAVALYVLPNMRQQESEFCLME
1140 1150
>>XP_005250591 (OMIM: 611902) PREDICTED: coiled-coil dom (1207 aa)
initn: 7697 init1: 7180 opt: 7185 Z-score: 2803.3 bits: 530.7 E(85289): 2.1e-149
Smith-Waterman score: 7185; 98.1% identity (99.0% similar) in 1148 aa overlap (1-1146:51-1191)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_005 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670 680 690
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
690 700 710 720 730 740
700 710 720 730 740 750
pF1KA1 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
750 760 770 780 790 800
760 770 780 790 800 810
pF1KA1 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
810 820 830 840 850 860
820 830 840 850 860 870
pF1KA1 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
870 880 890 900 910 920
880 890 900 910 920 930
pF1KA1 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
930 940 950 960 970 980
940 950 960 970 980 990
pF1KA1 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
990 1000 1010 1020 1030 1040
1000 1010 1020 1030 1040 1050
pF1KA1 ANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_005 ANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQV
1050 1060 1070 1080 1090 1100
1060 1070 1080 1090 1100 1110
pF1KA1 KEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEE
1110 1120 1130 1140 1150 1160
1120 1130 1140 1150
pF1KA1 NNPLRLSESKKSSPTPNPPIFSL--PLVGLVVISALLWCWWAETSS
:::::::::::. .:.: :.: :.. .. :.
XP_005 NNPLRLSESKKN-------MFGLWKPMVFLAIAAVALYVLPNMRQQESEFCLME
1170 1180 1190 1200
>>XP_016868021 (OMIM: 611902) PREDICTED: coiled-coil dom (1195 aa)
initn: 7535 init1: 5806 opt: 5939 Z-score: 2321.5 bits: 441.5 E(85289): 1.4e-122
Smith-Waterman score: 7074; 97.0% identity (97.9% similar) in 1148 aa overlap (1-1146:51-1179)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_016 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 S------------EELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA1 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA1 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA1 ANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_016 ANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQV
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KA1 KEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEE
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150
pF1KA1 NNPLRLSESKKSSPTPNPPIFSL--PLVGLVVISALLWCWWAETSS
:::::::::::. .:.: :.: :.. .. :.
XP_016 NNPLRLSESKKN-------MFGLWKPMVFLAIAAVALYVLPNMRQQESEFCLME
1150 1160 1170 1180 1190
>>XP_005250595 (OMIM: 611902) PREDICTED: coiled-coil dom (1007 aa)
initn: 5913 init1: 5913 opt: 5913 Z-score: 2312.4 bits: 439.6 E(85289): 4.6e-122
Smith-Waterman score: 5913; 100.0% identity (100.0% similar) in 921 aa overlap (1-921:51-971)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_005 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670 680 690
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
690 700 710 720 730 740
700 710 720 730 740 750
pF1KA1 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
750 760 770 780 790 800
760 770 780 790 800 810
pF1KA1 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
810 820 830 840 850 860
820 830 840 850 860 870
pF1KA1 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
870 880 890 900 910 920
880 890 900 910 920 930
pF1KA1 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNENMFGLWKPM
930 940 950 960 970 980
940 950 960 970 980 990
pF1KA1 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
XP_005 VFLAIAAVALYVLPNMRQQESEFCLME
990 1000
>>XP_016868023 (OMIM: 611902) PREDICTED: coiled-coil dom (995 aa)
initn: 4539 init1: 4539 opt: 4667 Z-score: 1830.7 bits: 350.4 E(85289): 3.1e-95
Smith-Waterman score: 5802; 98.7% identity (98.7% similar) in 921 aa overlap (1-921:51-959)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_016 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 S------------EELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQV
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNS
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQIS
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA1 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNENMFGLWKPM
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA1 ELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKN
XP_016 VFLAIAAVALYVLPNMRQQESEFCLME
970 980 990
>>XP_011514789 (OMIM: 611902) PREDICTED: coiled-coil dom (1197 aa)
initn: 7469 init1: 4346 opt: 4587 Z-score: 1798.7 bits: 344.8 E(85289): 1.9e-93
Smith-Waterman score: 7126; 97.7% identity (97.9% similar) in 1147 aa overlap (1-1123:51-1197)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_011 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQPRSQAQHAQRPDS
690 700 710 720 730 740
680 690 700 710 720
pF1KA1 -----------SKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELGQEIQELIQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
750 760 770 780 790 800
730 740 750 760 770 780
pF1KA1 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
810 820 830 840 850 860
790 800 810 820 830 840
pF1KA1 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
870 880 890 900 910 920
850 860 870 880 890 900
pF1KA1 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
930 940 950 960 970 980
910 920 930 940 950 960
pF1KA1 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KA1 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS
1050 1060 1070 1080 1090 1100
1030 1040 1050 1060 1070 1080
pF1KA1 QRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 QRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE
1110 1120 1130 1140 1150 1160
1090 1100 1110 1120 1130 1140
pF1KA1 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVVISALLW
:::::::::::::::::::::::::::::::::::.:
XP_011 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKKS
1170 1180 1190
1150
pF1KA1 CWWAETSS
>>XP_011514785 (OMIM: 611902) PREDICTED: coiled-coil dom (1231 aa)
initn: 7465 init1: 4346 opt: 4587 Z-score: 1798.6 bits: 344.8 E(85289): 1.9e-93
Smith-Waterman score: 7127; 96.1% identity (96.9% similar) in 1172 aa overlap (1-1146:51-1215)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_011 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQPRSQAQHAQRPDS
690 700 710 720 730 740
680 690 700 710 720
pF1KA1 -----------SKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELGQEIQELIQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
750 760 770 780 790 800
730 740 750 760 770 780
pF1KA1 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
810 820 830 840 850 860
790 800 810 820 830 840
pF1KA1 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
870 880 890 900 910 920
850 860 870 880 890 900
pF1KA1 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
930 940 950 960 970 980
910 920 930 940 950 960
pF1KA1 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KA1 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS
1050 1060 1070 1080 1090 1100
1030 1040 1050 1060 1070 1080
pF1KA1 QRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 QRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE
1110 1120 1130 1140 1150 1160
1090 1100 1110 1120 1130 1140
pF1KA1 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSL--PLVGLVVISAL
:::::::::::::::::::::::::::::::::::. .:.: :.: :.. ..
XP_011 EEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKN-------MFGLWKPMVFLAIAAVA
1170 1180 1190 1200 1210
1150
pF1KA1 LWCWWAETSS
:.
XP_011 LYVLPNMRQQESEFCLME
1220 1230
>>XP_011514787 (OMIM: 611902) PREDICTED: coiled-coil dom (1230 aa)
initn: 7453 init1: 4334 opt: 4576 Z-score: 1794.3 bits: 344.0 E(85289): 3.3e-93
Smith-Waterman score: 7129; 96.2% identity (97.0% similar) in 1171 aa overlap (1-1146:51-1214)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_011 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNK--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKPRSQAQHAQRPDSE
690 700 710 720 730 740
680 690 700 710 720
pF1KA1 ---------QSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEM
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGQEIQELIQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEM
750 760 770 780 790 800
730 740 750 760 770 780
pF1KA1 QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFL
810 820 830 840 850 860
790 800 810 820 830 840
pF1KA1 KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDME
870 880 890 900 910 920
850 860 870 880 890 900
pF1KA1 RFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECME
930 940 950 960 970 980
910 920 930 940 950 960
pF1KA1 CLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQL
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KA1 REKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQ
1050 1060 1070 1080 1090 1100
1030 1040 1050 1060 1070 1080
pF1KA1 RKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEE
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 RKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEE
1110 1120 1130 1140 1150 1160
1090 1100 1110 1120 1130 1140
pF1KA1 EEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSL--PLVGLVVISALL
::::::::::::::::::::::::::::::::::. .:.: :.: :.. .. :
XP_011 EEKEEDSEEEEDDADSSLESPEENNPLRLSESKKN-------MFGLWKPMVFLAIAAVAL
1170 1180 1190 1200 1210
1150
pF1KA1 WCWWAETSS
.
XP_011 YVLPNMRQQESEFCLME
1220 1230
>>XP_011514790 (OMIM: 611902) PREDICTED: coiled-coil dom (1194 aa)
initn: 6805 init1: 4346 opt: 4532 Z-score: 1777.5 bits: 340.9 E(85289): 2.9e-92
Smith-Waterman score: 6466; 96.7% identity (97.2% similar) in 1053 aa overlap (1-1029:51-1101)
10 20 30
pF1KA1 MQAMEGEVLLPALYEEEEEEEEEEEEVEEE
::::::::::::::::::::::::::::::
XP_011 PTVTTLGSYEASEGCERKKGQRWGSLERRGMQAMEGEVLLPALYEEEEEEEEEEEEVEEE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KA1 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQ
90 100 110 120 130 140
100 110 120 130 140 150
pF1KA1 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEI
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEP
210 220 230 240 250 260
220 230 240 250 260 270
pF1KA1 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWL
270 280 290 300 310 320
280 290 300 310 320 330
pF1KA1 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHH
330 340 350 360 370 380
340 350 360 370 380 390
pF1KA1 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLK
390 400 410 420 430 440
400 410 420 430 440 450
pF1KA1 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
450 460 470 480 490 500
460 470 480 490 500 510
pF1KA1 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLL
510 520 530 540 550 560
520 530 540 550 560 570
pF1KA1 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLED
570 580 590 600 610 620
580 590 600 610 620 630
pF1KA1 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQ
630 640 650 660 670 680
640 650 660 670
pF1KA1 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQPRSQAQHAQRPDS
690 700 710 720 730 740
680 690 700 710 720
pF1KA1 -----------SKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELGQEIQELIQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE
750 760 770 780 790 800
730 740 750 760 770 780
pF1KA1 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSF
810 820 830 840 850 860
790 800 810 820 830 840
pF1KA1 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDM
870 880 890 900 910 920
850 860 870 880 890 900
pF1KA1 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECM
930 940 950 960 970 980
910 920 930 940 950 960
pF1KA1 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQ
990 1000 1010 1020 1030 1040
970 980 990 1000 1010 1020
pF1KA1 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKAS
:::::::::::::::::::::::::::::::::::::::::::::::::... . : .
XP_011 LREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKKIRRKM--KRT
1050 1060 1070 1080 1090
1030 1040 1050 1060 1070 1080
pF1KA1 QRKLDGLAKEEEKKEEMEEEKKEVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE
.::
XP_011 KRKRRRKKTVKRRRMTPTLPLKVPKKITPSDFPRAKRSLKALRVKPKEFSHSLPLPQTQP
1100 1110 1120 1130 1140 1150
1154 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 11:22:40 2016 done: Thu Nov 3 11:22:43 2016
Total Scan time: 18.870 Total Display time: 0.610
Function used was FASTA [36.3.4 Apr, 2011]