Result of FASTA (omim) for
pF1KA0698
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0698, 891 aa
1>>>pF1KA0698 891 - 891 aa - 891 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8463+/-0.000457; mu= 17.2429+/- 0.028
mean_var=65.6150+/-13.207, 0's: 0 Z-trim(109.5): 32 B-trim: 3 in 1/49
Lambda= 0.158333
statistics sampled from 17643 (17671) to 17643 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.554), E-opt: 0.2 (0.207), width: 16
Scan time: 10.530
The best scores are: opt bits E(85289)
NP_055614 (OMIM: 300167) hephaestin isoform b [Hom ( 891) 6141 1412.5 0
XP_006724785 (OMIM: 300167) PREDICTED: hephaestin (1161) 6141 1412.5 0
NP_620074 (OMIM: 300167) hephaestin isoform a [Hom (1212) 6141 1412.5 0
NP_001124332 (OMIM: 300167) hephaestin isoform c p (1160) 6124 1408.6 0
XP_011529375 (OMIM: 300167) PREDICTED: hephaestin (1211) 6124 1408.6 0
XP_016885491 (OMIM: 300167) PREDICTED: hephaestin (1049) 4094 944.9 0
XP_016885490 (OMIM: 300167) PREDICTED: hephaestin (1050) 4094 944.9 0
XP_016885487 (OMIM: 300167) PREDICTED: hephaestin (1100) 4094 944.9 0
XP_011529377 (OMIM: 300167) PREDICTED: hephaestin (1101) 4094 944.9 0
NP_001269070 (OMIM: 300167) hephaestin isoform d p ( 969) 3184 737.0 1e-211
XP_016885488 (OMIM: 300167) PREDICTED: hephaestin (1090) 3181 736.3 1.8e-211
XP_011529376 (OMIM: 300167) PREDICTED: hephaestin (1141) 3181 736.3 1.9e-211
XP_016885489 (OMIM: 300167) PREDICTED: hephaestin (1089) 3164 732.5 2.7e-210
NP_000087 (OMIM: 117700,604290) ceruloplasmin prec (1065) 2417 561.8 6.1e-159
XP_006713564 (OMIM: 117700,604290) PREDICTED: ceru (1065) 2411 560.4 1.6e-158
XP_016861223 (OMIM: 117700,604290) PREDICTED: ceru (1069) 2411 560.4 1.6e-158
XP_006713563 (OMIM: 117700,604290) PREDICTED: ceru (1069) 2411 560.4 1.6e-158
XP_006713562 (OMIM: 117700,604290) PREDICTED: ceru (1090) 2411 560.5 1.6e-158
XP_011510737 (OMIM: 117700,604290) PREDICTED: ceru (1094) 2411 560.5 1.6e-158
XP_016861224 (OMIM: 117700,604290) PREDICTED: ceru (1012) 2181 507.9 9.8e-143
XP_016885492 (OMIM: 300167) PREDICTED: hephaestin ( 858) 1645 385.5 6.1e-106
XP_016856149 (OMIM: 188055,227400,600880,601367,61 (2087) 889 212.9 1.3e-53
NP_000121 (OMIM: 188055,227400,600880,601367,61230 (2224) 889 212.9 1.4e-53
NP_000123 (OMIM: 134500,300841,306700) coagulation (2351) 637 155.3 3.2e-36
>>NP_055614 (OMIM: 300167) hephaestin isoform b [Homo sa (891 aa)
initn: 6141 init1: 6141 opt: 6141 Z-score: 7573.2 bits: 1412.5 E(85289): 0
Smith-Waterman score: 6141; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:1-891)
10 20 30 40 50 60
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM
790 800 810 820 830 840
850 860 870 880 890
pF1KA0 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ
850 860 870 880 890
>>XP_006724785 (OMIM: 300167) PREDICTED: hephaestin isof (1161 aa)
initn: 6141 init1: 6141 opt: 6141 Z-score: 7571.2 bits: 1412.5 E(85289): 0
Smith-Waterman score: 6141; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:271-1161)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_006 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
790 800 810 820 830 840
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
850 860 870 880 890 900
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
910 920 930 940 950 960
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
970 980 990 1000 1010 1020
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
1030 1040 1050 1060 1070 1080
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1090 1100 1110 1120 1130 1140
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_006 KLRRNRRSILDDSFKLLSFKQ
1150 1160
>--
initn: 583 init1: 232 opt: 692 Z-score: 844.3 bits: 167.8 E(85289): 2.7e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:18-270)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_006 MWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
10 20 30 40
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_006 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
50 60 70 80 90 100
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_006 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_006 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_006 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_006 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
290 300 310 320 330 340
>>NP_620074 (OMIM: 300167) hephaestin isoform a [Homo sa (1212 aa)
initn: 6141 init1: 6141 opt: 6141 Z-score: 7570.9 bits: 1412.5 E(85289): 0
Smith-Waterman score: 6141; 100.0% identity (100.0% similar) in 891 aa overlap (1-891:322-1212)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
NP_620 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
300 310 320 330 340 350
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
360 370 380 390 400 410
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
420 430 440 450 460 470
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
480 490 500 510 520 530
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
540 550 560 570 580 590
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
600 610 620 630 640 650
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
660 670 680 690 700 710
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
720 730 740 750 760 770
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
780 790 800 810 820 830
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
840 850 860 870 880 890
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
900 910 920 930 940 950
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
960 970 980 990 1000 1010
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
1020 1030 1040 1050 1060 1070
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
1080 1090 1100 1110 1120 1130
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1140 1150 1160 1170 1180 1190
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
NP_620 KLRRNRRSILDDSFKLLSFKQ
1200 1210
>--
initn: 606 init1: 232 opt: 692 Z-score: 844.0 bits: 167.8 E(85289): 2.8e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:69-321)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
NP_620 VSAPSQDLLITKVMWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
NP_620 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
NP_620 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
NP_620 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
NP_620 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
NP_620 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
340 350 360 370 380 390
>>NP_001124332 (OMIM: 300167) hephaestin isoform c precu (1160 aa)
initn: 5661 init1: 5661 opt: 6124 Z-score: 7550.3 bits: 1408.6 E(85289): 0
Smith-Waterman score: 6124; 99.9% identity (99.9% similar) in 891 aa overlap (1-891:271-1160)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
NP_001 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
790 800 810 820 830 840
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
850 860 870 880 890 900
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
910 920 930 940 950 960
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
970 980 990 1000 1010 1020
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
1030 1040 1050 1060 1070 1080
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETEK-VPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1090 1100 1110 1120 1130
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
NP_001 KLRRNRRSILDDSFKLLSFKQ
1140 1150 1160
>--
initn: 583 init1: 232 opt: 692 Z-score: 844.3 bits: 167.8 E(85289): 2.7e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:18-270)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
NP_001 MWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
10 20 30 40
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
NP_001 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
50 60 70 80 90 100
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
NP_001 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
NP_001 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
NP_001 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
NP_001 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
290 300 310 320 330 340
>>XP_011529375 (OMIM: 300167) PREDICTED: hephaestin isof (1211 aa)
initn: 5661 init1: 5661 opt: 6124 Z-score: 7550.0 bits: 1408.6 E(85289): 0
Smith-Waterman score: 6124; 99.9% identity (99.9% similar) in 891 aa overlap (1-891:322-1211)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_011 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
300 310 320 330 340 350
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
360 370 380 390 400 410
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
420 430 440 450 460 470
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
480 490 500 510 520 530
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
540 550 560 570 580 590
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
600 610 620 630 640 650
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
660 670 680 690 700 710
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
720 730 740 750 760 770
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
780 790 800 810 820 830
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
840 850 860 870 880 890
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
900 910 920 930 940 950
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
960 970 980 990 1000 1010
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
1020 1030 1040 1050 1060 1070
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
1080 1090 1100 1110 1120 1130
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETEK-VPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1140 1150 1160 1170 1180 1190
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_011 KLRRNRRSILDDSFKLLSFKQ
1200 1210
>--
initn: 606 init1: 232 opt: 692 Z-score: 844.0 bits: 167.8 E(85289): 2.8e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:69-321)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_011 VSAPSQDLLITKVMWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_011 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_011 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_011 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_011 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_011 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
340 350 360 370 380 390
>>XP_016885491 (OMIM: 300167) PREDICTED: hephaestin isof (1049 aa)
initn: 4870 init1: 4094 opt: 4094 Z-score: 5044.9 bits: 944.9 E(85289): 0
Smith-Waterman score: 5115; 87.4% identity (87.4% similar) in 891 aa overlap (1-891:271-1049)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_016 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
790 800 810 820 830 840
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
:::::::::::::::::
XP_016 AHGVLESTTVWPLAAEP-------------------------------------------
850
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
XP_016 ------------------------------------------------------------
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------AINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
860 870 880 890 900
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
910 920 930 940 950 960
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETEK-VPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
970 980 990 1000 1010 1020
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_016 KLRRNRRSILDDSFKLLSFKQ
1030 1040
>--
initn: 583 init1: 232 opt: 692 Z-score: 845.1 bits: 167.8 E(85289): 2.5e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:18-270)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_016 MWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
10 20 30 40
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_016 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
50 60 70 80 90 100
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_016 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_016 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_016 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_016 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
290 300 310 320 330 340
>>XP_016885490 (OMIM: 300167) PREDICTED: hephaestin isof (1050 aa)
initn: 5350 init1: 4094 opt: 4094 Z-score: 5044.9 bits: 944.9 E(85289): 0
Smith-Waterman score: 5132; 87.5% identity (87.5% similar) in 891 aa overlap (1-891:271-1050)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_016 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
490 500 510 520 530 540
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
550 560 570 580 590 600
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
610 620 630 640 650 660
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
670 680 690 700 710 720
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
730 740 750 760 770 780
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
790 800 810 820 830 840
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
:::::::::::::::::
XP_016 AHGVLESTTVWPLAAEP-------------------------------------------
850
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
XP_016 ------------------------------------------------------------
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------AINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
860 870 880 890 900
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
910 920 930 940 950 960
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
970 980 990 1000 1010 1020
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_016 KLRRNRRSILDDSFKLLSFKQ
1030 1040 1050
>--
initn: 583 init1: 232 opt: 692 Z-score: 845.1 bits: 167.8 E(85289): 2.5e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:18-270)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_016 MWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
10 20 30 40
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_016 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
50 60 70 80 90 100
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_016 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_016 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_016 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_016 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
290 300 310 320 330 340
>>XP_016885487 (OMIM: 300167) PREDICTED: hephaestin isof (1100 aa)
initn: 4870 init1: 4094 opt: 4094 Z-score: 5044.6 bits: 944.9 E(85289): 0
Smith-Waterman score: 5115; 87.4% identity (87.4% similar) in 891 aa overlap (1-891:322-1100)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_016 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
300 310 320 330 340 350
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
360 370 380 390 400 410
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
420 430 440 450 460 470
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
480 490 500 510 520 530
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
540 550 560 570 580 590
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
600 610 620 630 640 650
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
660 670 680 690 700 710
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
720 730 740 750 760 770
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
780 790 800 810 820 830
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
840 850 860 870 880 890
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
:::::::::::::::::
XP_016 AHGVLESTTVWPLAAEP-------------------------------------------
900
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
XP_016 ------------------------------------------------------------
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------AINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
910 920 930 940 950 960
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
970 980 990 1000 1010 1020
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETEK-VPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1030 1040 1050 1060 1070
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_016 KLRRNRRSILDDSFKLLSFKQ
1080 1090 1100
>--
initn: 606 init1: 232 opt: 692 Z-score: 844.7 bits: 167.8 E(85289): 2.6e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:69-321)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_016 VSAPSQDLLITKVMWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_016 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_016 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_016 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_016 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_016 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
340 350 360 370 380 390
>>XP_011529377 (OMIM: 300167) PREDICTED: hephaestin isof (1101 aa)
initn: 5350 init1: 4094 opt: 4094 Z-score: 5044.6 bits: 944.9 E(85289): 0
Smith-Waterman score: 5132; 87.5% identity (87.5% similar) in 891 aa overlap (1-891:322-1101)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
XP_011 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
300 310 320 330 340 350
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
360 370 380 390 400 410
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
420 430 440 450 460 470
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
480 490 500 510 520 530
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
540 550 560 570 580 590
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
600 610 620 630 640 650
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
660 670 680 690 700 710
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
720 730 740 750 760 770
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
780 790 800 810 820 830
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
840 850 860 870 880 890
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
:::::::::::::::::
XP_011 AHGVLESTTVWPLAAEP-------------------------------------------
900
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
XP_011 ------------------------------------------------------------
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --------AINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
910 920 930 940 950 960
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
970 980 990 1000 1010 1020
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
1030 1040 1050 1060 1070 1080
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
XP_011 KLRRNRRSILDDSFKLLSFKQ
1090 1100
>--
initn: 606 init1: 232 opt: 692 Z-score: 844.7 bits: 167.8 E(85289): 2.6e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:69-321)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
XP_011 VSAPSQDLLITKVMWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
XP_011 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
XP_011 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
XP_011 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
XP_011 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
XP_011 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
340 350 360 370 380 390
>>NP_001269070 (OMIM: 300167) hephaestin isoform d precu (969 aa)
initn: 3605 init1: 3184 opt: 3184 Z-score: 3922.1 bits: 737.0 E(85289): 1e-211
Smith-Waterman score: 4422; 78.5% identity (78.5% similar) in 891 aa overlap (1-891:271-969)
10 20 30
pF1KA0 MHAINGFVFGNLPELNMCAQKRVAWHLFGM
::::::::::::::::::::::::::::::
NP_001 SWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGM
250 260 270 280 290 300
40 50 60 70 80 90
pF1KA0 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGM
310 320 330 340 350 360
100 110 120 130 140 150
pF1KA0 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFF
370 380 390 400 410 420
160 170 180 190 200 210
pF1KA0 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRAS
430 440 450 460 470 480
220 230 240 250 260 270
pF1KA0 QPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTW
::::::::::::::::::::::::
NP_001 QPFSMQPHGVFYEKDYEGTVYNDG------------------------------------
490 500
280 290 300 310 320 330
pF1KA0 MYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQ
NP_001 ------------------------------------------------------------
340 350 360 370 380 390
pF1KA0 AAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHG
NP_001 ------------------------------------------------------------
400 410 420 430 440 450
pF1KA0 VMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ
::::::::::::::::::::::::
NP_001 ------------------------------------TFEIYCQAGSHREAGMRAIYNVSQ
510 520
460 470 480 490 500 510
pF1KA0 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLL
530 540 550 560 570 580
520 530 540 550 560 570
pF1KA0 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVH
590 600 610 620 630 640
580 590 600 610 620 630
pF1KA0 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV
650 660 670 680 690 700
640 650 660 670 680 690
pF1KA0 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET
710 720 730 740 750 760
700 710 720 730 740 750
pF1KA0 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY
770 780 790 800 810 820
760 770 780 790 800 810
pF1KA0 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK
830 840 850 860 870 880
820 830 840 850 860 870
pF1KA0 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQR
890 900 910 920 930 940
880 890
pF1KA0 KLRRNRRSILDDSFKLLSFKQ
:::::::::::::::::::::
NP_001 KLRRNRRSILDDSFKLLSFKQ
950 960
>--
initn: 583 init1: 232 opt: 692 Z-score: 845.6 bits: 167.8 E(85289): 2.3e-40
Smith-Waterman score: 692; 41.7% identity (71.4% similar) in 259 aa overlap (100-352:18-270)
70 80 90 100 110 120
pF1KA0 PWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPM
:. : .: : .: :.. ...::.:.:
NP_001 MWAMESGHLLWALLFMQSLWP--QLTDGATRVYYLGIRDVQWNYAPK
10 20 30 40
130 140 150 160 170 180
pF1KA0 GHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGIL
:.. :.. : . ....:......:::::: :. :. ..:... .. . . ::.:
NP_001 GRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDE--VAQPAWLGFL
50 60 70 80 90 100
190 200 210 220 230 240
pF1KA0 GPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAK----PF
:::..:::::.: . . : :..:....::::::::: ::..: :::: : : : :
NP_001 GPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGP-LKADDSVPPG
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA0 EKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADG--K
. : ::.: .:: :::::::.: : .: :: .::.:::..:. ::: ... .
NP_001 GSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQ
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA0 QKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSN
.. ::..:::::.:.::: ::. : : :. : .... : ::.:::
NP_001 RQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA0 LPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPD
NP_001 LPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPW
290 300 310 320 330 340
891 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:43:30 2016 done: Sat Nov 5 06:43:31 2016
Total Scan time: 10.530 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]