Result of FASTA (omim) for
pF1KA1352
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1352, 1176 aa
1>>>pF1KA1352 1176 - 1176 aa - 1176 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4751+/-0.000432; mu= 21.8101+/- 0.027
mean_var=70.6169+/-14.049, 0's: 0 Z-trim(110.6): 38 B-trim: 501 in 1/52
Lambda= 0.152623
statistics sampled from 18996 (19030) to 18996 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.223), width: 16
Scan time: 13.070
The best scores are: opt bits E(85289)
NP_064502 (OMIM: 151350,615438) leucine--tRNA liga (1176) 7936 1757.5 0
NP_001304894 (OMIM: 151350,615438) leucine--tRNA l (1122) 7582 1679.5 0
XP_011535958 (OMIM: 151350,615438) PREDICTED: leuc (1122) 7582 1679.5 0
NP_057544 (OMIM: 151350,615438) leucine--tRNA liga (1149) 7256 1607.8 0
NP_001304893 (OMIM: 151350,615438) leucine--tRNA l (1130) 6953 1541.0 0
NP_038203 (OMIM: 600709,617093) isoleucine--tRNA l (1262) 173 48.2 0.0004
NP_002152 (OMIM: 600709,617093) isoleucine--tRNA l (1262) 173 48.2 0.0004
XP_016861531 (OMIM: 604544,615300,617021) PREDICTE ( 804) 161 45.4 0.0017
XP_011531856 (OMIM: 604544,615300,617021) PREDICTE ( 830) 161 45.4 0.0017
NP_056155 (OMIM: 604544,615300,617021) probable le ( 903) 161 45.5 0.0019
XP_005265063 (OMIM: 604544,615300,617021) PREDICTE ( 903) 161 45.5 0.0019
>>NP_064502 (OMIM: 151350,615438) leucine--tRNA ligase, (1176 aa)
initn: 7936 init1: 7936 opt: 7936 Z-score: 9433.5 bits: 1757.5 E(85289): 0
Smith-Waterman score: 7936; 100.0% identity (100.0% similar) in 1176 aa overlap (1-1176:1-1176)
10 20 30 40 50 60
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
1090 1100 1110 1120 1130 1140
1150 1160 1170
pF1KA1 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
::::::::::::::::::::::::::::::::::::
NP_064 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
1150 1160 1170
>>NP_001304894 (OMIM: 151350,615438) leucine--tRNA ligas (1122 aa)
initn: 7582 init1: 7582 opt: 7582 Z-score: 9012.5 bits: 1679.5 E(85289): 0
Smith-Waterman score: 7582; 100.0% identity (100.0% similar) in 1122 aa overlap (55-1176:1-1122)
30 40 50 60 70 80
pF1KA1 DTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCC
::::::::::::::::::::::::::::::
NP_001 MNGRLHLGHTFSLSKCEFAVGYQRLKGKCC
10 20 30
90 100 110 120 130 140
pF1KA1 LFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA1 SKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA1 FITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEY
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA1 TLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIF
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA1 ICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDK
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA1 GTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVT
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA1 ICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDA
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA1 LIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEAT
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA1 LGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLG
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA1 IRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA1 YLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA1 DAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAG
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA1 IIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA1 HLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKK
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA1 TDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKK
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA1 YMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEA
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KA1 EDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMN
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KA1 RGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIR
1060 1070 1080 1090 1100 1110
1170
pF1KA1 VDIGDTIIYLVH
::::::::::::
NP_001 VDIGDTIIYLVH
1120
>>XP_011535958 (OMIM: 151350,615438) PREDICTED: leucine- (1122 aa)
initn: 7582 init1: 7582 opt: 7582 Z-score: 9012.5 bits: 1679.5 E(85289): 0
Smith-Waterman score: 7582; 100.0% identity (100.0% similar) in 1122 aa overlap (55-1176:1-1122)
30 40 50 60 70 80
pF1KA1 DTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCC
::::::::::::::::::::::::::::::
XP_011 MNGRLHLGHTFSLSKCEFAVGYQRLKGKCC
10 20 30
90 100 110 120 130 140
pF1KA1 LFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA1 SKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA1 FITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEY
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA1 TLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIF
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA1 ICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDK
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA1 GTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVT
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA1 ICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDA
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA1 LIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEAT
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA1 LGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLG
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA1 IRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA1 YLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA1 DAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAG
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA1 IIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA1 HLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKK
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA1 TDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKK
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA1 YMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEA
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KA1 EDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMN
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KA1 RGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIR
1060 1070 1080 1090 1100 1110
1170
pF1KA1 VDIGDTIIYLVH
::::::::::::
XP_011 VDIGDTIIYLVH
1120
>>NP_057544 (OMIM: 151350,615438) leucine--tRNA ligase, (1149 aa)
initn: 7256 init1: 7256 opt: 7256 Z-score: 8624.4 bits: 1607.8 E(85289): 0
Smith-Waterman score: 7665; 97.7% identity (97.7% similar) in 1176 aa overlap (1-1176:1-1149)
10 20 30 40 50 60
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
::::::::::: ::::::::::::::::::::::
NP_057 LGHTFSLSKCE---------------------------ACADKLKREIELYGCPPDFPDE
70 80 90
130 140 150 160 170 180
pF1KA1 EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA1 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA1 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA1 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA1 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
520 530 540 550 560 570
610 620 630 640 650 660
pF1KA1 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
580 590 600 610 620 630
670 680 690 700 710 720
pF1KA1 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
640 650 660 670 680 690
730 740 750 760 770 780
pF1KA1 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
700 710 720 730 740 750
790 800 810 820 830 840
pF1KA1 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
760 770 780 790 800 810
850 860 870 880 890 900
pF1KA1 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
820 830 840 850 860 870
910 920 930 940 950 960
pF1KA1 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KA1 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KA1 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KA1 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
1060 1070 1080 1090 1100 1110
1150 1160 1170
pF1KA1 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
::::::::::::::::::::::::::::::::::::
NP_057 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
1120 1130 1140
>>NP_001304893 (OMIM: 151350,615438) leucine--tRNA ligas (1130 aa)
initn: 6953 init1: 6953 opt: 6953 Z-score: 8264.0 bits: 1541.0 E(85289): 0
Smith-Waterman score: 7526; 96.1% identity (96.1% similar) in 1176 aa overlap (1-1176:1-1130)
10 20 30 40 50 60
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
::::::::::::::::::::::::::::::::::::::
NP_001 LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIK----------------------
70 80 90
130 140 150 160 170 180
pF1KA1 EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
::::::::::::::::::::::::::::::::::::
NP_001 ------------------------SKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
100 110 120 130
190 200 210 220 230 240
pF1KA1 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
140 150 160 170 180 190
250 260 270 280 290 300
pF1KA1 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
200 210 220 230 240 250
310 320 330 340 350 360
pF1KA1 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
260 270 280 290 300 310
370 380 390 400 410 420
pF1KA1 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
320 330 340 350 360 370
430 440 450 460 470 480
pF1KA1 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
380 390 400 410 420 430
490 500 510 520 530 540
pF1KA1 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
440 450 460 470 480 490
550 560 570 580 590 600
pF1KA1 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA1 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
560 570 580 590 600 610
670 680 690 700 710 720
pF1KA1 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KA1 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
680 690 700 710 720 730
790 800 810 820 830 840
pF1KA1 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
740 750 760 770 780 790
850 860 870 880 890 900
pF1KA1 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
800 810 820 830 840 850
910 920 930 940 950 960
pF1KA1 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KA1 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KA1 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
980 990 1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA1 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
1040 1050 1060 1070 1080 1090
1150 1160 1170
pF1KA1 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
::::::::::::::::::::::::::::::::::::
NP_001 ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
1100 1110 1120 1130
>>NP_038203 (OMIM: 600709,617093) isoleucine--tRNA ligas (1262 aa)
initn: 117 init1: 73 opt: 173 Z-score: 195.1 bits: 48.2 E(85289): 0.0004
Smith-Waterman score: 213; 21.0% identity (46.8% similar) in 1136 aa overlap (17-1073:15-992)
10 20 30 40 50
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKY-FVTFPYPYMNGRL
:..: . : :: :. :... : :. : : :. .:
NP_038 MLQQVPENINFPAEEEKILEFW-TE--FNCFQECLKQSKHKPKFTFYDGP-PFATGLP
10 20 30 40 50
60 70 80 90 100 110
pF1KA1 HLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPD
: :: .. . .... : . .: :: : :.:.. :: . . : :
NP_038 HYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKT---LGIRG-P-----
60 70 80 90 100
120 130 140 150 160 170
pF1KA1 EEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEH
::. :: : ..:. . ... ....: ::
NP_038 ------------EDV--------------AKMGITEYN-NQCRAI------VMRYS-AE-
110 120 130
180 190 200 210 220 230
pF1KA1 WLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTI
: . ..:.: .:. .. : . : . : : : : ... . : .
NP_038 W--------KSTVSRLGRWIDFDNDYKT--LYPQFMESVWWVFKQLYDKGLVYRGVKVMP
140 150 160 170 180
240 250 260 270 280 290
pF1KA1 YSPKDGQPCMDHDRQTGEGVGPQEYTLLKL-KVLEPYPSKLSGLKGKNIFLVAATLRPET
.: . : . . . :.: .. .:. .: . . ... ::: : : :
NP_038 FSTACNTPLSNFESH-------QNYKDVQDPSVFVTFPLE----EDETVSLVAWTTTPWT
190 200 210 220
300 310 320 330 340 350
pF1KA1 MFGQTNCWVRPDMKYIGFETVN-GDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEI
. .. : :.:.:. .. : : ..: . :: . . .: ..... : .
NP_038 LPSNLAVCVNPEMQYVKIKDVARGRLLILME--ARLSALYKLESD---YEILERFPGAYL
230 240 250 260 270 280
360 370 380 390 400 410
pF1KA1 LGASLSAPLTSY----KVIYVLPMLT---IKEDKGTGVVTSVPSDSPDDIAALRDLKKKQ
: . :: .: : .. .:. .::..::::: ..: . .: . :..
NP_038 KGKKYR-PLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNI--
290 300 310 320 330 340
420 430 440 450 460 470
pF1KA1 ALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLK
:: : :: :: . : : .
NP_038 -------IRKDS-LPVCPV---DASG---------CFTTE--------------------
350 360
480 490 500 510 520
pF1KA1 GFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMS--RSSDECVVALCD
: : :: :.:. :.: . . . : :. .. ::. .
NP_038 --------VTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVP
370 380 390 400 410
530 540 550 560 570 580
pF1KA1 QWYLDYGEENWKKQTSQCLKN--LETFCEETRRNFEATLG-WLQEH---ACSRTYGLGTH
.:.. :: ...: :.: : . : : : .: ::.. . ::. ::
NP_038 SWFVRV--EN---MVDQLLRNNDLCYWVPELVR--EKRFGNWLKDARDWTISRNRYWGTP
420 430 440 450 460
590 600 610 620 630
pF1KA1 LPWDEQWLIESLSDSTIYMAFYTVAHL--LQGG---NLHGQAESPLGIRPQQMTK-----
.: :. ... . . . .::.: :.:. .:: .. . : : :.. :
NP_038 IPL---WVSDDFEE---VVCIGSVAELEELSGAKISDLHRESVDHLTI-PSRCGKGSLHR
470 480 490 500 510
640 650 660 670 680 690
pF1KA1 --EVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHV
::.: .:. . .: .:. . ... :.::: .:.:. . : : . . . : .
NP_038 ISEVFD-CWFESGSMPYAQV-HYPFEN-KREFEDAFPADFIAEGIDQTRGWFYTLLVLAT
520 530 540 550 560 570
700 710 720 730 740
pF1KA1 AMWPEQSDKWPTAVRANGHLLL-NSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDT
:.. . : : .:: .: ...:::: :. .. :.:..::..:: : .. .
NP_038 ALFGQPPFK---NVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVV
580 590 600 610 620 630
750 760 770 780 790
pF1KA1 -VEDANFVE-AMADAGILRLYTWVEWVK---------------EMVANWDSLRSGPASTF
.:. : : .. :. : : . . :.. : ...: .: :
NP_038 RAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNIT-
640 650 660 670 680 690
800 810 820 830 840
pF1KA1 NDRVFASELNA--GIIKTDQNYEKMMFKEALKTGFFEFQA---AKDKYRELAVE-GMHR-
:: . : ... :...:.. ... . : .. . .. . :.: : ::.
NP_038 -DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDC
700 710 720 730 740 750
850 860 870 880 890
pF1KA1 ----ELVFRFIEVQTLLLAPFCPHLCEHIWT---LLGKPDSI-----MNASWPVAGPVNE
: .: . :.::. : : : .. .: : :. .. . . : :
NP_038 VMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVRE
760 770 780 790 800 810
900 910 920 930 940
pF1KA1 VLIHSS--------QYLMEVTHDLRLR----LKNYMMPAKGKKTDKQPLQKPSHCTIYVA
:: .. : ..:. . .: : .: . . : . :. . :.
NP_038 ELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYII
820 830 840 850 860 870
950 960 970 980 990 1000
pF1KA1 KNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLE
.. ...:::. .... ::. :....: . .: : .. . . :...
NP_038 EELNV-RKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGA--FKAVMTSIKQLSSEELEQFQ
880 890 900 910 920
1010 1020 1030 1040 1050 1060
pF1KA1 KMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVF
: : ... . :: :: .. :.. ..:.. :.:. . : : . .
NP_038 KTGTIVVEGHELHDEDIRLMYTFDQATGGTA--QFEAH--SDAQALVLLDVTPDQSM---
930 940 950 960 970 980
1070 1080 1090 1100 1110 1120
pF1KA1 RIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDP
.. :.. ..:
NP_038 -VDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAP
990 1000 1010 1020 1030 1040
>>NP_002152 (OMIM: 600709,617093) isoleucine--tRNA ligas (1262 aa)
initn: 117 init1: 73 opt: 173 Z-score: 195.1 bits: 48.2 E(85289): 0.0004
Smith-Waterman score: 213; 21.0% identity (46.8% similar) in 1136 aa overlap (17-1073:15-992)
10 20 30 40 50
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKY-FVTFPYPYMNGRL
:..: . : :: :. :... : :. : : :. .:
NP_002 MLQQVPENINFPAEEEKILEFW-TE--FNCFQECLKQSKHKPKFTFYDGP-PFATGLP
10 20 30 40 50
60 70 80 90 100 110
pF1KA1 HLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPD
: :: .. . .... : . .: :: : :.:.. :: . . : :
NP_002 HYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKT---LGIRG-P-----
60 70 80 90 100
120 130 140 150 160 170
pF1KA1 EEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEH
::. :: : ..:. . ... ....: ::
NP_002 ------------EDV--------------AKMGITEYN-NQCRAI------VMRYS-AE-
110 120 130
180 190 200 210 220 230
pF1KA1 WLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTI
: . ..:.: .:. .. : . : . : : : : ... . : .
NP_002 W--------KSTVSRLGRWIDFDNDYKT--LYPQFMESVWWVFKQLYDKGLVYRGVKVMP
140 150 160 170 180
240 250 260 270 280 290
pF1KA1 YSPKDGQPCMDHDRQTGEGVGPQEYTLLKL-KVLEPYPSKLSGLKGKNIFLVAATLRPET
.: . : . . . :.: .. .:. .: . . ... ::: : : :
NP_002 FSTACNTPLSNFESH-------QNYKDVQDPSVFVTFPLE----EDETVSLVAWTTTPWT
190 200 210 220
300 310 320 330 340 350
pF1KA1 MFGQTNCWVRPDMKYIGFETVN-GDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEI
. .. : :.:.:. .. : : ..: . :: . . .: ..... : .
NP_002 LPSNLAVCVNPEMQYVKIKDVARGRLLILME--ARLSALYKLESD---YEILERFPGAYL
230 240 250 260 270 280
360 370 380 390 400 410
pF1KA1 LGASLSAPLTSY----KVIYVLPMLT---IKEDKGTGVVTSVPSDSPDDIAALRDLKKKQ
: . :: .: : .. .:. .::..::::: ..: . .: . :..
NP_002 KGKKYR-PLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNI--
290 300 310 320 330 340
420 430 440 450 460 470
pF1KA1 ALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLK
:: : :: :: . : : .
NP_002 -------IRKDS-LPVCPV---DASG---------CFTTE--------------------
350 360
480 490 500 510 520
pF1KA1 GFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMS--RSSDECVVALCD
: : :: :.:. :.: . . . : :. .. ::. .
NP_002 --------VTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVP
370 380 390 400 410
530 540 550 560 570 580
pF1KA1 QWYLDYGEENWKKQTSQCLKN--LETFCEETRRNFEATLG-WLQEH---ACSRTYGLGTH
.:.. :: ...: :.: : . : : : .: ::.. . ::. ::
NP_002 SWFVRV--EN---MVDQLLRNNDLCYWVPELVR--EKRFGNWLKDARDWTISRNRYWGTP
420 430 440 450 460
590 600 610 620 630
pF1KA1 LPWDEQWLIESLSDSTIYMAFYTVAHL--LQGG---NLHGQAESPLGIRPQQMTK-----
.: :. ... . . . .::.: :.:. .:: .. . : : :.. :
NP_002 IPL---WVSDDFEE---VVCIGSVAELEELSGAKISDLHRESVDHLTI-PSRCGKGSLHR
470 480 490 500 510
640 650 660 670 680 690
pF1KA1 --EVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHV
::.: .:. . .: .:. . ... :.::: .:.:. . : : . . . : .
NP_002 ISEVFD-CWFESGSMPYAQV-HYPFEN-KREFEDAFPADFIAEGIDQTRGWFYTLLVLAT
520 530 540 550 560 570
700 710 720 730 740
pF1KA1 AMWPEQSDKWPTAVRANGHLLL-NSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDT
:.. . : : .:: .: ...:::: :. .. :.:..::..:: : .. .
NP_002 ALFGQPPFK---NVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVV
580 590 600 610 620 630
750 760 770 780 790
pF1KA1 -VEDANFVE-AMADAGILRLYTWVEWVK---------------EMVANWDSLRSGPASTF
.:. : : .. :. : : . . :.. : ...: .: :
NP_002 RAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNIT-
640 650 660 670 680 690
800 810 820 830 840
pF1KA1 NDRVFASELNA--GIIKTDQNYEKMMFKEALKTGFFEFQA---AKDKYRELAVE-GMHR-
:: . : ... :...:.. ... . : .. . .. . :.: : ::.
NP_002 -DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDC
700 710 720 730 740 750
850 860 870 880 890
pF1KA1 ----ELVFRFIEVQTLLLAPFCPHLCEHIWT---LLGKPDSI-----MNASWPVAGPVNE
: .: . :.::. : : : .. .: : :. .. . . : :
NP_002 VMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVRE
760 770 780 790 800 810
900 910 920 930 940
pF1KA1 VLIHSS--------QYLMEVTHDLRLR----LKNYMMPAKGKKTDKQPLQKPSHCTIYVA
:: .. : ..:. . .: : .: . . : . :. . :.
NP_002 ELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYII
820 830 840 850 860 870
950 960 970 980 990 1000
pF1KA1 KNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLE
.. ...:::. .... ::. :....: . .: : .. . . :...
NP_002 EELNV-RKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGA--FKAVMTSIKQLSSEELEQFQ
880 890 900 910 920
1010 1020 1030 1040 1050 1060
pF1KA1 KMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVF
: : ... . :: :: .. :.. ..:.. :.:. . : : . .
NP_002 KTGTIVVEGHELHDEDIRLMYTFDQATGGTA--QFEAH--SDAQALVLLDVTPDQSM---
930 940 950 960 970 980
1070 1080 1090 1100 1110 1120
pF1KA1 RIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDP
.. :.. ..:
NP_002 -VDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAP
990 1000 1010 1020 1030 1040
>>XP_016861531 (OMIM: 604544,615300,617021) PREDICTED: p (804 aa)
initn: 294 init1: 114 opt: 161 Z-score: 183.7 bits: 45.4 E(85289): 0.0017
Smith-Waterman score: 161; 26.4% identity (59.3% similar) in 91 aa overlap (11-101:50-139)
10 20 30 40
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQ
.. . .:... :: .:. : .. : .
XP_016 NGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE-KWWHQRIKEQASKISEAD
20 30 40 50 60 70
50 60 70 80 90 100
pF1KA1 TSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKAC
:: :..: .:: .:.::.::. . . . .:...: . :.: :.: .
XP_016 KSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KA1 ADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGI
:
XP_016 AVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLA
140 150 160 170 180 190
>>XP_011531856 (OMIM: 604544,615300,617021) PREDICTED: p (830 aa)
initn: 294 init1: 114 opt: 161 Z-score: 183.5 bits: 45.4 E(85289): 0.0017
Smith-Waterman score: 161; 26.4% identity (59.3% similar) in 91 aa overlap (11-101:50-139)
10 20 30 40
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQ
.. . .:... :: .:. : .. : .
XP_011 NGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE-KWWHQRIKEQASKISEAD
20 30 40 50 60 70
50 60 70 80 90 100
pF1KA1 TSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKAC
:: :..: .:: .:.::.::. . . . .:...: . :.: :.: .
XP_011 KSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KA1 ADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGI
:
XP_011 AVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLA
140 150 160 170 180 190
>>NP_056155 (OMIM: 604544,615300,617021) probable leucin (903 aa)
initn: 295 init1: 114 opt: 161 Z-score: 183.0 bits: 45.5 E(85289): 0.0019
Smith-Waterman score: 161; 26.4% identity (59.3% similar) in 91 aa overlap (11-101:50-139)
10 20 30 40
pF1KA1 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQ
.. . .:... :: .:. : .. : .
NP_056 NGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE-KWWHQRIKEQASKISEAD
20 30 40 50 60 70
50 60 70 80 90 100
pF1KA1 TSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKAC
:: :..: .:: .:.::.::. . . . .:...: . :.: :.: .
NP_056 KSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENA
80 90 100 110 120 130
110 120 130 140 150 160
pF1KA1 ADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGI
:
NP_056 AVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLA
140 150 160 170 180 190
1176 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 11:02:07 2016 done: Thu Nov 3 11:02:09 2016
Total Scan time: 13.070 Total Display time: 0.420
Function used was FASTA [36.3.4 Apr, 2011]