Result of FASTA (omim) for
pF1KA0790
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0790, 1247 aa
1>>>pF1KA0790 1247 - 1247 aa - 1247 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4883+/-0.000425; mu= -10.4660+/- 0.027
mean_var=397.8990+/-81.646, 0's: 0 Z-trim(122.9): 26 B-trim: 0 in 0/59
Lambda= 0.064297
statistics sampled from 41810 (41836) to 41810 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.491), width: 16
Scan time: 18.000
The best scores are: opt bits E(85289)
NP_056093 (OMIM: 607955) SAM and SH3 domain-contai (1247) 8410 795.3 0
NP_001333434 (OMIM: 607955) SAM and SH3 domain-con (1202) 8030 760.0 2.1e-218
NP_001333435 (OMIM: 607955) SAM and SH3 domain-con (1123) 7525 713.1 2.5e-204
NP_001333436 (OMIM: 607955) SAM and SH3 domain-con (1008) 6747 640.9 1.2e-182
NP_001333438 (OMIM: 607955) SAM and SH3 domain-con (1130) 5710 544.8 1.2e-153
NP_001333437 (OMIM: 607955) SAM and SH3 domain-con (1171) 5710 544.8 1.3e-153
XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 (1286) 5710 544.8 1.4e-153
XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 (1291) 5710 544.8 1.4e-153
XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153
XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 (1317) 5710 544.8 1.4e-153
XP_016866090 (OMIM: 607955) PREDICTED: SAM and SH3 (1351) 5710 544.8 1.4e-153
XP_016866089 (OMIM: 607955) PREDICTED: SAM and SH3 (1365) 5710 544.8 1.4e-153
XP_016866088 (OMIM: 607955) PREDICTED: SAM and SH3 (1373) 5710 544.8 1.4e-153
XP_016866087 (OMIM: 607955) PREDICTED: SAM and SH3 (1410) 5710 544.8 1.5e-153
XP_011527986 (OMIM: 607978) PREDICTED: SAM domain- ( 355) 855 94.1 1.8e-18
NP_071419 (OMIM: 607978) SAM domain-containing pro ( 373) 855 94.1 1.9e-18
NP_001243299 (OMIM: 607978) SAM domain-containing ( 441) 855 94.2 2.1e-18
NP_061863 (OMIM: 300441) SAM and SH3 domain-contai ( 380) 827 91.5 1.1e-17
NP_001273452 (OMIM: 607978) SAM domain-containing ( 304) 793 88.3 8.5e-17
XP_011527988 (OMIM: 607978) PREDICTED: SAM domain- ( 309) 775 86.6 2.7e-16
XP_016883916 (OMIM: 607978) PREDICTED: SAM domain- ( 311) 773 86.5 3.1e-16
XP_011527987 (OMIM: 607978) PREDICTED: SAM domain- ( 323) 744 83.8 2.1e-15
XP_006724826 (OMIM: 300441) PREDICTED: SAM and SH3 ( 430) 568 67.5 2.2e-10
>>NP_056093 (OMIM: 607955) SAM and SH3 domain-containing (1247 aa)
initn: 8410 init1: 8410 opt: 8410 Z-score: 4232.3 bits: 795.3 E(85289): 0
Smith-Waterman score: 8410; 99.9% identity (100.0% similar) in 1247 aa overlap (1-1247:1-1247)
10 20 30 40 50 60
pF1KA0 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 DLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_056 DLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERD
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240
pF1KA0 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1210 1220 1230 1240
>>NP_001333434 (OMIM: 607955) SAM and SH3 domain-contain (1202 aa)
initn: 8030 init1: 8030 opt: 8030 Z-score: 4042.0 bits: 760.0 E(85289): 2.1e-218
Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1195 aa overlap (53-1247:8-1202)
30 40 50 60 70 80
pF1KA0 PAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERME
::::::::::::::::::::::::::::::
NP_001 MEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERME
10 20 30
90 100 110 120 130 140
pF1KA0 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRKRRVSQDLEVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSV
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMIT
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLH
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPE
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQ
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKS
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKL
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVH
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKR
520 530 540 550 560 570
630 640 650 660 670 680
pF1KA0 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_001 PTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPE
580 590 600 610 620 630
690 700 710 720 730 740
pF1KA0 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKA
640 650 660 670 680 690
750 760 770 780 790 800
pF1KA0 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPP
700 710 720 730 740 750
810 820 830 840 850 860
pF1KA0 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPP
760 770 780 790 800 810
870 880 890 900 910 920
pF1KA0 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGL
820 830 840 850 860 870
930 940 950 960 970 980
pF1KA0 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPS
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KA0 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPR
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KA0 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLH
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KA0 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIP
1060 1070 1080 1090 1100 1110
1170 1180 1190 1200 1210 1220
pF1KA0 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGI
1120 1130 1140 1150 1160 1170
1230 1240
pF1KA0 TEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::
NP_001 TEERHIRKLLSAARLFKLPPGPEAM
1180 1190 1200
>>NP_001333435 (OMIM: 607955) SAM and SH3 domain-contain (1123 aa)
initn: 7525 init1: 7525 opt: 7525 Z-score: 3789.2 bits: 713.1 E(85289): 2.5e-204
Smith-Waterman score: 7525; 99.7% identity (100.0% similar) in 1120 aa overlap (128-1247:4-1123)
100 110 120 130 140 150
pF1KA0 PDASPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQN
..::::::::::::::::::::::::::::
NP_001 MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQN
10 20 30
160 170 180 190 200 210
pF1KA0 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQH
40 50 60 70 80 90
220 230 240 250 260 270
pF1KA0 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIR
100 110 120 130 140 150
280 290 300 310 320 330
pF1KA0 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPS
160 170 180 190 200 210
340 350 360 370 380 390
pF1KA0 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGL
220 230 240 250 260 270
400 410 420 430 440 450
pF1KA0 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KA0 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSG
340 350 360 370 380 390
520 530 540 550 560 570
pF1KA0 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKL
400 410 420 430 440 450
580 590 600 610 620 630
pF1KA0 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKS
460 470 480 490 500 510
640 650 660 670 680 690
pF1KA0 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEY
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_001 VEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEY
520 530 540 550 560 570
700 710 720 730 740 750
pF1KA0 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKS
580 590 600 610 620 630
760 770 780 790 800 810
pF1KA0 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVS
640 650 660 670 680 690
820 830 840 850 860 870
pF1KA0 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASST
700 710 720 730 740 750
880 890 900 910 920 930
pF1KA0 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPP
760 770 780 790 800 810
940 950 960 970 980 990
pF1KA0 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLA
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KA0 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRP
880 890 900 910 920 930
1060 1070 1080 1090 1100 1110
pF1KA0 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKH
940 950 960 970 980 990
1120 1130 1140 1150 1160 1170
pF1KA0 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPG
1000 1010 1020 1030 1040 1050
1180 1190 1200 1210 1220 1230
pF1KA0 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARL
1060 1070 1080 1090 1100 1110
1240
pF1KA0 FKLPPGPEAM
::::::::::
NP_001 FKLPPGPEAM
1120
>>NP_001333436 (OMIM: 607955) SAM and SH3 domain-contain (1008 aa)
initn: 6747 init1: 6747 opt: 6747 Z-score: 3399.9 bits: 640.9 E(85289): 1.2e-182
Smith-Waterman score: 6747; 99.9% identity (100.0% similar) in 1004 aa overlap (244-1247:5-1008)
220 230 240 250 260 270
pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK
::::::::::::::::::::::::::::::
NP_001 MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK
10 20 30
280 290 300 310 320 330
pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
40 50 60 70 80 90
340 350 360 370 380 390
pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
100 110 120 130 140 150
400 410 420 430 440 450
pF1KA0 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKK
160 170 180 190 200 210
460 470 480 490 500 510
pF1KA0 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRS
220 230 240 250 260 270
520 530 540 550 560 570
pF1KA0 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD
280 290 300 310 320 330
580 590 600 610 620 630
pF1KA0 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPP
340 350 360 370 380 390
640 650 660 670 680 690
pF1KA0 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVEL
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
NP_001 QPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVEL
400 410 420 430 440 450
700 710 720 730 740 750
pF1KA0 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEP
460 470 480 490 500 510
760 770 780 790 800 810
pF1KA0 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRS
520 530 540 550 560 570
820 830 840 850 860 870
pF1KA0 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTT
580 590 600 610 620 630
880 890 900 910 920 930
pF1KA0 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYD
640 650 660 670 680 690
940 950 960 970 980 990
pF1KA0 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSR
700 710 720 730 740 750
1000 1010 1020 1030 1040 1050
pF1KA0 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPP
760 770 780 790 800 810
1060 1070 1080 1090 1100 1110
pF1KA0 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPY
820 830 840 850 860 870
1120 1130 1140 1150 1160 1170
pF1KA0 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKP
880 890 900 910 920 930
1180 1190 1200 1210 1220 1230
pF1KA0 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLS
940 950 960 970 980 990
1240
pF1KA0 AARLFKLPPGPEAM
::::::::::::::
NP_001 AARLFKLPPGPEAM
1000
>>NP_001333438 (OMIM: 607955) SAM and SH3 domain-contain (1130 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2879.3 bits: 544.8 E(85289): 1.2e-153
Smith-Waterman score: 6185; 85.5% identity (85.6% similar) in 1130 aa overlap (281-1247:1-1130)
260 270 280 290 300 310
pF1KA0 ETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGV
::::::::::::::::::::::::::::::
NP_001 MKKPSTEGGEEHVFENSPVLDERSALYSGV
10 20 30
320 330 340 350 360 370
pF1KA0 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMG
40 50 60 70 80 90
380 390 400
pF1KA0 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHG---------------------------
:::::::::::::::::::::::::::::::::
NP_001 TFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQS
100 110 120 130 140 150
pF1KA0 ------------------------------------------------------------
NP_001 VRKQIRLKKTDTNYSCSRAFLCQRPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGR
160 170 180 190 200 210
pF1KA0 ------------------------------------------------------------
NP_001 TSVSEFNITYVVERSLYSHLNLTQLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAAT
220 230 240 250 260 270
410 420 430 440
pF1KA0 ----------------RTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR
::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDRCTKRVLLRIHQKSRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASR
280 290 300 310 320 330
450 460 470 480 490 500
pF1KA0 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLGKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGS
340 350 360 370 380 390
510 520 530 540 550 560
pF1KA0 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTP
400 410 420 430 440 450
570 580 590 600 610 620
pF1KA0 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRR
460 470 480 490 500 510
630 640 650 660 670 680
pF1KA0 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVL
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_001 RKGRPPQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVL
520 530 540 550 560 570
690 700 710 720 730 740
pF1KA0 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTAVELLQEYDSNSDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSA
580 590 600 610 620 630
750 760 770 780 790 800
pF1KA0 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSTEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGL
640 650 660 670 680 690
810 820 830 840 850 860
pF1KA0 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPE
700 710 720 730 740 750
870 880 890 900 910 920
pF1KA0 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQKTTASSTKAQPLEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQC
760 770 780 790 800 810
930 940 950 960 970 980
pF1KA0 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRNYDAQPPGAKHGLARTPLEGHRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPV
820 830 840 850 860 870
990 1000 1010 1020 1030 1040
pF1KA0 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAKKSRERLANGLHPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQ
880 890 900 910 920 930
1050 1060 1070 1080 1090 1100
pF1KA0 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGSPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGID
940 950 960 970 980 990
1110 1120 1130 1140 1150 1160
pF1KA0 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLT
1000 1010 1020 1030 1040 1050
1170 1180 1190 1200 1210 1220
pF1KA0 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EICRKPVSPGCISSVSDWLISIGLPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERH
1060 1070 1080 1090 1100 1110
1230 1240
pF1KA0 IRKLLSAARLFKLPPGPEAM
::::::::::::::::::::
NP_001 IRKLLSAARLFKLPPGPEAM
1120 1130
>>NP_001333437 (OMIM: 607955) SAM and SH3 domain-contain (1171 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2879.1 bits: 544.8 E(85289): 1.3e-153
Smith-Waterman score: 6411; 85.9% identity (86.0% similar) in 1167 aa overlap (244-1247:5-1171)
220 230 240 250 260 270
pF1KA0 EAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRK
::::::::::::::::::::::::::::::
NP_001 MPKPSREQSDDETEESVKFKRLHKLVNSTRRVRK
10 20 30
280 290 300 310 320 330
pF1KA0 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLIRVEEMKKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLT
40 50 60 70 80 90
340 350 360 370 380 390
pF1KA0 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEM
100 110 120 130 140 150
400
pF1KA0 KKGLGSLSHG--------------------------------------------------
::::::::::
NP_001 KKGLGSLSHGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQ
160 170 180 190 200 210
pF1KA0 ------------------------------------------------------------
NP_001 RPSRKGVTSTTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLT
220 230 240 250 260 270
410
pF1KA0 -----------------------------------------------------RTCSFGG
:::::::
NP_001 QLVRPASDRTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGG
280 290 300 310 320 330
420 430 440 450 460 470
pF1KA0 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYS
340 350 360 370 380 390
480 490 500 510 520 530
pF1KA0 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVSEQDSGLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTD
400 410 420 430 440 450
540 550 560 570 580 590
pF1KA0 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPP
460 470 480 490 500 510
600 610 620 630 640 650
pF1KA0 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH
520 530 540 550 560 570
660 670 680 690 700 710
pF1KA0 MPTFLFNGYEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 MPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKL
580 590 600 610 620 630
720 730 740 750 760 770
pF1KA0 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLP
640 650 660 670 680 690
780 790 800 810 820 830
pF1KA0 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMKSGDALKQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQT
700 710 720 730 740 750
840 850 860 870 880 890
pF1KA0 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDTWPRSHSLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDN
760 770 780 790 800 810
900 910 920 930 940 950
pF1KA0 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLLTQSKRFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG
820 830 840 850 860 870
960 970 980 990 1000 1010
pF1KA0 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGA
880 890 900 910 920 930
1020 1030 1040 1050 1060 1070
pF1KA0 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSL
940 950 960 970 980 990
1080 1090 1100 1110 1120 1130
pF1KA0 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEHGVKLGPALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRY
1000 1010 1020 1030 1040 1050
1140 1150 1160 1170 1180 1190
pF1KA0 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDLDQPERDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIG
1060 1070 1080 1090 1100 1110
1200 1210 1220 1230 1240
pF1KA0 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPMYAGTLSTAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1120 1130 1140 1150 1160 1170
>>XP_016866094 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1286 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.5 bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:8-1286)
110 120 130 140 150 160
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
::::::::::::::::::::::::::::::
XP_016 MLFQRNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
10 20 30
170 180 190 200 210 220
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
40 50 60 70 80 90
230 240 250 260 270 280
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
100 110 120 130 140 150
290 300 310 320 330 340
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
160 170 180 190 200 210
350 360 370 380 390 400
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
220 230 240 250 260 270
pF1KA0 HG----------------------------------------------------------
::
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
280 290 300 310 320 330
pF1KA0 ------------------------------------------------------------
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
340 350 360 370 380 390
410
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
:::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
400 410 420 430 440 450
420 430 440 450 460 470
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
460 470 480 490 500 510
480 490 500 510 520 530
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
520 530 540 550 560 570
540 550 560 570 580 590
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
580 590 600 610 620 630
600 610 620 630 640 650
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
640 650 660 670 680 690
660 670 680 690 700 710
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
700 710 720 730 740 750
720 730 740 750 760 770
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
760 770 780 790 800 810
780 790 800 810 820 830
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
820 830 840 850 860 870
840 850 860 870 880 890
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
880 890 900 910 920 930
900 910 920 930 940 950
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
940 950 960 970 980 990
960 970 980 990 1000 1010
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
1000 1010 1020 1030 1040 1050
1020 1030 1040 1050 1060 1070
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
1060 1070 1080 1090 1100 1110
1080 1090 1100 1110 1120 1130
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
1120 1130 1140 1150 1160 1170
1140 1150 1160 1170 1180 1190
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
1180 1190 1200 1210 1220 1230
1200 1210 1220 1230 1240
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1240 1250 1260 1270 1280
>>XP_016866093 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1291 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.5 bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:13-1291)
110 120 130 140 150 160
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
::::::::::::::::::::::::::::::
XP_016 MLTEIKQAIMNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
10 20 30 40
170 180 190 200 210 220
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
50 60 70 80 90 100
230 240 250 260 270 280
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
110 120 130 140 150 160
290 300 310 320 330 340
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
170 180 190 200 210 220
350 360 370 380 390 400
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
230 240 250 260 270 280
pF1KA0 HG----------------------------------------------------------
::
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
290 300 310 320 330 340
pF1KA0 ------------------------------------------------------------
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
350 360 370 380 390 400
410
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
:::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
410 420 430 440 450 460
420 430 440 450 460 470
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
470 480 490 500 510 520
480 490 500 510 520 530
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
530 540 550 560 570 580
540 550 560 570 580 590
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
590 600 610 620 630 640
600 610 620 630 640 650
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
650 660 670 680 690 700
660 670 680 690 700 710
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
710 720 730 740 750 760
720 730 740 750 760 770
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
770 780 790 800 810 820
780 790 800 810 820 830
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
830 840 850 860 870 880
840 850 860 870 880 890
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
890 900 910 920 930 940
900 910 920 930 940 950
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
950 960 970 980 990 1000
960 970 980 990 1000 1010
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
1010 1020 1030 1040 1050 1060
1020 1030 1040 1050 1060 1070
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
1070 1080 1090 1100 1110 1120
1080 1090 1100 1110 1120 1130
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
1130 1140 1150 1160 1170 1180
1140 1150 1160 1170 1180 1190
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
1190 1200 1210 1220 1230 1240
1200 1210 1220 1230 1240
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1250 1260 1270 1280 1290
>>XP_016866091 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1317 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.4 bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317)
110 120 130 140 150 160
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
::::::::::::::::::::::::::::::
XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
10 20 30 40 50 60
170 180 190 200 210 220
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
70 80 90 100 110 120
230 240 250 260 270 280
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
130 140 150 160 170 180
290 300 310 320 330 340
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
190 200 210 220 230 240
350 360 370 380 390 400
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
250 260 270 280 290 300
pF1KA0 HG----------------------------------------------------------
::
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
310 320 330 340 350 360
pF1KA0 ------------------------------------------------------------
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
370 380 390 400 410 420
410
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
:::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
430 440 450 460 470 480
420 430 440 450 460 470
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
490 500 510 520 530 540
480 490 500 510 520 530
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
550 560 570 580 590 600
540 550 560 570 580 590
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
610 620 630 640 650 660
600 610 620 630 640 650
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
670 680 690 700 710 720
660 670 680 690 700 710
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
790 800 810 820 830 840
780 790 800 810 820 830
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
850 860 870 880 890 900
840 850 860 870 880 890
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
910 920 930 940 950 960
900 910 920 930 940 950
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
1150 1160 1170 1180 1190 1200
1140 1150 1160 1170 1180 1190
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
1210 1220 1230 1240 1250 1260
1200 1210 1220 1230 1240
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1270 1280 1290 1300 1310
>>XP_016866092 (OMIM: 607955) PREDICTED: SAM and SH3 dom (1317 aa)
initn: 5707 init1: 5707 opt: 5710 Z-score: 2878.4 bits: 544.8 E(85289): 1.4e-153
Smith-Waterman score: 7168; 87.2% identity (87.3% similar) in 1279 aa overlap (132-1247:39-1317)
110 120 130 140 150 160
pF1KA0 PTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
::::::::::::::::::::::::::::::
XP_016 IITTPVSPTCARGWRSCGNGGFPRTWKWNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKN
10 20 30 40 50 60
170 180 190 200 210 220
pF1KA0 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSA
70 80 90 100 110 120
230 240 250 260 270 280
pF1KA0 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDPADWPDGSYPTFDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEM
130 140 150 160 170 180
290 300 310 320 330 340
pF1KA0 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKPSTEGGEEHVFENSPVLDERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSL
190 200 210 220 230 240
350 360 370 380 390 400
pF1KA0 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS
250 260 270 280 290 300
pF1KA0 HG----------------------------------------------------------
::
XP_016 HGVSTDGVCFYDNHRRRHHLLVSLEEFQSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVT
310 320 330 340 350 360
pF1KA0 ------------------------------------------------------------
XP_016 STTCDLQLLRQKGKGGGSCGFPGRRVRGRTSVSEFNITYVVERSLYSHLNLTQLVRPASD
370 380 390 400 410 420
410
pF1KA0 ---------------------------------------------RTCSFGGFDLTNRSL
:::::::::::::::
XP_016 RTLSKAERQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGFDLTNRSL
430 440 450 460 470 480
420 430 440 450 460 470
pF1KA0 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVGSNNSDPMGKEGDFVYKEVIKSPTASRISLGKKVKSVKETMRKRMSKKYSSSVSEQDS
490 500 510 520 530 540
480 490 500 510 520 530
pF1KA0 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLDGMPGSPPPSQPDPEHLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRES
550 560 570 580 590 600
540 550 560 570 580 590
pF1KA0 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLL
610 620 630 640 650 660
600 610 620 630 640 650
pF1KA0 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEHMPTFLFNG
670 680 690 700 710 720
660 670 680 690 700 710
pF1KA0 YEDLDTFKLLEEEDLDELKIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 YEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDSQGLS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KA0 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCSPRDSGCYESSENLENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPTLPLMKSGDAL
790 800 810 820 830 840
780 790 800 810 820 830
pF1KA0 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGQEEGRLGGGLAPDTSKSCDPPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSH
850 860 870 880 890 900
840 850 860 870 880 890
pF1KA0 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDDLQVEPGAEQDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSK
910 920 930 940 950 960
900 910 920 930 940 950
pF1KA0 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFSEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEGHRKGHEFE
970 980 990 1000 1010 1020
960 970 980 990 1000 1010
pF1KA0 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGLHPVPMGPSGALPSPDAPC
1030 1040 1050 1060 1070 1080
1020 1030 1040 1050 1060 1070
pF1KA0 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPVKRGSPASPTSPSDCPPALAPRPLSGQAPGSPPSTRPPPWLSELPENTSLQEHGVKLG
1090 1100 1110 1120 1130 1140
1080 1090 1100 1110 1120 1130
pF1KA0 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALTRKVSCARGVDLETLTENKLHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPE
1150 1160 1170 1180 1190 1200
1140 1150 1160 1170 1180 1190
pF1KA0 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDVAANMDQIRVKQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTL
1210 1220 1230 1240 1250 1260
1200 1210 1220 1230 1240
pF1KA0 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM
1270 1280 1290 1300 1310
1247 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:01:19 2016 done: Fri Nov 4 01:01:22 2016
Total Scan time: 18.000 Total Display time: 0.600
Function used was FASTA [36.3.4 Apr, 2011]