Result of FASTA (omim) for
pF1KA0838
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0838, 669 aa
1>>>pF1KA0838 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3099+/-0.000461; mu= 2.0637+/- 0.029
mean_var=265.0322+/-53.172, 0's: 0 Z-trim(119.1): 11 B-trim: 130 in 1/54
Lambda= 0.078782
statistics sampled from 32685 (32696) to 32685 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.383), width: 16
Scan time: 11.810
The best scores are: opt bits E(85289)
NP_055720 (OMIM: 138280) glutaminase kidney isofor ( 669) 4554 531.5 3.9e-150
XP_006712498 (OMIM: 138280) PREDICTED: glutaminase ( 661) 4057 475.0 3.9e-133
XP_005246524 (OMIM: 138280) PREDICTED: glutaminase ( 559) 3758 440.9 5.9e-123
NP_001243239 (OMIM: 138280) glutaminase kidney iso ( 598) 3757 440.8 6.7e-123
XP_005268854 (OMIM: 606365) PREDICTED: glutaminase ( 566) 2764 328.0 6.1e-89
NP_037399 (OMIM: 606365) glutaminase liver isoform ( 602) 2758 327.3 1e-88
XP_016859318 (OMIM: 138280) PREDICTED: glutaminase ( 349) 2339 279.5 1.5e-74
NP_001267727 (OMIM: 606365) glutaminase liver isof ( 337) 1751 212.6 1.9e-54
XP_016874669 (OMIM: 606365) PREDICTED: glutaminase ( 337) 1751 212.6 1.9e-54
NP_001267726 (OMIM: 606365) glutaminase liver isof ( 337) 1751 212.6 1.9e-54
NP_001267725 (OMIM: 606365) glutaminase liver isof ( 326) 1517 186.0 1.9e-46
>>NP_055720 (OMIM: 138280) glutaminase kidney isoform, m (669 aa)
initn: 4554 init1: 4554 opt: 4554 Z-score: 2816.3 bits: 531.5 E(85289): 3.9e-150
Smith-Waterman score: 4554; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669)
10 20 30 40 50 60
pF1KA0 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
610 620 630 640 650 660
pF1KA0 VHKNLDGLL
:::::::::
NP_055 VHKNLDGLL
>>XP_006712498 (OMIM: 138280) PREDICTED: glutaminase kid (661 aa)
initn: 4082 init1: 4048 opt: 4057 Z-score: 2511.1 bits: 475.0 E(85289): 3.9e-133
Smith-Waterman score: 4057; 95.0% identity (96.5% similar) in 636 aa overlap (1-631:1-634)
10 20 30 40 50 60
pF1KA0 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: .
XP_006 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGGIT
550 560 570 580 590 600
610 620 630 640 650
pF1KA0 VVKFLLEACKVNP-----FPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNG
. .. : .. : :. ..: . : : :
XP_006 LP--WMKHCTLDTMMYLKFSKNTKSSTHLKEILTTGRKIKPSIRILMDCCNGLKSQDLNH
610 620 630 640 650
660
pF1KA0 KENQTVHKNLDGLL
XP_006 LPI
660
>>XP_005246524 (OMIM: 138280) PREDICTED: glutaminase kid (559 aa)
initn: 3792 init1: 3758 opt: 3758 Z-score: 2328.4 bits: 440.9 E(85289): 5.9e-123
Smith-Waterman score: 3758; 99.8% identity (100.0% similar) in 551 aa overlap (1-551:1-551)
10 20 30 40 50 60
pF1KA0 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
::::::::::.
XP_005 DPRREGGDQRLGPFFTQVH
550
>>NP_001243239 (OMIM: 138280) glutaminase kidney isoform (598 aa)
initn: 3757 init1: 3757 opt: 3757 Z-score: 2327.4 bits: 440.8 E(85289): 6.7e-123
Smith-Waterman score: 3757; 100.0% identity (100.0% similar) in 550 aa overlap (1-550:1-550)
10 20 30 40 50 60
pF1KA0 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
::::::::::
NP_001 DPRREGGDQRHSFGPLDYESLQQELALKETVWKKVSPESNEDISTTVVYRMESLGEKS
550 560 570 580 590
>>XP_005268854 (OMIM: 606365) PREDICTED: glutaminase liv (566 aa)
initn: 2761 init1: 2761 opt: 2764 Z-score: 1717.8 bits: 328.0 E(85289): 6.1e-89
Smith-Waterman score: 2764; 72.9% identity (91.0% similar) in 543 aa overlap (127-669:24-566)
100 110 120 130 140 150
pF1KA0 PAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPV
: .. ..:.: : ::::::::::::.::.
XP_005 MWNSLLPPVQVYWGLCVVFLRVLGSDSSESGMLSRLGDLLFYTIAEGQERIPI
10 20 30 40 50
160 170 180 190 200 210
pF1KA0 HKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFR
::: ::::.:::.::::::..::. .. ..: .:.: .::.:::.:::.:::::::::::
XP_005 HKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFR
60 70 80 90 100 110
220 230 240 250 260 270
pF1KA0 RKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTG
.::::::: ::.:.:...:..:. .::::: ::::::: .:::::::.:::::::::.:
XP_005 KKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVG
120 130 140 150 160 170
280 290 300 310 320 330
pF1KA0 DTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNA
::.::::::::::: :::... :::.:::..:::::::::.::: :::. ::::::::
XP_005 HTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNA
180 190 200 210 220 230
340 350 360 370 380 390
pF1KA0 GAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLK
:::::.::::. :.:::::.:.:.:::::::::.::::::::::.:.::::.:::::::
XP_005 GAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLK
240 250 260 270 280 290
400 410 420 430 440 450
pF1KA0 EKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNT
::::::.:.::.. ::.::::::.::::::.:::::::::::.:::::: ::: ::::::
XP_005 EKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNT
300 310 320 330 340 350
460 470 480 490 500 510
pF1KA0 LSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIH
::::::::::::::::::::::::::.:.:.::::::::::::: ::::::.::: .:
XP_005 LSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTS
360 370 380 390 400 410
520 530 540 550 560 570
pF1KA0 FCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSA
::. :::: :::::::::: :.::::::::.. : :.:.:::::::.:::::::::::::
XP_005 FCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSA
420 430 440 450 460 470
580 590 600 610 620 630
pF1KA0 MDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVF
:::::.::::::::::::::::.::::::.:::::::: ::::.: :.:.:..:.: .:
XP_005 MDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVV
480 490 500 510 520 530
640 650 660
pF1KA0 KILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
:.::.:: .:: . . .. . ..::....
XP_005 KLLQDYQDSYTLSETQAEAAAEALSKENLESMV
540 550 560
>>NP_037399 (OMIM: 606365) glutaminase liver isoform, mi (602 aa)
initn: 2755 init1: 2755 opt: 2758 Z-score: 1713.7 bits: 327.3 E(85289): 1e-88
Smith-Waterman score: 2760; 67.6% identity (84.6% similar) in 611 aa overlap (59-669:19-602)
30 40 50 60 70 80
pF1KA0 QPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGST
: ::: ..: : :: :: :
NP_037 MRSMKALQKALSRAGSHCGRGGW-GHP-----SRSPL-----LGGGVR
10 20 30
90 100 110 120 130 140
pF1KA0 HPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIA
: .: :: . :.. . . .::. :.: : ::::::::
NP_037 HH---LSEAAAQGRETPHSHQPQHQDHDSSES-------------GMLSRLGDLLFYTIA
40 50 60 70 80
150 160 170 180 190 200
pF1KA0 EGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNI
::::.::.::: ::::.:::.::::::..::. .. ..: .:.: .::.:::.:::.:::
NP_037 EGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNI
90 100 110 120 130 140
210 220 230 240 250 260
pF1KA0 VLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTV
::::::::.::::::: ::.:.:...:..:. .::::: ::::::: .:::::::.:::
NP_037 VLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTV
150 160 170 180 190 200
270 280 290 300 310 320
pF1KA0 DGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDK
::::::.: ::.::::::::::: :::... :::.:::..:::::::::.::: :::.
NP_037 DGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGI
210 220 230 240 250 260
330 340 350 360 370 380
pF1KA0 PHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRN
:::::::::::::.::::. :.:::::.:.:.:::::::::.::::::::::.:.::::
NP_037 PHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRN
270 280 290 300 310 320
390 400 410 420 430 440
pF1KA0 FAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVL
.:::::::::::::.:.::.. ::.::::::.::::::.:::::::::::.:::::: ::
NP_037 YAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVL
330 340 350 360 370 380
450 460 470 480 490 500
pF1KA0 SPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKM
: ::::::::::::::::::::::::::::::::.:.:.::::::::::::: ::::::.
NP_037 SAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKL
390 400 410 420 430 440
510 520 530 540 550 560
pF1KA0 GNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSA
::: .: ::. :::: :::::::::: :.::::::::.. : :.:.:::::::.:::::
NP_037 GNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSA
450 460 470 480 490 500
570 580 590 600 610 620
pF1KA0 LRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEAL
:::::::::::::.::::::::::::::::.::::::.:::::::: ::::.: :.:.:.
NP_037 LRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAV
510 520 530 540 550 560
630 640 650 660
pF1KA0 HFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
.:.: .: :.::.:: .:: . . .. . ..::....
NP_037 QFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
570 580 590 600
>>XP_016859318 (OMIM: 138280) PREDICTED: glutaminase kid (349 aa)
initn: 2339 init1: 2339 opt: 2339 Z-score: 1459.5 bits: 279.5 E(85289): 1.5e-74
Smith-Waterman score: 2339; 100.0% identity (100.0% similar) in 346 aa overlap (1-346:1-346)
10 20 30 40 50 60
pF1KA0 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKDWW
310 320 330 340
370 380 390 400 410 420
pF1KA0 FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
>>NP_001267727 (OMIM: 606365) glutaminase liver isoform, (337 aa)
initn: 1748 init1: 1748 opt: 1751 Z-score: 1098.5 bits: 212.6 E(85289): 1.9e-54
Smith-Waterman score: 1751; 75.7% identity (91.7% similar) in 337 aa overlap (333-669:1-337)
310 320 330 340 350 360
pF1KA0 EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
:::::::::.::::. :.:::::.:.:.:
NP_001 MVNAGAIVVSSLIKMDCNKAEKFDFVLQYL
10 20 30
370 380 390 400 410 420
pF1KA0 NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
::::::::.::::::::::.:.::::.:::::::::::::.:.::.. ::.::::::.::
NP_001 NKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEV
40 50 60 70 80 90
430 440 450 460 470 480
pF1KA0 TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
::::.:::::::::::.:::::: ::: ::::::::::::::::::::::::::::::::
NP_001 TCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
100 110 120 130 140 150
490 500 510 520 530 540
pF1KA0 GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
.:.:.::::::::::::: ::::::.::: .: ::. :::: :::::::::: :.::::
NP_001 AVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDP
160 170 180 190 200 210
550 560 570 580 590 600
pF1KA0 RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
::::.. : :.:.:::::::.::::::::::::::::::.::::::::::::::::.:::
NP_001 RREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVV
220 230 240 250 260 270
610 620 630 640 650 660
pF1KA0 KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
:::.:::::::: ::::.: :.:.:..:.: .: :.::.:: .:: . . .. . .
NP_001 KFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSK
280 290 300 310 320 330
pF1KA0 KNLDGLL
.::....
NP_001 ENLESMV
>>XP_016874669 (OMIM: 606365) PREDICTED: glutaminase liv (337 aa)
initn: 1748 init1: 1748 opt: 1751 Z-score: 1098.5 bits: 212.6 E(85289): 1.9e-54
Smith-Waterman score: 1751; 75.7% identity (91.7% similar) in 337 aa overlap (333-669:1-337)
310 320 330 340 350 360
pF1KA0 EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
:::::::::.::::. :.:::::.:.:.:
XP_016 MVNAGAIVVSSLIKMDCNKAEKFDFVLQYL
10 20 30
370 380 390 400 410 420
pF1KA0 NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
::::::::.::::::::::.:.::::.:::::::::::::.:.::.. ::.::::::.::
XP_016 NKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEV
40 50 60 70 80 90
430 440 450 460 470 480
pF1KA0 TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
::::.:::::::::::.:::::: ::: ::::::::::::::::::::::::::::::::
XP_016 TCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
100 110 120 130 140 150
490 500 510 520 530 540
pF1KA0 GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
.:.:.::::::::::::: ::::::.::: .: ::. :::: :::::::::: :.::::
XP_016 AVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDP
160 170 180 190 200 210
550 560 570 580 590 600
pF1KA0 RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
::::.. : :.:.:::::::.::::::::::::::::::.::::::::::::::::.:::
XP_016 RREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVV
220 230 240 250 260 270
610 620 630 640 650 660
pF1KA0 KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
:::.:::::::: ::::.: :.:.:..:.: .: :.::.:: .:: . . .. . .
XP_016 KFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSK
280 290 300 310 320 330
pF1KA0 KNLDGLL
.::....
XP_016 ENLESMV
>>NP_001267726 (OMIM: 606365) glutaminase liver isoform, (337 aa)
initn: 1748 init1: 1748 opt: 1751 Z-score: 1098.5 bits: 212.6 E(85289): 1.9e-54
Smith-Waterman score: 1751; 75.7% identity (91.7% similar) in 337 aa overlap (333-669:1-337)
310 320 330 340 350 360
pF1KA0 EYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFL
:::::::::.::::. :.:::::.:.:.:
NP_001 MVNAGAIVVSSLIKMDCNKAEKFDFVLQYL
10 20 30
370 380 390 400 410 420
pF1KA0 NKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEV
::::::::.::::::::::.:.::::.:::::::::::::.:.::.. ::.::::::.::
NP_001 NKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEV
40 50 60 70 80 90
430 440 450 460 470 480
pF1KA0 TCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
::::.:::::::::::.:::::: ::: ::::::::::::::::::::::::::::::::
NP_001 TCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS
100 110 120 130 140 150
490 500 510 520 530 540
pF1KA0 GVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDP
.:.:.::::::::::::: ::::::.::: .: ::. :::: :::::::::: :.::::
NP_001 AVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDP
160 170 180 190 200 210
550 560 570 580 590 600
pF1KA0 RREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVV
::::.. : :.:.:::::::.::::::::::::::::::.::::::::::::::::.:::
NP_001 RREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVV
220 230 240 250 260 270
610 620 630 640 650 660
pF1KA0 KFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVH
:::.:::::::: ::::.: :.:.:..:.: .: :.::.:: .:: . . .. . .
NP_001 KFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSK
280 290 300 310 320 330
pF1KA0 KNLDGLL
.::....
NP_001 ENLESMV
669 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:02:45 2016 done: Fri Nov 4 01:02:47 2016
Total Scan time: 11.810 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]