Result of FASTA (omim) for
pF1KA1113
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1113, 1127 aa
1>>>pF1KA1113 1127 - 1127 aa - 1127 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.3086+/-0.000409; mu= -8.0178+/- 0.026
mean_var=442.2292+/-92.741, 0's: 0 Z-trim(124.0): 137 B-trim: 587 in 1/58
Lambda= 0.060989
statistics sampled from 44528 (44738) to 44528 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.525), width: 16
Scan time: 18.380
The best scores are: opt bits E(85289)
NP_056990 (OMIM: 188550,605769) E3 ubiquitin-prote (1127) 7660 689.1 3.9e-197
NP_148980 (OMIM: 188550,605769) E3 ubiquitin-prote (1110) 7098 639.7 2.9e-182
XP_005270994 (OMIM: 188550,605769) PREDICTED: E3 u (1134) 5072 461.4 1.4e-128
XP_016856941 (OMIM: 188550,605769) PREDICTED: E3 u ( 735) 5006 455.5 5.6e-127
XP_005270993 (OMIM: 188550,605769) PREDICTED: E3 u (1151) 4717 430.2 3.5e-119
XP_011539870 (OMIM: 188550,605769) PREDICTED: E3 u (1150) 4709 429.5 5.7e-119
XP_016856942 (OMIM: 188550,605769) PREDICTED: E3 u ( 718) 4444 406.0 4.2e-112
XP_016856943 (OMIM: 188550,605769) PREDICTED: E3 u ( 638) 4227 386.9 2.1e-106
NP_056989 (OMIM: 188550,603406) transcription inte (1050) 2947 274.4 2.5e-72
NP_003843 (OMIM: 188550,603406) transcription inte (1016) 1747 168.8 1.5e-40
NP_005753 (OMIM: 601742) transcription intermediar ( 835) 1172 118.1 2.2e-25
XP_011518827 (OMIM: 612000) PREDICTED: tripartite (1020) 854 90.2 6.7e-17
XP_011518826 (OMIM: 612000) PREDICTED: tripartite (1032) 854 90.2 6.8e-17
XP_011518812 (OMIM: 612000) PREDICTED: tripartite (1364) 854 90.3 8.3e-17
XP_011518811 (OMIM: 612000) PREDICTED: tripartite (1367) 854 90.3 8.3e-17
XP_011518810 (OMIM: 612000) PREDICTED: tripartite (1385) 854 90.4 8.4e-17
XP_011518809 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17
XP_011518806 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17
XP_006718460 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17
XP_016874118 (OMIM: 612000) PREDICTED: tripartite (1392) 854 90.4 8.5e-17
XP_011518815 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17
XP_011518814 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17
XP_016874119 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17
XP_011518816 (OMIM: 612000) PREDICTED: tripartite (1306) 851 90.1 9.7e-17
XP_011518813 (OMIM: 612000) PREDICTED: tripartite (1355) 843 89.4 1.6e-16
NP_055633 (OMIM: 612000) tripartite motif-containi (1216) 812 86.6 9.9e-16
XP_011518817 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_006718461 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518820 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518819 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518818 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518825 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518821 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518824 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_016874120 (OMIM: 612000) PREDICTED: tripartite (1247) 812 86.6 1e-15
XP_011518829 (OMIM: 612000) PREDICTED: tripartite ( 743) 788 84.3 3e-15
XP_011518828 (OMIM: 612000) PREDICTED: tripartite (1001) 788 84.4 3.7e-15
NP_001139107 (OMIM: 609318) tripartite motif-conta ( 562) 442 53.8 3.5e-06
NP_079464 (OMIM: 609318) tripartite motif-containi ( 580) 442 53.8 3.6e-06
XP_011540501 (OMIM: 609318) PREDICTED: tripartite ( 476) 411 51.0 2e-05
XP_016858742 (OMIM: 608602) PREDICTED: nuclear bod ( 614) 370 47.5 0.0003
NP_001265382 (OMIM: 608602) nuclear body protein S ( 753) 370 47.5 0.00035
XP_016858741 (OMIM: 608602) PREDICTED: nuclear bod ( 756) 370 47.5 0.00035
XP_016858740 (OMIM: 608602) PREDICTED: nuclear bod ( 760) 370 47.5 0.00035
XP_016858739 (OMIM: 608602) PREDICTED: nuclear bod ( 777) 370 47.6 0.00036
XP_016858738 (OMIM: 608602) PREDICTED: nuclear bod ( 780) 370 47.6 0.00036
XP_016858737 (OMIM: 608602) PREDICTED: nuclear bod ( 803) 370 47.6 0.00037
XP_016858736 (OMIM: 608602) PREDICTED: nuclear bod ( 804) 370 47.6 0.00037
XP_005246313 (OMIM: 608602) PREDICTED: nuclear bod ( 806) 370 47.6 0.00037
NP_001265381 (OMIM: 608602) nuclear body protein S ( 807) 370 47.6 0.00037
>>NP_056990 (OMIM: 188550,605769) E3 ubiquitin-protein l (1127 aa)
initn: 7660 init1: 7660 opt: 7660 Z-score: 3660.3 bits: 689.1 E(85289): 3.9e-197
Smith-Waterman score: 7660; 99.9% identity (99.9% similar) in 1127 aa overlap (1-1127:1-1127)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KA1 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
:::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
1090 1100 1110 1120
>>NP_148980 (OMIM: 188550,605769) E3 ubiquitin-protein l (1110 aa)
initn: 7098 init1: 7098 opt: 7098 Z-score: 3393.1 bits: 639.7 E(85289): 2.9e-182
Smith-Waterman score: 7512; 98.4% identity (98.4% similar) in 1127 aa overlap (1-1127:1-1110)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA1 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA1 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA1 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA1 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_148 VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA1 PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
:::::::::::::::::::: :::::::::::::::::::::::
NP_148 PDDFVADVRLIFKNCERFNE-----------------ADSEVAQAGKAVALYFEDKLTEI
1030 1040 1050 1060
1090 1100 1110 1120
pF1KA1 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
:::::::::::::::::::::::::::::::::::::::::::::::
NP_148 YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
1070 1080 1090 1100 1110
>>XP_005270994 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1134 aa)
initn: 7084 init1: 4672 opt: 5072 Z-score: 2429.6 bits: 461.4 E(85289): 1.4e-128
Smith-Waterman score: 7454; 96.4% identity (96.4% similar) in 1151 aa overlap (1-1127:1-1134)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
610 620 630 640 650 660
670 680 690
pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ------------------------LEDAGSSSL
::::::::::::::::::::::::::: :::::::::
XP_005 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLEDAGSSSL
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 PLSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_005 PLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA1 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA1 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA1 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL
::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNE----------------
1030 1040 1050 1060
1060 1070 1080 1090 1100 1110
pF1KA1 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 -ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR
1070 1080 1090 1100 1110 1120
1120
pF1KA1 LKSDERPVHIK
:::::::::::
XP_005 LKSDERPVHIK
1130
>>XP_016856941 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (735 aa)
initn: 5006 init1: 5006 opt: 5006 Z-score: 2400.7 bits: 455.5 E(85289): 5.6e-127
Smith-Waterman score: 5006; 99.9% identity (99.9% similar) in 735 aa overlap (393-1127:1-735)
370 380 390 400 410 420
pF1KA1 KVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
::::::::::::::::::::::::::::::
XP_016 MKLLQQQNDITGLSRQVKHVMNFTNWAIAS
10 20 30
430 440 450 460 470 480
pF1KA1 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP
40 50 60 70 80 90
490 500 510 520 530 540
pF1KA1 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP
100 110 120 130 140 150
550 560 570 580 590 600
pF1KA1 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
160 170 180 190 200 210
610 620 630 640 650 660
pF1KA1 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV
220 230 240 250 260 270
670 680 690 700 710 720
pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
280 290 300 310 320 330
730 740 750 760 770 780
pF1KA1 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
340 350 360 370 380 390
790 800 810 820 830 840
pF1KA1 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEP
400 410 420 430 440 450
850 860 870 880 890 900
pF1KA1 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC
460 470 480 490 500 510
910 920 930 940 950 960
pF1KA1 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KA1 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KA1 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS
640 650 660 670 680 690
1090 1100 1110 1120
pF1KA1 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
700 710 720 730
>>XP_005270993 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1151 aa)
initn: 7646 init1: 4672 opt: 4717 Z-score: 2260.7 bits: 430.2 E(85289): 3.5e-119
Smith-Waterman score: 7602; 97.8% identity (97.8% similar) in 1151 aa overlap (1-1127:1-1151)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
610 620 630 640 650 660
670 680 690
pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ------------------------LEDAGSSSL
::::::::::::::::::::::::::: :::::::::
XP_005 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLEDAGSSSL
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 PLSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_005 PLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGG
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA1 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA1 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKI
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA1 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINL
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KA1 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKR
1090 1100 1110 1120 1130 1140
1120
pF1KA1 LKSDERPVHIK
:::::::::::
XP_005 LKSDERPVHIK
1150
>>XP_011539870 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (1150 aa)
initn: 7646 init1: 4672 opt: 4709 Z-score: 2256.9 bits: 429.5 E(85289): 5.7e-119
Smith-Waterman score: 7604; 97.9% identity (97.9% similar) in 1150 aa overlap (1-1127:1-1150)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
610 620 630 640 650 660
670 680 690
pF1KA1 SVTAIELIPSVTNPENLPSLPDIPPIQ-----------------------LEDAGSSSLD
::::::::::::::::::::::::::: ::::::::::
XP_011 SVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNLEDAGSSSLD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA1 NLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA1 GRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA1 LSTNLHLESELDALASLENHVKTEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGD
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 LSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGD
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA1 GNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKP
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA1 EVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKII
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KA1 KKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLK
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KA1 ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRL
1090 1100 1110 1120 1130 1140
1120
pF1KA1 KSDERPVHIK
::::::::::
XP_011 KSDERPVHIK
1150
>>XP_016856942 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (718 aa)
initn: 4444 init1: 4444 opt: 4444 Z-score: 2133.6 bits: 406.0 E(85289): 4.2e-112
Smith-Waterman score: 4858; 97.6% identity (97.6% similar) in 735 aa overlap (393-1127:1-718)
370 380 390 400 410 420
pF1KA1 KVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
::::::::::::::::::::::::::::::
XP_016 MKLLQQQNDITGLSRQVKHVMNFTNWAIAS
10 20 30
430 440 450 460 470 480
pF1KA1 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKP
40 50 60 70 80 90
490 500 510 520 530 540
pF1KA1 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAP
100 110 120 130 140 150
550 560 570 580 590 600
pF1KA1 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
160 170 180 190 200 210
610 620 630 640 650 660
pF1KA1 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSV
220 230 240 250 260 270
670 680 690 700 710 720
pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPG
280 290 300 310 320 330
730 740 750 760 770 780
pF1KA1 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
340 350 360 370 380 390
790 800 810 820 830 840
pF1KA1 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEP
400 410 420 430 440 450
850 860 870 880 890 900
pF1KA1 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCC
460 470 480 490 500 510
910 920 930 940 950 960
pF1KA1 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KA1 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPD
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KA1 DFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS
:::::::::::::::::: :::::::::::::::::::::::::
XP_016 DFVADVRLIFKNCERFNE-----------------ADSEVAQAGKAVALYFEDKLTEIYS
640 650 660 670
1090 1100 1110 1120
pF1KA1 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
680 690 700 710
>>XP_016856943 (OMIM: 188550,605769) PREDICTED: E3 ubiqu (638 aa)
initn: 4220 init1: 4220 opt: 4227 Z-score: 2031.1 bits: 386.9 E(85289): 2.1e-106
Smith-Waterman score: 4227; 98.0% identity (98.3% similar) in 638 aa overlap (1-631:1-638)
10 20 30 40 50 60
pF1KA1 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
550 560 570 580 590 600
610 620 630 640 650
pF1KA1 GIPRHSGPQYSMMQPHLQRQ-----H--SNPGHAGPFPVVSVHNTTINPTSPTTATMANA
:::::::::::::::::::: : .. : :::
XP_016 GIPRHSGPQYSMMQPHLQRQVCLELHFTQTQGMLDPFP
610 620 630
660 670 680 690 700 710
pF1KA1 NRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQP
>>NP_056989 (OMIM: 188550,603406) transcription intermed (1050 aa)
initn: 2703 init1: 1139 opt: 2947 Z-score: 1419.5 bits: 274.4 E(85289): 2.5e-72
Smith-Waterman score: 3335; 50.1% identity (72.1% similar) in 1108 aa overlap (67-1122:3-1046)
40 50 60 70 80 90
pF1KA1 PLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVST
::. .. .: ::.: ::: :: ..
NP_056 MEVAVEKAVAAAAAASAAAS------GGPSAA
10 20
100 110 120 130 140 150
pF1KA1 PAPAPASAPAPGPSAGPPPGPPA--SLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCL
:. . ::.. : : .::::::::.:..::: ::::::::::: :::
NP_056 PSGENEAESRQGPDS-ERGGEAARLNLLDTCAVCHQNIQSR---APKLLPCLHSFCQRCL
30 40 50 60 70 80
160 170 180 190
pF1KA1 PEPERQL--------------SVPIPG----GSNGDIQQVGVIRCPVCRQECRQIDLVDN
: :.: : :: :: ::. :::::::::: ::: . ..::
NP_056 PAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDN
90 100 110 120 130 140
200 210 220 230 240 250
pF1KA1 YFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLI
.:::::.:.:::. :::.:::::::::: : :::::: ::::::::.::::::::::: .
NP_056 FFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTV
150 160 170 180 190 200
260 270 280 290 300 310
pF1KA1 RKKEDVS-ESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEA
:.::.:: :.::...::::::: ::.:::::.:::::.::::::::::::::::::.:::
NP_056 RQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEA
210 220 230 240 250 260
320 330 340 350 360 370
pF1KA1 FQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINK
::::: :..:..::.:: .:..:...:.:::: :::...:.:::.::::::::. ::::
NP_056 FQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINK
270 280 290 300 310 320
380 390 400 410 420 430
pF1KA1 KGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLI
:::.::.:::...:...:::.:::....:::.:..:::.:..::..::::::::::::::
NP_056 KGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLI
330 340 350 360 370 380
440 450 460 470 480 490
pF1KA1 TFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTP--NVVVG
:..:::.:.:::: :..:..:.:::::.:::.:..:::.::::.: . : : ::
NP_056 TYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVE
390 400 410 420 430 440
500 510 520 530 540
pF1KA1 QV--PPG---TNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTT
: ::. .:..:: : ::.:::::::::::::.::..: .:. :::: .
NP_056 QNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQ------VQRRPAPVGLPNP
450 460 470 480 490
550 560 570 580 590 600
pF1KA1 TTQQHPRQAAPQMLQQQPPRLISVQTMQ-RGNMNCGAFQAHQMRLAQNAARIPGIPRHS-
.: : : :: :::::. :. . . : . .:.: : .:::..
NP_056 R-MQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQ----NIPRQAI
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA1 --GP-QYSMM-QPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANAN-RGPTSPS
.: :.... : ... . . :.. : ....:. .:.::: .. :. . .. ::
NP_056 KPNPLQMAFLAQQAIKQWQISSGQGTP---STTNSTSSTPSSPTITSAAGYDGKAFGSP-
560 570 580 590 600
670 680 690 700 710
pF1KA1 VTAIELIPSVTNPENLPSLPDIPPIQLEDAGSS-SLDNLLSRYISGSHLPPQPTSTMN-P
:.: : . :::::::: : .:. :::.. . . .: :.: :. .
NP_056 --MIDLSSPVGGSYNLPSLPDI------DCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQ
610 620 630 640 650
720 730 740 750 760 770
pF1KA1 SPGPSALSPGSSG---LSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLS----FKSDQ
::. :. ::: .: ... : :.: ::.::.::::: :::.. : : .
NP_056 SPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEP
660 670 680 690 700 710
780 790 800 810 820 830
pF1KA1 VKVKQEPGTEDEICSFSGG-VKQEKTEDGRRSACMLSSPESSLTP-PLSTNLHLESELDA
...::: . : .: ::::. :..: :... : . :.: :.: ..
NP_056 IRIKQENSGPPENYDFPVVIVKQESDEESR--------PQNANYPRSILTSLLLNSSQSS
720 730 740 750 760 770
840 850 860 870 880
pF1KA1 LASLENHVKTEPADMNESCKQSGL--SSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNED
.: :. .... : . : :: .. :::: . ..: :. . :.::::::
NP_056 -TSEETVLRSDAPD--STGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGE-TRKEDDPNED
780 790 800 810 820
890 900 910 920 930 940
pF1KA1 WCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQH
:::::::::.:::::::::::::.:::::: .::::.::::::::..::::::::: .:
NP_056 WCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSH
830 840 850 860 870 880
950 960 970 980 990 1000
pF1KA1 SKKGKTAQGL---SPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLST
... : ..:: .:.:.::::::::.:::::.:. ::.::: ..:.::::::.::::::
NP_056 NSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLST
890 900 910 920 930 940
1010 1020 1030 1040 1050 1060
pF1KA1 VKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQA
.::.::. .:. :. :.::::: ::::.:: .::: :::::.:
NP_056 IKKRLQEDYSM-YSKPEDFVADFRLIFQNCAEFNE-----------------PDSEVANA
950 960 970 980
1070 1080 1090 1100 1110 1120
pF1KA1 GKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKS-DERPV
: . :::. : ..: .. : : :::..: .:.. ..:::.::.:::.::::: .::
NP_056 GIKLENYFEELLKNLYPEKRF-PKPEFRNESEDNKFSDDSDDDFVQPRKKRLKSIEERQL
990 1000 1010 1020 1030 1040
pF1KA1 HIK
NP_056 LK
1050
>>NP_003843 (OMIM: 188550,603406) transcription intermed (1016 aa)
initn: 2873 init1: 1092 opt: 1747 Z-score: 849.1 bits: 168.8 E(85289): 1.5e-40
Smith-Waterman score: 3219; 49.0% identity (70.6% similar) in 1107 aa overlap (67-1122:3-1012)
40 50 60 70 80 90
pF1KA1 PLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVST
::. .. .: ::.: ::: :: ..
NP_003 MEVAVEKAVAAAAAASAAAS------GGPSAA
10 20
100 110 120 130 140 150
pF1KA1 PAPAPASAPAPGPSAGPPPGPPA--SLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCL
:. . ::.. : : .::::::::.:..::: ::::::::::: :::
NP_003 PSGENEAESRQGPDS-ERGGEAARLNLLDTCAVCHQNIQSR---APKLLPCLHSFCQRCL
30 40 50 60 70 80
160 170 180 190
pF1KA1 PEPERQL--------------SVPIPG----GSNGDIQQVGVIRCPVCRQECRQIDLVDN
: :.: : :: :: ::. :::::::::: ::: . ..::
NP_003 PAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIIDN
90 100 110 120 130 140
200 210 220 230 240 250
pF1KA1 YFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLI
.:::::.:.:::. :::.:::::::::: : :::::: ::::::::.::::::::::: .
NP_003 FFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTV
150 160 170 180 190 200
260 270 280 290 300 310
pF1KA1 RKKEDVS-ESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEA
:.::.:: :.::...::::::: ::.:::::.:::::.::::::::::::::::::.:::
NP_003 RQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEA
210 220 230 240 250 260
320 330 340 350 360 370
pF1KA1 FQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINK
::::: :..:..::.:: .:..:...:.:::: :::...:.:::.::::::::. ::::
NP_003 FQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINK
270 280 290 300 310 320
380 390 400 410 420 430
pF1KA1 KGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLI
:::.::.:::...:...:::.:::....:::.:..:::.:..::..::::::::::::::
NP_003 KGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLI
330 340 350 360 370 380
440 450 460 470 480 490
pF1KA1 TFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTP--NVVVG
:..:::.:.:::: :..:..:.:::::.:::.:..:::.::::.: . : : ::
NP_003 TYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVE
390 400 410 420 430 440
500 510 520 530 540
pF1KA1 QV--PPG---TNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTT
: ::. .:..:: : ::.:::::::::::: ::: : .
NP_003 QNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQ---------------QPP---PRLIN
450 460 470 480
550 560 570 580 590 600
pF1KA1 TTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHS--
.. :. .: . :: . .:.: : .:::..
NP_003 FQNHSPKPNGPVL----PP------------------HPQQLRYPPNQ----NIPRQAIK
490 500 510
610 620 630 640 650 660
pF1KA1 -GP-QYSMM-QPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANAN-RGPTSPSV
.: :.... : ... . . :.. : ....:. .:.::: .. :. . .. ::
NP_003 PNPLQMAFLAQQAIKQWQISSGQGTP---STTNSTSSTPSSPTITSAAGYDGKAFGSP--
520 530 540 550 560 570
670 680 690 700 710 720
pF1KA1 TAIELIPSVTNPENLPSLPDIPPIQLEDAGSS-SLDNLLSRYISGSHLPPQPTSTMN-PS
:.: : . :::::::: : .:. :::.. . . .: :.: :. . :
NP_003 -MIDLSSPVGGSYNLPSLPDI------DCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
580 590 600 610 620
730 740 750 760 770
pF1KA1 PGPSALSPGSSG---LSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLS----FKSDQV
:. :. ::: .: ... : :.: ::.::.::::: :::.. : : . .
NP_003 PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
630 640 650 660 670 680
780 790 800 810 820 830
pF1KA1 KVKQEPGTEDEICSFSGG-VKQEKTEDGRRSACMLSSPESSLTP-PLSTNLHLESELDAL
..::: . : .: ::::. :..: :... : . :.: :.: ..
NP_003 RIKQENSGPPENYDFPVVIVKQESDEESR--------PQNANYPRSILTSLLLNSSQSS-
690 700 710 720 730
840 850 860 870 880
pF1KA1 ASLENHVKTEPADMNESCKQSGL--SSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDW
.: :. .... : . : :: .. :::: . ..: :. . :.:::::::
NP_003 TSEETVLRSDAPD--STGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGE-TRKEDDPNEDW
740 750 760 770 780 790
890 900 910 920 930 940
pF1KA1 CAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHS
::::::::.:::::::::::::.:::::: .::::.::::::::..::::::::: .:.
NP_003 CAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHN
800 810 820 830 840 850
950 960 970 980 990 1000
pF1KA1 KKGKTAQGL---SPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTV
.. : ..:: .:.:.::::::::.:::::.:. ::.::: ..:.::::::.::::::.
NP_003 SEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTI
860 870 880 890 900 910
1010 1020 1030 1040 1050 1060
pF1KA1 KKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAG
::.::. .:. :. :.::::: ::::.:: .::: :::::.::
NP_003 KKRLQEDYSM-YSKPEDFVADFRLIFQNCAEFNE-----------------PDSEVANAG
920 930 940 950
1070 1080 1090 1100 1110 1120
pF1KA1 KAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKS-DERPVH
. :::. : ..: .. : : :::..: .:.. ..:::.::.:::.::::: .::
NP_003 IKLENYFEELLKNLYPEKRF-PKPEFRNESEDNKFSDDSDDDFVQPRKKRLKSIEERQLL
960 970 980 990 1000 1010
pF1KA1 IK
NP_003 K
1127 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:52:48 2016 done: Thu Nov 3 19:52:51 2016
Total Scan time: 18.380 Total Display time: 0.380
Function used was FASTA [36.3.4 Apr, 2011]