Result of FASTA (omim) for
pF1KA1776
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1776, 2809 aa
1>>>pF1KA1776 2809 - 2809 aa - 2809 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7325+/-0.000589; mu= 15.2860+/- 0.036
mean_var=241.5025+/-50.827, 0's: 0 Z-trim(114.7): 580 B-trim: 144 in 2/50
Lambda= 0.082530
statistics sampled from 23944 (24638) to 23944 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.289), width: 16
Scan time: 17.850
The best scores are: opt bits E(85289)
XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 (2809) 21452 2570.6 0
NP_115823 (OMIM: 608529) fibrillin-3 precursor [Ho (2809) 21452 2570.6 0
NP_001308360 (OMIM: 608529) fibrillin-3 precursor (2809) 21452 2570.6 0
XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 20377 2442.6 0
XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 (2851) 19503 2338.6 0
XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 (2766) 15802 1897.9 0
XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 (2789) 15655 1880.4 0
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 15312 1839.6 0
XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 14885 1788.5 0
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 14009 1684.4 0
XP_016882864 (OMIM: 608529) PREDICTED: fibrillin-3 (2768) 12827 1543.7 0
NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871) 12732 1532.4 0
XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 12180 1466.3 0
NP_000419 (OMIM: 251750,600975,602091,613086,61481 (1821) 1604 207.2 1.9e-51
XP_011535067 (OMIM: 251750,600975,602091,613086,61 (1694) 1475 191.8 7.6e-47
XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611) 1457 189.6 3.3e-46
XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 1319 173.2 3e-41
NP_996826 (OMIM: 150390) latent-transforming growt (1721) 1308 171.9 7.4e-41
XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 1240 163.8 2e-38
XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 1240 163.8 2e-38
NP_000618 (OMIM: 150390) latent-transforming growt (1395) 1237 163.3 2.3e-38
XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436) 1225 161.9 6.3e-38
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 1195 158.5 9.2e-37
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 1170 155.4 6.1e-36
NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 1171 155.8 7.6e-36
XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549) 1167 155.0 7.9e-36
XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 1170 155.6 8.3e-36
XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 1169 155.5 9e-36
XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591) 1163 154.6 1.1e-35
XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593) 1162 154.5 1.2e-35
XP_016859598 (OMIM: 150390) PREDICTED: latent-tran (1679) 1153 153.4 2.6e-35
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 1151 153.1 2.8e-35
NP_001036010 (OMIM: 604710,613177) latent-transfor (1557) 1151 153.1 3e-35
NP_003564 (OMIM: 604710,613177) latent-transformin (1587) 1151 153.2 3e-35
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 1150 153.0 3e-35
XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595) 1151 153.2 3e-35
NP_001036009 (OMIM: 604710,613177) latent-transfor (1624) 1151 153.2 3e-35
XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635) 1151 153.2 3.1e-35
XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662) 1151 153.2 3.1e-35
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 1149 152.9 3.5e-35
XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35
XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35
XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 1150 153.3 4.3e-35
XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478) 1146 152.5 4.3e-35
XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480) 1146 152.5 4.3e-35
XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593) 1139 151.7 8.1e-35
NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 1137 151.4 8.6e-35
XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 1137 151.5 9.8e-35
XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 1137 151.5 9.8e-35
XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 1132 150.9 1.5e-34
>>XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2809 aa)
initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0
Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2770 2780 2790 2800
>>NP_115823 (OMIM: 608529) fibrillin-3 precursor [Homo s (2809 aa)
initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0
Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_115 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2770 2780 2790 2800
>>NP_001308360 (OMIM: 608529) fibrillin-3 precursor [Hom (2809 aa)
initn: 21452 init1: 21452 opt: 21452 Z-score: 13814.4 bits: 2570.6 E(85289): 0
Smith-Waterman score: 21452; 99.9% identity (100.0% similar) in 2809 aa overlap (1-2809:1-2809)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_001 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2770 2780 2790 2800
>>XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2777 aa)
initn: 20328 init1: 20328 opt: 20377 Z-score: 13122.7 bits: 2442.6 E(85289): 0
Smith-Waterman score: 21122; 98.7% identity (98.9% similar) in 2809 aa overlap (1-2809:1-2777)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRA---
70 80 90 100 110
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
:::::::::::::::::::::::::::::::
XP_016 -----------------------------ICDRGCHNGGRCIGPNRCACVYGFMGPQCER
120 130 140
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
150 160 170 180 190 200
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
330 340 350 360 370 380
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
390 400 410 420 430 440
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
450 460 470 480 490 500
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
510 520 530 540 550 560
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
570 580 590 600 610 620
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
630 640 650 660 670 680
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
690 700 710 720 730 740
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
750 760 770 780 790 800
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
810 820 830 840 850 860
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2010 2020 2030 2040 2050 2060
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2070 2080 2090 2100 2110 2120
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2130 2140 2150 2160 2170 2180
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2190 2200 2210 2220 2230 2240
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2250 2260 2270 2280 2290 2300
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2310 2320 2330 2340 2350 2360
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2370 2380 2390 2400 2410 2420
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2430 2440 2450 2460 2470 2480
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2490 2500 2510 2520 2530 2540
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2550 2560 2570 2580 2590 2600
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2610 2620 2630 2640 2650 2660
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2670 2680 2690 2700 2710 2720
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2730 2740 2750 2760 2770
>>XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2851 aa)
initn: 19383 init1: 19383 opt: 19503 Z-score: 12560.2 bits: 2338.6 E(85289): 0
Smith-Waterman score: 21297; 98.4% identity (98.5% similar) in 2841 aa overlap (11-2809:11-2851)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDVNECLSLSGLC
250 260 270 280 290 300
290 300 310
pF1KA1 -------------------------------YRAGACFSVLFGGRCAGDLAGHYTRRQCC
:::::::::::::::::::::::::::::
XP_016 SGGDCTNTVGSYVCTCSQGFASSLDGTHCLNYRAGACFSVLFGGRCAGDLAGHYTRRQCC
310 320 330 340 350 360
320 330 340 350 360 370
pF1KA1 CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPA
370 380 390 400 410 420
380 390 400 410 420 430
pF1KA1 RLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVG
430 440 450 460 470 480
440 450 460 470 480 490
pF1KA1 YTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGG
490 500 510 520 530 540
500 510 520 530 540 550
pF1KA1 LCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCK
550 560 570 580 590 600
560 570 580 590 600 610
pF1KA1 PGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRS
610 620 630 640 650 660
620 630 640 650 660 670
pF1KA1 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQALCSSGLGITT
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_016 TCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITT
670 680 690 700 710 720
680 690 700 710 720 730
pF1KA1 DGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG
730 740 750 760 770 780
740 750 760 770 780 790
pF1KA1 WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLD
790 800 810 820 830 840
800 810 820 830 840 850
pF1KA1 PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARG
850 860 870 880 890 900
860 870 880 890 900 910
pF1KA1 FARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCF
910 920 930 940 950 960
920 930 940 950 960 970
pF1KA1 LRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KA1 SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KA1 CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQC
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KA1 PPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KA1 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KA1 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KA1 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECISQEHRCSPRGDC
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
XP_016 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDC
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KA1 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTED
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KA1 HRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCING
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KA1 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRAS
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KA1 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGD
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KA1 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQ
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KA1 VNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPD
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KA1 YQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSIL
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KA1 LACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGQNECREIPNVCSH
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
XP_016 LACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSH
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KA1 GDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVV
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KA1 THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAG
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KA1 TCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPP
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KA1 GFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQ
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KA1 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KA1 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KA1 FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPP
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KA1 GMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQG
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KA1 PCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYT
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KA1 AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KA1 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KA1 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRC
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KA1 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KA1 FDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGP
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGP
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KA1 QDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGLNLSHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGLNLSHLG
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KA1 RAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVV
2770 2780 2790 2800 2810 2820
2780 2790 2800
pF1KA1 SHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::
XP_016 SHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2830 2840 2850
>>XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2766 aa)
initn: 14479 init1: 14479 opt: 15802 Z-score: 10178.8 bits: 1897.9 E(85289): 0
Smith-Waterman score: 21031; 98.3% identity (98.5% similar) in 2809 aa overlap (1-2809:1-2766)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::
XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVD----------------------------------
1870 1880
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---------TNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1890 1900 1910 1920 1930
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1940 1950 1960 1970 1980 1990
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2000 2010 2020 2030 2040 2050
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2060 2070 2080 2090 2100 2110
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2120 2130 2140 2150 2160 2170
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2180 2190 2200 2210 2220 2230
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2240 2250 2260 2270 2280 2290
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2300 2310 2320 2330 2340 2350
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2360 2370 2380 2390 2400 2410
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2420 2430 2440 2450 2460 2470
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2480 2490 2500 2510 2520 2530
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2540 2550 2560 2570 2580 2590
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2600 2610 2620 2630 2640 2650
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2660 2670 2680 2690 2700 2710
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2720 2730 2740 2750 2760
>>XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 iso (2789 aa)
initn: 21271 init1: 15632 opt: 15655 Z-score: 10084.1 bits: 1880.4 E(85289): 0
Smith-Waterman score: 21235; 99.1% identity (99.3% similar) in 2809 aa overlap (1-2809:1-2789)
10 20 30 40 50 60
pF1KA1 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 KNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 DLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KA1 GACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KA1 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KA1 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KA1 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KA1 CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
:. ::::::::::::::::::::::::::::::::::::::
XP_016 CT--------------------AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KA1 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
2090 2100 2110 2120 2130 2140
2170 2180 2190 2200 2210 2220
pF1KA1 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
2150 2160 2170 2180 2190 2200
2230 2240 2250 2260 2270 2280
pF1KA1 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
2210 2220 2230 2240 2250 2260
2290 2300 2310 2320 2330 2340
pF1KA1 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
2270 2280 2290 2300 2310 2320
2350 2360 2370 2380 2390 2400
pF1KA1 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
2330 2340 2350 2360 2370 2380
2410 2420 2430 2440 2450 2460
pF1KA1 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
2390 2400 2410 2420 2430 2440
2470 2480 2490 2500 2510 2520
pF1KA1 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
2450 2460 2470 2480 2490 2500
2530 2540 2550 2560 2570 2580
pF1KA1 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
2510 2520 2530 2540 2550 2560
2590 2600 2610 2620 2630 2640
pF1KA1 SASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGY
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
2570 2580 2590 2600 2610 2620
2650 2660 2670 2680 2690 2700
pF1KA1 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
2630 2640 2650 2660 2670 2680
2710 2720 2730 2740 2750 2760
pF1KA1 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
2690 2700 2710 2720 2730 2740
2770 2780 2790 2800
pF1KA1 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
2750 2760 2770 2780
>>XP_016864717 (OMIM: 121050,612570,616118) PREDICTED: f (2861 aa)
initn: 12727 init1: 7367 opt: 15312 Z-score: 9863.3 bits: 1839.6 E(85289): 0
Smith-Waterman score: 15396; 67.3% identity (86.5% similar) in 2811 aa overlap (39-2808:68-2860)
10 20 30 40 50 60
pF1KA1 ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC
:: .::::::. .:.::::::::::.::
XP_016 PRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYC
40 50 60 70 80 90
70 80 90 100 110 120
pF1KA1 CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG
::::.:.:: .::.::::: .::.::::.::.:::..: .. .:: . . ::: :::::
XP_016 CPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGG
100 110 120 130 140 150
130 140 150 160 170 180
pF1KA1 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF
:: : ::::: :: ::::.:. ::.::::::::::::::::: ::::::::::::::
XP_016 TCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF
160 170 180 190 200 210
190 200 210 220 230 240
pF1KA1 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDV
::. . :: ::::.::::.:::::.::::: :::.:::::.::::::::::.:::::::
XP_016 TQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV
220 230 240 250 260 270
250 260 270 280 290 300
pF1KA1 DECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFG----GRC
:::::.::.::::.:.: ::::.::::.::. :... ::: : :.. : :.:
XP_016 DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCED--IDEC-SIIPGICETGEC
280 290 300 310 320 330
310 320 330 340 350 360
pF1KA1 AGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPL--LPGHPGLFPG
.. ..... : : :: : : .:...:: . ::. .:: : ::
XP_016 SNTVGSYF----CVCPRGY------VTSTDGSRCIEEYRRLCMDGLPMGGIPGSAGSRPG
340 350 360 370 380
370 380 390 400
pF1KA1 LLGFGSNGMGPPLGPARLNPHGSDARGIP-----SLGPGNSNIGTA----------TLNQ
: :.::..: . .: :. :: : : :....:.. :::
XP_016 --GTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQ
390 400 410 420 430 440
410 420 430 440 450 460
pF1KA1 TIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIP
:::::.: .::::::::.:: ::::::::.:: ::. :.:::::::::.:: .::::: :
XP_016 TIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTP
450 460 470 480 490 500
470 480 490 500 510 520
pF1KA1 GTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGK
:.:.:.:. ::: :::.:::.:.:::: .: ::. ::::::.:::::.:::::::. :::
XP_016 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK
510 520 530 540 550 560
530 540 550 560 570 580
pF1KA1 NCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHC
:::::.::.:..::.::.:.::::::.:.:::::.:::.:.:: :.:::::::::.::::
XP_016 NCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHC
570 580 590 600 610 620
590 600 610 620 630 640
pF1KA1 TNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANP
:.::::::.: ::::: :::::::::.::::::.:.:: :.:::::.:::::::::::
XP_016 INSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANP
630 640 650 660 670 680
650 660 670 680 690 700
pF1KA1 DHGFGEPCQLCPAKNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRC
:.::::::: :::::::::..:::::.:::.::::::::::::..::::.::::::::::
XP_016 DYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRC
690 700 710 720 730 740
710 720 730 740 750 760
pF1KA1 VCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDV
:: ::: :::..: :.::: .: :::::: :.:.::::::.::::. : .:: :.:.
XP_016 NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI
750 760 770 780 790 800
770 780 790 800 810 820
pF1KA1 DECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG
.:: :.:::.:.::: ::..:.:.:::.:. .: .:.:: ::::::.::.::::::..:
XP_016 NECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING
810 820 830 840 850 860
830 840 850 860 870 880
pF1KA1 ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVN
:.:.:::::::::::::::::::.: :: ::.::. ::::.:::::: ::::::::::::
XP_016 ATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVN
870 880 890 900 910 920
890 900 910 920 930 940
pF1KA1 TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVW
. :::.::::::: ::..::.:.:.:.: :.:.:::::: .:::.:::.:::..::.:
XP_016 SKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAW
930 940 950 960 970 980
950 960 970 980 990 1000
pF1KA1 GVECEACPDPESLEFASLCPRGLGFASR-DFLSGRPFYKDVNECKVFPGLCTHGTCRNTV
:.::: :: : . :. .::::: :::.: : :.:::::::.::::.:::.::.: ::::.
XP_016 GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTI
990 1000 1010 1020 1030 1040
1010 1020 1030 1040 1050 1060
pF1KA1 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM
:::.: : .::::: .::::::::::::::::::.: ::::::::::::: :::::::.:
XP_016 GSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM
1050 1060 1070 1080 1090 1100
1070 1080 1090 1100 1110 1120
pF1KA1 KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPH
:::::.::: :.:::::::::.::.::..:.:: ::::. . : ::.::::::.:: .
XP_016 KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRN
1110 1120 1130 1140 1150 1160
1130 1140 1150 1160 1170 1180
pF1KA1 GQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYS
:.:::.::..::::. :.:.:::::::.::.:: ..:::::..: :.::::.:::..::.
XP_016 GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYA
1170 1180 1190 1200 1210 1220
1190 1200 1210 1220 1230 1240
pF1KA1 LMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNP
::::::.:::.::::.:: .:: :.:::.:: .::::::::::. ::.::.::.:::::
XP_016 LMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNS
1230 1240 1250 1260 1270 1280
1250 1260 1270 1280 1290 1300
pF1KA1 HICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSC
.::. :.::::::::.::::::: :.::.:::.::::::.:.:::: :::::::::::.:
XP_016 NICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKC
1290 1300 1310 1320 1330 1340
1310 1320 1330 1340 1350 1360
pF1KA1 RCLPGWVGDGFECHDLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDEC
: ::.:.:..: ::::: . :.:: ..:.:.::::::.: .::.:::: : : :::
XP_016 SCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDEC
1350 1360 1370 1380 1390 1400
1370 1380 1390 1400 1410 1420
pF1KA1 AENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMF
:::..::.::::::.::.::::::::: :. : :.:::.:::. :.:.::.:.::::::
XP_016 AENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMF
1410 1420 1430 1440 1450 1460
1430 1440 1450 1460 1470 1480
pF1KA1 RCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVD
.:::. :::::: :::::::.:::::.::.::.:.:::: : :.:: ::.:::.::::::
XP_016 HCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVD
1470 1480 1490 1500 1510 1520
1490 1500 1510 1520 1530 1540
pF1KA1 TRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLC
.:.:::.:. :::...::..::::::.:.:::::::.::::::: :: .:.::: :::
XP_016 NRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLC
1530 1540 1550 1560 1570 1580
1550 1560 1570 1580 1590 1600
pF1KA1 PGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDI
::::::.:: ::.::::::::::::::::::.:.::::::::::: ::.::: :::::::
XP_016 PGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI
1590 1600 1610 1620 1630 1640
1610 1620 1630 1640 1650 1660
pF1KA1 DECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNEL
::: .: :.:::::::::::::::.:: ::.:::::.:::::::: :.: :::: :.:::
XP_016 DECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENEL
1650 1660 1670 1680 1690 1700
1670 1680 1690 1700 1710 1720
pF1KA1 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC
::::..::::.::.:.:::.::: :::: . :.. .::: ::: :::::: .:::::
XP_016 PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGN-IPGFTFDIHTGKAVDIDEC
1710 1720 1730 1740 1750 1760
1730 1740 1750 1760 1770 1780
pF1KA1 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG
:::.:::::.:::::::::::::.::.::..::.:::.:::.. .. ::.:::::: ::
XP_016 KEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG
1770 1780 1790 1800 1810 1820
1790 1800 1810 1820 1830 1840
pF1KA1 SYRCKCTRGYKLSPGGACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLC
::::.:. :.::::.:::: .::: ::::::::: :.: .:::.:.:: ::.:: :::.:
XP_016 SYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMC
1830 1840 1850 1860 1870 1880
1850 1860 1870 1880 1890 1900
pF1KA1 MDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLN
::.:::.:.::::::::: .:::::::.::: .:::.::.:.:::... ::::: :.:.:
XP_016 MDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFN
1890 1900 1910 1920 1930 1940
1910 1920 1930 1940 1950 1960
pF1KA1 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD
:::.:::..:.::: :::::.:::::..: :.: ::::::::::::::::::..:.:.
XP_016 EIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSE
1950 1960 1970 1980 1990 2000
1970 1980 1990 2000 2010 2020
pF1KA1 HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGK
.::::.::.:.::.::::.:::.::.:::::::::::::::.:::::::::::: :: ::
XP_016 NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGK
2010 2020 2030 2040 2050 2060
2030 2040 2050 2060 2070 2080
pF1KA1 CSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDV
:::::::::::..::::: :::::::::::::.. .:::.:::.:::.::. :.::::
XP_016 CSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDV
2070 2080 2090 2100 2110 2120
2090 2100 2110 2120 2130 2140
pF1KA1 NECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVI
::: :.::.:.:: :.:::::::::::.::.::.::. ::::::::.:.:::.:::::::
XP_016 NECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVI
2130 2140 2150 2160 2170 2180
2150 2160 2170 2180 2190 2200
pF1KA1 GGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMC
:.::: : .::::: ::.::::.::. ::::::::: :: ::: :::: ::.:::: ::
XP_016 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC
2190 2200 2210 2220 2230 2240
2210 2220 2230 2240 2250 2260
pF1KA1 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN
.:.::::.: .::..::: :::::::: :.::::: : .::::.:.:::...: .: :
XP_016 KDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP-DGEGCVDENECRTKPGICEN
2250 2260 2270 2280 2290 2300
2270 2280 2290 2300 2310 2320
pF1KA1 GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC
::::: ::.::.:.:::: : . ::: : ::: ::::::::.:. ::: . ::..:::
XP_016 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC
2310 2320 2330 2340 2350 2360
2330 2340 2350 2360 2370 2380
pF1KA1 CGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGS
: :::::: .:::::::::. :.:.:::: :::..:::.:::... .::..:.:::..::
XP_016 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGS
2370 2380 2390 2400 2410 2420
2390 2400 2410 2420 2430 2440
pF1KA1 FRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCK
::: :..::: : ..:.:.:.::::: ::::...::::.::. :::::::.:.:::.:::
XP_016 FRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCK
2430 2440 2450 2460 2470 2480
2450 2460 2470 2480 2490 2500
pF1KA1 DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNT
::::: ..:::::::::::.:.:::.::::::::: ::.::.::..::. :::.: :.::
XP_016 DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNT
2490 2500 2510 2520 2530 2540
2510 2520 2530 2540 2550 2560
pF1KA1 PGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQ
:::: :::..::.: ..: .::::.:::: ::::::::: ::::::.::::. :: :: :
XP_016 PGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQ
2550 2560 2570 2580 2590 2600
2570 2580 2590 2600 2610 2620
pF1KA1 CVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSC
:::::::. .: .:::::: ::::...:.:::::.::: ..:.::.::.. ..::.:.:
XP_016 CVDENECS-NPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGC
2610 2620 2630 2640 2650
2630 2640 2650 2660 2670 2680
pF1KA1 ANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ---DTP-DKEELLSSEACYECKINGL
.:: ::.::::: ::.:.::::::::.::. : :: :.:. :: ::::::::::
XP_016 SNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGY
2660 2670 2680 2690 2700 2710
2690 2700 2710 2720 2730
pF1KA1 SPRD-RPRRSAHRD-----HQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEG
: .: : .:: :. .:..: ..: .. ... .:::::: :.:::::::.. :..
XP_016 SKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQPLNN
2720 2730 2740 2750 2760 2770
2740 2750 2760 2770 2780 2790
pF1KA1 RIRYVIVRGNEQGFFRMHHLRGVSSLQLGRRRPGPGTYRLEVVS---HMAGPWGVQPEGQ
.::::: .::... ::.:. :.: :. .... :::: ::..: . :..
XP_016 HIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKKKELKKLEESN
2780 2790 2800 2810 2820 2830
2800
pF1KA1 P-----GPWGQALRLKVQLQLL
: :.:::...:.::
XP_016 EDDYLLGELGEALRMRLQIQLY
2840 2850 2860
>>XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 iso (1948 aa)
initn: 14885 init1: 14885 opt: 14885 Z-score: 9590.4 bits: 1788.5 E(85289): 0
Smith-Waterman score: 14885; 99.8% identity (100.0% similar) in 1948 aa overlap (862-2809:1-1948)
840 850 860 870 880 890
pF1KA1 SECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGS
::::::::::::::::::::::::::::::
XP_016 MTGVTCDDVNECESFPGVCPNGRCVNTAGS
10 20 30
900 910 920 930 940 950
pF1KA1 FRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVEC
40 50 60 70 80 90
960 970 980 990 1000 1010
pF1KA1 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC
100 110 120 130 140 150
1020 1030 1040 1050 1060 1070
pF1KA1 ACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMD
160 170 180 190 200 210
1080 1090 1100 1110 1120 1130
pF1KA1 VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVN
220 230 240 250 260 270
1140 1150 1160 1170 1180 1190
pF1KA1 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG
280 290 300 310 320 330
1200 1210 1220 1230 1240 1250
pF1KA1 RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLH
340 350 360 370 380 390
1260 1270 1280 1290 1300 1310
pF1KA1 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG
400 410 420 430 440 450
1320 1330 1340 1350 1360 1370
pF1KA1 WVGDGFECHDLDECISQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVD
460 470 480 490 500 510
1380 1390 1400 1410 1420 1430
pF1KA1 LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICN
520 530 540 550 560 570
1440 1450 1460 1470 1480 1490
pF1KA1 GGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGN
580 590 600 610 620 630
1500 1510 1520 1530 1540 1550
pF1KA1 CFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEG
640 650 660 670 680 690
1560 1570 1580 1590 1600 1610
pF1KA1 FQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECST
700 710 720 730 740 750
1620 1630 1640 1650 1660 1670
pF1KA1 HSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTR
760 770 780 790 800 810
1680 1690 1700 1710 1720 1730
pF1KA1 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAI
820 830 840 850 860 870
1740 1750 1760 1770 1780 1790
pF1KA1 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC
880 890 900 910 920 930
1800 1810 1820 1830 1840 1850
pF1KA1 TRGYKLSPGGACVGQNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDEC
940 950 960 970 980 990
1860 1870 1880 1890 1900 1910
pF1KA1 DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH
1000 1010 1020 1030 1040 1050
1920 1930 1940 1950 1960 1970
pF1KA1 CLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDID
1060 1070 1080 1090 1100 1110
1980 1990 2000 2010 2020 2030
pF1KA1 ECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKA
1120 1130 1140 1150 1160 1170
2040 2050 2060 2070 2080 2090
pF1KA1 FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAEN
1180 1190 1200 1210 1220 1230
2100 2110 2120 2130 2140 2150
pF1KA1 PGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECA
1240 1250 1260 1270 1280 1290
2160 2170 2180 2190 2200 2210
pF1KA1 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDEC
1300 1310 1320 1330 1340 1350
2220 2230 2240 2250 2260 2270
pF1KA1 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNT
1360 1370 1380 1390 1400 1410
2280 2290 2300 2310 2320 2330
pF1KA1 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG
1420 1430 1440 1450 1460 1470
2340 2350 2360 2370 2380 2390
pF1KA1 WGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ
1480 1490 1500 1510 1520 1530
2400 2410 2420 2430 2440 2450
pF1KA1 AGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT
1540 1550 1560 1570 1580 1590
2460 2470 2480 2490 2500 2510
pF1KA1 SRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRC
1600 1610 1620 1630 1640 1650
2520 2530 2540 2550 2560 2570
pF1KA1 ECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE
1660 1670 1680 1690 1700 1710
2580 2590 2600 2610 2620 2630
pF1KA1 CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGG
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGG
1720 1730 1740 1750 1760 1770
2640 2650 2660 2670 2680 2690
pF1KA1 FLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSA
1780 1790 1800 1810 1820 1830
2700 2710 2720 2730 2740 2750
pF1KA1 HRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRDHQVNLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFR
1840 1850 1860 1870 1880 1890
2760 2770 2780 2790 2800
pF1KA1 MHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MHHLRGVSSLQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
1900 1910 1920 1930 1940
>>NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 pre (2912 aa)
initn: 12727 init1: 7367 opt: 14009 Z-score: 9024.8 bits: 1684.4 E(85289): 0
Smith-Waterman score: 15541; 67.1% identity (85.9% similar) in 2849 aa overlap (39-2808:68-2911)
10 20 30 40 50 60
pF1KA1 ARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYC
:: .::::::. .:.::::::::::.::
NP_001 PRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYC
40 50 60 70 80 90
70 80 90 100 110 120
pF1KA1 CPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGG
::::.:.:: .::.::::: .::.::::.::.:::..: .. .:: . . ::: :::::
NP_001 CPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGG
100 110 120 130 140 150
130 140 150 160 170 180
pF1KA1 TCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF
:: : ::::: :: ::::.:. ::.::::::::::::::::: ::::::::::::::
NP_001 TCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF
160 170 180 190 200 210
190 200 210 220 230 240
pF1KA1 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDV
::. . :: ::::.::::.:::::.::::: :::.:::::.::::::::::.:::::::
NP_001 TQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDV
220 230 240 250 260 270
250 260 270 280 290
pF1KA1 DECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDY------------------
:::::.::.::::.:.: ::::.::::.::. :... :::
NP_001 DECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNT
280 290 300 310 320 330
300 310 320
pF1KA1 ------------------------RAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWA
:.: ::: : .:::: .: :..:. ::::. ::::.
NP_001 VGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWG
340 350 360 370 380 390
330 340 350 360 370 380
pF1KA1 AGPVPELCPPRGSNEFQQLCAQRLPL--LPGHPGLFPGLLGFGSNGMGPPLGPARLNPHG
: .:: :: :::.:...:: . ::. .:: : :: : :.::..: . .: :
NP_001 IGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRPG--GTGGNGFAPSGNGNGYGPGG
400 410 420 430 440 450
390 400 410 420
pF1KA1 SDARGIP-----SLGPGNSNIGTA----------TLNQTIDICRHFTNLCLNGRCLPTPS
. :: : : :....:.. ::::::::.: .::::::::.:: :
NP_001 TGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVS
460 470 480 490 500 510
430 440 450 460 470 480
pF1KA1 SYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVD
:::::::.:: ::. :.:::::::::.:: .::::: ::.:.:.:. ::: :::.:::.:
NP_001 SYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACID
520 530 540 550 560 570
490 500 510 520 530 540
pF1KA1 VDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNE
.:::: .: ::. ::::::.:::::.:::::::. ::::::::.::.:..::.::.:.::
NP_001 IDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINE
580 590 600 610 620 630
550 560 570 580 590 600
pF1KA1 DGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGR
::::.:.:::::.:::.:.:: :.:::::::::.:::: :.::::::.: ::::: :::
NP_001 DGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGR
640 650 660 670 680 690
610 620 630 640 650 660
pF1KA1 VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKNSAEFQAL
::::::.::::::.:.:: :.:::::.::::::::::::.::::::: :::::::::..:
NP_001 VCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGL
700 710 720 730 740 750
670 680 690 700 710 720
pF1KA1 CSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECA
::::.:::.::::::::::::..::::.:::::::::: :: ::: :::..: :.:::
NP_001 CSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECL
760 770 780 790 800 810
730 740 750 760 770 780
pF1KA1 LNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTC
.: :::::: :.:.::::::.::::. : .:: :.:..:: :.:::.:.::: ::..:
NP_001 VNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNC
820 830 840 850 860 870
790 800 810 820 830 840
pF1KA1 KCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERC
.:.:::.:. .: .:.:: ::::::.::.::::::..::.:.::::::::::::::::::
NP_001 ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERC
880 890 900 910 920 930
850 860 870 880 890 900
pF1KA1 EIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLC
:.: :: ::.::. ::::.:::::: ::::::::::::. :::.::::::: ::..::.:
NP_001 ELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC
940 950 960 970 980 990
910 920 930 940 950 960
pF1KA1 VDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRG
.:.:.: :.:.:::::: .:::.:::.:::..::.::.::: :: : . :. .:::::
NP_001 LDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRG
1000 1010 1020 1030 1040 1050
970 980 990 1000 1010 1020
pF1KA1 LGFASR-DFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTD
:::.: : :.:::::::.::::.:::.::.: ::::.:::.: : .::::: .::::::
NP_001 AGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTD
1060 1070 1080 1090 1100 1110
1030 1040 1050 1060 1070 1080
pF1KA1 IDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCT
::::::::::::.: ::::::::::::: :::::::.::::::.::: :.:::::::::.
NP_001 IDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCV
1120 1130 1140 1150 1160 1170
1090 1100 1110 1120 1130 1140
pF1KA1 NTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTP
::.::..:.:: ::::. . : ::.::::::.:: .:.:::.::..::::. :.:.::
NP_001 NTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATP
1180 1190 1200 1210 1220 1230
1150 1160 1170 1180 1190 1200
pF1KA1 DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCD
:::::.::.:: ..:::::..: :.::::.:::..::.::::::.:::.::::.:: .::
NP_001 DRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICD
1240 1250 1260 1270 1280 1290
1210 1220 1230 1240 1250 1260
pF1KA1 QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLG
:.:::.:: .::::::::::. ::.::.::.::::: .::. :.::::::::.::::::
NP_001 GGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLG
1300 1310 1320 1330 1340 1350
1270 1280 1290 1300 1310 1320
pF1KA1 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECISQ
: :.::.:::.::::::.:.:::: :::::::::::.: : ::.:.:..: ::::: .
NP_001 YSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNG
1360 1370 1380 1390 1400 1410
1330 1340 1350 1360 1370 1380
pF1KA1 EHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCE
:.:: ..:.:.::::::.: .::.:::: : : ::::::..::.::::::.::.::::
NP_001 THQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCE
1420 1430 1440 1450 1460 1470
1390 1400 1410 1420 1430 1440
pF1KA1 CEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINE
::::: :. : :.:::.:::. :.:.::.:.::::::.:::. :::::: :::::::.:
NP_001 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDE
1480 1490 1500 1510 1520 1530
1450 1460 1470 1480 1490 1500
pF1KA1 CADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSA
::::.::.::.:.:::: : :.:: ::.:::.::::::.:.:::.:. :::...::..
NP_001 CADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNT
1540 1550 1560 1570 1580 1590
1510 1520 1530 1540 1550 1560
pF1KA1 EIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQ
::::::.:.:::::::.::::::: :: .:.::: :::::::::.:: ::.:::::::::
NP_001 EIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQ
1600 1610 1620 1630 1640 1650
1570 1580 1590 1600 1610 1620
pF1KA1 ELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTCYNTLGNY
:::::::::.:.::::::::::: ::.::: :::::::::: .: :.:::::::::::::
NP_001 ELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNY
1660 1670 1680 1690 1700 1710
1630 1640 1650 1660 1670 1680
pF1KA1 TCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNELAFNVTRKMCCCSYNIGQAWNRP
::.:: ::.:::::.:::::::: :.: :::: :.::: ::::..::::.::.:.:::.:
NP_001 TCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP
1720 1730 1740 1750 1760 1770
1690 1700 1710 1720 1730 1740
pF1KA1 CEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCE
:: :::: . :.. .::: ::: :::::: .::::: :::.:::::.:::::::::::
NP_001 CEPCPTPGTADFKTICGN-IPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCE
1780 1790 1800 1810 1820 1830
1750 1760 1770 1780 1790 1800
pF1KA1 CPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGQN
::.::.::..::.:::.:::.. .. ::.:::::: ::::::.:. :.::::.:::: .:
NP_001 CPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRN
1840 1850 1860 1870 1880 1890
1810 1820 1830 1840 1850 1860
pF1KA1 ECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGS
:: ::::::::: :.: .:::.:.:: ::.:: :::.:::.:::.:.::::::::: .::
NP_001 ECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGS
1900 1910 1920 1930 1940 1950
1870 1880 1890 1900 1910 1920
pF1KA1 YNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNC
:::::.::: .:::.::.:.:::... ::::: :.:.: :::.:::..:.::: :::::
NP_001 YNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNC
1960 1970 1980 1990 2000 2010
1930 1940 1950 1960 1970 1980
pF1KA1 VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTN
.:::::..: :.: ::::::::::::::::::..:.:..::::.::.:.::.::::.:::
NP_001 IDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTN
2020 2030 2040 2050 2060 2070
1990 2000 2010 2020 2030 2040
pF1KA1 SPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGE
.::.:::::::::::::::.:::::::::::: :: :::::::::::::..::::: :::
NP_001 TPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGE
2080 2090 2100 2110 2120 2130
2050 2060 2070 2080 2090 2100
pF1KA1 GWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSF
::::::::::.. .:::.:::.:::.::. :.::::::: :.::.:.:: :.::::::
NP_001 GWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSF
2140 2150 2160 2170 2180 2190
2110 2120 2130 2140 2150 2160
pF1KA1 RCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDI
:::::.::.::.::. ::::::::.:.:::.::::::::.::: : .::::: ::.::::
NP_001 RCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDI
2200 2210 2220 2230 2240 2250
2170 2180 2190 2200 2210 2220
pF1KA1 DECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKN
.::. ::::::::: :: ::: :::: ::.:::: ::.:.::::.: .::..::: :::
NP_001 NECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKN
2260 2270 2280 2290 2300 2310
2230 2240 2250 2260 2270 2280
pF1KA1 LIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSP
::::: :.::::: : .::::.:.:::...: .: :::::: ::.::.:.:::: :
NP_001 LIGTFMCICPPGMARRP-DGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSS
2320 2330 2340 2350 2360 2370
2290 2300 2310 2320 2330 2340
pF1KA1 TLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAY
. ::: : ::: ::::::::.:. ::: . ::..:::: :::::: .:::::::::. :
NP_001 SGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY
2380 2390 2400 2410 2420 2430
2350 2360 2370 2380 2390 2400
pF1KA1 RKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMD
.:.:::: :::..:::.:::... .::..:.:::..::::: :..::: : ..:.:.:.:
NP_001 KKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLD
2440 2450 2460 2470 2480 2490
2410 2420 2430 2440 2450 2460
pF1KA1 ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGA
:::: ::::...::::.::. :::::::.:.:::.:::::::: ..:::::::::::.:.
NP_001 ECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGG
2500 2510 2520 2530 2540 2550
2470 2480 2490 2500 2510 2520
pF1KA1 FTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE
:::.::::::::: ::.::.::..::. :::.: :.:::::: :::..::.: ..: .::
NP_001 FTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCE
2560 2570 2580 2590 2600 2610
2530 2540 2550 2560 2570 2580
pF1KA1 DVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNT
::.:::: ::::::::: ::::::.::::. :: :: ::::::::. .: .:::::: ::
NP_001 DVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECS-NPNACGSASCYNT
2620 2630 2640 2650 2660 2670
2590 2600 2610 2620 2630 2640
pF1KA1 LGGFRCVCPSGFDFDQALGGCQDVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGH
::...:.:::::.::: ..:.::.::.. ..::.:.:.:: ::.::::: ::.:.::::
NP_001 LGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGH
2680 2690 2700 2710 2720 2730
2650 2660 2670 2680 2690
pF1KA1 CVSGLGFSPGPQ---DTP-DKEELLSSEACYECKINGLSPRD-RPRRSAHRD-----HQV
::::.::. : :: :.:. :: :::::::::: : .: : .:: :. .:.
NP_001 CVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGYSKKDSRQKRSIHEPDPTAVEQI
2740 2750 2760 2770 2780 2790
2700 2710 2720 2730 2740 2750
pF1KA1 NLATLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRG
.: ..: .. ... .:::::: :.:::::::.. :...::::: .::... ::.:. :
NP_001 SLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQPLNNHIRYVISQGNDDSVFRIHQRNG
2800 2810 2820 2830 2840 2850
2760 2770 2780 2790 2800
pF1KA1 VSSLQLGRRRPGPGTYRLEVVS---HMAGPWGVQPEGQP-----GPWGQALRLKVQLQLL
.: :. .... :::: ::..: . :.. : :.:::...:.::
NP_001 LSYLHTAKKKLMPGTYTLEITSIPLYKKKELKKLEESNEDDYLLGELGEALRMRLQIQLY
2860 2870 2880 2890 2900 2910
2809 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:12:13 2016 done: Thu Nov 3 20:12:16 2016
Total Scan time: 17.850 Total Display time: 2.980
Function used was FASTA [36.3.4 Apr, 2011]