Result of FASTA (ccds) for
pF1KA0687
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0687, 1037 aa
1>>>pF1KA0687 1037 - 1037 aa - 1037 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.3908+/-0.00118; mu= -0.7641+/- 0.070
mean_var=356.8045+/-75.277, 0's: 0 Z-trim(111.1): 649 B-trim: 0 in 0/53
Lambda= 0.067898
statistics sampled from 11338 (12082) to 11338 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.371), width: 16
Scan time: 4.640
The best scores are: opt bits E(32554)
CCDS82487.1 MAP4K4 gene_id:9448|Hs108|chr2 (1165) 4360 442.4 2.5e-123
CCDS56130.1 MAP4K4 gene_id:9448|Hs108|chr2 (1239) 2597 269.8 2.6e-71
CCDS74546.1 MAP4K4 gene_id:9448|Hs108|chr2 (1273) 2597 269.8 2.6e-71
CCDS54673.1 TNIK gene_id:23043|Hs108|chr3 (1268) 2311 241.8 7.1e-63
CCDS54674.1 TNIK gene_id:23043|Hs108|chr3 (1276) 2311 241.8 7.1e-63
CCDS54677.1 TNIK gene_id:23043|Hs108|chr3 (1297) 2311 241.8 7.2e-63
CCDS54678.1 TNIK gene_id:23043|Hs108|chr3 (1305) 2311 241.8 7.3e-63
CCDS54675.1 TNIK gene_id:23043|Hs108|chr3 (1323) 2311 241.8 7.3e-63
CCDS54676.1 TNIK gene_id:23043|Hs108|chr3 (1331) 2311 241.8 7.4e-63
CCDS54679.1 TNIK gene_id:23043|Hs108|chr3 (1352) 2311 241.8 7.4e-63
CCDS46956.1 TNIK gene_id:23043|Hs108|chr3 (1360) 2311 241.8 7.5e-63
CCDS45589.1 MINK1 gene_id:50488|Hs108|chr17 (1303) 2275 238.3 8.3e-62
CCDS45590.1 MINK1 gene_id:50488|Hs108|chr17 (1312) 2275 238.3 8.4e-62
CCDS45588.1 MINK1 gene_id:50488|Hs108|chr17 (1332) 2275 238.3 8.5e-62
CCDS65305.1 NRK gene_id:203447|Hs108|chrX (1582) 1217 134.7 1.5e-30
CCDS7148.1 MYO3A gene_id:53904|Hs108|chr10 (1616) 1025 115.9 7e-25
CCDS46446.1 MYO3B gene_id:140469|Hs108|chr2 (1314) 999 113.3 3.6e-24
CCDS42773.1 MYO3B gene_id:140469|Hs108|chr2 (1341) 999 113.3 3.6e-24
CCDS58707.1 MAP4K3 gene_id:8491|Hs108|chr2 ( 873) 910 104.4 1.1e-21
CCDS1803.1 MAP4K3 gene_id:8491|Hs108|chr2 ( 894) 910 104.4 1.1e-21
CCDS42564.1 MAP4K1 gene_id:11184|Hs108|chr19 ( 821) 820 95.5 4.8e-19
CCDS59385.1 MAP4K1 gene_id:11184|Hs108|chr19 ( 833) 820 95.5 4.9e-19
CCDS2549.1 STK25 gene_id:10494|Hs108|chr2 ( 426) 809 94.2 6.4e-19
CCDS81582.1 MAP4K2 gene_id:5871|Hs108|chr11 ( 812) 804 94.0 1.4e-18
CCDS8082.1 MAP4K2 gene_id:5871|Hs108|chr11 ( 820) 804 94.0 1.4e-18
CCDS34290.1 STK10 gene_id:6793|Hs108|chr5 ( 968) 799 93.5 2.3e-18
CCDS14631.1 STK26 gene_id:51765|Hs108|chrX ( 416) 790 92.3 2.3e-18
CCDS76334.1 SLK gene_id:9748|Hs108|chr10 (1204) 785 92.3 6.8e-18
CCDS7553.1 SLK gene_id:9748|Hs108|chr10 (1235) 785 92.3 7e-18
CCDS32001.1 STK24 gene_id:8428|Hs108|chr13 ( 431) 773 90.7 7.5e-18
CCDS13341.1 STK4 gene_id:6789|Hs108|chr20 ( 487) 772 90.6 8.7e-18
CCDS47900.1 STK3 gene_id:6788|Hs108|chr8 ( 491) 770 90.4 1e-17
CCDS59108.1 STK3 gene_id:6788|Hs108|chr8 ( 519) 770 90.4 1e-17
CCDS9488.1 STK24 gene_id:8428|Hs108|chr13 ( 443) 768 90.2 1.1e-17
CCDS63200.1 STK25 gene_id:10494|Hs108|chr2 ( 349) 713 84.7 3.8e-16
CCDS48168.1 STK26 gene_id:51765|Hs108|chrX ( 339) 686 82.0 2.3e-15
CCDS63199.1 STK25 gene_id:10494|Hs108|chr2 ( 332) 685 81.9 2.4e-15
CCDS66573.1 STK24 gene_id:8428|Hs108|chr13 ( 412) 607 74.4 5.7e-13
CCDS9188.1 TAOK3 gene_id:51347|Hs108|chr12 ( 898) 608 74.8 9.2e-13
CCDS56024.1 TAOK1 gene_id:57551|Hs108|chr17 ( 853) 607 74.7 9.5e-13
CCDS32601.1 TAOK1 gene_id:57551|Hs108|chr17 (1001) 607 74.8 1.1e-12
CCDS10662.1 TAOK2 gene_id:9344|Hs108|chr16 (1049) 593 73.4 2.8e-12
CCDS58448.1 TAOK2 gene_id:9344|Hs108|chr16 (1122) 593 73.4 3e-12
CCDS10663.1 TAOK2 gene_id:9344|Hs108|chr16 (1235) 593 73.5 3.2e-12
CCDS42770.1 STK39 gene_id:27347|Hs108|chr2 ( 545) 579 71.7 4.6e-12
CCDS14554.1 PAK3 gene_id:5063|Hs108|chrX ( 544) 561 70.0 1.6e-11
CCDS48153.1 PAK3 gene_id:5063|Hs108|chrX ( 559) 561 70.0 1.6e-11
CCDS48152.1 PAK3 gene_id:5063|Hs108|chrX ( 565) 561 70.0 1.6e-11
CCDS48151.1 PAK3 gene_id:5063|Hs108|chrX ( 580) 561 70.0 1.6e-11
CCDS3321.1 PAK2 gene_id:5062|Hs108|chr3 ( 524) 559 69.8 1.8e-11
>>CCDS82487.1 MAP4K4 gene_id:9448|Hs108|chr2 (1165 aa)
initn: 6508 init1: 3925 opt: 4360 Z-score: 2327.5 bits: 442.4 E(32554): 2.5e-123
Smith-Waterman score: 5995; 87.9% identity (87.9% similar) in 1070 aa overlap (97-1037:97-1165)
70 80 90 100 110 120
pF1KA0 KLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK
::::::::::::::::::::::::::::::
CCDS82 KLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 EDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER
310 320 330 340 350 360
370 380
pF1KA0 SEALRRQQLLQEQQLREQE-----------------------------------------
:::::::::::::::::::
CCDS82 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE
370 380 390 400 410 420
pF1KA0 ------------------------------------------------------------
CCDS82 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL
430 440 450 460 470 480
390 400 410
pF1KA0 ----------------------------RSKPSFHAPEPKAHYEPADRAREVPVRTTSRS
::::::::::::::::::::::::::::::::
CCDS82 LQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRS
490 500 510 520 530 540
420 430 440 450 460 470
pF1KA0 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
CCDS82 PVLSRRDSPLQGSGQQNSQAGQRNSTS-IEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
550 560 570 580 590 600
480 490 500 510 520 530
pF1KA0 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
610 620 630 640 650 660
540 550 560 570 580 590
pF1KA0 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
670 680 690 700 710 720
600 610 620 630 640 650
pF1KA0 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
730 740 750 760 770 780
660 670 680 690 700 710
pF1KA0 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
790 800 810 820 830 840
720 730 740 750 760 770
pF1KA0 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
850 860 870 880 890 900
780 790 800 810 820 830
pF1KA0 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
910 920 930 940 950 960
840 850 860 870 880 890
pF1KA0 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
970 980 990 1000 1010 1020
900 910 920 930 940 950
pF1KA0 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
1030 1040 1050 1060 1070 1080
960 970 980 990 1000 1010
pF1KA0 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
1090 1100 1110 1120 1130 1140
1020 1030
pF1KA0 SGGSSQVYFMTLGRTSLLSW
::::::::::::::::::::
CCDS82 SGGSSQVYFMTLGRTSLLSW
1150 1160
>--
initn: 619 init1: 619 opt: 619 Z-score: 347.0 bits: 76.0 E(32554): 5.2e-13
Smith-Waterman score: 619; 100.0% identity (100.0% similar) in 96 aa overlap (1-96:1-96)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::::::::::::::::::::::::::::::::
CCDS82 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
CCDS82 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
>>CCDS56130.1 MAP4K4 gene_id:9448|Hs108|chr2 (1239 aa)
initn: 5563 init1: 2592 opt: 2597 Z-score: 1393.8 bits: 269.8 E(32554): 2.6e-71
Smith-Waterman score: 5200; 79.7% identity (79.7% similar) in 1073 aa overlap (1-859:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
310 320 330 340 350 360
370 380
pF1KA0 QENKERSEALRRQQLLQEQQLREQE-----------------------------------
:::::::::::::::::::::::::
CCDS56 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
370 380 390 400 410 420
pF1KA0 ------------------------------------------------------------
CCDS56 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
430 440 450 460 470 480
pF1KA0 ------------------------------------------------------------
CCDS56 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP
490 500 510 520 530 540
390 400
pF1KA0 -----RSKPSFHAPEPKAHYEPADRAREV-------------------------------
::::::::::::::::::::::::
CCDS56 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS
550 560 570 580 590 600
410 420 430 440
pF1KA0 -----------------------PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSI
::::::::::::::::::::::::::::::::::: :
CCDS56 ESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTS-I
610 620 630 640 650
450 460 470 480 490 500
pF1KA0 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQR
660 670 680 690 700 710
510 520 530 540 550 560
pF1KA0 LENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDE
::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
CCDS56 LENAVKKPEDKKEVFRPLKPA---DLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDE
720 730 740 750 760 770
570 580 590 600 610 620
pF1KA0 EDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLI
780 790 800 810 820 830
630 640 650 660 670 680
pF1KA0 VRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPT
840 850 860 870 880 890
690 700 710 720 730 740
pF1KA0 RKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQG
900 910 920 930 940 950
750 760 770 780 790 800
pF1KA0 KVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTT
960 970 980 990 1000 1010
810 820 830 840 850 860
pF1KA0 VGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDL
:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDL
1020 1030 1040 1050 1060 1070
870 880 890 900 910 920
pF1KA0 TVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNT
CCDS56 TVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVC
1080 1090 1100 1110 1120 1130
>--
initn: 856 init1: 856 opt: 1116 Z-score: 609.8 bits: 124.7 E(32554): 1.2e-27
Smith-Waterman score: 1116; 95.5% identity (95.5% similar) in 178 aa overlap (860-1037:1070-1239)
830 840 850 860 870 880
pF1KA0 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV
::::::::::::::::::::::::::::::
CCDS56 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV
1040 1050 1060 1070 1080 1090
890 900 910 920 930 940
pF1KA0 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT
::::::::::::: :::::::::::::::::::::::::::::::::::::::
CCDS56 DSGSVYDIYLPTH--------IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT
1100 1110 1120 1130 1140 1150
950 960 970 980 990 1000
pF1KA0 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
1160 1170 1180 1190 1200 1210
1010 1020 1030
pF1KA0 KVFFASVRSGGSSQVYFMTLGRTSLLSW
::::::::::::::::::::::::::::
CCDS56 KVFFASVRSGGSSQVYFMTLGRTSLLSW
1220 1230
>>CCDS74546.1 MAP4K4 gene_id:9448|Hs108|chr2 (1273 aa)
initn: 5072 init1: 2597 opt: 2597 Z-score: 1393.7 bits: 269.8 E(32554): 2.6e-71
Smith-Waterman score: 4912; 76.7% identity (76.7% similar) in 1072 aa overlap (1-825:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
310 320 330 340 350 360
370 380
pF1KA0 QENKERSEALRRQQLLQEQQLREQE-----------------------------------
:::::::::::::::::::::::::
CCDS74 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
370 380 390 400 410 420
pF1KA0 ------------------------------------------------------------
CCDS74 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
430 440 450 460 470 480
390 400
pF1KA0 ----------------------------------RSKPSFHAPEPKAHYEPADRAREV--
::::::::::::::::::::::::
CCDS74 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED
490 500 510 520 530 540
410
pF1KA0 ----------------------------------------------------PVRTTSRS
::::::::
CCDS74 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS
550 560 570 580 590 600
420 430 440 450 460 470
pF1KA0 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
610 620 630 640 650 660
480 490 500 510 520 530
pF1KA0 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
CCDS74 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPA---DLTALAK
670 680 690 700 710
540 550 560 570 580 590
pF1KA0 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
720 730 740 750 760 770
600 610 620
pF1KA0 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQ----------------------------
::::::::::::::::::::::::::::::::
CCDS74 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQ
780 790 800 810 820 830
630 640 650
pF1KA0 ------------------------------------TQSASSTLQKHKSSSSFTPFIDPR
::::::::::::::::::::::::
CCDS74 QSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPR
840 850 860 870 880 890
660 670 680 690 700 710
pF1KA0 LLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 LLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK
900 910 920 930 940 950
720 730 740 750 760 770
pF1KA0 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS
960 970 980 990 1000 1010
780 790 800 810 820 830
pF1KA0 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS
::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS
1020 1030 1040 1050 1060 1070
840 850 860 870 880 890
pF1KA0 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS
CCDS74 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS
1080 1090 1100 1110 1120 1130
>--
initn: 862 init1: 856 opt: 1345 Z-score: 730.9 bits: 147.1 E(32554): 2.2e-34
Smith-Waterman score: 1345; 96.2% identity (96.2% similar) in 212 aa overlap (826-1037:1070-1273)
800 810 820 830 840 850
pF1KA0 PEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFG
::::::::::::::::::::::::::::::
CCDS74 PEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFG
1040 1050 1060 1070 1080 1090
860 870 880 890 900 910
pF1KA0 ELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSI
::::::::::::::::::::::::::::::::::::::::::::::: :::::
CCDS74 ELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTH--------IQCSI
1100 1110 1120 1130 1140 1150
920 930 940 950 960 970
pF1KA0 KPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 KPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWG
1160 1170 1180 1190 1200 1210
980 990 1000 1010 1020 1030
pF1KA0 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLL
1220 1230 1240 1250 1260 1270
pF1KA0 SW
::
CCDS74 SW
>>CCDS54673.1 TNIK gene_id:23043|Hs108|chr3 (1268 aa)
initn: 4564 init1: 2071 opt: 2311 Z-score: 1242.3 bits: 241.8 E(32554): 7.1e-63
Smith-Waterman score: 3359; 57.3% identity (67.2% similar) in 1074 aa overlap (1-830:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 QER---------------------------------------------------------
:::
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
420 430 440 450 460 470
390
pF1KA0 -------SKPSFHAPE--------------------------------------------
.:: .: :
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGF
480 490 500 510 520 530
400 410
pF1KA0 -------------PKAHYEPA-------------DRAR----------EVPVRTTSRSPV
:. . .:. ::. .:: :::: ::.
CCDS54 QEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
540 550 560 570 580 590
420 430 440 450 460 470
pF1KA0 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP--
:.:..:: .::. ..: .:. . : .:. . : .:::::.::. .:::
CCDS54 LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS
600 610 620 630 640 650
480 490 500 510 520 530
pF1KA0 --GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTAL
::.::::.::.:: :::..::::::: : : :::..... :: .:: :::::
CCDS54 QGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTAL
660 670 680 690 700 710
540 550 560 570
pF1KA0 AKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------------------
::::: . : :: .:::::::::::: ...::..: :.:
CCDS54 AKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTG
720 730 740 750 760 770
580 590 600 610
pF1KA0 --GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES-----
:..:. : : : ..: : : ..: .: :: . : :.: ..
CCDS54 APGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHI
780 790 800 810 820 830
620 630 640 650 660
pF1KA0 ----------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPS
:: ::.. . ..: .: . .:: :::::.:::. : ::.
CCDS54 NLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPT
840 850 860 870 880 890
670 680 690 700 710
pF1KA0 S----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFN
. .... :. . .: : . . .:: ::::::::: ::.::::::::::::::
CCDS54 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN
900 910 920 930 940 950
720 730 740 750 760 770
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
::::::::::::::::::.:::::::::::::: ::::::::::::::::::::::::::
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
960 970 980 990 1000 1010
780 790 800 810 820 830
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
.::::::::::::.:::::::::::::: ::::::::.::::::::::::::::
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
1020 1030 1040 1050 1060 1070
840 850 860 870 880 890
pF1KA0 VYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYD
CCDS54 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD
1080 1090 1100 1110 1120 1130
>--
initn: 1211 init1: 780 opt: 1165 Z-score: 635.6 bits: 129.5 E(32554): 4.4e-29
Smith-Waterman score: 1165; 81.6% identity (93.2% similar) in 207 aa overlap (831-1037:1070-1268)
810 820 830 840 850 860
pF1KA0 KQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHK
::..::.:::::::::::::::::..: ::
CCDS54 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK
1040 1050 1060 1070 1080 1090
870 880 890 900 910 920
pF1KA0 PLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAI
:::::::::::::::::.:: .:::..:::::. ::::.:.:.. : : ::::
CCDS54 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAI
1100 1110 1120 1130 1140 1150
930 940 950 960 970 980
pF1KA0 IILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIE
.:::.:::::.:::::::::::::::::::::::::::::::::::.::: :::::::::
CCDS54 VILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIE
1160 1170 1180 1190 1200 1210
990 1000 1010 1020 1030
pF1KA0 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
::::::::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
1220 1230 1240 1250 1260
>>CCDS54674.1 TNIK gene_id:23043|Hs108|chr3 (1276 aa)
initn: 4614 init1: 2071 opt: 2311 Z-score: 1242.2 bits: 241.8 E(32554): 7.1e-63
Smith-Waterman score: 3308; 56.7% identity (66.9% similar) in 1071 aa overlap (1-822:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 QER---------------------------------------------------------
:::
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
420 430 440 450 460 470
390
pF1KA0 -------SKPSFHAPE--------------------------------------------
.:: .: :
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGF
480 490 500 510 520 530
400 410
pF1KA0 -------------PKAHYEPA-------------DRAR----------EVPVRTTSRSPV
:. . .:. ::. .:: :::: ::.
CCDS54 QEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
540 550 560 570 580 590
420 430 440 450 460 470
pF1KA0 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP--
:.:..:: .::. ..: .:. . : .:. . : .:::::.::. .:::
CCDS54 LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS
600 610 620 630 640 650
480 490 500 510 520 530
pF1KA0 --GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EV
::.::::.::.:: :::..::::::: : : :::..... :: .::. .
CCDS54 QGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDE
660 670 680 690 700 710
540 550 560 570
pF1KA0 DLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE-------------
:::::::::: . : :: .:::::::::::: ...::..: :.:
CCDS54 DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPR
720 730 740 750 760 770
580 590 600 610
pF1KA0 -------GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES
:..:. : : : ..: : : ..: .: :: . : :.: ..
CCDS54 LIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNG
780 790 800 810 820 830
620 630 640 650
pF1KA0 ---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLL
:: ::.. . ..: .: . .:: :::::.:::.
CCDS54 FAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVY
840 850 860 870 880 890
660 670 680 690 700 710
pF1KA0 QISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY
: ::.. .... :. . .: : . . .:: ::::::::: ::.:::::::::
CCDS54 QTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKY
900 910 920 930 940 950
720 730 740 750 760 770
pF1KA0 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT
:::::::::::::::::::::::.:::::::::::::: :::::::::::::::::::::
CCDS54 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVT
960 970 980 990 1000 1010
780 790 800 810 820 830
pF1KA0 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL
:::::.::::::::::::.:::::::::::::: ::::::::.::::::::
CCDS54 ISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIAL
1020 1030 1040 1050 1060 1070
840 850 860 870 880 890
pF1KA0 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS
CCDS54 KNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDS
1080 1090 1100 1110 1120 1130
>--
initn: 1257 init1: 780 opt: 1211 Z-score: 659.9 bits: 134.0 E(32554): 2e-30
Smith-Waterman score: 1211; 82.3% identity (93.5% similar) in 215 aa overlap (823-1037:1070-1276)
800 810 820 830 840 850
pF1KA0 HNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK
::::::::::..::.:::::::::::::::
CCDS54 HNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFK
1040 1050 1060 1070 1080 1090
860 870 880 890 900 910
pF1KA0 SFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQ
::..: :::::::::::::::::::.:: .:::..:::::. ::::.:.:.. :
CCDS54 SFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN------
1100 1110 1120 1130 1140 1150
920 930 940 950 960 970
pF1KA0 CSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTM
: ::::.:::.:::::.:::::::::::::::::::::::::::::::::::.::: :
CCDS54 --ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIM
1160 1170 1180 1190 1200 1210
980 990 1000 1010 1020 1030
pF1KA0 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT
::::::::::::::::::::::::::::::::::::::::::::::::::::.::::.:.
CCDS54 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRN
1220 1230 1240 1250 1260 1270
pF1KA0 SLLSW
:...:
CCDS54 SMMNW
>>CCDS54677.1 TNIK gene_id:23043|Hs108|chr3 (1297 aa)
initn: 4564 init1: 2071 opt: 2311 Z-score: 1242.1 bits: 241.8 E(32554): 7.2e-63
Smith-Waterman score: 3110; 54.7% identity (64.6% similar) in 1074 aa overlap (1-801:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 ------------------------------------------------------------
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
420 430 440 450 460 470
390
pF1KA0 ----------------QERS-----------------KPSFHAPE---------------
:::. :: .: :
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIP
480 490 500 510 520 530
400
pF1KA0 ------------------------------------------PKAHYEPA----------
:. . .:.
CCDS54 HLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI
540 550 560 570 580 590
410 420 430 440 450
pF1KA0 ---DRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRL
::. .:: :::: ::.:.:..:: .::. ..: .:. . :
CCDS54 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRR
600 610 620 630 640 650
460 470 480 490 500
pF1KA0 LWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQR
.:. . : .:::::.::. .::: ::.::::.::.:: :::..:::::::
CCDS54 TEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLP
660 670 680 690 700 710
510 520 530 540 550 560
pF1KA0 LENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGT
: : :::..... :: .:: :::::::::: . : :: .:::::::::::: .
CCDS54 HEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESES
720 730 740 750 760 770
570 580 590
pF1KA0 TDEEDDDVEQE--------------------GADES-------TSGPEDTRAAS-SLNLS
..::..: :.: :..:. : : : ..: : : ..:
CCDS54 SEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSIS
780 790 800 810 820 830
600 610 620 630
pF1KA0 -NG-----ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQTQSAS
.: :: . : :.: .. :: ::.. . ..: .
CCDS54 REGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMD
840 850 860 870 880 890
640 650 660 670 680
pF1KA0 STLQKHKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTR
: . .:: :::::.:::. : ::.. .... :. . .: : . . .:
CCDS54 SGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEAR
900 910 920 930 940 950
690 700 710 720 730 740
pF1KA0 KGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGK
: ::::::::: ::.::::::::::::::::::::::::::::::::.::::::::::::
CCDS54 KISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK
960 970 980 990 1000 1010
750 760 770 780 790 800
pF1KA0 VYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTV
:: ::::::::::::::::::::::::::.::::::::::::.:::::::::::
CCDS54 VYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITV
1020 1030 1040 1050 1060 1070
810 820 830 840 850 860
pF1KA0 GDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLT
CCDS54 GDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLT
1080 1090 1100 1110 1120 1130
>--
initn: 1402 init1: 780 opt: 1356 Z-score: 736.6 bits: 148.2 E(32554): 1e-34
Smith-Waterman score: 1356; 83.1% identity (93.6% similar) in 236 aa overlap (802-1037:1070-1297)
780 790 800 810 820 830
pF1KA0 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL
::: ::::::::.:::::::::::::::::
CCDS54 ISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIAL
1040 1050 1060 1070 1080 1090
840 850 860 870 880 890
pF1KA0 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS
:..::.:::::::::::::::::..: :::::::::::::::::::.:: .:::..::::
CCDS54 KNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDS
1100 1110 1120 1130 1140 1150
900 910 920 930 940 950
pF1KA0 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD
:. ::::.:.:.. : : ::::.:::.:::::.::::::::::::::::::::
CCDS54 GNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKD
1160 1170 1180 1190 1200 1210
960 970 980 990 1000 1010
pF1KA0 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
:::::::::::::::.::: ::::::::::::::::::::::::::::::::::::::::
CCDS54 VVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
1220 1230 1240 1250 1260 1270
1020 1030
pF1KA0 FFASVRSGGSSQVYFMTLGRTSLLSW
:::::::::::::.::::.:.:...:
CCDS54 FFASVRSGGSSQVFFMTLNRNSMMNW
1280 1290
>>CCDS54678.1 TNIK gene_id:23043|Hs108|chr3 (1305 aa)
initn: 4614 init1: 2071 opt: 2311 Z-score: 1242.1 bits: 241.8 E(32554): 7.3e-63
Smith-Waterman score: 3051; 54.2% identity (64.2% similar) in 1071 aa overlap (1-793:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 QER---------------------------------------------------------
:::
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
420 430 440 450 460 470
390
pF1KA0 ------------------------------------SKPSFHAPE---------------
.:: .: :
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIP
480 490 500 510 520 530
400
pF1KA0 ------------------------------------------PKAHYEPA----------
:. . .:.
CCDS54 HLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI
540 550 560 570 580 590
410 420 430 440 450
pF1KA0 ---DRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRL
::. .:: :::: ::.:.:..:: .::. ..: .:. . :
CCDS54 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRR
600 610 620 630 640 650
460 470 480 490 500
pF1KA0 LWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQR
.:. . : .:::::.::. .::: ::.::::.::.:: :::..:::::::
CCDS54 TEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLP
660 670 680 690 700 710
510 520 530 540 550
pF1KA0 LENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDYSSSS
: : :::..... :: .::. . :::::::::: . : :: .:::::::::
CCDS54 HEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSS
720 730 740 750 760 770
560 570 580 590
pF1KA0 EESGTTDEEDDDVEQE--------------------GADES-------TSGPEDTRAAS-
::: ...::..: :.: :..:. : : : ..: :
CCDS54 EESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSF
780 790 800 810 820 830
600 610 620
pF1KA0 SLNLS-NG-----ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQ
: ..: .: :: . : :.: .. :: ::.. . .
CCDS54 SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH
840 850 860 870 880 890
630 640 650 660 670 680
pF1KA0 TQSASSTLQKHKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIR
.: .: . .:: :::::.:::. : ::.. .... :. . .: : .
CCDS54 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK
900 910 920 930 940 950
690 700 710 720 730 740
pF1KA0 QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDR
. .:: ::::::::: ::.::::::::::::::::::::::::::::::::.:::::::
CCDS54 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR
960 970 980 990 1000 1010
750 760 770 780 790 800
pF1KA0 SGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQ
::::::: ::::::::::::::::::::::::::.::::::::::::.:::
CCDS54 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ
1020 1030 1040 1050 1060 1070
810 820 830 840 850 860
pF1KA0 GWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPL
CCDS54 GWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPL
1080 1090 1100 1110 1120 1130
>--
initn: 1471 init1: 780 opt: 1410 Z-score: 765.1 bits: 153.5 E(32554): 2.7e-36
Smith-Waterman score: 1410; 83.6% identity (93.9% similar) in 244 aa overlap (794-1037:1070-1305)
770 780 790 800 810 820
pF1KA0 EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYER
::::::::::: ::::::::.:::::::::
CCDS54 EGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYER
1040 1050 1060 1070 1080 1090
830 840 850 860 870 880
pF1KA0 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAG
:::::::::..::.:::::::::::::::::..: :::::::::::::::::::.:: .:
CCDS54 IKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTG
1100 1110 1120 1130 1140 1150
890 900 910 920 930 940
pF1KA0 FHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVN
::..:::::. ::::.:.:.. : : ::::.:::.:::::.::::::::::::
CCDS54 FHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVN
1160 1170 1180 1190 1200 1210
950 960 970 980 990 1000
pF1KA0 TYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
:::::::::::::::::::::::.::: ::::::::::::::::::::::::::::::::
CCDS54 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
1220 1230 1240 1250 1260 1270
1010 1020 1030
pF1KA0 LCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
:::::::::::::::::::::.::::.:.:...:
CCDS54 LCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
1280 1290 1300
>>CCDS54675.1 TNIK gene_id:23043|Hs108|chr3 (1323 aa)
initn: 4564 init1: 2071 opt: 2311 Z-score: 1242.0 bits: 241.8 E(32554): 7.3e-63
Smith-Waterman score: 2891; 52.6% identity (62.3% similar) in 1074 aa overlap (1-775:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 -----------------------------------------------QERS---------
:::.
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
420 430 440 450 460 470
390
pF1KA0 --------KPSFHAPE------------------------------------------PK
:: .: : :.
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR
480 490 500 510 520 530
400
pF1KA0 A-------------------------------------------HYEPA-----------
. : .:.
CCDS54 SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN
540 550 560 570 580 590
410 420
pF1KA0 -----------------------------DRAR----------EVPVRTTSRSPVLSRRD
::. .:: :::: ::.:.:..
CCDS54 VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKN
600 610 620 630 640 650
430 440 450 460 470 480
pF1KA0 SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSH
:: .::. ..: .:. . : .:. . : .:::::.::. .::: ::.
CCDS54 SPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQ
660 670 680 690 700 710
490 500 510 520 530 540
pF1KA0 PGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELR
::::.::.:: :::..::::::: : : :::..... :: .:: ::::::::::
CCDS54 PGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELR
720 730 740 750 760 770
550 560 570
pF1KA0 AV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE--------------------GAD
. : :: .:::::::::::: ...::..: :.: :..
CCDS54 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN
780 790 800 810 820 830
580 590 600 610
pF1KA0 ES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES----------
:. : : : ..: : : ..: .: :: . : :.: ..
CCDS54 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL
840 850 860 870 880 890
620 630 640 650 660
pF1KA0 -----EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPSS----
:: ::.. . ..: .: . .:: :::::.:::. : ::..
CCDS54 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE
900 910 920 930 940 950
670 680 690 700 710 720
pF1KA0 GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILC
.... :. . .: : . . .:: ::::::::: ::.:::::::::::::::::::
CCDS54 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC
960 970 980 990 1000 1010
730 740 750 760 770 780
pF1KA0 AALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRV
:::::::::::::.:::::::::::::: :::::::::::::::::::::::::
CCDS54 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV
1020 1030 1040 1050 1060 1070
790 800 810 820 830 840
pF1KA0 YYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWA
CCDS54 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA
1080 1090 1100 1110 1120 1130
>--
initn: 1577 init1: 780 opt: 1524 Z-score: 825.4 bits: 164.7 E(32554): 1.2e-39
Smith-Waterman score: 1524; 84.0% identity (94.3% similar) in 262 aa overlap (776-1037:1070-1323)
750 760 770 780 790 800
pF1KA0 GKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWT
:.::::::::::::.::::::::::::::
CCDS54 GKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWI
1040 1050 1060 1070 1080 1090
810 820 830 840 850 860
pF1KA0 TVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVD
::::::::.::::::::::::::::::..::.:::::::::::::::::..: :::::::
CCDS54 TVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVD
1100 1110 1120 1130 1140 1150
870 880 890 900 910 920
pF1KA0 LTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPN
::::::::::::.:: .:::..:::::. ::::.:.:.. : : ::::.:::.
CCDS54 LTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPK
1160 1170 1180 1190 1200 1210
930 940 950 960 970 980
pF1KA0 TDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE
:::::.:::::::::::::::::::::::::::::::::::.::: ::::::::::::::
CCDS54 TDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVE
1220 1230 1240 1250 1260 1270
990 1000 1010 1020 1030
pF1KA0 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
:::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
1280 1290 1300 1310 1320
>>CCDS54676.1 TNIK gene_id:23043|Hs108|chr3 (1331 aa)
initn: 4614 init1: 2071 opt: 2311 Z-score: 1242.0 bits: 241.8 E(32554): 7.4e-63
Smith-Waterman score: 2842; 52.0% identity (61.9% similar) in 1071 aa overlap (1-767:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 QER---------------------------------------------------------
:::
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
420 430 440 450 460 470
390
pF1KA0 -------SKPSFHAPE------------------------------------------PK
.:: .: : :.
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR
480 490 500 510 520 530
400
pF1KA0 A-------------------------------------------HYEPA-----------
. : .:.
CCDS54 SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN
540 550 560 570 580 590
410 420
pF1KA0 -----------------------------DRAR----------EVPVRTTSRSPVLSRRD
::. .:: :::: ::.:.:..
CCDS54 VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKN
600 610 620 630 640 650
430 440 450 460 470 480
pF1KA0 SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSH
:: .::. ..: .:. . : .:. . : .:::::.::. .::: ::.
CCDS54 SPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQ
660 670 680 690 700 710
490 500 510 520 530
pF1KA0 PGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTAL
::::.::.:: :::..::::::: : : :::..... :: .::. . :::::
CCDS54 PGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTAL
720 730 740 750 760 770
540 550 560 570
pF1KA0 AKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------------------
::::: . : :: .:::::::::::: ...::..: :.:
CCDS54 AKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTG
780 790 800 810 820 830
580 590 600 610
pF1KA0 --GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES-----
:..:. : : : ..: : : ..: .: :: . : :.: ..
CCDS54 APGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHI
840 850 860 870 880 890
620 630 640 650 660
pF1KA0 ----------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPS
:: ::.. . ..: .: . .:: :::::.:::. : ::.
CCDS54 NLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPT
900 910 920 930 940 950
670 680 690 700 710
pF1KA0 S----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFN
. .... :. . .: : . . .:: ::::::::: ::.::::::::::::::
CCDS54 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN
960 970 980 990 1000 1010
720 730 740 750 760 770
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
::::::::::::::::::.:::::::::::::: :::::::::::::::::
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
1020 1030 1040 1050 1060 1070
780 790 800 810 820 830
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
1080 1090 1100 1110 1120 1130
>--
initn: 1635 init1: 824 opt: 1568 Z-score: 848.7 bits: 169.0 E(32554): 6e-41
Smith-Waterman score: 1568; 84.8% identity (94.4% similar) in 270 aa overlap (768-1037:1070-1331)
740 750 760 770 780 790
pF1KA0 MLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPE
:::::::::.::::::::::::.:::::::
CCDS54 MLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPE
1040 1050 1060 1070 1080 1090
800 810 820 830 840 850
pF1KA0 VEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGEL
::::::: ::::::::.::::::::::::::::::..::.:::::::::::::::::..:
CCDS54 VEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADL
1100 1110 1120 1130 1140 1150
860 870 880 890 900 910
pF1KA0 VHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKP
:::::::::::::::::::.:: .:::..:::::. ::::.:.: :: .: :
CCDS54 QHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSH--------IQGNITP
1160 1170 1180 1190 1200 1210
920 930 940 950 960 970
pF1KA0 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK
:::.:::.:::::.:::::::::::::::::::::::::::::::::::.::: ::::::
CCDS54 HAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEK
1220 1230 1240 1250 1260 1270
980 990 1000 1010 1020 1030
pF1KA0 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
:::::::::::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
1280 1290 1300 1310 1320 1330
>>CCDS54679.1 TNIK gene_id:23043|Hs108|chr3 (1352 aa)
initn: 4564 init1: 2071 opt: 2311 Z-score: 1241.9 bits: 241.8 E(32554): 7.4e-63
Smith-Waterman score: 2661; 50.0% identity (59.7% similar) in 1074 aa overlap (1-746:1-1069)
10 20 30 40 50 60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::.::::.:: .::::.::::::::::::.:::::::::::::::::::::::::::::
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
:::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
:::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
:::::::::.:::::::::::::::::::::: .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
310 320 330 340 350
370 380
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
::::::::::::: :.::: ::
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
360 370 380 390 400 410
pF1KA0 QER---------------------------------------------------------
:::
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
420 430 440 450 460 470
390
pF1KA0 ------------------------------------SKPSFHAPE---------------
.:: .: :
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVE
480 490 500 510 520 530
pF1KA0 ---------------------------PKA------------------------------
:..
CCDS54 ERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAV
540 550 560 570 580 590
400
pF1KA0 -------------HYEPA----------------------------------------DR
: .:. ::
CCDS54 KSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDR
600 610 620 630 640 650
410 420 430 440 450
pF1KA0 AR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERV
. .:: :::: ::.:.:..:: .::. ..: .:. . : .
CCDS54 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL
660 670 680 690 700 710
460 470 480 490 500 510
pF1KA0 EKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAV
:. . : .:::::.::. .::: ::.::::.::.:: :::..::::::: : :
CCDS54 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK
720 730 740 750 760 770
520 530 540 550 560
pF1KA0 KKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEED
:::..... :: .:: :::::::::: . : :: .:::::::::::: ...::.
CCDS54 VKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE
780 790 800 810 820 830
570 580 590
pF1KA0 DDVEQE--------------------GADES-------TSGPEDTRAAS-SLNLS-NG--
.: :.: :..:. : : : ..: : : ..: .:
CCDS54 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL
840 850 860 870 880 890
600 610 620 630
pF1KA0 ---ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQTQSASSTLQK
:: . : :.: .. :: ::.. . ..: .: .
CCDS54 MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY
900 910 920 930 940 950
640 650 660 670 680 690
pF1KA0 HKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVV
.:: :::::.:::. : ::.. .... :. . .: : . . .:: :::
CCDS54 GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV
960 970 980 990 1000 1010
700 710 720 730 740 750
pF1KA0 NVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLI
:::::: ::.::::::::::::::::::::::::::::::::.:::::::::::
CCDS54 NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI
1020 1030 1040 1050 1060 1070
760 770 780 790 800 810
pF1KA0 NRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG
CCDS54 NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG
1080 1090 1100 1110 1120 1130
>--
initn: 1763 init1: 952 opt: 1696 Z-score: 916.3 bits: 181.6 E(32554): 1e-44
Smith-Waterman score: 1696; 85.2% identity (94.5% similar) in 291 aa overlap (747-1037:1070-1352)
720 730 740 750 760 770
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
::: ::::::::::::::::::::::::::
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
1040 1050 1060 1070 1080 1090
780 790 800 810 820 830
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
.::::::::::::.:::::::::::::: ::::::::.::::::::::::::::::..::
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
1100 1110 1120 1130 1140 1150
840 850 860 870 880 890
pF1KA0 VYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYD
.:::::::::::::::::..: :::::::::::::::::::.:: .:::..:::::. ::
CCDS54 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD
1160 1170 1180 1190 1200 1210
900 910 920 930 940 950
pF1KA0 IYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQW
::.:.:.. : : ::::.:::.:::::.:::::::::::::::::::::::::
CCDS54 IYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQW
1220 1230 1240 1250 1260 1270
960 970 980 990 1000 1010
pF1KA0 GEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
::::::::::.::: :::::::::::::::::::::::::::::::::::::::::::::
CCDS54 GEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
1280 1290 1300 1310 1320 1330
1020 1030
pF1KA0 RSGGSSQVYFMTLGRTSLLSW
::::::::.::::.:.:...:
CCDS54 RSGGSSQVFFMTLNRNSMMNW
1340 1350
1037 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:32:52 2016 done: Wed Nov 2 19:32:53 2016
Total Scan time: 4.640 Total Display time: 0.470
Function used was FASTA [36.3.4 Apr, 2011]