Result of FASTA (omim) for
pF1KA0777
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0777, 1100 aa
1>>>pF1KA0777 1100 - 1100 aa - 1100 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.4718+/-0.000411; mu= -0.7168+/- 0.026
mean_var=349.5198+/-75.059, 0's: 0 Z-trim(121.8): 179 B-trim: 42 in 1/57
Lambda= 0.068602
statistics sampled from 38663 (38862) to 38663 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.746), E-opt: 0.2 (0.456), width: 16
Scan time: 17.820
The best scores are: opt bits E(85289)
NP_066547 (OMIM: 616349) sorbin and SH3 domain-con (1100) 7594 766.6 0
NP_001257700 (OMIM: 616349) sorbin and SH3 domain- (1200) 7594 766.6 0
NP_001139146 (OMIM: 616349) sorbin and SH3 domain- (1004) 6750 683.0 2.3e-195
XP_016864238 (OMIM: 616349) PREDICTED: sorbin and (1262) 4272 437.9 1.8e-121
XP_016864236 (OMIM: 616349) PREDICTED: sorbin and (1354) 4272 437.9 1.9e-121
XP_016864233 (OMIM: 616349) PREDICTED: sorbin and (1377) 4272 437.9 2e-121
XP_016864234 (OMIM: 616349) PREDICTED: sorbin and (1377) 4272 437.9 2e-121
XP_016864232 (OMIM: 616349) PREDICTED: sorbin and (1385) 4272 437.9 2e-121
XP_016864231 (OMIM: 616349) PREDICTED: sorbin and (1394) 4272 437.9 2e-121
XP_016864229 (OMIM: 616349) PREDICTED: sorbin and (1408) 4272 437.9 2e-121
XP_016864227 (OMIM: 616349) PREDICTED: sorbin and (1408) 4272 437.9 2e-121
XP_016864228 (OMIM: 616349) PREDICTED: sorbin and (1408) 4272 437.9 2e-121
XP_016864235 (OMIM: 616349) PREDICTED: sorbin and (1355) 4215 432.2 9.7e-120
XP_016864262 (OMIM: 616349) PREDICTED: sorbin and ( 619) 2104 223.0 4.3e-57
XP_016864261 (OMIM: 616349) PREDICTED: sorbin and ( 619) 2104 223.0 4.3e-57
XP_016864257 (OMIM: 616349) PREDICTED: sorbin and ( 636) 2104 223.0 4.4e-57
XP_016864256 (OMIM: 616349) PREDICTED: sorbin and ( 642) 2104 223.0 4.5e-57
XP_016864255 (OMIM: 616349) PREDICTED: sorbin and ( 642) 2104 223.0 4.5e-57
XP_016864254 (OMIM: 616349) PREDICTED: sorbin and ( 650) 2104 223.0 4.5e-57
XP_016864253 (OMIM: 616349) PREDICTED: sorbin and ( 650) 2104 223.0 4.5e-57
XP_016864252 (OMIM: 616349) PREDICTED: sorbin and ( 659) 2104 223.0 4.5e-57
XP_016864251 (OMIM: 616349) PREDICTED: sorbin and ( 673) 2104 223.0 4.6e-57
XP_016864248 (OMIM: 616349) PREDICTED: sorbin and ( 752) 2104 223.1 5e-57
XP_016864245 (OMIM: 616349) PREDICTED: sorbin and ( 828) 2104 223.1 5.3e-57
XP_016864244 (OMIM: 616349) PREDICTED: sorbin and ( 874) 2104 223.1 5.6e-57
XP_016864242 (OMIM: 616349) PREDICTED: sorbin and (1045) 2104 223.2 6.3e-57
XP_016864237 (OMIM: 616349) PREDICTED: sorbin and (1300) 2104 223.3 7.4e-57
NP_001139144 (OMIM: 616349) sorbin and SH3 domain- ( 661) 1867 199.6 5.2e-50
XP_006714453 (OMIM: 616349) PREDICTED: sorbin and ( 661) 1867 199.6 5.2e-50
XP_005263368 (OMIM: 616349) PREDICTED: sorbin and ( 692) 1867 199.6 5.4e-50
XP_016864263 (OMIM: 616349) PREDICTED: sorbin and ( 564) 1848 197.6 1.7e-49
XP_016864260 (OMIM: 616349) PREDICTED: sorbin and ( 645) 1848 197.7 1.9e-49
XP_005263369 (OMIM: 616349) PREDICTED: sorbin and ( 691) 1848 197.7 2e-49
XP_016864249 (OMIM: 616349) PREDICTED: sorbin and ( 714) 1848 197.7 2e-49
NP_001139147 (OMIM: 616349) sorbin and SH3 domain- ( 492) 1844 197.2 2.1e-49
XP_006714451 (OMIM: 616349) PREDICTED: sorbin and ( 722) 1848 197.7 2.1e-49
NP_001139143 (OMIM: 616349) sorbin and SH3 domain- ( 731) 1848 197.7 2.1e-49
NP_003594 (OMIM: 616349) sorbin and SH3 domain-con ( 666) 1847 197.6 2.1e-49
XP_005263365 (OMIM: 616349) PREDICTED: sorbin and ( 745) 1848 197.7 2.1e-49
XP_005263367 (OMIM: 616349) PREDICTED: sorbin and ( 697) 1847 197.6 2.1e-49
NP_001139145 (OMIM: 616349) sorbin and SH3 domain- ( 824) 1848 197.8 2.3e-49
XP_016864259 (OMIM: 616349) PREDICTED: sorbin and ( 627) 1844 197.3 2.4e-49
XP_016864258 (OMIM: 616349) PREDICTED: sorbin and ( 635) 1844 197.3 2.5e-49
NP_001139142 (OMIM: 616349) sorbin and SH3 domain- ( 644) 1844 197.3 2.5e-49
XP_005263364 (OMIM: 616349) PREDICTED: sorbin and ( 959) 1848 197.8 2.5e-49
XP_005263370 (OMIM: 616349) PREDICTED: sorbin and ( 658) 1844 197.3 2.5e-49
XP_016864247 (OMIM: 616349) PREDICTED: sorbin and ( 759) 1844 197.3 2.8e-49
XP_016864240 (OMIM: 616349) PREDICTED: sorbin and (1117) 1848 197.9 2.8e-49
XP_016864241 (OMIM: 616349) PREDICTED: sorbin and (1092) 1847 197.8 3e-49
XP_016864243 (OMIM: 616349) PREDICTED: sorbin and (1030) 1844 197.5 3.5e-49
>>NP_066547 (OMIM: 616349) sorbin and SH3 domain-contain (1100 aa)
initn: 7594 init1: 7594 opt: 7594 Z-score: 4079.2 bits: 766.6 E(85289): 0
Smith-Waterman score: 7594; 100.0% identity (100.0% similar) in 1100 aa overlap (1-1100:1-1100)
10 20 30 40 50 60
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 EKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 AWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 NGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 AKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNW
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 YEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 KGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 IHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFV
1030 1040 1050 1060 1070 1080
1090 1100
pF1KA0 GTSRRTKFFGTFPGNYVKRL
::::::::::::::::::::
NP_066 GTSRRTKFFGTFPGNYVKRL
1090 1100
>>NP_001257700 (OMIM: 616349) sorbin and SH3 domain-cont (1200 aa)
initn: 7594 init1: 7594 opt: 7594 Z-score: 4078.7 bits: 766.6 E(85289): 0
Smith-Waterman score: 7594; 100.0% identity (100.0% similar) in 1100 aa overlap (1-1100:101-1200)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
NP_001 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
80 90 100 110 120 130
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
140 150 160 170 180 190
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KA0 KSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPR
260 270 280 290 300 310
220 230 240 250 260 270
pF1KA0 SIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLG
320 330 340 350 360 370
280 290 300 310 320 330
pF1KA0 DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSS
380 390 400 410 420 430
340 350 360 370 380 390
pF1KA0 ELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLND
440 450 460 470 480 490
400 410 420 430 440 450
pF1KA0 DCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFL
500 510 520 530 540 550
460 470 480 490 500 510
pF1KA0 KMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRI
560 570 580 590 600 610
520 530 540 550 560 570
pF1KA0 SEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRG
620 630 640 650 660 670
580 590 600 610 620 630
pF1KA0 CQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFT
680 690 700 710 720 730
640 650 660 670 680 690
pF1KA0 SSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEM
740 750 760 770 780 790
700 710 720 730 740 750
pF1KA0 DPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGS
800 810 820 830 840 850
760 770 780 790 800 810
pF1KA0 LPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPR
860 870 880 890 900 910
820 830 840 850 860 870
pF1KA0 SASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKA
920 930 940 950 960 970
880 890 900 910 920 930
pF1KA0 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR
980 990 1000 1010 1020 1030
940 950 960 970 980 990
pF1KA0 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFP
1040 1050 1060 1070 1080 1090
1000 1010 1020 1030 1040 1050
pF1KA0 VSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALY
1100 1110 1120 1130 1140 1150
1060 1070 1080 1090 1100
pF1KA0 NYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
1160 1170 1180 1190 1200
>>NP_001139146 (OMIM: 616349) sorbin and SH3 domain-cont (1004 aa)
initn: 6743 init1: 6743 opt: 6750 Z-score: 3628.3 bits: 683.0 E(85289): 2.3e-195
Smith-Waterman score: 6866; 98.5% identity (98.5% similar) in 1011 aa overlap (90-1100:9-1004)
60 70 80 90 100 110
pF1KA0 EEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYN
::::::::::::::::::::::
NP_001 MKATTPLQTVDRPKDWYKTMFKQIHMVHKP--------
10 20 30
120 130 140 150 160 170
pF1KA0 TPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------GLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPP
40 50 60 70 80
180 190 200 210 220 230
pF1KA0 LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRS
90 100 110 120 130 140
240 250 260 270 280 290
pF1KA0 LERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSS
150 160 170 180 190 200
300 310 320 330 340 350
pF1KA0 PSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQ
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA0 MARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCP
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA0 MAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQ
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA0 YESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPP
390 400 410 420 430 440
540 550 560 570 580 590
pF1KA0 QNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSD
450 460 470 480 490 500
600 610 620 630 640 650
pF1KA0 QDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKG
510 520 530 540 550 560
660 670 680 690 700 710
pF1KA0 RCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTE
570 580 590 600 610 620
720 730 740 750 760 770
pF1KA0 KAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALR
630 640 650 660 670 680
780 790 800 810 820 830
pF1KA0 RSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESP
690 700 710 720 730 740
840 850 860 870 880 890
pF1KA0 RSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQN
750 760 770 780 790 800
900 910 920 930 940 950
pF1KA0 WYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSL
810 820 830 840 850 860
960 970 980 990 1000 1010
pF1KA0 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSD
870 880 890 900 910 920
1020 1030 1040 1050 1060 1070
pF1KA0 RIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWF
930 940 950 960 970 980
1080 1090 1100
pF1KA0 VGTSRRTKFFGTFPGNYVKRL
:::::::::::::::::::::
NP_001 VGTSRRTKFFGTFPGNYVKRL
990 1000
>>XP_016864238 (OMIM: 616349) PREDICTED: sorbin and SH3 (1262 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.6 bits: 437.9 E(85289): 1.8e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:395-1260)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
370 380 390 400 410 420
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
430 440 450 460 470 480
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
490 500 510 520 530 540
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
550 560 570 580 590 600
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
610 620 630 640 650 660
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
670 680 690 700 710 720
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
730 740 750 760 770 780
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
790 800 810 820 830 840
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
850 860 870 880 890 900
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
910 920 930 940 950 960
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
970 980 990 1000 1010 1020
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1030 1040 1050 1060 1070 1080
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1090 1100 1110 1120 1130 1140
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1150 1160 1170 1180 1190 1200
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1210 1220 1230 1240 1250 1260
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 248.1 bits: 57.9 E(85289): 4.4e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:327-394)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 CRVLGNQNLPASVLESQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
300 310 320 330 340 350
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
360 370 380 390 400 410
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
420 430 440 450 460 470
>>XP_016864236 (OMIM: 616349) PREDICTED: sorbin and SH3 (1354 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.2 bits: 437.9 E(85289): 1.9e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:487-1352)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
460 470 480 490 500 510
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
520 530 540 550 560 570
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
580 590 600 610 620 630
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
640 650 660 670 680 690
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
700 710 720 730 740 750
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
760 770 780 790 800 810
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
820 830 840 850 860 870
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
880 890 900 910 920 930
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
940 950 960 970 980 990
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1000 1010 1020 1030 1040 1050
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1060 1070 1080 1090 1100 1110
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1120 1130 1140 1150 1160 1170
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1180 1190 1200 1210 1220 1230
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1240 1250 1260 1270 1280 1290
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1300 1310 1320 1330 1340 1350
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.7 bits: 57.9 E(85289): 4.6e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:419-486)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
390 400 410 420 430 440
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
450 460 470 480 490 500
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
510 520 530 540 550 560
>>XP_016864233 (OMIM: 616349) PREDICTED: sorbin and SH3 (1377 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.1 bits: 437.9 E(85289): 2e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:510-1375)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
480 490 500 510 520 530
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
540 550 560 570 580 590
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
600 610 620 630 640 650
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
660 670 680 690 700 710
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
720 730 740 750 760 770
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
780 790 800 810 820 830
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
840 850 860 870 880 890
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
900 910 920 930 940 950
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
960 970 980 990 1000 1010
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1020 1030 1040 1050 1060 1070
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1080 1090 1100 1110 1120 1130
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1140 1150 1160 1170 1180 1190
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1200 1210 1220 1230 1240 1250
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1260 1270 1280 1290 1300 1310
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1320 1330 1340 1350 1360 1370
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.6 bits: 57.9 E(85289): 4.7e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:442-509)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
420 430 440 450 460 470
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
480 490 500 510 520 530
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
540 550 560 570 580 590
>>XP_016864234 (OMIM: 616349) PREDICTED: sorbin and SH3 (1377 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.1 bits: 437.9 E(85289): 2e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:510-1375)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
480 490 500 510 520 530
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
540 550 560 570 580 590
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
600 610 620 630 640 650
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
660 670 680 690 700 710
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
720 730 740 750 760 770
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
780 790 800 810 820 830
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
840 850 860 870 880 890
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
900 910 920 930 940 950
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
960 970 980 990 1000 1010
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1020 1030 1040 1050 1060 1070
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1080 1090 1100 1110 1120 1130
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1140 1150 1160 1170 1180 1190
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1200 1210 1220 1230 1240 1250
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1260 1270 1280 1290 1300 1310
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1320 1330 1340 1350 1360 1370
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.6 bits: 57.9 E(85289): 4.7e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:442-509)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
420 430 440 450 460 470
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
480 490 500 510 520 530
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
540 550 560 570 580 590
>>XP_016864232 (OMIM: 616349) PREDICTED: sorbin and SH3 (1385 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.0 bits: 437.9 E(85289): 2e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:518-1383)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
490 500 510 520 530 540
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
550 560 570 580 590 600
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
610 620 630 640 650 660
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
670 680 690 700 710 720
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
730 740 750 760 770 780
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
790 800 810 820 830 840
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
850 860 870 880 890 900
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
910 920 930 940 950 960
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
970 980 990 1000 1010 1020
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1030 1040 1050 1060 1070 1080
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1090 1100 1110 1120 1130 1140
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1150 1160 1170 1180 1190 1200
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1210 1220 1230 1240 1250 1260
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1270 1280 1290 1300 1310 1320
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1330 1340 1350 1360 1370 1380
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.6 bits: 57.9 E(85289): 4.7e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:450-517)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
420 430 440 450 460 470
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
480 490 500 510 520 530
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
540 550 560 570 580 590
>>XP_016864231 (OMIM: 616349) PREDICTED: sorbin and SH3 (1394 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.0 bits: 437.9 E(85289): 2e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:527-1392)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
500 510 520 530 540 550
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
560 570 580 590 600 610
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
620 630 640 650 660 670
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
680 690 700 710 720 730
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
740 750 760 770 780 790
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
800 810 820 830 840 850
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
860 870 880 890 900 910
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
920 930 940 950 960 970
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
980 990 1000 1010 1020 1030
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1040 1050 1060 1070 1080 1090
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1100 1110 1120 1130 1140 1150
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1160 1170 1180 1190 1200 1210
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1220 1230 1240 1250 1260 1270
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1280 1290 1300 1310 1320 1330
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1340 1350 1360 1370 1380 1390
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.6 bits: 57.9 E(85289): 4.7e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:459-526)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
430 440 450 460 470 480
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
490 500 510 520 530 540
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
550 560 570 580 590 600
>>XP_016864229 (OMIM: 616349) PREDICTED: sorbin and SH3 (1408 aa)
initn: 4185 init1: 4185 opt: 4272 Z-score: 2301.0 bits: 437.9 E(85289): 2e-121
Smith-Waterman score: 5129; 88.5% identity (88.5% similar) in 866 aa overlap (69-834:541-1406)
40 50 60 70 80 90
pF1KA0 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
::::::::::::::::::::::::::::::
XP_016 QHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWY
520 530 540 550 560 570
100 110 120 130 140 150
pF1KA0 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP
580 590 600 610 620 630
160 170 180 190 200 210
pF1KA0 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG
640 650 660 670 680 690
220
pF1KA0 KSSILQHERP--------------------------------------------------
::::::::::
XP_016 KSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALS
700 710 720 730 740 750
230
pF1KA0 --------------------------------------------------ASLYQSSIDR
::::::::::
XP_016 PTRTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDR
760 770 780 790 800 810
240 250 260 270 280 290
pF1KA0 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSS
820 830 840 850 860 870
300 310 320 330 340 350
pF1KA0 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGW
880 890 900 910 920 930
360 370 380 390 400 410
pF1KA0 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESC
940 950 960 970 980 990
420 430 440 450 460 470
pF1KA0 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRIL
1000 1010 1020 1030 1040 1050
480 490 500 510 520 530
pF1KA0 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEP
1060 1070 1080 1090 1100 1110
540 550 560 570 580 590
pF1KA0 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDS
1120 1130 1140 1150 1160 1170
600 610 620 630 640 650
pF1KA0 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCK
1180 1190 1200 1210 1220 1230
660 670 680 690 700 710
pF1KA0 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQT
1240 1250 1260 1270 1280 1290
720 730 740 750 760 770
pF1KA0 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRAL
1300 1310 1320 1330 1340 1350
780 790 800 810 820 830
pF1KA0 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQGG
1360 1370 1380 1390 1400
840 850 860 870 880 890
pF1KA0 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ
>--
initn: 433 init1: 433 opt: 433 Z-score: 247.5 bits: 57.9 E(85289): 4.8e-07
Smith-Waterman score: 433; 100.0% identity (100.0% similar) in 68 aa overlap (1-68:473-540)
10 20 30
pF1KA0 MSYYQRPFSPSAYSLPASLNSSIVMQHGTS
::::::::::::::::::::::::::::::
XP_016 AVTDGTTLTTPAATHSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTS
450 460 470 480 490 500
40 50 60 70 80 90
pF1KA0 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
::::::::::::::::::::::::::::::::::::::
XP_016 LDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT
510 520 530 540 550 560
100 110 120 130 140 150
pF1KA0 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
XP_016 VDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLS
570 580 590 600 610 620
1100 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 10:18:43 2016 done: Thu Nov 3 10:18:46 2016
Total Scan time: 17.820 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]