Result of FASTA (omim) for
pF1KA1336
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1336, 1181 aa
1>>>pF1KA1336 1181 - 1181 aa - 1181 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0038+/-0.000586; mu= 18.7414+/- 0.036
mean_var=81.1263+/-16.488, 0's: 0 Z-trim(107.1): 78 B-trim: 485 in 1/47
Lambda= 0.142395
statistics sampled from 15082 (15148) to 15082 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.502), E-opt: 0.2 (0.178), width: 16
Scan time: 11.780
The best scores are: opt bits E(85289)
NP_001006658 (OMIM: 613602,613610,614091) WD repea (1181) 7904 1634.9 0
NP_065830 (OMIM: 613602,613610,614091) WD repeat-c (1170) 5092 1057.2 0
XP_011531309 (OMIM: 613602,613610,614091) PREDICTE ( 746) 4918 1021.4 0
XP_016862326 (OMIM: 218330,606045) PREDICTED: intr ( 800) 212 54.6 2.9e-06
XP_016862324 (OMIM: 218330,606045) PREDICTED: intr (1059) 212 54.7 3.7e-06
XP_016862320 (OMIM: 218330,606045) PREDICTED: intr (1118) 212 54.7 3.8e-06
XP_016862321 (OMIM: 218330,606045) PREDICTED: intr (1118) 212 54.7 3.8e-06
XP_016862319 (OMIM: 218330,606045) PREDICTED: intr (1118) 212 54.7 3.8e-06
NP_443716 (OMIM: 218330,606045) intraflagellar tra (1131) 212 54.7 3.9e-06
XP_016862317 (OMIM: 218330,606045) PREDICTED: intr (1157) 212 54.7 4e-06
XP_005247666 (OMIM: 218330,606045) PREDICTED: intr (1183) 212 54.7 4e-06
XP_016862312 (OMIM: 218330,606045) PREDICTED: intr (1209) 212 54.7 4.1e-06
XP_016862311 (OMIM: 218330,606045) PREDICTED: intr (1216) 212 54.7 4.1e-06
NP_001267470 (OMIM: 218330,606045) intraflagellar (1234) 212 54.7 4.2e-06
XP_006713752 (OMIM: 218330,606045) PREDICTED: intr (1242) 212 54.7 4.2e-06
XP_016862306 (OMIM: 218330,606045) PREDICTED: intr (1268) 212 54.7 4.3e-06
XP_016862327 (OMIM: 218330,606045) PREDICTED: intr ( 773) 207 53.6 5.7e-06
XP_011511274 (OMIM: 218330,606045) PREDICTED: intr ( 975) 208 53.9 6e-06
NP_001267475 (OMIM: 218330,606045) intraflagellar (1032) 207 53.7 7.3e-06
NP_001267474 (OMIM: 218330,606045) intraflagellar (1091) 207 53.7 7.7e-06
XP_016862318 (OMIM: 218330,606045) PREDICTED: intr (1130) 207 53.7 7.9e-06
NP_060732 (OMIM: 218330,606045) intraflagellar tra (1182) 207 53.7 8.2e-06
XP_016862313 (OMIM: 218330,606045) PREDICTED: intr (1208) 207 53.7 8.4e-06
NP_443715 (OMIM: 218330,606045) intraflagellar tra (1241) 207 53.7 8.6e-06
XP_016862307 (OMIM: 218330,606045) PREDICTED: intr (1267) 207 53.7 8.7e-06
NP_443711 (OMIM: 218330,606045) intraflagellar tra (1292) 207 53.7 8.9e-06
XP_006713758 (OMIM: 218330,606045) PREDICTED: intr ( 877) 167 45.4 0.0019
XP_011544016 (OMIM: 605000,615401) PREDICTED: coro ( 461) 162 44.2 0.0022
NP_001180262 (OMIM: 605000,615401) coronin-1A [Hom ( 461) 162 44.2 0.0022
NP_009005 (OMIM: 605000,615401) coronin-1A [Homo s ( 461) 162 44.2 0.0022
XP_016878374 (OMIM: 605000,615401) PREDICTED: coro ( 463) 162 44.2 0.0022
XP_016878375 (OMIM: 605000,615401) PREDICTED: coro ( 463) 162 44.2 0.0022
NP_065174 (OMIM: 609849) coronin-1B [Homo sapiens] ( 489) 161 44.1 0.0027
NP_001018080 (OMIM: 609849) coronin-1B [Homo sapie ( 489) 161 44.1 0.0027
>>NP_001006658 (OMIM: 613602,613610,614091) WD repeat-co (1181 aa)
initn: 7904 init1: 7904 opt: 7904 Z-score: 8770.9 bits: 1634.9 E(85289): 0
Smith-Waterman score: 7904; 100.0% identity (100.0% similar) in 1181 aa overlap (1-1181:1-1181)
10 20 30 40 50 60
pF1KA1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180
pF1KA1 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
:::::::::::::::::::::::::::::::::::::::::
NP_001 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
1150 1160 1170 1180
>>NP_065830 (OMIM: 613602,613610,614091) WD repeat-conta (1170 aa)
initn: 7821 init1: 5092 opt: 5092 Z-score: 5648.9 bits: 1057.2 E(85289): 0
Smith-Waterman score: 7803; 99.1% identity (99.1% similar) in 1181 aa overlap (1-1181:1-1170)
10 20 30 40 50 60
pF1KA1 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVVRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANGEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQIMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGTLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCVVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGT
:::::::::::::::::::::::::::::::::::::: :::::::::::
NP_065 WDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQ-----------FVLVLCNSIGT
370 380 390 400
430 440 450 460 470 480
pF1KA1 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIY
410 420 430 440 450 460
490 500 510 520 530 540
pF1KA1 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQKY
470 480 490 500 510 520
550 560 570 580 590 600
pF1KA1 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KA1 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNK
590 600 610 620 630 640
670 680 690 700 710 720
pF1KA1 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFV
650 660 670 680 690 700
730 740 750 760 770 780
pF1KA1 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLGDW
710 720 730 740 750 760
790 800 810 820 830 840
pF1KA1 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLE
770 780 790 800 810 820
850 860 870 880 890 900
pF1KA1 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQWNK
830 840 850 860 870 880
910 920 930 940 950 960
pF1KA1 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEAKK
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KA1 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDRFT
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KA1 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACASRA
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KA1 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTC
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180
pF1KA1 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
:::::::::::::::::::::::::::::::::::::::::
NP_065 VATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
1130 1140 1150 1160 1170
>>XP_011531309 (OMIM: 613602,613610,614091) PREDICTED: W (746 aa)
initn: 4918 init1: 4918 opt: 4918 Z-score: 5458.8 bits: 1021.4 E(85289): 0
Smith-Waterman score: 4918; 100.0% identity (100.0% similar) in 746 aa overlap (436-1181:1-746)
410 420 430 440 450 460
pF1KA1 FGATFVLVLCNSIGTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEI
::::::::::::::::::::::::::::::
XP_011 MTKTHVIAASKEAFYTWQYRVAKKLTALEI
10 20 30
470 480 490 500 510 520
pF1KA1 NQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQITRSRKEGRERIYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGT
40 50 60 70 80 90
530 540 550 560 570 580
pF1KA1 IQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVV
100 110 120 130 140 150
590 600 610 620 630 640
pF1KA1 GELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKS
160 170 180 190 200 210
650 660 670 680 690 700
pF1KA1 VLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEA
220 230 240 250 260 270
710 720 730 740 750 760
pF1KA1 ALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALQKLDLYTAEQAFVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMD
280 290 300 310 320 330
770 780 790 800 810 820
pF1KA1 RRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQ
340 350 360 370 380 390
830 840 850 860 870 880
pF1KA1 GRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRNQERLAECYYMLEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQP
400 410 420 430 440 450
890 900 910 920 930 940
pF1KA1 KAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFD
460 470 480 490 500 510
950 960 970 980 990 1000
pF1KA1 AAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAKLMFKIADEEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALA
520 530 540 550 560 570
1010 1020 1030 1040 1050 1060
pF1KA1 GLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPV
580 590 600 610 620 630
1070 1080 1090 1100 1110 1120
pF1KA1 EIYSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIYSLLALCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPE
640 650 660 670 680 690
1130 1140 1150 1160 1170 1180
pF1KA1 LDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
700 710 720 730 740
>>XP_016862326 (OMIM: 218330,606045) PREDICTED: intrafla (800 aa)
initn: 149 init1: 100 opt: 212 Z-score: 233.5 bits: 54.6 E(85289): 2.9e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:20-612)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 MESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
10 20 30 40
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
50 60 70 80 90
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
100 110 120 130 140 150
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
160 170 180 190 200
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
210 220 230 240 250 260
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
270 280 290 300 310
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
320 330 340 350 360 370
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
380 390 400 410 420 430
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
440 450 460 470 480 490
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
500 510 520 530
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
540 550 560 570 580
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
590 600 610 620 630 640
>>XP_016862324 (OMIM: 218330,606045) PREDICTED: intrafla (1059 aa)
initn: 188 init1: 100 opt: 212 Z-score: 231.6 bits: 54.7 E(85289): 3.7e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:279-871)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
250 260 270 280 290 300
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
310 320 330 340 350
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
360 370 380 390 400 410
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
420 430 440 450 460
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
470 480 490 500 510
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
520 530 540 550 560 570
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
580 590 600 610 620 630
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
640 650 660 670 680 690
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
700 710 720 730 740
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
750 760 770 780 790
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
800 810 820 830 840
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
850 860 870 880 890 900
>>XP_016862320 (OMIM: 218330,606045) PREDICTED: intrafla (1118 aa)
initn: 188 init1: 100 opt: 212 Z-score: 231.3 bits: 54.7 E(85289): 3.8e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:338-930)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
310 320 330 340 350 360
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
370 380 390 400 410
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
420 430 440 450 460 470
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
480 490 500 510
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
520 530 540 550 560 570
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
580 590 600 610 620 630
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
640 650 660 670 680 690
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
760 770 780 790 800
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
810 820 830 840 850
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
860 870 880 890 900
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
910 920 930 940 950 960
>>XP_016862321 (OMIM: 218330,606045) PREDICTED: intrafla (1118 aa)
initn: 188 init1: 100 opt: 212 Z-score: 231.3 bits: 54.7 E(85289): 3.8e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:338-930)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
310 320 330 340 350 360
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
370 380 390 400 410
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
420 430 440 450 460 470
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
480 490 500 510
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
520 530 540 550 560 570
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
580 590 600 610 620 630
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
640 650 660 670 680 690
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
760 770 780 790 800
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
810 820 830 840 850
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
860 870 880 890 900
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
910 920 930 940 950 960
>>XP_016862319 (OMIM: 218330,606045) PREDICTED: intrafla (1118 aa)
initn: 188 init1: 100 opt: 212 Z-score: 231.3 bits: 54.7 E(85289): 3.8e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:338-930)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
310 320 330 340 350 360
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
370 380 390 400 410
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
420 430 440 450 460 470
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
480 490 500 510
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
520 530 540 550 560 570
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
580 590 600 610 620 630
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
640 650 660 670 680 690
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
760 770 780 790 800
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
810 820 830 840 850
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
860 870 880 890 900
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
910 920 930 940 950 960
>>NP_443716 (OMIM: 218330,606045) intraflagellar transpo (1131 aa)
initn: 232 init1: 100 opt: 212 Z-score: 231.2 bits: 54.7 E(85289): 3.9e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:377-969)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
NP_443 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
350 360 370 380 390 400
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
NP_443 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
410 420 430 440 450
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
NP_443 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
460 470 480 490 500
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
NP_443 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
510 520 530 540 550
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
NP_443 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
560 570 580 590 600 610
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
NP_443 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
620 630 640 650 660 670
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
NP_443 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
680 690 700 710 720 730
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
NP_443 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
740 750 760 770 780 790
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
NP_443 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
800 810 820 830 840
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
NP_443 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
850 860 870 880 890
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
NP_443 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
900 910 920 930 940
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
NP_443 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
950 960 970 980 990 1000
>>XP_016862317 (OMIM: 218330,606045) PREDICTED: intrafla (1157 aa)
initn: 232 init1: 100 opt: 212 Z-score: 231.0 bits: 54.7 E(85289): 4e-06
Smith-Waterman score: 257; 20.7% identity (51.4% similar) in 657 aa overlap (517-1160:377-969)
490 500 510 520 530 540
pF1KA1 SGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPN----VGLIQKYSL
:.:: ..: : . . : : : : ..
XP_016 SFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAV
350 360 370 380 390 400
550 560 570 580 590 600
pF1KA1 NCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWDMKWA
: :... . ..::..: . . .:.:.. ::: ... .. .. :
XP_016 RC----LDMSASRKKLAVVDENDTCLVYDIDTK-----------ELL-FQEPNANSVAWN
410 420 430 440 450
610 620 630 640 650 660
pF1KA1 KDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPNKDY
. :.. . . . . : . . .:.. ... .: . . : . : :..
XP_016 TQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSI-SAVEVPQSAP
460 470 480 490 500
670 680 690 700 710 720
pF1KA1 LINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQAFVRC
. .. :.: : .:. :.. :: :: ::. ::. ::..::.:
XP_016 MYQYLDRKLFKEAYQIACLGVTDTD-----------WRELAMEALEGLDFETAKKAFIRV
510 520 530 540 550
730 740 750 760 770
pF1KA1 KDYQGIKFV------KRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLK
.: . .... :. :. .... :.: .: :.:.:: . : . ...::. .
XP_016 QDLRYLELISSIEERKKRGET-NNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTD
560 570 580 590 600 610
780 790 800 810 820 830
pF1KA1 LGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECY
: . . ..: :::: .. . ...: :. . .. ::..:... .. . :
XP_016 LCMFEYAKDFL--GSGDPKETKMLITKQA--DWARNIKEPKAAVEMYISAGEHVKAIEIC
620 630 640 650 660 670
840 850 860 870 880 890
pF1KA1 YMLEDYEGLENLAISLPENHKL-LPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHL
. : ..: .: . .. : : .. .. :. ..:: .. :. :. :.
XP_016 GDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVET
680 690 700 710 720 730
900 910 920 930 940 950
pF1KA1 NQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIAD
..:..: :...: . .. ::. : :... .: . ..::. .:.... ....
XP_016 QRWDEAFALGEKHP-EFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTN
740 750 760 770 780 790
960 970 980 990 1000 1010
pF1KA1 EEAKKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLST
. . .. . ..:: .. : ::. . :: . . :: : . .
XP_016 NAVAESRFNDAAYYYWMLSMQCLDI--AQADPAQKDTMLGKFYH-FQRLAELYHG--YHA
800 810 820 830 840
1020 1030 1040 1050 1060 1070
pF1KA1 TDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCA
: :.. . . .: ... :. .: :: . : :.: :: .
XP_016 IHRHTEDPFSVHRPETLFNISRFLLH------SLP-----KDTPSGISKVKILFTLAKQS
850 860 870 880 890
1080 1090 1100 1110 1120 1130
pF1KA1 CASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEG
: :. .:. ::..: . ::. . : .: .. :: :: :
XP_016 KALGAYRLARHAYDKLRGLYIPARFQKS----IELGTLTIRA-----KPFHDS-----EE
900 910 920 930 940
1140 1150 1160 1170 1180
pF1KA1 KLPTCV--ATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG
.: : .:..:. . .: :..
XP_016 LVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLID
950 960 970 980 990 1000
1181 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 10:55:13 2016 done: Thu Nov 3 10:55:15 2016
Total Scan time: 11.780 Total Display time: 0.350
Function used was FASTA [36.3.4 Apr, 2011]