Result of FASTA (omim) for
pF1KA1521
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1521, 1478 aa
1>>>pF1KA1521 1478 - 1478 aa - 1478 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3668+/-0.000406; mu= 9.3009+/- 0.025
mean_var=176.5068+/-35.558, 0's: 0 Z-trim(116.4): 62 B-trim: 0 in 0/53
Lambda= 0.096537
statistics sampled from 27512 (27574) to 27512 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.323), width: 16
Scan time: 12.440
The best scores are: opt bits E(85289)
NP_001269608 (OMIM: 611714) GTPase-activating prot (1478) 9713 1366.5 0
XP_016870093 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 6936 979.7 0
XP_016870092 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 6936 979.7 0
XP_016870091 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 6936 979.7 0
XP_016870090 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 6936 979.7 0
XP_005251958 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 6936 979.7 0
NP_001269609 (OMIM: 611714) GTPase-activating prot (1460) 6936 979.7 0
NP_001317707 (OMIM: 611714) GTPase-activating prot (1433) 6511 920.5 0
XP_005251961 (OMIM: 611714) PREDICTED: GTPase-acti (1433) 6511 920.5 0
XP_016870098 (OMIM: 611714) PREDICTED: GTPase-acti (1433) 6511 920.5 0
XP_011516809 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 5476 776.4 0
XP_016870094 (OMIM: 611714) PREDICTED: GTPase-acti (1460) 5476 776.4 0
XP_011516808 (OMIM: 611714) PREDICTED: GTPase-acti (1466) 5304 752.4 5.8e-216
XP_011516802 (OMIM: 611714) PREDICTED: GTPase-acti (1487) 5256 745.7 6.1e-214
XP_011516804 (OMIM: 611714) PREDICTED: GTPase-acti (1487) 5256 745.7 6.1e-214
XP_011516801 (OMIM: 611714) PREDICTED: GTPase-acti (1487) 5256 745.7 6.1e-214
NP_056450 (OMIM: 611714) GTPase-activating protein (1487) 5256 745.7 6.1e-214
XP_016870089 (OMIM: 611714) PREDICTED: GTPase-acti (1487) 5256 745.7 6.1e-214
NP_001317706 (OMIM: 611714) GTPase-activating prot (1412) 3659 523.3 5.2e-147
XP_006717107 (OMIM: 611714) PREDICTED: GTPase-acti (1439) 3659 523.3 5.3e-147
XP_016870097 (OMIM: 611714) PREDICTED: GTPase-acti (1439) 3659 523.3 5.3e-147
XP_016870096 (OMIM: 611714) PREDICTED: GTPase-acti (1439) 3659 523.3 5.3e-147
XP_016870095 (OMIM: 611714) PREDICTED: GTPase-acti (1439) 3659 523.3 5.3e-147
NP_001269610 (OMIM: 611714) GTPase-activating prot (1439) 3659 523.3 5.3e-147
NP_001273991 (OMIM: 609700) rab5 GDP/GTP exchange ( 491) 290 53.8 3.9e-06
NP_055319 (OMIM: 609700) rab5 GDP/GTP exchange fac ( 491) 290 53.8 3.9e-06
NP_001273990 (OMIM: 609700) rab5 GDP/GTP exchange ( 505) 290 53.8 4e-06
NP_001273989 (OMIM: 609700) rab5 GDP/GTP exchange ( 299) 285 53.0 4.3e-06
>>NP_001269608 (OMIM: 611714) GTPase-activating protein (1478 aa)
initn: 9713 init1: 9713 opt: 9713 Z-score: 7316.8 bits: 1366.5 E(85289): 0
Smith-Waterman score: 9713; 100.0% identity (100.0% similar) in 1478 aa overlap (1-1478:1-1478)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1390 1400 1410 1420 1430 1440
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
NP_001 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1450 1460 1470
>>XP_016870093 (OMIM: 611714) PREDICTED: GTPase-activati (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_016 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_016 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>XP_016870092 (OMIM: 611714) PREDICTED: GTPase-activati (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_016 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_016 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>XP_016870091 (OMIM: 611714) PREDICTED: GTPase-activati (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_016 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_016 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>XP_016870090 (OMIM: 611714) PREDICTED: GTPase-activati (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_016 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_016 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>XP_005251958 (OMIM: 611714) PREDICTED: GTPase-activati (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_005 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_005 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>NP_001269609 (OMIM: 611714) GTPase-activating protein (1460 aa)
initn: 9575 init1: 6919 opt: 6936 Z-score: 5226.6 bits: 979.7 E(85289): 0
Smith-Waterman score: 9543; 98.8% identity (98.8% similar) in 1478 aa overlap (1-1478:1-1460)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
NP_001 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1370 1380 1390 1400 1410 1420
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
NP_001 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1430 1440 1450 1460
>>NP_001317707 (OMIM: 611714) GTPase-activating protein (1433 aa)
initn: 6482 init1: 6482 opt: 6511 Z-score: 4906.8 bits: 920.5 E(85289): 0
Smith-Waterman score: 9295; 97.0% identity (97.0% similar) in 1478 aa overlap (1-1478:1-1433)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
:::::::::::::::::::::::::::: :::::
NP_001 EERKDSDDEKSDRNRPWWRKRFVSAMPK---------------------------DDPSP
970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
NP_001 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1040 1050 1060 1070 1080 1090
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1100 1110 1120 1130 1140 1150
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1160 1170 1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1340 1350 1360 1370 1380 1390
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
NP_001 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1400 1410 1420 1430
>>XP_005251961 (OMIM: 611714) PREDICTED: GTPase-activati (1433 aa)
initn: 6482 init1: 6482 opt: 6511 Z-score: 4906.8 bits: 920.5 E(85289): 0
Smith-Waterman score: 9295; 97.0% identity (97.0% similar) in 1478 aa overlap (1-1478:1-1433)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
:::::::::::::::::::::::::::: :::::
XP_005 EERKDSDDEKSDRNRPWWRKRFVSAMPK---------------------------DDPSP
970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_005 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1040 1050 1060 1070 1080 1090
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1100 1110 1120 1130 1140 1150
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1160 1170 1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1340 1350 1360 1370 1380 1390
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_005 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1400 1410 1420 1430
>>XP_016870098 (OMIM: 611714) PREDICTED: GTPase-activati (1433 aa)
initn: 6482 init1: 6482 opt: 6511 Z-score: 4906.8 bits: 920.5 E(85289): 0
Smith-Waterman score: 9295; 97.0% identity (97.0% similar) in 1478 aa overlap (1-1478:1-1433)
10 20 30 40 50 60
pF1KA1 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGET
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 EERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSP
:::::::::::::::::::::::::::: :::::
XP_016 EERKDSDDEKSDRNRPWWRKRFVSAMPK---------------------------DDPSP
970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDG
:::::::::::::::::::::::::::::::::::: ::::::
XP_016 RLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYEST------------------EVMGDG
1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA1 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLT
1040 1050 1060 1070 1080 1090
1150 1160 1170 1180 1190 1200
pF1KA1 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLL
1100 1110 1120 1130 1140 1150
1210 1220 1230 1240 1250 1260
pF1KA1 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLES
1160 1170 1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KA1 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERS
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KA1 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSE
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KA1 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLS
1340 1350 1360 1370 1380 1390
1450 1460 1470
pF1KA1 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
::::::::::::::::::::::::::::::::::::::
XP_016 TVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
1400 1410 1420 1430
1478 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:22:14 2016 done: Wed Nov 2 21:22:16 2016
Total Scan time: 12.440 Total Display time: 0.750
Function used was FASTA [36.3.4 Apr, 2011]