Result of FASTA (omim) for
pF1KA1633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1633, 1814 aa
1>>>pF1KA1633 1814 - 1814 aa - 1814 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4456+/-0.000693; mu= -9.8811+/- 0.042
mean_var=520.8897+/-106.860, 0's: 0 Z-trim(115.7): 328 B-trim: 0 in 0/55
Lambda= 0.056195
statistics sampled from 25992 (26316) to 25992 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.309), width: 16
Scan time: 19.920
The best scores are: opt bits E(85289)
NP_001011649 (OMIM: 604804,608201) CDK5 regulatory (1814) 11608 958.5 0
NP_060719 (OMIM: 604804,608201) CDK5 regulatory su (1893) 10032 830.8 0
XP_011517162 (OMIM: 604804,608201) PREDICTED: CDK5 (1892) 10014 829.3 0
XP_016870411 (OMIM: 604804,608201) PREDICTED: CDK5 (1615) 8289 689.4 7.5e-197
XP_016870413 (OMIM: 604804,608201) PREDICTED: CDK5 (1079) 7013 585.7 7.8e-166
XP_016870412 (OMIM: 604804,608201) PREDICTED: CDK5 (1585) 5716 480.8 4.6e-134
XP_016870410 (OMIM: 604804,608201) PREDICTED: CDK5 (1860) 5564 468.5 2.7e-130
XP_006717245 (OMIM: 604804,608201) PREDICTED: CDK5 (1861) 5564 468.5 2.7e-130
XP_006717248 (OMIM: 604804,608201) PREDICTED: CDK5 (1664) 4387 373.0 1.3e-101
NP_001258968 (OMIM: 604804,608201) CDK5 regulatory (1663) 4140 353.0 1.4e-95
XP_016858391 (OMIM: 608117) PREDICTED: myomegalin (2255) 556 62.6 5.1e-08
NP_001185761 (OMIM: 608117) myomegalin isoform 8 [ (2240) 554 62.4 5.6e-08
XP_016858392 (OMIM: 608117) PREDICTED: myomegalin (2243) 554 62.4 5.6e-08
XP_016858388 (OMIM: 608117) PREDICTED: myomegalin (2302) 554 62.4 5.7e-08
XP_011508478 (OMIM: 608117) PREDICTED: myomegalin (2311) 554 62.4 5.8e-08
XP_016858387 (OMIM: 608117) PREDICTED: myomegalin (2345) 547 61.9 8.6e-08
XP_016858369 (OMIM: 608117) PREDICTED: myomegalin (2460) 547 61.9 8.9e-08
XP_011508477 (OMIM: 608117) PREDICTED: myomegalin (2482) 547 61.9 9e-08
XP_016858367 (OMIM: 608117) PREDICTED: myomegalin (2483) 547 61.9 9e-08
XP_006711709 (OMIM: 608117) PREDICTED: myomegalin (2495) 547 61.9 9e-08
XP_011508475 (OMIM: 608117) PREDICTED: myomegalin (2565) 547 61.9 9.2e-08
XP_011508474 (OMIM: 608117) PREDICTED: myomegalin (2566) 547 61.9 9.2e-08
NP_001002812 (OMIM: 608117) myomegalin isoform 2 [ ( 969) 520 59.3 2.1e-07
XP_006711713 (OMIM: 608117) PREDICTED: myomegalin (2432) 521 59.8 3.8e-07
XP_011508481 (OMIM: 608117) PREDICTED: myomegalin (2345) 520 59.7 3.9e-07
NP_055459 (OMIM: 608117) myomegalin isoform 1 [Hom (2346) 520 59.7 3.9e-07
NP_001185763 (OMIM: 608117) myomegalin isoform 9 [ (2362) 520 59.7 4e-07
XP_006711715 (OMIM: 608117) PREDICTED: myomegalin (2428) 520 59.7 4e-07
XP_006711714 (OMIM: 608117) PREDICTED: myomegalin (2429) 520 59.7 4e-07
XP_016858375 (OMIM: 608117) PREDICTED: myomegalin (2398) 428 52.2 7e-05
XP_016858390 (OMIM: 608117) PREDICTED: myomegalin (2257) 427 52.1 7.1e-05
XP_016858389 (OMIM: 608117) PREDICTED: myomegalin (2273) 427 52.1 7.2e-05
XP_016858374 (OMIM: 608117) PREDICTED: myomegalin (2399) 427 52.1 7.4e-05
XP_006711711 (OMIM: 608117) PREDICTED: myomegalin (2482) 427 52.2 7.6e-05
NP_071754 (OMIM: 608117) myomegalin isoform 3 [Hom ( 310) 400 49.1 8.1e-05
NP_001182190 (OMIM: 608117) myomegalin isoform 7 [ ( 176) 374 46.7 0.00024
NP_001002810 (OMIM: 608117) myomegalin isoform 4 [ ( 173) 373 46.6 0.00025
XP_016858381 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858382 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858380 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858385 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858384 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858383 (OMIM: 608117) PREDICTED: myomegalin (2367) 395 49.5 0.00044
XP_016858379 (OMIM: 608117) PREDICTED: myomegalin (2383) 395 49.6 0.00045
XP_016858378 (OMIM: 608117) PREDICTED: myomegalin (2397) 395 49.6 0.00045
XP_016858377 (OMIM: 608117) PREDICTED: myomegalin (2397) 395 49.6 0.00045
XP_016858376 (OMIM: 608117) PREDICTED: myomegalin (2397) 395 49.6 0.00045
XP_016858373 (OMIM: 608117) PREDICTED: myomegalin (2429) 395 49.6 0.00045
XP_016858372 (OMIM: 608117) PREDICTED: myomegalin (2445) 395 49.6 0.00045
XP_016858370 (OMIM: 608117) PREDICTED: myomegalin (2447) 395 49.6 0.00046
>>NP_001011649 (OMIM: 604804,608201) CDK5 regulatory sub (1814 aa)
initn: 11608 init1: 11608 opt: 11608 Z-score: 5108.7 bits: 958.5 E(85289): 0
Smith-Waterman score: 11608; 99.9% identity (100.0% similar) in 1814 aa overlap (1-1814:1-1814)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_001 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA1 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA1 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KA1 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KA1 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG
1750 1760 1770 1780 1790 1800
1810
pF1KA1 GAHPGTCSPSRPGS
::::::::::::::
NP_001 GAHPGTCSPSRPGS
1810
>>NP_060719 (OMIM: 604804,608201) CDK5 regulatory subuni (1893 aa)
initn: 10031 init1: 10031 opt: 10032 Z-score: 4417.9 bits: 830.8 E(85289): 0
Smith-Waterman score: 11122; 95.6% identity (95.7% similar) in 1846 aa overlap (1-1767:1-1846)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_060 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_060 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1510 1520 1530 1540 1550 1560
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
NP_060 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1570 1580 1590 1600 1610 1620
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
NP_060 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1630 1640 1650 1660 1670 1680
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1690 1700 1710 1720 1730 1740
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1750 1760 1770 1780 1790 1800
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::
NP_060 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1810 1820 1830 1840 1850 1860
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
NP_060 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1870 1880 1890
>>XP_011517162 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1892 aa)
initn: 6199 init1: 6199 opt: 10014 Z-score: 4410.0 bits: 829.3 E(85289): 0
Smith-Waterman score: 11104; 95.6% identity (95.7% similar) in 1846 aa overlap (1-1767:1-1845)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_011 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 YQNLRKTLEEQISEIRRREE-SFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_011 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1500 1510 1520 1530 1540 1550
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
XP_011 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1560 1570 1580 1590 1600 1610
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
XP_011 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1620 1630 1640 1650 1660 1670
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1680 1690 1700 1710 1720 1730
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1740 1750 1760 1770 1780 1790
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1800 1810 1820 1830 1840 1850
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
XP_011 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1860 1870 1880 1890
>>XP_016870411 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1615 aa)
initn: 8288 init1: 8288 opt: 8289 Z-score: 3655.1 bits: 689.4 E(85289): 7.5e-197
Smith-Waterman score: 9379; 94.8% identity (95.0% similar) in 1568 aa overlap (279-1767:1-1568)
250 260 270 280 290 300
pF1KA1 CPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLREKEREIAT
::::::::::.:::::::::::::::::::
XP_016 MEHQKERNSFEERIQALEEDLREKEREIAT
10 20 30
310 320 330 340 350 360
pF1KA1 EKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED
40 50 60 70 80 90
370 380 390 400 410 420
pF1KA1 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE
100 110 120 130 140 150
430 440 450 460 470 480
pF1KA1 KSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ
160 170 180 190 200 210
490 500 510 520 530 540
pF1KA1 KDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS
220 230 240 250 260 270
550 560 570 580 590 600
pF1KA1 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL
280 290 300 310 320 330
610 620 630 640 650 660
pF1KA1 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELY
340 350 360 370 380 390
670 680 690 700 710 720
pF1KA1 TDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQH
400 410 420 430 440 450
730 740 750 760 770 780
pF1KA1 LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLL
460 470 480 490 500 510
790 800 810 820 830 840
pF1KA1 LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDE
520 530 540 550 560 570
850 860 870 880 890 900
pF1KA1 LKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHR
580 590 600 610 620 630
910 920 930 940 950 960
pF1KA1 PENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQI
640 650 660 670 680 690
970 980 990 1000 1010 1020
pF1KA1 LELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK
700 710 720 730 740 750
1030 1040 1050 1060 1070 1080
pF1KA1 TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQP
760 770 780 790 800 810
1090 1100 1110 1120 1130 1140
pF1KA1 SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLC
820 830 840 850 860 870
1150 1160 1170 1180 1190 1200
pF1KA1 GTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE
880 890 900 910 920 930
1210 1220 1230 1240 1250 1260
pF1KA1 QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV
940 950 960 970 980 990
1270 1280 1290 1300 1310 1320
pF1KA1 ISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNT
1000 1010 1020 1030 1040 1050
1330 1340 1350 1360 1370 1380
pF1KA1 QNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVN
1060 1070 1080 1090 1100 1110
1390 1400 1410 1420 1430 1440
pF1KA1 SFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSL
1120 1130 1140 1150 1160 1170
1450 1460 1470 1480 1490 1500
pF1KA1 TSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERL
1180 1190 1200 1210 1220 1230
1510 1520 1530 1540 1550 1560
pF1KA1 QKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVELKAYEKLD
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_016 QKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLD
1240 1250 1260 1270 1280 1290
1570
pF1KA1 EEHRRLR-----------------------------------------------------
:::::::
XP_016 EEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAE
1300 1310 1320 1330 1340 1350
1580 1590 1600
pF1KA1 --------------------------DGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLS
::::::::::::::::::::::::::::::::::
XP_016 KAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLS
1360 1370 1380 1390 1400 1410
1610 1620 1630 1640 1650 1660
pF1KA1 GNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLL
1420 1430 1440 1450 1460 1470
1670 1680 1690 1700 1710 1720
pF1KA1 AEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPED
1480 1490 1500 1510 1520 1530
1730 1740 1750 1760 1770 1780
pF1KA1 GQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILR
::::::::::::::::::::::::::::::::::::::
XP_016 GQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILR
1540 1550 1560 1570 1580 1590
1790 1800 1810
pF1KA1 KARGNLELRPGGAHPGTCSPSRPGS
XP_016 KARGNLELRPGGAHPGTCSPSRPGS
1600 1610
>>XP_016870413 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1079 aa)
initn: 7013 init1: 7013 opt: 7013 Z-score: 3098.2 bits: 585.7 E(85289): 7.8e-166
Smith-Waterman score: 7013; 99.9% identity (100.0% similar) in 1079 aa overlap (736-1814:1-1079)
710 720 730 740 750 760
pF1KA1 SKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAP
::::::::::::::::::::::::::::::
XP_016 MKDLSKGGCKNGYLRHTESKISDCDGAHAP
10 20 30
770 780 790 800 810 820
pF1KA1 GCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEK
40 50 60 70 80 90
830 840 850 860 870 880
pF1KA1 TPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRF
100 110 120 130 140 150
890 900 910 920 930 940
pF1KA1 KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS
160 170 180 190 200 210
950 960 970 980 990 1000
pF1KA1 RSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKT
220 230 240 250 260 270
1010 1020 1030 1040 1050 1060
pF1KA1 LLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSC
280 290 300 310 320 330
1070 1080 1090 1100 1110 1120
pF1KA1 KENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEG
340 350 360 370 380 390
1130 1140 1150 1160 1170 1180
pF1KA1 YQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKI
400 410 420 430 440 450
1190 1200 1210 1220 1230 1240
pF1KA1 LGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL
460 470 480 490 500 510
1250 1260 1270 1280 1290 1300
pF1KA1 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC
520 530 540 550 560 570
1310 1320 1330 1340 1350 1360
pF1KA1 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS
580 590 600 610 620 630
1370 1380 1390 1400 1410 1420
pF1KA1 EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER
640 650 660 670 680 690
1430 1440 1450 1460 1470 1480
pF1KA1 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS
700 710 720 730 740 750
1490 1500 1510 1520 1530 1540
pF1KA1 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_016 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ
760 770 780 790 800 810
1550 1560 1570 1580 1590 1600
pF1KA1 LLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSET
820 830 840 850 860 870
1610 1620 1630 1640 1650 1660
pF1KA1 PPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQG
880 890 900 910 920 930
1670 1680 1690 1700 1710 1720
pF1KA1 QRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVS
940 950 960 970 980 990
1730 1740 1750 1760 1770 1780
pF1KA1 LPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTH
1000 1010 1020 1030 1040 1050
1790 1800 1810
pF1KA1 KILRKARGNLELRPGGAHPGTCSPSRPGS
:::::::::::::::::::::::::::::
XP_016 KILRKARGNLELRPGGAHPGTCSPSRPGS
1060 1070
>>XP_016870412 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1585 aa)
initn: 10089 init1: 5716 opt: 5716 Z-score: 2527.8 bits: 480.8 E(85289): 4.6e-134
Smith-Waterman score: 9635; 87.3% identity (87.4% similar) in 1814 aa overlap (1-1814:1-1585)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_016 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::
XP_016 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE------------------
670 680 690 700
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
XP_016 ------------------------------------------------------------
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
XP_016 ------------------------------------------------------------
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
XP_016 ------------------------------------------------------------
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
:::::::::::::::::::::::::::::
XP_016 -------------------------------EAKKSRLPILIKPSRSLGNMYRLPATQEV
710 720 730
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
740 750 760 770 780 790
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
800 810 820 830 840 850
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
860 870 880 890 900 910
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
920 930 940 950 960 970
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
980 990 1000 1010 1020 1030
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1040 1050 1060 1070 1080 1090
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1100 1110 1120 1130 1140 1150
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1160 1170 1180 1190 1200 1210
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1220 1230 1240 1250 1260 1270
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_016 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1280 1290 1300 1310 1320 1330
1570 1580 1590 1600 1610 1620
pF1KA1 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS
1340 1350 1360 1370 1380 1390
1630 1640 1650 1660 1670 1680
pF1KA1 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP
1400 1410 1420 1430 1440 1450
1690 1700 1710 1720 1730 1740
pF1KA1 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG
1460 1470 1480 1490 1500 1510
1750 1760 1770 1780 1790 1800
pF1KA1 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG
1520 1530 1540 1550 1560 1570
1810
pF1KA1 GAHPGTCSPSRPGS
::::::::::::::
XP_016 GAHPGTCSPSRPGS
1580
>>XP_016870410 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1860 aa)
initn: 9287 init1: 5449 opt: 5564 Z-score: 2460.3 bits: 468.5 E(85289): 2.7e-130
Smith-Waterman score: 10827; 93.8% identity (93.9% similar) in 1846 aa overlap (1-1767:1-1813)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_016 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_016 YQNLRKTLEEQISEIRRREE-SFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::
XP_016 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE------------------
660 670 680 690 700
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------------IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
710 720 730 740
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
750 760 770 780 790 800
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
810 820 830 840 850 860
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_016 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1470 1480 1490 1500 1510 1520
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
XP_016 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1530 1540 1550 1560 1570 1580
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
XP_016 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1590 1600 1610 1620 1630 1640
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1650 1660 1670 1680 1690 1700
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1710 1720 1730 1740 1750 1760
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1770 1780 1790 1800 1810 1820
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
XP_016 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1830 1840 1850 1860
>>XP_006717245 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1861 aa)
initn: 6016 init1: 5449 opt: 5564 Z-score: 2460.3 bits: 468.5 E(85289): 2.7e-130
Smith-Waterman score: 10845; 93.9% identity (94.0% similar) in 1846 aa overlap (1-1767:1-1814)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_006 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::
XP_006 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE------------------
670 680 690 700
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 --------------IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
710 720 730 740
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
750 760 770 780 790 800
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
810 820 830 840 850 860
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_006 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1470 1480 1490 1500 1510 1520
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
XP_006 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1530 1540 1550 1560 1570 1580
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
XP_006 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1590 1600 1610 1620 1630 1640
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1650 1660 1670 1680 1690 1700
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1710 1720 1730 1740 1750 1760
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1770 1780 1790 1800 1810 1820
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
XP_006 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1830 1840 1850 1860
>>XP_006717248 (OMIM: 604804,608201) PREDICTED: CDK5 reg (1664 aa)
initn: 8512 init1: 4387 opt: 4387 Z-score: 1945.2 bits: 373.0 E(85289): 1.3e-101
Smith-Waterman score: 9467; 83.6% identity (83.7% similar) in 1893 aa overlap (1-1814:1-1664)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_006 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::
XP_006 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE------------------
670 680 690 700
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
XP_006 ------------------------------------------------------------
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
XP_006 ------------------------------------------------------------
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
XP_006 ------------------------------------------------------------
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
:::::::::::::::::::::::::::::
XP_006 -------------------------------EAKKSRLPILIKPSRSLGNMYRLPATQEV
710 720 730
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
740 750 760 770 780 790
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
800 810 820 830 840 850
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
860 870 880 890 900 910
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
920 930 940 950 960 970
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
980 990 1000 1010 1020 1030
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1040 1050 1060 1070 1080 1090
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1100 1110 1120 1130 1140 1150
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1160 1170 1180 1190 1200 1210
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1220 1230 1240 1250 1260 1270
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
XP_006 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1280 1290 1300 1310 1320 1330
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
XP_006 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1340 1350 1360 1370 1380 1390
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
XP_006 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1400 1410 1420 1430 1440 1450
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1460 1470 1480 1490 1500 1510
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1520 1530 1540 1550 1560 1570
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1580 1590 1600 1610 1620 1630
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
:::::::::::::::::::::::::::::::::
XP_006 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1640 1650 1660
>>NP_001258968 (OMIM: 604804,608201) CDK5 regulatory sub (1663 aa)
initn: 7977 init1: 4139 opt: 4140 Z-score: 1837.0 bits: 353.0 E(85289): 1.4e-95
Smith-Waterman score: 9131; 83.2% identity (83.3% similar) in 1846 aa overlap (1-1767:1-1616)
10 20 30 40 50 60
pF1KA1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFQERIQALEEDLR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 YQNLRKTLEEQISEIRRREE-SFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
610 620 630 640 650
670 680 690 700 710 720
pF1KA1 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
::::::::::::::::::::::::::::::::::::::::::
NP_001 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE------------------
660 670 680 690 700
730 740 750 760 770 780
pF1KA1 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
NP_001 ------------------------------------------------------------
790 800 810 820 830 840
pF1KA1 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
NP_001 ------------------------------------------------------------
850 860 870 880 890 900
pF1KA1 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
NP_001 ------------------------------------------------------------
910 920 930 940 950 960
pF1KA1 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
:::::::::::::::::::::::::::::
NP_001 -------------------------------EAKKSRLPILIKPSRSLGNMYRLPATQEV
710 720 730
970 980 990 1000 1010 1020
pF1KA1 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
740 750 760 770 780 790
1030 1040 1050 1060 1070 1080
pF1KA1 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
800 810 820 830 840 850
1090 1100 1110 1120 1130 1140
pF1KA1 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
860 870 880 890 900 910
1150 1160 1170 1180 1190 1200
pF1KA1 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
920 930 940 950 960 970
1210 1220 1230 1240 1250 1260
pF1KA1 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
980 990 1000 1010 1020 1030
1270 1280 1290 1300 1310 1320
pF1KA1 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
1040 1050 1060 1070 1080 1090
1330 1340 1350 1360 1370 1380
pF1KA1 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
1100 1110 1120 1130 1140 1150
1390 1400 1410 1420 1430 1440
pF1KA1 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
1160 1170 1180 1190 1200 1210
1450 1460 1470 1480 1490 1500
pF1KA1 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
1220 1230 1240 1250 1260 1270
1510 1520 1530 1540 1550 1560
pF1KA1 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEELKLRQQLLSQNDKLLQSLRVE
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_001 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
1280 1290 1300 1310 1320 1330
1570
pF1KA1 LKAYEKLDEEHRRLR---------------------------------------------
:::::::::::::::
NP_001 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
1340 1350 1360 1370 1380 1390
1580 1590 1600
pF1KA1 ----------------------------------DGDKYPMESDNSFDLFDSSQAVTPKS
::::::::::::::::::::::::::
NP_001 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
1400 1410 1420 1430 1440 1450
1610 1620 1630 1640 1650 1660
pF1KA1 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
1460 1470 1480 1490 1500 1510
1670 1680 1690 1700 1710 1720
pF1KA1 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
1520 1530 1540 1550 1560 1570
1730 1740 1750 1760 1770 1780
pF1KA1 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
1580 1590 1600 1610 1620 1630
1790 1800 1810
pF1KA1 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
NP_001 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
1640 1650 1660
1814 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:22:48 2016 done: Sat Nov 5 02:22:51 2016
Total Scan time: 19.920 Total Display time: 0.960
Function used was FASTA [36.3.4 Apr, 2011]