Result of FASTA (omim) for
pF1KA1286
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1286, 1205 aa
1>>>pF1KA1286 1205 - 1205 aa - 1205 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.8839+/-0.000428; mu= -8.1502+/- 0.027
mean_var=328.9109+/-67.816, 0's: 0 Z-trim(122.4): 110 B-trim: 1890 in 2/53
Lambda= 0.070719
statistics sampled from 40371 (40529) to 40371 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.475), width: 16
Scan time: 19.680
The best scores are: opt bits E(85289)
XP_005249067 (OMIM: 616856) PREDICTED: bromodomain (1205) 8177 848.9 0
XP_011512791 (OMIM: 616856) PREDICTED: bromodomain (1205) 8177 848.9 0
NP_056510 (OMIM: 616856) bromodomain and PHD finge (1205) 8177 848.9 0
XP_005249068 (OMIM: 616856) PREDICTED: bromodomain (1205) 8177 848.9 0
XP_011512792 (OMIM: 616856) PREDICTED: bromodomain (1144) 7770 807.3 0
XP_011512793 (OMIM: 616856) PREDICTED: bromodomain (1131) 7433 772.9 0
XP_016866231 (OMIM: 616856) PREDICTED: bromodomain (1088) 6976 726.3 2.5e-208
XP_011512794 (OMIM: 616856) PREDICTED: bromodomain ( 832) 5628 588.7 5.1e-167
XP_016866232 (OMIM: 616856) PREDICTED: bromodomain ( 572) 3848 407.0 1.7e-112
NP_001003694 (OMIM: 602410) peregrin isoform 1 [Ho (1220) 1949 213.5 6.9e-54
XP_005265507 (OMIM: 602410) PREDICTED: peregrin is (1219) 1947 213.3 8e-54
XP_011532404 (OMIM: 602410) PREDICTED: peregrin is (1248) 1923 210.8 4.4e-53
XP_011532403 (OMIM: 602410) PREDICTED: peregrin is (1248) 1923 210.8 4.4e-53
XP_005265506 (OMIM: 602410) PREDICTED: peregrin is (1247) 1920 210.5 5.5e-53
NP_001305979 (OMIM: 602410) peregrin isoform 4 [Ho (1213) 1915 210.0 7.6e-53
NP_004625 (OMIM: 602410) peregrin isoform 2 [Homo (1214) 1915 210.0 7.7e-53
XP_005265509 (OMIM: 602410) PREDICTED: peregrin is (1125) 1905 208.9 1.5e-52
NP_001305978 (OMIM: 602410) peregrin isoform 3 [Ho (1119) 1890 207.4 4.2e-52
XP_016884210 (OMIM: 604589) PREDICTED: bromodomain ( 941) 1846 202.9 8.1e-51
XP_016884209 (OMIM: 604589) PREDICTED: bromodomain ( 955) 1846 202.9 8.2e-51
XP_016884208 (OMIM: 604589) PREDICTED: bromodomain ( 958) 1846 202.9 8.3e-51
XP_016884207 (OMIM: 604589) PREDICTED: bromodomain (1023) 1846 202.9 8.7e-51
NP_001291738 (OMIM: 604589) bromodomain-containing (1058) 1846 202.9 9e-51
XP_016884203 (OMIM: 604589) PREDICTED: bromodomain (1187) 1846 202.9 9.9e-51
XP_016884206 (OMIM: 604589) PREDICTED: bromodomain (1189) 1846 202.9 9.9e-51
XP_016884204 (OMIM: 604589) PREDICTED: bromodomain (1189) 1846 202.9 9.9e-51
NP_001291737 (OMIM: 604589) bromodomain-containing (1189) 1846 202.9 9.9e-51
XP_016884205 (OMIM: 604589) PREDICTED: bromodomain (1189) 1846 202.9 9.9e-51
XP_011528375 (OMIM: 604589) PREDICTED: bromodomain ( 784) 1408 158.2 2e-37
XP_016884211 (OMIM: 604589) PREDICTED: bromodomain ( 802) 1408 158.2 2e-37
XP_016884212 (OMIM: 604589) PREDICTED: bromodomain ( 643) 1382 155.5 1.1e-36
NP_001274370 (OMIM: 610514) protein Jade-1 isoform ( 509) 673 83.1 5.2e-15
NP_079176 (OMIM: 610514) protein Jade-1 isoform 2 ( 509) 673 83.1 5.2e-15
XP_016864116 (OMIM: 610514) PREDICTED: protein Jad ( 529) 673 83.1 5.3e-15
XP_016864115 (OMIM: 610514) PREDICTED: protein Jad ( 529) 673 83.1 5.3e-15
NP_001274366 (OMIM: 610514) protein Jade-1 isoform ( 830) 673 83.2 7.8e-15
NP_001274369 (OMIM: 610514) protein Jade-1 isoform ( 842) 673 83.2 7.9e-15
XP_005263289 (OMIM: 610514) PREDICTED: protein Jad ( 842) 673 83.2 7.9e-15
NP_955352 (OMIM: 610514) protein Jade-1 isoform 1 ( 842) 673 83.2 7.9e-15
NP_001274368 (OMIM: 610514) protein Jade-1 isoform ( 842) 673 83.2 7.9e-15
NP_001274371 (OMIM: 610514) protein Jade-1 isoform ( 842) 673 83.2 7.9e-15
NP_001274372 (OMIM: 610514) protein Jade-1 isoform ( 842) 673 83.2 7.9e-15
NP_055550 (OMIM: 300618) protein Jade-3 [Homo sapi ( 823) 647 80.5 4.8e-14
NP_001070913 (OMIM: 300618) protein Jade-3 [Homo s ( 823) 647 80.5 4.8e-14
NP_056103 (OMIM: 610515) protein Jade-2 isoform 3 ( 790) 629 78.7 1.7e-13
NP_001276913 (OMIM: 610515) protein Jade-2 isoform ( 791) 629 78.7 1.7e-13
XP_016864771 (OMIM: 610515) PREDICTED: protein Jad ( 833) 629 78.7 1.7e-13
NP_001295072 (OMIM: 610515) protein Jade-2 isoform ( 834) 629 78.7 1.8e-13
XP_011541593 (OMIM: 610515) PREDICTED: protein Jad ( 834) 629 78.7 1.8e-13
XP_005272002 (OMIM: 610515) PREDICTED: protein Jad ( 834) 629 78.7 1.8e-13
>>XP_005249067 (OMIM: 616856) PREDICTED: bromodomain and (1205 aa)
initn: 8177 init1: 8177 opt: 8177 Z-score: 4522.5 bits: 848.9 E(85289): 0
Smith-Waterman score: 8177; 99.9% identity (100.0% similar) in 1205 aa overlap (1-1205:1-1205)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_005 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
1150 1160 1170 1180 1190 1200
pF1KA1 TSSYL
:::::
XP_005 TSSYL
>>XP_011512791 (OMIM: 616856) PREDICTED: bromodomain and (1205 aa)
initn: 8177 init1: 8177 opt: 8177 Z-score: 4522.5 bits: 848.9 E(85289): 0
Smith-Waterman score: 8177; 99.9% identity (100.0% similar) in 1205 aa overlap (1-1205:1-1205)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_011 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
1150 1160 1170 1180 1190 1200
pF1KA1 TSSYL
:::::
XP_011 TSSYL
>>NP_056510 (OMIM: 616856) bromodomain and PHD finger-co (1205 aa)
initn: 8177 init1: 8177 opt: 8177 Z-score: 4522.5 bits: 848.9 E(85289): 0
Smith-Waterman score: 8177; 99.9% identity (100.0% similar) in 1205 aa overlap (1-1205:1-1205)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_056 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
1150 1160 1170 1180 1190 1200
pF1KA1 TSSYL
:::::
NP_056 TSSYL
>>XP_005249068 (OMIM: 616856) PREDICTED: bromodomain and (1205 aa)
initn: 8177 init1: 8177 opt: 8177 Z-score: 4522.5 bits: 848.9 E(85289): 0
Smith-Waterman score: 8177; 99.9% identity (100.0% similar) in 1205 aa overlap (1-1205:1-1205)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_005 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
1150 1160 1170 1180 1190 1200
pF1KA1 TSSYL
:::::
XP_005 TSSYL
>>XP_011512792 (OMIM: 616856) PREDICTED: bromodomain and (1144 aa)
initn: 7770 init1: 7770 opt: 7770 Z-score: 4298.5 bits: 807.3 E(85289): 0
Smith-Waterman score: 7770; 99.9% identity (100.0% similar) in 1144 aa overlap (1-1144:1-1144)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_011 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
::::
XP_011 NKRT
>>XP_011512793 (OMIM: 616856) PREDICTED: bromodomain and (1131 aa)
initn: 7482 init1: 7433 opt: 7433 Z-score: 4112.7 bits: 772.9 E(85289): 0
Smith-Waterman score: 7433; 99.5% identity (99.7% similar) in 1098 aa overlap (1-1098:1-1098)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_011 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
::::::::::::: . :
XP_011 WAKCRGYPSYPALAVASKGQSPALGCGRHRGQAQDAGRPQDQHPQVSAGGL
1090 1100 1110 1120 1130
>>XP_016866231 (OMIM: 616856) PREDICTED: bromodomain and (1088 aa)
initn: 7348 init1: 6970 opt: 6976 Z-score: 3861.0 bits: 726.3 E(85289): 2.5e-208
Smith-Waterman score: 7117; 90.2% identity (90.2% similar) in 1205 aa overlap (1-1205:1-1088)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGINRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASPASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 GLAFEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELV
:::::::
XP_016 GLAFEACR----------------------------------------------------
1090 1100 1110 1120 1130 1140
pF1KA1 WAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFD
XP_016 ------------------------------------------------------------
1150 1160 1170 1180 1190 1200
pF1KA1 NKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -----QWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFV
1030 1040 1050 1060 1070 1080
pF1KA1 TSSYL
:::::
XP_016 TSSYL
>>XP_011512794 (OMIM: 616856) PREDICTED: bromodomain and (832 aa)
initn: 5628 init1: 5628 opt: 5628 Z-score: 3119.5 bits: 588.7 E(85289): 5.1e-167
Smith-Waterman score: 5628; 100.0% identity (100.0% similar) in 828 aa overlap (1-828:1-828)
10 20 30 40 50 60
pF1KA1 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVDIDGRLHRISIYDPLKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKESCSKHASGTSFHLPQPSFR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANTVFLEPIEGIDNIPPARWKLTCYICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIEPMRETSLNGTIFTVRKTAYCEAHSPPGAATARRKGDSPRSISETGDEEGLKEGDGEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEEEVEEEEQEAQGGVSGSLKGVPKKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYRLNKICSGLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREQDE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTSAVKEELKYWQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDLLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVTNCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFSWEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEP
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLAQPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDSLFF
790 800 810 820 830
850 860 870 880 890 900
pF1KA1 TGPAPSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLS
>>XP_016866232 (OMIM: 616856) PREDICTED: bromodomain and (572 aa)
initn: 3848 init1: 3848 opt: 3848 Z-score: 2140.4 bits: 407.0 E(85289): 1.7e-112
Smith-Waterman score: 3848; 99.8% identity (100.0% similar) in 572 aa overlap (634-1205:1-572)
610 620 630 640 650 660
pF1KA1 LLQEKDPAHIFAEPVNLSEVPDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVT
::::::::::::::::::::::::::::::
XP_016 MDFSTMRRKLESHLYRTLEEFEEDFNLIVT
10 20 30
670 680 690 700 710 720
pF1KA1 NCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCMKYNAKDTIFHRAAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFS
40 50 60 70 80 90
730 740 750 760 770 780
pF1KA1 WEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEDVDNILIPENRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLA
100 110 120 130 140 150
790 800 810 820 830 840
pF1KA1 QPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPPPQPPSLNKTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGP
160 170 180 190 200 210
850 860 870 880 890 900
pF1KA1 APSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APSLSEQESPPEPPTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNG
220 230 240 250 260 270
910 920 930 940 950 960
pF1KA1 INRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INRLSLMAPDTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASP
280 290 300 310 320 330
970 980 990 1000 1010 1020
pF1KA1 ASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASIEEERHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLA
340 350 360 370 380 390
1030 1040 1050 1060 1070 1080
pF1KA1 FEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLKPLELVWAK
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_016 FEACSGLTPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAK
400 410 420 430 440 450
1090 1100 1110 1120 1130 1140
pF1KA1 CRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKR
460 470 480 490 500 510
1150 1160 1170 1180 1190 1200
pF1KA1 TWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSS
520 530 540 550 560 570
pF1KA1 YL
::
XP_016 YL
>>NP_001003694 (OMIM: 602410) peregrin isoform 1 [Homo s (1220 aa)
initn: 3154 init1: 1515 opt: 1949 Z-score: 1088.4 bits: 213.5 E(85289): 6.9e-54
Smith-Waterman score: 3801; 50.8% identity (71.8% similar) in 1241 aa overlap (1-1202:58-1217)
10 20
pF1KA1 MRKPRRKSRQN-AEGRRSPSPYSLKCSPTR
.:: ..:.::. ...:::: .. :: :
NP_001 CRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGR
30 40 50 60 70 80
30 40 50 60 70 80
pF1KA1 ETLTYAQAQRIVEVDIDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGK
:...::::::.::::. ::.:::::.: : ...::: . .. : .:::::.: : :
NP_001 EVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPK
90 100 110 120 130 140
90 100 110 120 130 140
pF1KA1 SKKPSSKGKKKESCSKH----ASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPP
: : ..: :.:.: .: ...:. .::. .: ... :.::: :..:::::::
NP_001 SGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDT-PDAPPRPTSYYRYIEKSA
150 160 170 180 190 200
150 160 170 180 190 200
pF1KA1 EDLDAEVEYDMDEEDLAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQ
:.:: :::::::::: :::..::.:...: : . . :: :.::::::::.::...:
NP_001 EELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDP
210 220 230 240 250 260
210 220 230 240 250 260
pF1KA1 QSLIDEDAFCCVCLDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSR
..:.:::: ::.: : ::.:::::::::.::::::::::::::::::::::: :::::::
NP_001 NALVDEDAVCCICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSR
270 280 290 300 310 320
270 280 290 300 310 320
pF1KA1 PVDCILCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTC
::: ::::::::::::.::.:::::::.::::::::::::::::..:..::::::::::
NP_001 AVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTC
330 340 350 360 370 380
330 340 350 360 370 380
pF1KA1 YICKQKGLGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEA
:::::.: :: :::::.::::::::::::.:::.::.::.:::. ::: :.:::::::.
NP_001 YICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDI
390 400 410 420 430 440
390 400 410 420 430 440
pF1KA1 HSPPGAATARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVP
:.::: .::: : .:....:::.: .:::.:..: : ..: .
NP_001 HTPPG--SARRL---P----------ALSHSEGEEDE----DEEEDEGKGWSSEKVKKAK
450 460 470 480
450 460 470 480 490 500
pF1KA1 KKSKMSLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHN
::....:. : :. .. :...:: :: .::.:: . :..:::.:::::::.
NP_001 AKSRIKMKKARKILAEKR-----AAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHS
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA1 YWLLKRQARNGVPLIRRLHSHLQSQRNAEQ--REQDEKTSAVKEELKYWQKLRHDLERAR
:: ::::.::::::.:::..::::::: .: :....:. :.::.:: ::.:::::::::
NP_001 YWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERAR
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA1 LLIELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEV
::.:::::::::::: .:::: :::..: :: .::: ::. ::::: ..::.::: ::::
NP_001 LLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEV
610 620 630 640 650 660
630 640 650 660 670
pF1KA1 ------PDYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHR
::::. :.::::: ::...::.. : ....:::::::::.::.:::::::::.:
NP_001 TELDEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYR
670 680 690 700 710 720
680 690 700 710 720 730
pF1KA1 AAVRLRDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDV---DNILIPE
::::::. :::.::.::::::..: : : : :.:.: .. . . ::. . ... :
NP_001 AAVRLREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHT-EDAAEEERLVLLE
730 740 750 760 770 780
740 750 760 770 780 790
pF1KA1 NRAHLSPEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLN
:. :: : ::: :::.:: :.: ..: .:.::......:..:::.:::.
NP_001 NQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAH----------
790 800 810 820 830
800 810 820 830 840 850
pF1KA1 KTVSNGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPP-PPTLEPTGPAPSLSEQESP
. .: .: :: : . ..: : : . . : . : .:. :
NP_001 ------QRETGRDG------------PERHGPSSRGSLTPHPAACDKDGQTDSAAEESSS
840 850 860 870
860 870 880 890 900 910
pF1KA1 PEPPT-LKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAP
: : : .: : . . .: . .:.: : : .: . :: : :.:
NP_001 QETSKGLGPNMSSTPAHEVGRRTSVL---FSKKNPKTAG--PPKRP-GRPPKNRESQMTP
880 890 900 910 920
920 930 940 950 960 970
pF1KA1 DTPAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHS
. .:.:.. ... : : ::: :.: .. . .. .
NP_001 -SHGGSPVGPPQLPIMSSLRQRKRG----RSP--------------RPSSSSDSDSDKST
930 940 950 960
980 990 1000 1010 1020 1030
pF1KA1 RKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTP
. : . . : .: .. . : . .:.:::: : . :.. : . : ::
NP_001 EDPPMDLPANGFSGGNQPVKKSFLVYRNDCSL-PRSSSDSESSSSSSSSAASDRTS-TTP
970 980 990 1000 1010 1020
1040 1050 1060 1070
pF1KA1 PKRSRGKPALSRVPFLEGVNGDSD------YN-GSGR----SLLLPFEDRG---------
:..::::..:: : : . :.. :. :.:: :.. ::
NP_001 SKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDED
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KA1 -DLKPLELVWAKCRGYPSYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGE
: :.:::::::::::::::::::::::::..:.:::::::::.::::::: :: :
NP_001 SPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEARE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KA1 KLFLVLFFDNKRTWQWLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLS
.:.:::::::::::::::: :..::::.. .:: :::::::..::::::.:: ::. : :
NP_001 HLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS
1150 1160 1170 1180 1190 1200
1200
pF1KA1 RVRGPHSFVTSSYL
.:.: .: ::
NP_001 KVQGEQSSETSDSD
1210 1220
1205 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:56:47 2016 done: Thu Nov 3 19:56:50 2016
Total Scan time: 19.680 Total Display time: 0.420
Function used was FASTA [36.3.4 Apr, 2011]