Result of FASTA (omim) for
pF1KA0623
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0623, 1036 aa
1>>>pF1KA0623 1036 - 1036 aa - 1036 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.9759+/-0.000544; mu= -7.4391+/- 0.034
mean_var=642.6040+/-140.069, 0's: 0 Z-trim(120.4): 1646 B-trim: 0 in 0/58
Lambda= 0.050594
statistics sampled from 33423 (35557) to 33423 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.417), width: 16
Scan time: 13.810
The best scores are: opt bits E(85289)
NP_001136082 (OMIM: 608650) serine/threonine-prote (1036) 6936 522.9 3.6e-147
NP_055498 (OMIM: 608650) serine/threonine-protein (1036) 6936 522.9 3.6e-147
XP_016880913 (OMIM: 608650) PREDICTED: serine/thre (1057) 6302 476.6 3.1e-133
XP_016880914 (OMIM: 608650) PREDICTED: serine/thre (1057) 6302 476.6 3.1e-133
XP_011522389 (OMIM: 608650) PREDICTED: serine/thre ( 918) 6176 467.3 1.7e-130
XP_016880916 (OMIM: 608650) PREDICTED: serine/thre ( 777) 5231 398.3 8.9e-110
XP_016880915 (OMIM: 608650) PREDICTED: serine/thre (1030) 4129 318.0 1.7e-85
XP_016880917 (OMIM: 608650) PREDICTED: serine/thre ( 750) 3058 239.6 4.9e-62
XP_011537101 (OMIM: 603168) PREDICTED: serine/thre (1044) 2511 199.9 6.2e-50
NP_003556 (OMIM: 603168) serine/threonine-protein (1050) 2333 186.9 5.1e-46
XP_011537100 (OMIM: 603168) PREDICTED: serine/thre (1073) 1751 144.4 3.2e-33
NP_001271293 (OMIM: 613472) serine/threonine-prote ( 470) 655 64.0 2.3e-09
NP_001092906 (OMIM: 613472) serine/threonine-prote ( 472) 655 64.0 2.3e-09
XP_016877557 (OMIM: 613472) PREDICTED: serine/thre ( 481) 620 61.4 1.4e-08
XP_005254346 (OMIM: 613472) PREDICTED: serine/thre ( 483) 620 61.4 1.4e-08
NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970) 603 60.6 5e-08
XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971) 600 60.4 5.8e-08
XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936) 578 58.7 1.7e-07
XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937) 575 58.5 2e-07
XP_016873649 (OMIM: 607670) PREDICTED: serine/thre ( 448) 560 57.0 2.7e-07
XP_016873648 (OMIM: 607670) PREDICTED: serine/thre ( 448) 560 57.0 2.7e-07
XP_016873646 (OMIM: 607670) PREDICTED: serine/thre ( 473) 543 55.8 6.7e-07
XP_011518599 (OMIM: 607670) PREDICTED: serine/thre ( 473) 543 55.8 6.7e-07
XP_016873654 (OMIM: 607670) PREDICTED: serine/thre ( 473) 543 55.8 6.7e-07
NP_001275987 (OMIM: 607670) serine/threonine-prote ( 473) 543 55.8 6.7e-07
XP_016873647 (OMIM: 607670) PREDICTED: serine/thre ( 473) 543 55.8 6.7e-07
XP_011518596 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873635 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_011518590 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873638 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_011518594 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873644 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873641 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_011518592 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873642 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873634 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873636 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873633 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
NP_001275990 (OMIM: 607670) serine/threonine-prote ( 514) 543 55.8 7e-07
XP_011518595 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873643 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873640 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_011518597 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873632 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873645 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873637 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
NP_112168 (OMIM: 607670) serine/threonine-protein ( 514) 543 55.8 7e-07
XP_016873639 (OMIM: 607670) PREDICTED: serine/thre ( 514) 543 55.8 7e-07
XP_016873653 (OMIM: 607670) PREDICTED: serine/thre ( 378) 539 55.4 7.2e-07
XP_016873652 (OMIM: 607670) PREDICTED: serine/thre ( 378) 539 55.4 7.2e-07
>>NP_001136082 (OMIM: 608650) serine/threonine-protein k (1036 aa)
initn: 6936 init1: 6936 opt: 6936 Z-score: 2763.1 bits: 522.9 E(85289): 3.6e-147
Smith-Waterman score: 6936; 99.8% identity (99.9% similar) in 1036 aa overlap (1-1036:1-1036)
10 20 30 40 50 60
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDKQRFIDEINSVT
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_001 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
970 980 990 1000 1010 1020
1030
pF1KA0 SIERRLSALCHSTATV
::::::::::::::::
NP_001 SIERRLSALCHSTATV
1030
>>NP_055498 (OMIM: 608650) serine/threonine-protein kina (1036 aa)
initn: 6936 init1: 6936 opt: 6936 Z-score: 2763.1 bits: 522.9 E(85289): 3.6e-147
Smith-Waterman score: 6936; 99.8% identity (99.9% similar) in 1036 aa overlap (1-1036:1-1036)
10 20 30 40 50 60
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 SSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
:::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDKQRFIDEINSVT
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_055 LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
970 980 990 1000 1010 1020
1030
pF1KA0 SIERRLSALCHSTATV
::::::::::::::::
NP_055 SIERRLSALCHSTATV
1030
>>XP_016880913 (OMIM: 608650) PREDICTED: serine/threonin (1057 aa)
initn: 6302 init1: 6302 opt: 6302 Z-score: 2512.9 bits: 476.6 E(85289): 3.1e-133
Smith-Waterman score: 6884; 97.8% identity (97.9% similar) in 1057 aa overlap (1-1036:1-1057)
10 20 30 40 50 60
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
10 20 30 40 50 60
70 80 90
pF1KA0 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQ---------------------A
:::::::::::::::::::::::::::::::::::::: :
XP_016 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQGNCVCVSVFSKDSAAACLILRA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA0 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA0 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA0 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA0 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA0 STSSKNSSCDTDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETA
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 STSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA0 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA0 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA0 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 IAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA0 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA0 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA0 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLT
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA0 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
970 980 990 1000 1010 1020
1000 1010 1020 1030
pF1KA0 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
:::::::::::::::::::::::::::::::::::::
XP_016 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
1030 1040 1050
>>XP_016880914 (OMIM: 608650) PREDICTED: serine/threonin (1057 aa)
initn: 6302 init1: 6302 opt: 6302 Z-score: 2512.9 bits: 476.6 E(85289): 3.1e-133
Smith-Waterman score: 6884; 97.8% identity (97.9% similar) in 1057 aa overlap (1-1036:1-1057)
10 20 30 40 50 60
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
10 20 30 40 50 60
70 80 90
pF1KA0 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQ---------------------A
:::::::::::::::::::::::::::::::::::::: :
XP_016 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQGNCVCVSVFSKDSAAACLILRA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA0 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA0 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA0 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA0 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA0 STSSKNSSCDTDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETA
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 STSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA0 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA0 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA0 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 IAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA0 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA0 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
850 860 870 880 890 900
880 890 900 910 920 930
pF1KA0 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLT
910 920 930 940 950 960
940 950 960 970 980 990
pF1KA0 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
970 980 990 1000 1010 1020
1000 1010 1020 1030
pF1KA0 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
:::::::::::::::::::::::::::::::::::::
XP_016 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
1030 1040 1050
>>XP_011522389 (OMIM: 608650) PREDICTED: serine/threonin (918 aa)
initn: 6176 init1: 6176 opt: 6176 Z-score: 2463.9 bits: 467.3 E(85289): 1.7e-130
Smith-Waterman score: 6176; 99.8% identity (99.9% similar) in 918 aa overlap (119-1036:1-918)
90 100 110 120 130 140
pF1KA0 NGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSS
::::::::::::::::::::::::::::::
XP_011 MRILHSKGIIHRDLKPQNILLSYANRRKSS
10 20 30
150 160 170 180 190 200
pF1KA0 VSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCL
40 50 60 70 80 90
210 220 230 240 250 260
pF1KA0 VGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSH
100 110 120 130 140 150
270 280 290 300 310 320
pF1KA0 PFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KA0 PNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQC
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_011 PNYLQVSKDSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQC
220 230 240 250 260 270
390 400 410 420 430 440
pF1KA0 QPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLR
280 290 300 310 320 330
450 460 470 480 490 500
pF1KA0 PGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSG
340 350 360 370 380 390
510 520 530 540 550 560
pF1KA0 SPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRP
400 410 420 430 440 450
570 580 590 600 610 620
pF1KA0 GSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGP
460 470 480 490 500 510
630 640 650 660 670 680
pF1KA0 AEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGS
520 530 540 550 560 570
690 700 710 720 730 740
pF1KA0 TDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRT
580 590 600 610 620 630
750 760 770 780 790 800
pF1KA0 TSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITF
640 650 660 670 680 690
810 820 830 840 850 860
pF1KA0 EAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVV
700 710 720 730 740 750
870 880 890 900 910 920
pF1KA0 VDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERY
760 770 780 790 800 810
930 940 950 960 970 980
pF1KA0 KFCITMRKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDI
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDI
820 830 840 850 860 870
990 1000 1010 1020 1030
pF1KA0 VYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
880 890 900 910
>>XP_016880916 (OMIM: 608650) PREDICTED: serine/threonin (777 aa)
initn: 5231 init1: 5231 opt: 5231 Z-score: 2091.9 bits: 398.3 E(85289): 8.9e-110
Smith-Waterman score: 5231; 99.7% identity (99.9% similar) in 777 aa overlap (260-1036:1-777)
230 240 250 260 270 280
pF1KA0 RSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSG
::::::::::::::::::::::::::::::
XP_016 MDFEAFFSHPFLEQGPVKKSCPVPVPMYSG
10 20 30
290 300 310 320 330 340
pF1KA0 SVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCD
40 50 60 70 80 90
350 360 370 380 390 400
pF1KA0 TDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRN
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_016 TDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRN
100 110 120 130 140 150
410 420 430 440 450 460
pF1KA0 YQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLST
160 170 180 190 200 210
470 480 490 500 510 520
pF1KA0 GSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSA
220 230 240 250 260 270
530 540 550 560 570 580
pF1KA0 PTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWF
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQ
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGV
400 410 420 430 440 450
710 720 730 740 750 760
pF1KA0 LAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCV
460 470 480 490 500 510
770 780 790 800 810 820
pF1KA0 GSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRH
520 530 540 550 560 570
830 840 850 860 870 880
pF1KA0 LNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYM
580 590 600 610 620 630
890 900 910 920 930 940
pF1KA0 KAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDK
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_016 KAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDK
640 650 660 670 680 690
950 960 970 980 990 1000
pF1KA0 QRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDP
700 710 720 730 740 750
1010 1020 1030
pF1KA0 ADIENVHKYKCSIERRLSALCHSTATV
:::::::::::::::::::::::::::
XP_016 ADIENVHKYKCSIERRLSALCHSTATV
760 770
>>XP_016880915 (OMIM: 608650) PREDICTED: serine/threonin (1030 aa)
initn: 4144 init1: 4113 opt: 4129 Z-score: 1655.8 bits: 318.0 E(85289): 1.7e-85
Smith-Waterman score: 6646; 95.3% identity (95.4% similar) in 1057 aa overlap (1-1036:1-1030)
10 20 30 40 50 60
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
10 20 30 40 50 60
70 80 90
pF1KA0 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQ---------------------A
:::::::::::::::::::::::::::::::::::::: :
XP_016 KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQGNCVCVSVFSKDSAAACLILRA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA0 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADF
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA0 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA0 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA0 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA0 STSSKNSSCDTDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETA
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_016 STSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA0 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADT
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA0 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA0 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEP
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 IAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
: ::::::::::::::::::::::::::::::::
XP_016 I---------------------------GSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGS
730 740 750
760 770 780 790 800 810
pF1KA0 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLM
760 770 780 790 800 810
820 830 840 850 860 870
pF1KA0 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDW
820 830 840 850 860 870
880 890 900 910 920 930
pF1KA0 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 GRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLT
880 890 900 910 920 930
940 950 960 970 980 990
pF1KA0 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLL
940 950 960 970 980 990
1000 1010 1020 1030
pF1KA0 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
:::::::::::::::::::::::::::::::::::::
XP_016 EGLSRILQDPADIENVHKYKCSIERRLSALCHSTATV
1000 1010 1020 1030
>>XP_016880917 (OMIM: 608650) PREDICTED: serine/threonin (750 aa)
initn: 3073 init1: 3042 opt: 3058 Z-score: 1234.8 bits: 239.6 E(85289): 4.9e-62
Smith-Waterman score: 4993; 96.3% identity (96.4% similar) in 777 aa overlap (260-1036:1-750)
230 240 250 260 270 280
pF1KA0 RSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSG
::::::::::::::::::::::::::::::
XP_016 MDFEAFFSHPFLEQGPVKKSCPVPVPMYSG
10 20 30
290 300 310 320 330 340
pF1KA0 SVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCD
40 50 60 70 80 90
350 360 370 380 390 400
pF1KA0 TDDFVLVPHNISSDHSCDMPMGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRN
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_016 TDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRN
100 110 120 130 140 150
410 420 430 440 450 460
pF1KA0 YQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLST
160 170 180 190 200 210
470 480 490 500 510 520
pF1KA0 GSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSA
220 230 240 250 260 270
530 540 550 560 570 580
pF1KA0 PTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWF
280 290 300 310 320 330
590 600 610 620 630 640
pF1KA0 FKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQ
340 350 360 370 380 390
650 660 670 680 690 700
pF1KA0 GSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDI---------
400 410 420 430 440
710 720 730 740 750 760
pF1KA0 LAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCV
::::::::::::::::::::::::::::::::::::::::::
XP_016 ------------------GSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCV
450 460 470 480
770 780 790 800 810 820
pF1KA0 GSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSPPGPGFGSSPPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRH
490 500 510 520 530 540
830 840 850 860 870 880
pF1KA0 LNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYM
550 560 570 580 590 600
890 900 910 920 930 940
pF1KA0 KAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDK
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_016 KAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDK
610 620 630 640 650 660
950 960 970 980 990 1000
pF1KA0 QRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDP
670 680 690 700 710 720
1010 1020 1030
pF1KA0 ADIENVHKYKCSIERRLSALCHSTATV
:::::::::::::::::::::::::::
XP_016 ADIENVHKYKCSIERRLSALCHSTATV
730 740 750
>>XP_011537101 (OMIM: 603168) PREDICTED: serine/threonin (1044 aa)
initn: 2861 init1: 1478 opt: 2511 Z-score: 1017.5 bits: 199.9 E(85289): 6.2e-50
Smith-Waterman score: 3205; 52.3% identity (73.6% similar) in 1072 aa overlap (2-1029:9-1038)
10 20 30 40 50
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILL
:.:: ::.:..::.:::::::::.::::.: : :::.: ::::::.::: ::
XP_011 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 GKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH
::::::::::.::::::::: ::. :::.:::::::::::::::.: ::::::::.::.
XP_011 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAT
:::.:::.::::::::::::::::::: :... ..::.:::::::::::.:::::::
XP_011 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA0 LCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLM
:::::::::::::::::::.:::::::::..::::.:: ::::.::::::.:::::..:.
XP_011 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA0 PSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP-VKKSCPVPVPMYSGSVS
:.:::::: : .:::.:::::.::::::. :: ::::. .: :.:: ::::: : .: :
XP_011 PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA0 GSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDD
::: .:: . ..:::::: .::..:. .:.:: ..:. :.::.. ::.:::::::
XP_011 GSSSSSSSTSHLASPPSLGEMQQLQK-TLASPA-DTAGFLHSSRDSGG--SKDSSCDTDD
310 320 330 340 350
360 370 380 390
pF1KA0 FVLVPHNISSDHSCDMP----------------MGTAGRRASNEFLVCGGQCQPTVSPHS
::.:: .. .: . : ...:: .. .. . :. . :: .
XP_011 FVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSG
360 370 380 390 400 410
400 410 420 430 440
pF1KA0 E-----------TAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMG
. ..:::::::..::::::.:: : .. : :::. .:::.:
XP_011 RAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQT-----PRSG-----STSPLG
420 430 440 450 460
450 460 470 480 490 500
pF1KA0 FLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRN
: : . :. :. . ...:..: :..:::.::: ::::::. . ::: . :.
XP_011 FARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGR
470 480 490 500 510 520
510 520 530 540 550 560
pF1KA0 SS--GSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSP
: :: .:. .::.. : ::.:::.:.:.. . :: : .::. :: .: :
XP_011 SPRPGSSAPE-HSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPL-----GAVFS-PP
530 540 550 560 570
570 580 590 600 610 620
pF1KA0 QPSRPG-SLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLAL
: : : : : . ..: .::. :.. ..::: :.:::::.. : .::: .:.:::::
XP_011 QASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLAL
580 590 600 610 620 630
630 640 650 660 670
pF1KA0 VTRHGPAEEQSKDGNEPRECAHCLLVQGSERQ---RAEQQSKAVFGRSVSTGKLSDQQGK
..:.: . .. . : . .. .:. : .. :. :::: ::..:.: :
XP_011 LARQGVVMTPPRNRTLP-DLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLK
640 650 660 670 680 690
680 690 700 710 720 730
pF1KA0 TPICRHQ---GSTDSLNTERPMDIAPAGACGGVLAPPA--GTAASSKAVLFTVGSPPHSA
. . . :::.::. :.::.:::... :: : : : : ..: . :.::::::: ..
XP_011 AAFGTQAPDPGSTESLQ-EKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGS
700 710 720 730 740 750
740 750 760 770 780 790
pF1KA0 AAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVP
. : ::: :.::..:..: :.: : ::: : : :: :
XP_011 TPPQGP----RTRMFSAGPTGSASS----SARHLV---PGPC--SEAP----APELPAPG
760 770 780 790 800
800 810 820 830 840
pF1KA0 YG---ASP--PSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGG
.: :.: .::: .:::::.::::::::.:::. :: : :.:.. ::...:..:.
XP_011 HGCSFADPITANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGS
810 820 830 840 850 860
850 860 870 880 890 900
pF1KA0 NPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSG
: ... ::.:::::.:::: ::..:: .::::::.:.:.::...:. : ::..:
XP_011 ASE--AAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAG
870 880 890 900 910
910 920 930 940 950 960
pF1KA0 KLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCA
:: :..:::::. ::: :: .. . :. .:.::: ::::..:.:.:.:::.::.. :
XP_011 KLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHA
920 930 940 950 960 970
970 980 990 1000 1010 1020
pF1KA0 VEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSAL
:.::::::::::::. : : ::::: ::::::...:.: :::::: : : ::::::::
XP_011 VQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSAL
980 990 1000 1010 1020 1030
1030
pF1KA0 CHSTATV
XP_011 LTGICA
1040
>>NP_003556 (OMIM: 603168) serine/threonine-protein kina (1050 aa)
initn: 2883 init1: 1478 opt: 2333 Z-score: 947.2 bits: 186.9 E(85289): 5.1e-46
Smith-Waterman score: 3237; 52.6% identity (74.0% similar) in 1073 aa overlap (2-1029:9-1044)
10 20 30 40 50
pF1KA0 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILL
:.:: ::.:..::.:::::::::.::::.: : :::.: ::::::.::: ::
NP_003 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 GKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH
::::::::::.::::::::: ::. :::.:::::::::::::::.: ::::::::.::.
NP_003 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAT
:::.:::.::::::::::::::::::: :... ..::.:::::::::::.:::::::
NP_003 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KA0 LCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLM
:::::::::::::::::::.:::::::::..::::.:: ::::.::::::.:::::..:.
NP_003 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KA0 PSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP-VKKSCPVPVPMYSGSVS
:.:::::: : .:::.:::::.::::::. :: ::::. .: :.:: ::::: : .: :
NP_003 PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KA0 GSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDD
::: .:: . ..:::::: .::..:. .:.:: ..:. :.::.. ::.:::::::
NP_003 GSSSSSSSTSHLASPPSLGEMQQLQK-TLASPA-DTAGFLHSSRDSGG--SKDSSCDTDD
310 320 330 340 350
360 370 380 390
pF1KA0 FVLVPHNISSDHSCDMP----------------MGTAGRRASNEFLVCGGQCQPTVSPHS
::.:: .. .: . : ...:: .. .. . :. . :: .
NP_003 FVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSG
360 370 380 390 400 410
400 410 420 430 440
pF1KA0 E-----------TAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRS-NTSPM
. ..:::::::..::::::.:: : .. : :::...::: .:::.
NP_003 RAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQT-----PRSSAIRRSGSTSPL
420 430 440 450 460 470
450 460 470 480 490 500
pF1KA0 GFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSR
:: : . :. :. . ...:..: :..:::.::: ::::::. . ::: . :.
NP_003 GFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGG
480 490 500 510 520 530
510 520 530 540 550 560
pF1KA0 NSS--GSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYS
: :: .:. .::.. : ::.:::.:.:.. . :: : .::. :: .:
NP_003 RSPRPGSSAPE-HSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPL-----GAVFS-P
540 550 560 570 580
570 580 590 600 610 620
pF1KA0 PQPSRPG-SLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLA
:: : : : : . ..: .::. :.. ..::: :.:::::.. : .::: .:.::::
NP_003 PQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLA
590 600 610 620 630 640
630 640 650 660 670
pF1KA0 LVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQ---RAEQQSKAVFGRSVSTGKLSDQQG
:..:.: . .. . : . .. .:. : .. :. :::: ::..:.:
NP_003 LLARQGVVMTPPRNRTLP-DLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLL
650 660 670 680 690 700
680 690 700 710 720 730
pF1KA0 KTPICRHQ---GSTDSLNTERPMDIAPAGACGGVLAPPA--GTAASSKAVLFTVGSPPHS
:. . . :::.::. :.::.:::... :: : : : : ..: . :.::::::: .
NP_003 KAAFGTQAPDPGSTESLQ-EKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSG
710 720 730 740 750 760
740 750 760 770 780 790
pF1KA0 AAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYV
.. : ::: :.::..:..: :.: : ::: : : :: :
NP_003 STPPQGP----RTRMFSAGPTGSASS----SARHLV---PGPC--SEAP----APELPAP
770 780 790 800
800 810 820 830 840
pF1KA0 PYG---ASP--PSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRG
.: :.: .::: .:::::.::::::::.:::. :: : :.:.. ::...:..:
NP_003 GHGCSFADPIAANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKG
810 820 830 840 850 860
850 860 870 880 890 900
pF1KA0 GNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKS
. : ... ::.:::::.:::: ::..:: .::::::.:.:.::...:. : ::..
NP_003 SASE--AAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRA
870 880 890 900 910 920
910 920 930 940 950 960
pF1KA0 GKLSPSTAVKQVVKNLNERYKFCITMRKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNC
::: :..:::::. ::: :: .. . :. .:.::: ::::..:.:.:.:::.::..
NP_003 GKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSH
930 940 950 960 970 980
970 980 990 1000 1010 1020
pF1KA0 AVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSA
::.::::::::::::. : : ::::: ::::::...:.: :::::: : : :::::::
NP_003 AVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSA
990 1000 1010 1020 1030 1040
1030
pF1KA0 LCHSTATV
:
NP_003 LLTGICA
1050
1036 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:59:03 2016 done: Thu Nov 3 09:59:05 2016
Total Scan time: 13.810 Total Display time: 0.300
Function used was FASTA [36.3.4 Apr, 2011]