Result of FASTA (omim) for
pF1KA0942
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0942, 513 aa
1>>>pF1KA0942 513 - 513 aa - 513 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9853+/-0.000406; mu= 9.9340+/- 0.025
mean_var=110.9815+/-22.091, 0's: 0 Z-trim(114.5): 210 B-trim: 84 in 1/53
Lambda= 0.121744
statistics sampled from 24192 (24454) to 24192 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.287), width: 16
Scan time: 8.560
The best scores are: opt bits E(85289)
NP_996792 (OMIM: 614440) PH and SEC7 domain-contai ( 513) 3379 604.7 2e-172
XP_016868754 (OMIM: 614440) PREDICTED: PH and SEC7 ( 511) 3279 587.2 3.9e-167
XP_016868750 (OMIM: 614440) PREDICTED: PH and SEC7 (1014) 3279 587.3 7.1e-167
XP_016868749 (OMIM: 614440) PREDICTED: PH and SEC7 (1046) 3279 587.3 7.3e-167
NP_056125 (OMIM: 614440) PH and SEC7 domain-contai (1047) 3279 587.3 7.3e-167
XP_016868748 (OMIM: 614440) PREDICTED: PH and SEC7 (1060) 3279 587.3 7.3e-167
XP_016868747 (OMIM: 614440) PREDICTED: PH and SEC7 (1067) 3279 587.3 7.4e-167
NP_001257895 (OMIM: 602327) PH and SEC7 domain-con ( 645) 1904 345.7 2.4e-94
XP_016871922 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 1904 345.8 3.6e-94
NP_001257894 (OMIM: 602327) PH and SEC7 domain-con (1024) 1904 345.8 3.6e-94
NP_002770 (OMIM: 602327) PH and SEC7 domain-contai (1024) 1904 345.8 3.6e-94
XP_016871923 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 1904 345.8 3.6e-94
XP_011538271 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 1904 345.8 3.6e-94
XP_011538270 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 1904 345.8 3.6e-94
XP_005263691 (OMIM: 614442) PREDICTED: PH and SEC7 (1056) 1286 237.3 1.7e-61
NP_036587 (OMIM: 614442) PH and SEC7 domain-contai (1056) 1286 237.3 1.7e-61
XP_011542773 (OMIM: 614440) PREDICTED: PH and SEC7 ( 976) 1178 218.3 8.3e-56
XP_011542775 (OMIM: 614440) PREDICTED: PH and SEC7 ( 972) 1169 216.7 2.5e-55
XP_011542771 (OMIM: 614440) PREDICTED: PH and SEC7 ( 985) 1169 216.7 2.5e-55
XP_011542770 (OMIM: 614440) PREDICTED: PH and SEC7 ( 997) 1169 216.7 2.5e-55
XP_011542769 (OMIM: 614440) PREDICTED: PH and SEC7 (1006) 1169 216.7 2.6e-55
XP_016868751 (OMIM: 614440) PREDICTED: PH and SEC7 (1008) 1169 216.7 2.6e-55
XP_016868753 (OMIM: 614440) PREDICTED: PH and SEC7 ( 701) 972 182.0 4.9e-45
XP_016868752 (OMIM: 614440) PREDICTED: PH and SEC7 ( 945) 972 182.1 6.3e-45
XP_006712456 (OMIM: 614442) PREDICTED: PH and SEC7 ( 965) 826 156.5 3.4e-37
XP_006712455 (OMIM: 614442) PREDICTED: PH and SEC7 (1055) 765 145.8 6.1e-34
XP_006712457 (OMIM: 614442) PREDICTED: PH and SEC7 ( 964) 696 133.6 2.5e-30
NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens ( 399) 384 78.6 3.7e-14
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 363 74.9 4e-13
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 363 74.9 4e-13
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338) 363 74.9 4.2e-13
NP_001278947 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 363 74.9 4.2e-13
XP_011523779 (OMIM: 182115) PREDICTED: cytohesin-1 ( 339) 363 74.9 4.2e-13
NP_001278948 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 363 74.9 4.2e-13
XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 ( 380) 363 74.9 4.6e-13
NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Ho ( 397) 363 74.9 4.8e-13
NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Ho ( 398) 363 74.9 4.8e-13
XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 ( 399) 363 74.9 4.8e-13
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394) 358 74.1 8.7e-13
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399) 358 74.1 8.8e-13
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400) 358 74.1 8.9e-13
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421) 358 74.1 9.3e-13
XP_011528449 (OMIM: 606514) PREDICTED: cytohesin-4 ( 337) 323 67.9 5.4e-11
NP_001304953 (OMIM: 606514) cytohesin-4 isoform 2 ( 337) 323 67.9 5.4e-11
NP_037517 (OMIM: 606514) cytohesin-4 isoform 1 [Ho ( 394) 323 67.9 6.2e-11
XP_011515744 (OMIM: 604141) PREDICTED: brefeldin A (1649) 332 69.8 7e-11
XP_005251193 (OMIM: 604141) PREDICTED: brefeldin A (1800) 332 69.8 7.5e-11
XP_005251192 (OMIM: 604141) PREDICTED: brefeldin A (1843) 332 69.8 7.7e-11
NP_006412 (OMIM: 604141) brefeldin A-inhibited gua (1849) 332 69.8 7.7e-11
XP_005251191 (OMIM: 604141) PREDICTED: brefeldin A (1849) 332 69.8 7.7e-11
>>NP_996792 (OMIM: 614440) PH and SEC7 domain-containing (513 aa)
initn: 3379 init1: 3379 opt: 3379 Z-score: 3216.4 bits: 604.7 E(85289): 2e-172
Smith-Waterman score: 3379; 100.0% identity (100.0% similar) in 513 aa overlap (1-513:1-513)
10 20 30 40 50 60
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL
430 440 450 460 470 480
490 500 510
pF1KA0 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
:::::::::::::::::::::::::::::::::
NP_996 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
490 500 510
>>XP_016868754 (OMIM: 614440) PREDICTED: PH and SEC7 dom (511 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3121.5 bits: 587.2 E(85289): 3.9e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:10-511)
10 20 30 40 50 60
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MILLYSRTSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERER
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KA0 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRIGSTTNPF
180 190 200 210 220 230
250 260 270 280 290 300
pF1KA0 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA0 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINC
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSL
420 430 440 450 460 470
490 500 510
pF1KA0 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
:::::::::::::::::::::::::::::::::
XP_016 NPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
480 490 500 510
>>XP_016868750 (OMIM: 614440) PREDICTED: PH and SEC7 dom (1014 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3117.0 bits: 587.3 E(85289): 7.1e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:513-1014)
10 20 30 40
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLS
::::::::::::::::::::::::::::::
XP_016 GYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLS
490 500 510 520 530 540
50 60 70 80 90 100
pF1KA0 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
550 560 570 580 590 600
110 120 130 140 150 160
pF1KA0 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
610 620 630 640 650 660
170 180 190 200 210 220
pF1KA0 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
670 680 690 700 710 720
230 240 250 260 270 280
pF1KA0 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
730 740 750 760 770 780
290 300 310 320 330 340
pF1KA0 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
790 800 810 820 830 840
350 360 370 380 390 400
pF1KA0 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
850 860 870 880 890 900
410 420 430 440 450 460
pF1KA0 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
910 920 930 940 950 960
470 480 490 500 510
pF1KA0 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
970 980 990 1000 1010
>>XP_016868749 (OMIM: 614440) PREDICTED: PH and SEC7 dom (1046 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3116.8 bits: 587.3 E(85289): 7.3e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:545-1046)
10 20 30 40
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLS
::::::::::::::::::::::::::::::
XP_016 GYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLS
520 530 540 550 560 570
50 60 70 80 90 100
pF1KA0 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
580 590 600 610 620 630
110 120 130 140 150 160
pF1KA0 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
640 650 660 670 680 690
170 180 190 200 210 220
pF1KA0 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
700 710 720 730 740 750
230 240 250 260 270 280
pF1KA0 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
760 770 780 790 800 810
290 300 310 320 330 340
pF1KA0 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
820 830 840 850 860 870
350 360 370 380 390 400
pF1KA0 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
880 890 900 910 920 930
410 420 430 440 450 460
pF1KA0 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
940 950 960 970 980 990
470 480 490 500 510
pF1KA0 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
1000 1010 1020 1030 1040
>>NP_056125 (OMIM: 614440) PH and SEC7 domain-containing (1047 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3116.8 bits: 587.3 E(85289): 7.3e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:546-1047)
10 20 30 40
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLS
::::::::::::::::::::::::::::::
NP_056 GYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLS
520 530 540 550 560 570
50 60 70 80 90 100
pF1KA0 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
580 590 600 610 620 630
110 120 130 140 150 160
pF1KA0 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
640 650 660 670 680 690
170 180 190 200 210 220
pF1KA0 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
700 710 720 730 740 750
230 240 250 260 270 280
pF1KA0 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
760 770 780 790 800 810
290 300 310 320 330 340
pF1KA0 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
820 830 840 850 860 870
350 360 370 380 390 400
pF1KA0 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
880 890 900 910 920 930
410 420 430 440 450 460
pF1KA0 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
940 950 960 970 980 990
470 480 490 500 510
pF1KA0 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
1000 1010 1020 1030 1040
>>XP_016868748 (OMIM: 614440) PREDICTED: PH and SEC7 dom (1060 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3116.7 bits: 587.3 E(85289): 7.3e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:559-1060)
10 20 30 40
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLS
::::::::::::::::::::::::::::::
XP_016 GYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLS
530 540 550 560 570 580
50 60 70 80 90 100
pF1KA0 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
590 600 610 620 630 640
110 120 130 140 150 160
pF1KA0 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
650 660 670 680 690 700
170 180 190 200 210 220
pF1KA0 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
710 720 730 740 750 760
230 240 250 260 270 280
pF1KA0 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
770 780 790 800 810 820
290 300 310 320 330 340
pF1KA0 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
830 840 850 860 870 880
350 360 370 380 390 400
pF1KA0 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
890 900 910 920 930 940
410 420 430 440 450 460
pF1KA0 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
950 960 970 980 990 1000
470 480 490 500 510
pF1KA0 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
1010 1020 1030 1040 1050 1060
>>XP_016868747 (OMIM: 614440) PREDICTED: PH and SEC7 dom (1067 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3116.6 bits: 587.3 E(85289): 7.4e-167
Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 502 aa overlap (12-513:566-1067)
10 20 30 40
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLS
::::::::::::::::::::::::::::::
XP_016 GYSSGVTNGLNDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLS
540 550 560 570 580 590
50 60 70 80 90 100
pF1KA0 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQS
600 610 620 630 640 650
110 120 130 140 150 160
pF1KA0 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHN
660 670 680 690 700 710
170 180 190 200 210 220
pF1KA0 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEK
720 730 740 750 760 770
230 240 250 260 270 280
pF1KA0 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFY
780 790 800 810 820 830
290 300 310 320 330 340
pF1KA0 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLKGTVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVL
840 850 860 870 880 890
350 360 370 380 390 400
pF1KA0 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSH
900 910 920 930 940 950
410 420 430 440 450 460
pF1KA0 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELL
960 970 980 990 1000 1010
470 480 490 500 510
pF1KA0 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
1020 1030 1040 1050 1060
>>NP_001257895 (OMIM: 602327) PH and SEC7 domain-contain (645 aa)
initn: 1920 init1: 981 opt: 1904 Z-score: 1814.8 bits: 345.7 E(85289): 2.4e-94
Smith-Waterman score: 1938; 59.0% identity (82.0% similar) in 505 aa overlap (21-511:149-644)
10 20 30 40 50
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEA
.. ::. ::: : . ..:::: ....::
NP_001 EPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEA
120 130 140 150 160 170
60 70 80 90 100 110
pF1KA0 AKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFS
:.:::::::.:: :...:::.::::::.:::::: :::::: ::::::::.:: :.: ..
NP_001 AQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELA
180 190 200 210 220 230
120 130 140 150 160 170
pF1KA0 LVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQE
:.:::::::::: :::.::: :::....:.::.: ::::.::::::::::::::.::: .
NP_001 LMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGD
240 250 260 270 280 290
180 190 200 210 220 230
pF1KA0 FIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTI
::.::.:.:.: :: ..::::::.:::::::.::.:.:: ..: :: .. .::.:
NP_001 FIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP-----NPKVI
300 310 320 330 340 350
240 250 260 270 280
pF1KA0 SRI----GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKG
.:: :: ..::::. .:.::::: : :.::.::: : .::::::::::.:...:::
NP_001 KRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKG
360 370 380 390 400 410
290 300 310 320 330 340
pF1KA0 TVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQ
.:::::.:::: ::::: .::::.:.:::::..:.:: :.:.:: :.::::::.:::.
NP_001 MILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAP
420 430 440 450 460 470
350 360 370 380 390 400
pF1KA0 SPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLK
: :.::.::..:: :::.:::::::::..:::::::::::...:.::::::...::.:::
NP_001 SLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLK
480 490 500 510 520 530
410 420 430 440 450 460
pF1KA0 QITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL----KEGGKEL--
...:: :::. :: ..:...: . :. ::::::.:: :...: : :..::
NP_001 AMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDA
540 550 560 570 580 590
470 480 490 500 510
pF1KA0 ----LSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
:.. : :: :::::::.: : ...:. :: :: . : ..:
NP_001 VEAALAQAGSTEDGLPPSHSSPSLQPKPSS-QPRAQRHSSE---PRPGAGSGRRKP
600 610 620 630 640
>>XP_016871922 (OMIM: 602327) PREDICTED: PH and SEC7 dom (1024 aa)
initn: 1920 init1: 981 opt: 1904 Z-score: 1811.7 bits: 345.8 E(85289): 3.6e-94
Smith-Waterman score: 1938; 59.0% identity (82.0% similar) in 505 aa overlap (21-511:528-1023)
10 20 30 40 50
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEA
.. ::. ::: : . ..:::: ....::
XP_016 EPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEA
500 510 520 530 540 550
60 70 80 90 100 110
pF1KA0 AKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFS
:.:::::::.:: :...:::.::::::.:::::: :::::: ::::::::.:: :.: ..
XP_016 AQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELA
560 570 580 590 600 610
120 130 140 150 160 170
pF1KA0 LVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQE
:.:::::::::: :::.::: :::....:.::.: ::::.::::::::::::::.::: .
XP_016 LMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGD
620 630 640 650 660 670
180 190 200 210 220 230
pF1KA0 FIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTI
::.::.:.:.: :: ..::::::.:::::::.::.:.:: ..: :: .. .::.:
XP_016 FIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP-----NPKVI
680 690 700 710 720 730
240 250 260 270 280
pF1KA0 SRI----GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKG
.:: :: ..::::. .:.::::: : :.::.::: : .::::::::::.:...:::
XP_016 KRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKG
740 750 760 770 780 790
290 300 310 320 330 340
pF1KA0 TVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQ
.:::::.:::: ::::: .::::.:.:::::..:.:: :.:.:: :.::::::.:::.
XP_016 MILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAP
800 810 820 830 840 850
350 360 370 380 390 400
pF1KA0 SPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLK
: :.::.::..:: :::.:::::::::..:::::::::::...:.::::::...::.:::
XP_016 SLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLK
860 870 880 890 900 910
410 420 430 440 450 460
pF1KA0 QITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL----KEGGKEL--
...:: :::. :: ..:...: . :. ::::::.:: :...: : :..::
XP_016 AMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDA
920 930 940 950 960 970
470 480 490 500 510
pF1KA0 ----LSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
:.. : :: :::::::.: : ...:. :: :: . : ..:
XP_016 VEAALAQAGSTEDGLPPSHSSPSLQPKPSS-QPRAQRHSSE---PRPGAGSGRRKP
980 990 1000 1010 1020
>>NP_001257894 (OMIM: 602327) PH and SEC7 domain-contain (1024 aa)
initn: 1920 init1: 981 opt: 1904 Z-score: 1811.7 bits: 345.8 E(85289): 3.6e-94
Smith-Waterman score: 1938; 59.0% identity (82.0% similar) in 505 aa overlap (21-511:528-1023)
10 20 30 40 50
pF1KA0 MGSSWCLYGCCNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEA
.. ::. ::: : . ..:::: ....::
NP_001 EPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEA
500 510 520 530 540 550
60 70 80 90 100 110
pF1KA0 AKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFS
:.:::::::.:: :...:::.::::::.:::::: :::::: ::::::::.:: :.: ..
NP_001 AQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELA
560 570 580 590 600 610
120 130 140 150 160 170
pF1KA0 LVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQE
:.:::::::::: :::.::: :::....:.::.: ::::.::::::::::::::.::: .
NP_001 LMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGD
620 630 640 650 660 670
180 190 200 210 220 230
pF1KA0 FIANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTI
::.::.:.:.: :: ..::::::.:::::::.::.:.:: ..: :: .. .::.:
NP_001 FIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADP-----NPKVI
680 690 700 710 720 730
240 250 260 270 280
pF1KA0 SRI----GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKG
.:: :: ..::::. .:.::::: : :.::.::: : .::::::::::.:...:::
NP_001 KRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKG
740 750 760 770 780 790
290 300 310 320 330 340
pF1KA0 TVLYLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQ
.:::::.:::: ::::: .::::.:.:::::..:.:: :.:.:: :.::::::.:::.
NP_001 MILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAP
800 810 820 830 840 850
350 360 370 380 390 400
pF1KA0 SPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLK
: :.::.::..:: :::.:::::::::..:::::::::::...:.::::::...::.:::
NP_001 SLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLK
860 870 880 890 900 910
410 420 430 440 450 460
pF1KA0 QITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSIL----KEGGKEL--
...:: :::. :: ..:...: . :. ::::::.:: :...: : :..::
NP_001 AMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEELDA
920 930 940 950 960 970
470 480 490 500 510
pF1KA0 ----LSNDESEAAGLKKSHSSPSLNPDTSPITAKVKRNVSERKDHRPETPSIKQKVT
:.. : :: :::::::.: : ...:. :: :: . : ..:
NP_001 VEAALAQAGSTEDGLPPSHSSPSLQPKPSS-QPRAQRHSSE---PRPGAGSGRRKP
980 990 1000 1010 1020
513 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:09:17 2016 done: Fri Nov 4 01:09:18 2016
Total Scan time: 8.560 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]