Result of FASTA (omim) for
pF1KA0900
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0900, 502 aa
1>>>pF1KA0900 502 - 502 aa - 502 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.8619+/-0.000489; mu= -33.4836+/- 0.031
mean_var=813.2336+/-165.747, 0's: 0 Z-trim(125.4): 75 B-trim: 0 in 0/61
Lambda= 0.044975
statistics sampled from 48830 (48918) to 48830 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.81), E-opt: 0.2 (0.574), width: 16
Scan time: 12.570
The best scores are: opt bits E(85289)
NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome ( 502) 3451 238.9 2.7e-62
XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 3451 238.9 2.7e-62
XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Ald ( 502) 3451 238.9 2.7e-62
NP_001278894 (OMIM: 605068) wiskott-Aldrich syndro ( 499) 3103 216.3 1.7e-55
NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome ( 498) 1590 118.1 5.9e-26
XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_016866926 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome ( 559) 1182 91.7 6e-18
NP_001020107 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1182 91.7 6e-18
XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_005267260 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_005267264 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_011534536 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
NP_001020106 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1182 91.7 6e-18
NP_001020105 (OMIM: 605035) wiskott-Aldrich syndro ( 559) 1182 91.7 6e-18
XP_011534535 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_005267263 (OMIM: 605035) PREDICTED: wiskott-Ald ( 559) 1182 91.7 6e-18
XP_016866928 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_016866930 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_016866932 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_011534537 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_016866933 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_016866929 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
XP_016866931 (OMIM: 605035) PREDICTED: wiskott-Ald ( 558) 1173 91.1 9e-18
NP_001188333 (OMIM: 605875) wiskott-Aldrich syndro ( 281) 944 76.0 1.6e-13
>>NP_006637 (OMIM: 605068) wiskott-Aldrich syndrome prot (502 aa)
initn: 3451 init1: 3451 opt: 3451 Z-score: 1239.5 bits: 238.9 E(85289): 2.7e-62
Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
430 440 450 460 470 480
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
::::::::::::::::::::::
NP_006 RIAVEYSDSDDDSEFDENDWSD
490 500
>>XP_011533191 (OMIM: 605068) PREDICTED: wiskott-Aldrich (502 aa)
initn: 3451 init1: 3451 opt: 3451 Z-score: 1239.5 bits: 238.9 E(85289): 2.7e-62
Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
430 440 450 460 470 480
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
::::::::::::::::::::::
XP_011 RIAVEYSDSDDDSEFDENDWSD
490 500
>>XP_011533192 (OMIM: 605068) PREDICTED: wiskott-Aldrich (502 aa)
initn: 3451 init1: 3451 opt: 3451 Z-score: 1239.5 bits: 238.9 E(85289): 2.7e-62
Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
430 440 450 460 470 480
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
::::::::::::::::::::::
XP_011 RIAVEYSDSDDDSEFDENDWSD
490 500
>>NP_001278894 (OMIM: 605068) wiskott-Aldrich syndrome p (499 aa)
initn: 1882 init1: 1882 opt: 3103 Z-score: 1117.5 bits: 216.3 E(85289): 1.7e-55
Smith-Waterman score: 3103; 90.9% identity (95.4% similar) in 504 aa overlap (1-502:1-499)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQK-RIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD-NRLSQSVYHGASSEGSLSPDT
..: ... . . .:::.:.:..::. . :. : ..: :. :...: . : .
NP_001 REKHKLNPNRNQQVNVRKVRTRKEEWERRKMGIEFMSDAKKLEQA---GSAKEDRV-P-S
190 200 210 220 230
240 250 260 270 280 290
pF1KA0 RSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMAL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMAL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KA0 NRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KA0 FVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSP
360 370 380 390 400 410
420 430 440 450 460 470
pF1KA0 MHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATIL
420 430 440 450 460 470
480 490 500
pF1KA0 SRRIAVEYSDSDDDSEFDENDWSD
::::::::::::::::::::::::
NP_001 SRRIAVEYSDSDDDSEFDENDWSD
480 490
>>NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome prot (498 aa)
initn: 869 init1: 869 opt: 1590 Z-score: 586.9 bits: 118.1 E(85289): 5.9e-26
Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-502:1-498)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
:::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..::
NP_008 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: :
NP_008 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
: . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::...
NP_008 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR
120 130 140 150 160 170
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD
..:. :. .: . :: ..:..::. : . .:. . ..:. : : . ..::..
NP_008 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG--
180 190 200 210 220 230
240 250 260 270 280 290
pF1KA0 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH
. .: ::: :. . .: .::.. ..:: :: : .... :. ..
NP_008 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR
240 250 260 270 280 290
300 310 320 330 340
pF1KA0 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP
.. :..::: :: .: : . : : : :. : .. : ::::
NP_008 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KA0 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP
:: .: . :..: : :: ::. : :: :: ::::: :::::::::
NP_008 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP
360 370 380 390 400
410 420 430 440 450 460
pF1KA0 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR
: .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::
NP_008 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR
410 420 430 440 450 460
470 480 490 500
pF1KA0 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD
. ::::::::::::::::::::.::: ::::.::::
NP_008 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
470 480 490
>>XP_016866927 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa)
initn: 1494 init1: 915 opt: 1182 Z-score: 443.2 bits: 91.7 E(85289): 6e-18
Smith-Waterman score: 1424; 48.2% identity (63.3% similar) in 537 aa overlap (1-477:1-534)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::.:::::. :::.:: .::::::: .:: ::::::::::.::::::::::::.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: .:.::::.:.:::.:.::::: ::.:::::.:.:::.:::.::::. .....: :
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
. . :. ..::::::::::::: :.::::::.::::::::::::::::::::::::.::
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD--NRLSQS--VYHGASSEGSLSP
:: .: . : : ..::.::. .: :: : : : . : .: .:. :
XP_016 -QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRP
190 200 210 220 230
240 250 260 270 280
pF1KA0 DTRSHASDVTDYSYPATPNHSL---------------H-PQPVTPSYAAGDVPPHGPASQ
.: : .:: : : .. : : : : ..:::. : .
XP_016 QTYVDHMD-GSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCIS
240 250 260 270 280 290
290 300 310 320 330
pF1KA0 AAEH--EYRPPS-ASARHMALNRPQQPPPPPP-PQAPEGSQASAPMA----PADYGMLPA
.: : :: : :..: .. : :::::: :.: :. : :. : :
XP_016 SATGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPP
300 310 320 330 340 350
340 350 360 370 380
pF1KA0 QIIEYYNPSGPPPPPP----PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPST
:. :::: : : :. : .. :: .: .:: .: ...: ::
XP_016 PATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQP-SPPVARAAPVCETVPVHPLPQ
360 370 380 390 400 410
390 400 410 420
pF1KA0 GLLVTAPPPPGPPP-PPPG--------------PPG---------PGSSLSSSPMHGP--
: . :::: ::: :::: ::. :: . : :
XP_016 GEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQ
420 430 440 450 460 470
430 440 450 460 470 480
pF1KA0 --PVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
:..: ::. . : :::::: :: ::: ::::.::.::::::::.: . ::::::
XP_016 VIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSR
480 490 500 510 520 530
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
XP_016 RIAVEYSDSEDDSEFDEVDWLE
540 550
>>XP_016866926 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa)
initn: 1494 init1: 915 opt: 1182 Z-score: 443.2 bits: 91.7 E(85289): 6e-18
Smith-Waterman score: 1424; 48.2% identity (63.3% similar) in 537 aa overlap (1-477:1-534)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::.:::::. :::.:: .::::::: .:: ::::::::::.::::::::::::.
XP_016 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: .:.::::.:.:::.:.::::: ::.:::::.:.:::.:::.::::. .....: :
XP_016 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
. . :. ..::::::::::::: :.::::::.::::::::::::::::::::::::.::
XP_016 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD--NRLSQS--VYHGASSEGSLSP
:: .: . : : ..::.::. .: :: : : : . : .: .:. :
XP_016 -QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRP
190 200 210 220 230
240 250 260 270 280
pF1KA0 DTRSHASDVTDYSYPATPNHSL---------------H-PQPVTPSYAAGDVPPHGPASQ
.: : .:: : : .. : : : : ..:::. : .
XP_016 QTYVDHMD-GSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCIS
240 250 260 270 280 290
290 300 310 320 330
pF1KA0 AAEH--EYRPPS-ASARHMALNRPQQPPPPPP-PQAPEGSQASAPMA----PADYGMLPA
.: : :: : :..: .. : :::::: :.: :. : :. : :
XP_016 SATGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPP
300 310 320 330 340 350
340 350 360 370 380
pF1KA0 QIIEYYNPSGPPPPPP----PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPST
:. :::: : : :. : .. :: .: .:: .: ...: ::
XP_016 PATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQP-SPPVARAAPVCETVPVHPLPQ
360 370 380 390 400 410
390 400 410 420
pF1KA0 GLLVTAPPPPGPPP-PPPG--------------PPG---------PGSSLSSSPMHGP--
: . :::: ::: :::: ::. :: . : :
XP_016 GEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQ
420 430 440 450 460 470
430 440 450 460 470 480
pF1KA0 --PVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
:..: ::. . : :::::: :: ::: ::::.::.::::::::.: . ::::::
XP_016 VIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSR
480 490 500 510 520 530
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
XP_016 RIAVEYSDSEDDSEFDEVDWLE
540 550
>>NP_003922 (OMIM: 605035) wiskott-Aldrich syndrome prot (559 aa)
initn: 1494 init1: 915 opt: 1182 Z-score: 443.2 bits: 91.7 E(85289): 6e-18
Smith-Waterman score: 1424; 48.2% identity (63.3% similar) in 537 aa overlap (1-477:1-534)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::.:::::. :::.:: .::::::: .:: ::::::::::.::::::::::::.
NP_003 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: .:.::::.:.:::.:.::::: ::.:::::.:.:::.:::.::::. .....: :
NP_003 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
. . :. ..::::::::::::: :.::::::.::::::::::::::::::::::::.::
NP_003 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD--NRLSQS--VYHGASSEGSLSP
:: .: . : : ..::.::. .: :: : : : . : .: .:. :
NP_003 -QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRP
190 200 210 220 230
240 250 260 270 280
pF1KA0 DTRSHASDVTDYSYPATPNHSL---------------H-PQPVTPSYAAGDVPPHGPASQ
.: : .:: : : .. : : : : ..:::. : .
NP_003 QTYVDHMD-GSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCIS
240 250 260 270 280 290
290 300 310 320 330
pF1KA0 AAEH--EYRPPS-ASARHMALNRPQQPPPPPP-PQAPEGSQASAPMA----PADYGMLPA
.: : :: : :..: .. : :::::: :.: :. : :. : :
NP_003 SATGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPP
300 310 320 330 340 350
340 350 360 370 380
pF1KA0 QIIEYYNPSGPPPPPP----PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPST
:. :::: : : :. : .. :: .: .:: .: ...: ::
NP_003 PATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQP-SPPVARAAPVCETVPVHPLPQ
360 370 380 390 400 410
390 400 410 420
pF1KA0 GLLVTAPPPPGPPP-PPPG--------------PPG---------PGSSLSSSPMHGP--
: . :::: ::: :::: ::. :: . : :
NP_003 GEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQ
420 430 440 450 460 470
430 440 450 460 470 480
pF1KA0 --PVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
:..: ::. . : :::::: :: ::: ::::.::.::::::::.: . ::::::
NP_003 VIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSR
480 490 500 510 520 530
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
NP_003 RIAVEYSDSEDDSEFDEVDWLE
540 550
>>NP_001020107 (OMIM: 605035) wiskott-Aldrich syndrome p (559 aa)
initn: 1494 init1: 915 opt: 1182 Z-score: 443.2 bits: 91.7 E(85289): 6e-18
Smith-Waterman score: 1424; 48.2% identity (63.3% similar) in 537 aa overlap (1-477:1-534)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::.:::::. :::.:: .::::::: .:: ::::::::::.::::::::::::.
NP_001 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: .:.::::.:.:::.:.::::: ::.:::::.:.:::.:::.::::. .....: :
NP_001 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
. . :. ..::::::::::::: :.::::::.::::::::::::::::::::::::.::
NP_001 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD--NRLSQS--VYHGASSEGSLSP
:: .: . : : ..::.::. .: :: : : : . : .: .:. :
NP_001 -QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRP
190 200 210 220 230
240 250 260 270 280
pF1KA0 DTRSHASDVTDYSYPATPNHSL---------------H-PQPVTPSYAAGDVPPHGPASQ
.: : .:: : : .. : : : : ..:::. : .
NP_001 QTYVDHMD-GSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCIS
240 250 260 270 280 290
290 300 310 320 330
pF1KA0 AAEH--EYRPPS-ASARHMALNRPQQPPPPPP-PQAPEGSQASAPMA----PADYGMLPA
.: : :: : :..: .. : :::::: :.: :. : :. : :
NP_001 SATGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPP
300 310 320 330 340 350
340 350 360 370 380
pF1KA0 QIIEYYNPSGPPPPPP----PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPST
:. :::: : : :. : .. :: .: .:: .: ...: ::
NP_001 PATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQP-SPPVARAAPVCETVPVHPLPQ
360 370 380 390 400 410
390 400 410 420
pF1KA0 GLLVTAPPPPGPPP-PPPG--------------PPG---------PGSSLSSSPMHGP--
: . :::: ::: :::: ::. :: . : :
NP_001 GEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQ
420 430 440 450 460 470
430 440 450 460 470 480
pF1KA0 --PVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
:..: ::. . : :::::: :: ::: ::::.::.::::::::.: . ::::::
NP_001 VIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSR
480 490 500 510 520 530
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
NP_001 RIAVEYSDSEDDSEFDEVDWLE
540 550
>>XP_005267262 (OMIM: 605035) PREDICTED: wiskott-Aldrich (559 aa)
initn: 1494 init1: 915 opt: 1182 Z-score: 443.2 bits: 91.7 E(85289): 6e-18
Smith-Waterman score: 1424; 48.2% identity (63.3% similar) in 537 aa overlap (1-477:1-534)
10 20 30 40 50 60
pF1KA0 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN
::::::::.:::::. :::.:: .::::::: .:: ::::::::::.::::::::::::.
XP_005 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP
.: .:.::::.:.:::.:.::::: ::.:::::.:.:::.:::.::::. .....: :
XP_005 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK
. . :. ..::::::::::::: :.::::::.::::::::::::::::::::::::.::
XP_005 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPD--NRLSQS--VYHGASSEGSLSP
:: .: . : : ..::.::. .: :: : : : . : .: .:. :
XP_005 -QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRP
190 200 210 220 230
240 250 260 270 280
pF1KA0 DTRSHASDVTDYSYPATPNHSL---------------H-PQPVTPSYAAGDVPPHGPASQ
.: : .:: : : .. : : : : ..:::. : .
XP_005 QTYVDHMD-GSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPIPTCIS
240 250 260 270 280 290
290 300 310 320 330
pF1KA0 AAEH--EYRPPS-ASARHMALNRPQQPPPPPP-PQAPEGSQASAPMA----PADYGMLPA
.: : :: : :..: .. : :::::: :.: :. : :. : :
XP_005 SATGLIENRPQSPATGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPP
300 310 320 330 340 350
340 350 360 370 380
pF1KA0 QIIEYYNPSGPPPPPP----PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPST
:. :::: : : :. : .. :: .: .:: .: ...: ::
XP_005 PATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQP-SPPVARAAPVCETVPVHPLPQ
360 370 380 390 400 410
390 400 410 420
pF1KA0 GLLVTAPPPPGPPP-PPPG--------------PPG---------PGSSLSSSPMHGP--
: . :::: ::: :::: ::. :: . : :
XP_005 GEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQ
420 430 440 450 460 470
430 440 450 460 470 480
pF1KA0 --PVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSR
:..: ::. . : :::::: :: ::: ::::.::.::::::::.: . ::::::
XP_005 VIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSR
480 490 500 510 520 530
490 500
pF1KA0 RIAVEYSDSDDDSEFDENDWSD
XP_005 RIAVEYSDSEDDSEFDEVDWLE
540 550
502 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:54:41 2016 done: Wed Nov 2 19:54:43 2016
Total Scan time: 12.570 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]