Result of FASTA (omim) for
pF1KA0671
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0671, 536 aa
1>>>pF1KA0671 536 - 536 aa - 536 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1949+/-0.000373; mu= 14.4540+/- 0.023
mean_var=99.7404+/-20.195, 0's: 0 Z-trim(115.3): 80 B-trim: 558 in 1/52
Lambda= 0.128422
statistics sampled from 25512 (25592) to 25512 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.3), width: 16
Scan time: 7.070
The best scores are: opt bits E(85289)
NP_054730 (OMIM: 607094) suppressor of cytokine si ( 536) 3679 692.4 8.8e-199
NP_659198 (OMIM: 607094) suppressor of cytokine si ( 536) 3679 692.4 8.8e-199
XP_011534727 (OMIM: 616337) PREDICTED: suppressor ( 440) 1160 225.7 2.3e-58
XP_011534728 (OMIM: 616337) PREDICTED: suppressor ( 440) 1160 225.7 2.3e-58
NP_543143 (OMIM: 616337) suppressor of cytokine si ( 440) 1160 225.7 2.3e-58
NP_955453 (OMIM: 616337) suppressor of cytokine si ( 440) 1160 225.7 2.3e-58
NP_004223 (OMIM: 605118) suppressor of cytokine si ( 535) 244 56.0 3.4e-07
XP_016881575 (OMIM: 605118) PREDICTED: suppressor ( 535) 244 56.0 3.4e-07
XP_016881576 (OMIM: 605118) PREDICTED: suppressor ( 535) 244 56.0 3.4e-07
XP_005266840 (OMIM: 605118) PREDICTED: suppressor ( 535) 244 56.0 3.4e-07
NP_003736 (OMIM: 603597) suppressor of cytokine si ( 211) 191 45.9 0.00014
XP_016880041 (OMIM: 608788) PREDICTED: suppressor ( 576) 189 45.8 0.00042
NP_055413 (OMIM: 608788) suppressor of cytokine si ( 581) 189 45.9 0.00042
XP_016880040 (OMIM: 608788) PREDICTED: suppressor ( 611) 189 45.9 0.00044
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258) 177 43.4 0.001
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264) 177 43.4 0.001
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275) 177 43.4 0.0011
XP_016875639 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875636 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875640 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875643 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875637 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875642 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875641 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
XP_016875638 (OMIM: 605117) PREDICTED: suppressor ( 243) 173 42.6 0.0016
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198) 170 42.0 0.002
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198) 170 42.0 0.002
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198) 170 42.0 0.002
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198) 170 42.0 0.002
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198) 170 42.0 0.002
XP_016875645 (OMIM: 605117) PREDICTED: suppressor ( 198) 170 42.0 0.002
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198) 170 42.0 0.002
XP_016875644 (OMIM: 605117) PREDICTED: suppressor ( 222) 170 42.0 0.0022
XP_011537237 (OMIM: 605117) PREDICTED: suppressor ( 212) 166 41.3 0.0036
XP_011537238 (OMIM: 605117) PREDICTED: suppressor ( 204) 165 41.1 0.004
XP_011537231 (OMIM: 605117) PREDICTED: suppressor ( 220) 165 41.1 0.0042
>>NP_054730 (OMIM: 607094) suppressor of cytokine signal (536 aa)
initn: 3679 init1: 3679 opt: 3679 Z-score: 3689.7 bits: 692.4 E(85289): 8.8e-199
Smith-Waterman score: 3679; 100.0% identity (100.0% similar) in 536 aa overlap (1-536:1-536)
10 20 30 40 50 60
pF1KA0 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
430 440 450 460 470 480
490 500 510 520 530
pF1KA0 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
490 500 510 520 530
>>NP_659198 (OMIM: 607094) suppressor of cytokine signal (536 aa)
initn: 3679 init1: 3679 opt: 3679 Z-score: 3689.7 bits: 692.4 E(85289): 8.8e-199
Smith-Waterman score: 3679; 100.0% identity (100.0% similar) in 536 aa overlap (1-536:1-536)
10 20 30 40 50 60
pF1KA0 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 ENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 GGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 SPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 PKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 TQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 RYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTF
430 440 450 460 470 480
490 500 510 520 530
pF1KA0 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 PFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
490 500 510 520 530
>>XP_011534727 (OMIM: 616337) PREDICTED: suppressor of c (440 aa)
initn: 1399 init1: 1035 opt: 1160 Z-score: 1168.7 bits: 225.7 E(85289): 2.3e-58
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (93-525:7-430)
70 80 90 100 110 120
pF1KA0 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
.: :. : : : : .: . . :.:
XP_011 MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
10 20 30
130 140 150 160 170
pF1KA0 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
:: : : :..: ::. : .:. .:. .::... ::.. :.: : . : .: :::.
XP_011 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
:.:::.:: :::... :.. . . .:::::.:::::.::::: :::: .::.::.:::
XP_011 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
:.. .: . . : : .:: .. .:..: ..::... ..... :.. : : .
XP_011 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
160 170 180 190 200
300 310 320 330 340 350
pF1KA0 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
:: . :. .:..: : ... ::... ::: .::.... . . :.. .. . :
XP_011 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA0 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
XP_011 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA0 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
::::.:::::::::::::::::::::::::: .:::::::::::.::::::::. : :
XP_011 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA0 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
:::::::.:::.::: ::::::::.::.:: .. .:::::::.::::
XP_011 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
390 400 410 420 430 440
>>XP_011534728 (OMIM: 616337) PREDICTED: suppressor of c (440 aa)
initn: 1399 init1: 1035 opt: 1160 Z-score: 1168.7 bits: 225.7 E(85289): 2.3e-58
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (93-525:7-430)
70 80 90 100 110 120
pF1KA0 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
.: :. : : : : .: . . :.:
XP_011 MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
10 20 30
130 140 150 160 170
pF1KA0 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
:: : : :..: ::. : .:. .:. .::... ::.. :.: : . : .: :::.
XP_011 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
:.:::.:: :::... :.. . . .:::::.:::::.::::: :::: .::.::.:::
XP_011 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
:.. .: . . : : .:: .. .:..: ..::... ..... :.. : : .
XP_011 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
160 170 180 190 200
300 310 320 330 340 350
pF1KA0 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
:: . :. .:..: : ... ::... ::: .::.... . . :.. .. . :
XP_011 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA0 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
XP_011 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA0 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
::::.:::::::::::::::::::::::::: .:::::::::::.::::::::. : :
XP_011 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA0 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
:::::::.:::.::: ::::::::.::.:: .. .:::::::.::::
XP_011 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
390 400 410 420 430 440
>>NP_543143 (OMIM: 616337) suppressor of cytokine signal (440 aa)
initn: 1399 init1: 1035 opt: 1160 Z-score: 1168.7 bits: 225.7 E(85289): 2.3e-58
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (93-525:7-430)
70 80 90 100 110 120
pF1KA0 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
.: :. : : : : .: . . :.:
NP_543 MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
10 20 30
130 140 150 160 170
pF1KA0 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
:: : : :..: ::. : .:. .:. .::... ::.. :.: : . : .: :::.
NP_543 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
:.:::.:: :::... :.. . . .:::::.:::::.::::: :::: .::.::.:::
NP_543 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
:.. .: . . : : .:: .. .:..: ..::... ..... :.. : : .
NP_543 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
160 170 180 190 200
300 310 320 330 340 350
pF1KA0 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
:: . :. .:..: : ... ::... ::: .::.... . . :.. .. . :
NP_543 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA0 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
NP_543 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA0 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
::::.:::::::::::::::::::::::::: .:::::::::::.::::::::. : :
NP_543 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA0 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
:::::::.:::.::: ::::::::.::.:: .. .:::::::.::::
NP_543 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
390 400 410 420 430 440
>>NP_955453 (OMIM: 616337) suppressor of cytokine signal (440 aa)
initn: 1399 init1: 1035 opt: 1160 Z-score: 1168.7 bits: 225.7 E(85289): 2.3e-58
Smith-Waterman score: 1496; 54.2% identity (77.3% similar) in 437 aa overlap (93-525:7-430)
70 80 90 100 110 120
pF1KA0 IALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGG
.: :. : : : : .: . . :.:
NP_955 MAENNENISKNVD--VRPKTSRSRSADRKDGYVWSG
10 20 30
130 140 150 160 170
pF1KA0 KKKHSCSTKTQSSLDADKKFG--RTRSGLQRRERRYGVSSVH-DMD-SVSSRTVGSRSLR
:: : : :..: ::. : .:. .:. .::... ::.. :.: : . : .: :::.
NP_955 KKL-SWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLG-RSLK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 QRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA
:.:::.:: :::... :.. . . .:::::.:::::.::::: :::: .::.::.:::
NP_955 QKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTA
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 PVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYK
:.. .: . . : : .:: .. .:..: ..::... ..... :.. : : .
NP_955 PINSKSDEWVSTD--LSQTELRDGQLKRR---NMEENINCFSHTNVQPCVITTD-NALCR
160 170 180 190 200
300 310 320 330 340 350
pF1KA0 LGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWK
:: . :. .:..: : ... ::... ::: .::.... . . :.. .. . :
NP_955 EGPMTGSVMNLVSNNS--IEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEI-LQLETPPK
210 220 230 240 250 260
360 370 380 390 400 410
pF1KA0 VHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVS
::::::.::::::::::..:::::::::.: ::::::::::::::::::::::::::::
NP_955 YHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVS
270 280 290 300 310 320
420 430 440 450 460 470
pF1KA0 FRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNR
::::.:::::::::::::::::::::::::: .:::::::::::.::::::::. : :
NP_955 FRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIR
330 340 350 360 370 380
480 490 500 510 520 530
pF1KA0 TFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
:::::::.:::.::: ::::::::.::.:: .. .:::::::.::::
NP_955 TFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
390 400 410 420 430 440
>>NP_004223 (OMIM: 605118) suppressor of cytokine signal (535 aa)
initn: 330 init1: 211 opt: 244 Z-score: 250.3 bits: 56.0 E(85289): 3.4e-07
Smith-Waterman score: 355; 25.0% identity (51.1% similar) in 501 aa overlap (96-519:49-535)
70 80 90 100 110 120
pF1KA0 QLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKK
:: :: : . :. : :
NP_004 KEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLK
20 30 40 50 60 70
130 140 150 160 170 180
pF1KA0 HSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDM--DSVSSRTVGSRSLRQRLQD
. :.: .:. : : : :: . : .. ::. . : ..: . : :::.. .
NP_004 RRLSAKQKSK----GKAG-TPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYS
80 90 100 110 120 130
190 200 210 220 230
pF1KA0 TVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA-----
. .:.: ... . : ..... :. . : :: . . . .: ....:.
NP_004 PAP--WPLRPTNSEETCI---KMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQA
140 150 160 170 180
240 250 260 270 280 290
pF1KA0 ----PVSPHS----TFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEAT
. :. .: : ... . : .. . ..::. : ... . ....
NP_004 NSLKSSASHNGDLHLHLDEHVPVVIGLMPQ-DYIQ--YTVPLDEGMYPLEGSRSYCLDSS
190 200 210 220 230 240
300 310 320 330
pF1KA0 A--QVNPLY-KLGPKLAP-GMTEISGDSSAIPQANCDSEED-----TTTLCLQSRR----
. .:. . ..: . : .... : . :. :. . :: . ::: :
NP_004 SPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHD
250 260 270 280 290 300
340 350 360
pF1KA0 ---------------QKQRQISGDSHT--HV-------------SRQGAWKVHTQID---
: ::..:: . : :: : :. .:. ...
NP_004 DVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 --YIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY
. :. .: ... . ::: . :.:::. : . :.:.::.:::... ::.:.::: .
NP_004 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFP
...::.:::. : ::: ..: : .... :.:: .: . : . . :.:
NP_004 GKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYP
430 440 450 460 470 480
490 500 510 520
pF1KA0 F-------------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWL
::::.:: :: . : : :. ::::. ..:.:.: ::
NP_004 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
530
pF1KA0 EREPVKAK
>>XP_016881575 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 330 init1: 211 opt: 244 Z-score: 250.3 bits: 56.0 E(85289): 3.4e-07
Smith-Waterman score: 355; 25.0% identity (51.1% similar) in 501 aa overlap (96-519:49-535)
70 80 90 100 110 120
pF1KA0 QLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKK
:: :: : . :. : :
XP_016 KEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLK
20 30 40 50 60 70
130 140 150 160 170 180
pF1KA0 HSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDM--DSVSSRTVGSRSLRQRLQD
. :.: .:. : : : :: . : .. ::. . : ..: . : :::.. .
XP_016 RRLSAKQKSK----GKAG-TPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYS
80 90 100 110 120 130
190 200 210 220 230
pF1KA0 TVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA-----
. .:.: ... . : ..... :. . : :: . . . .: ....:.
XP_016 PAP--WPLRPTNSEETCI---KMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQA
140 150 160 170 180
240 250 260 270 280 290
pF1KA0 ----PVSPHS----TFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEAT
. :. .: : ... . : .. . ..::. : ... . ....
XP_016 NSLKSSASHNGDLHLHLDEHVPVVIGLMPQ-DYIQ--YTVPLDEGMYPLEGSRSYCLDSS
190 200 210 220 230 240
300 310 320 330
pF1KA0 A--QVNPLY-KLGPKLAP-GMTEISGDSSAIPQANCDSEED-----TTTLCLQSRR----
. .:. . ..: . : .... : . :. :. . :: . ::: :
XP_016 SPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHD
250 260 270 280 290 300
340 350 360
pF1KA0 ---------------QKQRQISGDSHT--HV-------------SRQGAWKVHTQID---
: ::..:: . : :: : :. .:. ...
XP_016 DVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 --YIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY
. :. .: ... . ::: . :.:::. : . :.:.::.:::... ::.:.::: .
XP_016 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFP
...::.:::. : ::: ..: : .... :.:: .: . : . . :.:
XP_016 GKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYP
430 440 450 460 470 480
490 500 510 520
pF1KA0 F-------------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWL
::::.:: :: . : : :. ::::. ..:.:.: ::
XP_016 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
530
pF1KA0 EREPVKAK
>>XP_016881576 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 330 init1: 211 opt: 244 Z-score: 250.3 bits: 56.0 E(85289): 3.4e-07
Smith-Waterman score: 355; 25.0% identity (51.1% similar) in 501 aa overlap (96-519:49-535)
70 80 90 100 110 120
pF1KA0 QLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKK
:: :: : . :. : :
XP_016 KEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLK
20 30 40 50 60 70
130 140 150 160 170 180
pF1KA0 HSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDM--DSVSSRTVGSRSLRQRLQD
. :.: .:. : : : :: . : .. ::. . : ..: . : :::.. .
XP_016 RRLSAKQKSK----GKAG-TPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYS
80 90 100 110 120 130
190 200 210 220 230
pF1KA0 TVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA-----
. .:.: ... . : ..... :. . : :: . . . .: ....:.
XP_016 PAP--WPLRPTNSEETCI---KMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQA
140 150 160 170 180
240 250 260 270 280 290
pF1KA0 ----PVSPHS----TFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEAT
. :. .: : ... . : .. . ..::. : ... . ....
XP_016 NSLKSSASHNGDLHLHLDEHVPVVIGLMPQ-DYIQ--YTVPLDEGMYPLEGSRSYCLDSS
190 200 210 220 230 240
300 310 320 330
pF1KA0 A--QVNPLY-KLGPKLAP-GMTEISGDSSAIPQANCDSEED-----TTTLCLQSRR----
. .:. . ..: . : .... : . :. :. . :: . ::: :
XP_016 SPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHD
250 260 270 280 290 300
340 350 360
pF1KA0 ---------------QKQRQISGDSHT--HV-------------SRQGAWKVHTQID---
: ::..:: . : :: : :. .:. ...
XP_016 DVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 --YIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY
. :. .: ... . ::: . :.:::. : . :.:.::.:::... ::.:.::: .
XP_016 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFP
...::.:::. : ::: ..: : .... :.:: .: . : . . :.:
XP_016 GKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYP
430 440 450 460 470 480
490 500 510 520
pF1KA0 F-------------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWL
::::.:: :: . : : :. ::::. ..:.:.: ::
XP_016 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
530
pF1KA0 EREPVKAK
>>XP_005266840 (OMIM: 605118) PREDICTED: suppressor of c (535 aa)
initn: 330 init1: 211 opt: 244 Z-score: 250.3 bits: 56.0 E(85289): 3.4e-07
Smith-Waterman score: 355; 25.0% identity (51.1% similar) in 501 aa overlap (96-519:49-535)
70 80 90 100 110 120
pF1KA0 QLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKK
:: :: : . :. : :
XP_005 KEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLK
20 30 40 50 60 70
130 140 150 160 170 180
pF1KA0 HSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDM--DSVSSRTVGSRSLRQRLQD
. :.: .:. : : : :: . : .. ::. . : ..: . : :::.. .
XP_005 RRLSAKQKSK----GKAG-TPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYS
80 90 100 110 120 130
190 200 210 220 230
pF1KA0 TVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTA-----
. .:.: ... . : ..... :. . : :: . . . .: ....:.
XP_005 PAP--WPLRPTNSEETCI---KMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQA
140 150 160 170 180
240 250 260 270 280 290
pF1KA0 ----PVSPHS----TFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEAT
. :. .: : ... . : .. . ..::. : ... . ....
XP_005 NSLKSSASHNGDLHLHLDEHVPVVIGLMPQ-DYIQ--YTVPLDEGMYPLEGSRSYCLDSS
190 200 210 220 230 240
300 310 320 330
pF1KA0 A--QVNPLY-KLGPKLAP-GMTEISGDSSAIPQANCDSEED-----TTTLCLQSRR----
. .:. . ..: . : .... : . :. :. . :: . ::: :
XP_005 SPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHD
250 260 270 280 290 300
340 350 360
pF1KA0 ---------------QKQRQISGDSHT--HV-------------SRQGAWKVHTQID---
: ::..:: . : :: : :. .:. ...
XP_005 DVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 --YIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY
. :. .: ... . ::: . :.:::. : . :.:.::.:::... ::.:.::: .
XP_005 PMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEH-YKDPSSCMFFEPLLTISLNRTFP
...::.:::. : ::: ..: : .... :.:: .: . : . . :.:
XP_005 GKTLHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYP
430 440 450 460 470 480
490 500 510 520
pF1KA0 F-------------SLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWL
::::.:: :: . : : :. ::::. ..:.:.: ::
XP_005 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
490 500 510 520 530
530
pF1KA0 EREPVKAK
536 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:46:01 2016 done: Thu Nov 3 19:46:02 2016
Total Scan time: 7.070 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]