FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1492, 789 aa 1>>>pF1KA1492 789 - 789 aa - 789 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3419+/-0.000532; mu= 19.8893+/- 0.033 mean_var=67.0692+/-13.784, 0's: 0 Z-trim(106.9): 113 B-trim: 0 in 0/49 Lambda= 0.156608 statistics sampled from 14904 (15018) to 14904 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.529), E-opt: 0.2 (0.176), width: 16 Scan time: 11.110 The best scores are: opt bits E(85289) NP_001308835 (OMIM: 608209) inactive dipeptidyl pe ( 789) 5211 1187.4 0 NP_001004360 (OMIM: 608209) inactive dipeptidyl pe ( 789) 5211 1187.4 0 NP_001171508 (OMIM: 608209) inactive dipeptidyl pe ( 792) 5136 1170.5 0 NP_001171505 (OMIM: 608209) inactive dipeptidyl pe ( 800) 5131 1169.3 0 NP_065919 (OMIM: 608209) inactive dipeptidyl pepti ( 796) 5126 1168.2 0 NP_001308834 (OMIM: 608209) inactive dipeptidyl pe ( 813) 5125 1168.0 0 NP_001171507 (OMIM: 608209) inactive dipeptidyl pe ( 746) 4931 1124.1 0 NP_001308840 (OMIM: 608209) inactive dipeptidyl pe ( 746) 4931 1124.1 0 NP_001308839 (OMIM: 608209) inactive dipeptidyl pe ( 746) 4931 1124.1 0 NP_001308837 (OMIM: 608209) inactive dipeptidyl pe ( 766) 4884 1113.5 0 XP_016860055 (OMIM: 608209) PREDICTED: inactive di ( 755) 4883 1113.3 0 NP_001308838 (OMIM: 608209) inactive dipeptidyl pe ( 757) 4671 1065.4 0 NP_001308841 (OMIM: 608209) inactive dipeptidyl pe ( 681) 4476 1021.3 0 NP_001308842 (OMIM: 608209) inactive dipeptidyl pe ( 542) 3586 820.2 0 NP_001308843 (OMIM: 608209) inactive dipeptidyl pe ( 542) 3586 820.2 0 XP_016867299 (OMIM: 126141,612956,616311) PREDICTE ( 804) 2892 663.5 1e-189 XP_016867300 (OMIM: 126141,612956,616311) PREDICTE ( 804) 2892 663.5 1e-189 XP_016867298 (OMIM: 126141,612956,616311) PREDICTE ( 804) 2892 663.5 1e-189 XP_016867297 (OMIM: 126141,612956,616311) PREDICTE ( 804) 2892 663.5 1e-189 NP_570629 (OMIM: 126141,612956,616311) dipeptidyl ( 865) 2885 661.9 3.3e-189 NP_001034439 (OMIM: 126141,612956,616311) dipeptid ( 801) 2877 660.1 1.1e-188 NP_001927 (OMIM: 126141,612956,616311) dipeptidyl ( 803) 2875 659.6 1.5e-188 NP_001308836 (OMIM: 608209) inactive dipeptidyl pe ( 783) 2809 644.7 4.5e-184 XP_016860054 (OMIM: 608209) PREDICTED: inactive di ( 776) 2808 644.5 5.2e-184 XP_016867301 (OMIM: 126141,612956,616311) PREDICTE ( 657) 2417 556.1 1.8e-157 NP_001277181 (OMIM: 126141,612956,616311) dipeptid ( 758) 2270 522.9 2e-147 NP_001926 (OMIM: 102720) dipeptidyl peptidase 4 [H ( 766) 1677 388.9 4.3e-107 XP_005246428 (OMIM: 102720) PREDICTED: dipeptidyl ( 765) 1673 388.0 8e-107 NP_004451 (OMIM: 600403) prolyl endopeptidase FAP ( 760) 1617 375.4 5.1e-103 XP_011509098 (OMIM: 600403) PREDICTED: prolyl endo ( 750) 1597 370.9 1.2e-101 NP_001278736 (OMIM: 600403) prolyl endopeptidase F ( 735) 1445 336.5 2.5e-91 XP_011509099 (OMIM: 600403) PREDICTED: prolyl endo ( 491) 900 213.3 2.1e-54 XP_016859074 (OMIM: 600403) PREDICTED: prolyl endo ( 475) 854 202.9 2.7e-51 XP_011526712 (OMIM: 608258) PREDICTED: dipeptidyl ( 863) 521 127.8 2e-28 NP_631898 (OMIM: 608258) dipeptidyl peptidase 9 [H ( 892) 521 127.8 2e-28 XP_011526710 (OMIM: 608258) PREDICTED: dipeptidyl ( 892) 521 127.8 2e-28 XP_005259730 (OMIM: 608258) PREDICTED: dipeptidyl ( 892) 521 127.8 2e-28 XP_011526707 (OMIM: 608258) PREDICTED: dipeptidyl ( 946) 521 127.8 2.2e-28 XP_016882942 (OMIM: 608258) PREDICTED: dipeptidyl ( 946) 521 127.8 2.2e-28 XP_016882943 (OMIM: 608258) PREDICTED: dipeptidyl ( 946) 521 127.8 2.2e-28 XP_011526708 (OMIM: 608258) PREDICTED: dipeptidyl ( 946) 521 127.8 2.2e-28 XP_005254562 (OMIM: 606819) PREDICTED: dipeptidyl ( 479) 503 123.6 2e-27 XP_016877871 (OMIM: 606819) PREDICTED: dipeptidyl ( 514) 503 123.6 2.2e-27 XP_016877872 (OMIM: 606819) PREDICTED: dipeptidyl ( 514) 503 123.6 2.2e-27 XP_016877866 (OMIM: 606819) PREDICTED: dipeptidyl ( 781) 503 123.7 3.1e-27 XP_011520035 (OMIM: 606819) PREDICTED: dipeptidyl ( 824) 503 123.7 3.2e-27 XP_016877864 (OMIM: 606819) PREDICTED: dipeptidyl ( 839) 503 123.7 3.3e-27 XP_011520033 (OMIM: 606819) PREDICTED: dipeptidyl ( 840) 503 123.7 3.3e-27 XP_011520032 (OMIM: 606819) PREDICTED: dipeptidyl ( 855) 503 123.7 3.3e-27 NP_569118 (OMIM: 606819) dipeptidyl peptidase 8 is ( 882) 503 123.7 3.4e-27 >>NP_001308835 (OMIM: 608209) inactive dipeptidyl peptid (789 aa) initn: 5211 init1: 5211 opt: 5211 Z-score: 6358.7 bits: 1187.4 E(85289): 0 Smith-Waterman score: 5211; 99.9% identity (99.9% similar) in 789 aa overlap (1-789:1-789) 10 20 30 40 50 60 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 RLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTW :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: NP_001 LMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 HFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 QLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 FKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTAD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 TKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISV 730 740 750 760 770 780 pF1KA1 LPQEPEEDE ::::::::: NP_001 LPQEPEEDE >>NP_001004360 (OMIM: 608209) inactive dipeptidyl peptid (789 aa) initn: 5211 init1: 5211 opt: 5211 Z-score: 6358.7 bits: 1187.4 E(85289): 0 Smith-Waterman score: 5211; 99.9% identity (99.9% similar) in 789 aa overlap (1-789:1-789) 10 20 30 40 50 60 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 RLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 GERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 LMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTW :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: NP_001 LMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 LSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 ILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 HFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 QLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 GLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 FKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTAD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 TKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISV 730 740 750 760 770 780 pF1KA1 LPQEPEEDE ::::::::: NP_001 LPQEPEEDE >>NP_001171508 (OMIM: 608209) inactive dipeptidyl peptid (792 aa) initn: 5136 init1: 5136 opt: 5136 Z-score: 6267.1 bits: 1170.5 E(85289): 0 Smith-Waterman score: 5136; 99.4% identity (99.9% similar) in 781 aa overlap (9-789:12-792) 10 20 30 40 50 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNS .:...:::::::::::::::::::::::::::::::::::::::::::: NP_001 MVITEVAEGPVDGSEKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 SETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 FKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 WGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWW 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 SPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 TLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTS ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_001 TLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 DTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 VIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 MNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 LPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGS 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 GFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 EKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 TADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEE 730 740 750 760 770 780 780 pF1KA1 ISVLPQEPEEDE :::::::::::: NP_001 ISVLPQEPEEDE 790 >>NP_001171505 (OMIM: 608209) inactive dipeptidyl peptid (800 aa) initn: 5131 init1: 5131 opt: 5131 Z-score: 6260.9 bits: 1169.3 E(85289): 0 Smith-Waterman score: 5131; 99.0% identity (99.6% similar) in 784 aa overlap (6-789:17-800) 10 20 30 40 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILL :... . .:::::::::::::::::::::::::::::::::::: NP_001 MTAAKQEPQPTPGARASQAQPADQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 TPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 LENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 DSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 HSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYV 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 VNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGAC ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 VNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGAC 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 SKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 HLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCT 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 YFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIK 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 ILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIV 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 ARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYI 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 ASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKE 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 ENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKF 730 740 750 760 770 780 770 780 pF1KA1 FSDCLKEEISVLPQEPEEDE :::::::::::::::::::: NP_001 FSDCLKEEISVLPQEPEEDE 790 800 >>NP_065919 (OMIM: 608209) inactive dipeptidyl peptidase (796 aa) initn: 5126 init1: 5126 opt: 5126 Z-score: 6254.9 bits: 1168.2 E(85289): 0 Smith-Waterman score: 5126; 99.7% identity (99.9% similar) in 777 aa overlap (13-789:20-796) 10 20 30 40 50 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDE .:::::::::::::::::::::::::::::::::::::::: NP_065 MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KA1 LTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KA1 TFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KA1 QYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KA1 AHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KA1 GPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKY ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_065 GPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKY 310 320 330 340 350 360 360 370 380 390 400 410 pF1KA1 EMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KA1 GNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KA1 SFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHI 490 500 510 520 530 540 540 550 560 570 580 590 pF1KA1 DDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFD 550 560 570 580 590 600 600 610 620 630 640 650 pF1KA1 GRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMI 610 620 630 640 650 660 660 670 680 690 700 710 pF1KA1 LKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENIL 670 680 690 700 710 720 720 730 740 750 760 770 pF1KA1 IIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDC 730 740 750 760 770 780 780 pF1KA1 LKEEISVLPQEPEEDE :::::::::::::::: NP_065 LKEEISVLPQEPEEDE 790 >>NP_001308834 (OMIM: 608209) inactive dipeptidyl peptid (813 aa) initn: 5125 init1: 5125 opt: 5125 Z-score: 6253.5 bits: 1168.0 E(85289): 0 Smith-Waterman score: 5125; 99.9% identity (99.9% similar) in 776 aa overlap (14-789:38-813) 10 20 30 40 pF1KA1 MRKVESRGEGGREELGSNSPPQRNWKGIAIALLVILVVCSLIT :::::::::::::::::::::::::::::: NP_001 SWNETLSRNTRIHCCLHGPIKWSYDYFLVYELGSNSPPQRNWKGIAIALLVILVVCSLIT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KA1 MSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIET 70 80 90 100 110 120 110 120 130 140 150 160 pF1KA1 NATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWEL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KA1 NPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KA1 YEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNP 250 260 270 280 290 300 290 300 310 320 330 340 pF1KA1 TIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRPQNISILTVCE ::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::: NP_001 TIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KA1 TTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLIQSKS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KA1 EQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNF 430 440 450 460 470 480 470 480 490 500 510 520 pF1KA1 MKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKI 490 500 510 520 530 540 530 540 550 560 570 580 pF1KA1 GKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLID 550 560 570 580 590 600 590 600 610 620 630 640 pF1KA1 MDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGK 610 620 630 640 650 660 650 660 670 680 690 700 pF1KA1 GYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHN 670 680 690 700 710 720 710 720 730 740 750 760 pF1KA1 VHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLY 730 740 750 760 770 780 770 780 pF1KA1 STILKFFSDCLKEEISVLPQEPEEDE :::::::::::::::::::::::::: NP_001 STILKFFSDCLKEEISVLPQEPEEDE 790 800 810 >>NP_001171507 (OMIM: 608209) inactive dipeptidyl peptid (746 aa) initn: 4931 init1: 4931 opt: 4931 Z-score: 6017.2 bits: 1124.1 E(85289): 0 Smith-Waterman score: 4931; 99.9% identity (99.9% similar) in 746 aa overlap (44-789:1-746) 20 30 40 50 60 70 pF1KA1 ELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFV :::::::::::::::::::::::::::::: NP_001 MSVILLTPDELTNSSETRLSLEDLFRKDFV 10 20 30 80 90 100 110 120 130 pF1KA1 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KA1 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KA1 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KA1 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KA1 ITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 ITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD 280 290 300 310 320 330 380 390 400 410 420 430 pF1KA1 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF 340 350 360 370 380 390 440 450 460 470 480 490 pF1KA1 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV 400 410 420 430 440 450 500 510 520 530 540 550 pF1KA1 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KA1 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG 520 530 540 550 560 570 620 630 640 650 660 670 pF1KA1 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL 580 590 600 610 620 630 680 690 700 710 720 730 pF1KA1 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK 640 650 660 670 680 690 740 750 760 770 780 pF1KA1 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE 700 710 720 730 740 >>NP_001308840 (OMIM: 608209) inactive dipeptidyl peptid (746 aa) initn: 4931 init1: 4931 opt: 4931 Z-score: 6017.2 bits: 1124.1 E(85289): 0 Smith-Waterman score: 4931; 99.9% identity (99.9% similar) in 746 aa overlap (44-789:1-746) 20 30 40 50 60 70 pF1KA1 ELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFV :::::::::::::::::::::::::::::: NP_001 MSVILLTPDELTNSSETRLSLEDLFRKDFV 10 20 30 80 90 100 110 120 130 pF1KA1 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KA1 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KA1 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KA1 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KA1 ITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 ITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD 280 290 300 310 320 330 380 390 400 410 420 430 pF1KA1 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF 340 350 360 370 380 390 440 450 460 470 480 490 pF1KA1 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV 400 410 420 430 440 450 500 510 520 530 540 550 pF1KA1 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KA1 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG 520 530 540 550 560 570 620 630 640 650 660 670 pF1KA1 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL 580 590 600 610 620 630 680 690 700 710 720 730 pF1KA1 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK 640 650 660 670 680 690 740 750 760 770 780 pF1KA1 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE 700 710 720 730 740 >>NP_001308839 (OMIM: 608209) inactive dipeptidyl peptid (746 aa) initn: 4931 init1: 4931 opt: 4931 Z-score: 6017.2 bits: 1124.1 E(85289): 0 Smith-Waterman score: 4931; 99.9% identity (99.9% similar) in 746 aa overlap (44-789:1-746) 20 30 40 50 60 70 pF1KA1 ELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFV :::::::::::::::::::::::::::::: NP_001 MSVILLTPDELTNSSETRLSLEDLFRKDFV 10 20 30 80 90 100 110 120 130 pF1KA1 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KA1 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KA1 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KA1 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KA1 ITMVKWVSNTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 ITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRD 280 290 300 310 320 330 380 390 400 410 420 430 pF1KA1 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSKFFMTVPVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYF 340 350 360 370 380 390 440 450 460 470 480 490 pF1KA1 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPV 400 410 420 430 440 450 500 510 520 530 540 550 pF1KA1 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQ 460 470 480 490 500 510 560 570 580 590 600 610 pF1KA1 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLG 520 530 540 550 560 570 620 630 640 650 660 670 pF1KA1 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDL 580 590 600 610 620 630 680 690 700 710 720 730 pF1KA1 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIK 640 650 660 670 680 690 740 750 760 770 780 pF1KA1 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE 700 710 720 730 740 >>NP_001308837 (OMIM: 608209) inactive dipeptidyl peptid (766 aa) initn: 4884 init1: 4884 opt: 4884 Z-score: 5959.6 bits: 1113.5 E(85289): 0 Smith-Waterman score: 4884; 99.9% identity (99.9% similar) in 738 aa overlap (52-789:29-766) 30 40 50 60 70 80 pF1KA1 QRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARW :::::::::::::::::::::::::::::: NP_001 MQMDMELSWNETLSRNTRYTYMKSGFRTDELTNSSETRLSLEDLFRKDFVLHDPEARW 10 20 30 40 50 90 100 110 120 130 140 pF1KA1 INDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQI 60 70 80 90 100 110 150 160 170 180 190 200 pF1KA1 FHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKS 120 130 140 150 160 170 210 220 230 240 250 260 pF1KA1 SSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPR 180 190 200 210 220 230 270 280 290 300 310 320 pF1KA1 FTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVS 240 250 260 270 280 290 330 340 350 360 370 380 pF1KA1 NTKTVVRWLNRPQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTV ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTV 300 310 320 330 340 350 390 400 410 420 430 440 pF1KA1 PVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVKQGGRGEFHHIAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPR 360 370 380 390 400 410 450 460 470 480 490 500 pF1KA1 GRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDN 420 430 440 450 460 470 510 520 530 540 550 560 pF1KA1 PAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMD 480 490 500 510 520 530 570 580 590 600 610 620 pF1KA1 EEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQI 540 550 560 570 580 590 630 640 650 660 670 680 pF1KA1 TAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFS 600 610 620 630 640 650 690 700 710 720 730 740 pF1KA1 ERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVN 660 670 680 690 700 710 750 760 770 780 pF1KA1 YTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE 720 730 740 750 760 789 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 21:18:58 2016 done: Wed Nov 2 21:18:59 2016 Total Scan time: 11.110 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]