Result of FASTA (omim) for
pF1KA0605
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0605, 951 aa
1>>>pF1KA0605 951 - 951 aa - 951 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1168+/-0.000406; mu= 18.4470+/- 0.025
mean_var=126.0455+/-24.787, 0's: 0 Z-trim(115.8): 212 B-trim: 0 in 0/53
Lambda= 0.114238
statistics sampled from 26348 (26584) to 26348 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.312), width: 16
Scan time: 10.090
The best scores are: opt bits E(85289)
NP_055509 (OMIM: 231050,612277) ADAMTS-like protei ( 951) 6876 1145.6 0
NP_001138792 (OMIM: 231050,612277) ADAMTS-like pro ( 951) 6876 1145.6 0
XP_005272296 (OMIM: 231050,612277) PREDICTED: ADAM ( 951) 6876 1145.6 0
XP_005272294 (OMIM: 231050,612277) PREDICTED: ADAM (1060) 6876 1145.6 0
XP_011517544 (OMIM: 231050,612277) PREDICTED: ADAM ( 973) 6327 1055.1 0
XP_005272295 (OMIM: 231050,612277) PREDICTED: ADAM ( 961) 5539 925.2 0
XP_011517543 (OMIM: 231050,612277) PREDICTED: ADAM (1021) 5524 922.8 0
XP_016875468 (OMIM: 611681) PREDICTED: A disintegr (1506) 828 149.0 1.7e-34
NP_079279 (OMIM: 611681) A disintegrin and metallo (1910) 828 149.1 2e-34
XP_011537056 (OMIM: 611681) PREDICTED: A disintegr (1911) 828 149.1 2e-34
XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 695 126.8 4.4e-28
XP_011541426 (OMIM: 605008) PREDICTED: A disintegr ( 673) 687 125.4 9.6e-28
XP_011541425 (OMIM: 605008) PREDICTED: A disintegr ( 738) 687 125.5 1e-27
XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 688 125.7 1e-27
XP_011541423 (OMIM: 605008) PREDICTED: A disintegr ( 863) 687 125.5 1.1e-27
XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 687 125.5 1.1e-27
XP_011541419 (OMIM: 605008) PREDICTED: A disintegr ( 966) 687 125.6 1.2e-27
XP_011541415 (OMIM: 605008) PREDICTED: A disintegr (1117) 687 125.6 1.4e-27
XP_011541416 (OMIM: 605008) PREDICTED: A disintegr (1117) 687 125.6 1.4e-27
NP_922932 (OMIM: 605008) A disintegrin and metallo (1117) 687 125.6 1.4e-27
NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 685 125.4 1.8e-27
XP_016878477 (OMIM: 607512,615458) PREDICTED: A di ( 809) 660 121.1 2.4e-26
XP_016878478 (OMIM: 607512,615458) PREDICTED: A di ( 809) 660 121.1 2.4e-26
XP_011521226 (OMIM: 607512,615458) PREDICTED: A di ( 978) 660 121.1 2.7e-26
NP_001313287 (OMIM: 607512,615458) A disintegrin a (1049) 660 121.2 2.9e-26
XP_011521225 (OMIM: 607512,615458) PREDICTED: A di (1049) 660 121.2 2.9e-26
NP_955387 (OMIM: 607512,615458) A disintegrin and (1221) 660 121.2 3.2e-26
NP_079093 (OMIM: 614476) thrombospondin type-1 dom (1018) 626 115.5 1.4e-24
XP_006720755 (OMIM: 614476) PREDICTED: thrombospon (1018) 626 115.5 1.4e-24
XP_016872634 (OMIM: 605175) PREDICTED: A disintegr ( 873) 594 110.2 4.7e-23
NP_008968 (OMIM: 605175) A disintegrin and metallo ( 889) 594 110.2 4.8e-23
XP_011537611 (OMIM: 607506) PREDICTED: A disintegr ( 746) 587 109.0 9.4e-23
XP_011537604 (OMIM: 607506) PREDICTED: A disintegr ( 914) 587 109.1 1.1e-22
XP_011537603 (OMIM: 607506) PREDICTED: A disintegr ( 914) 587 109.1 1.1e-22
NP_542453 (OMIM: 607506) A disintegrin and metallo (1223) 587 109.2 1.3e-22
NP_631894 (OMIM: 607506) A disintegrin and metallo (1226) 587 109.2 1.3e-22
XP_011541427 (OMIM: 605008) PREDICTED: A disintegr ( 628) 582 108.1 1.5e-22
XP_011541417 (OMIM: 605008) PREDICTED: A disintegr (1067) 585 108.8 1.5e-22
XP_016882829 (OMIM: 277600,608990) PREDICTED: A di ( 624) 580 107.8 1.8e-22
XP_016882828 (OMIM: 277600,608990) PREDICTED: A di ( 626) 580 107.8 1.9e-22
XP_011541418 (OMIM: 605008) PREDICTED: A disintegr (1021) 582 108.3 2.1e-22
XP_006722980 (OMIM: 277600,608990) PREDICTED: A di ( 784) 580 107.9 2.2e-22
XP_016882827 (OMIM: 277600,608990) PREDICTED: A di (1103) 580 108.0 2.8e-22
NP_112219 (OMIM: 277600,608990) A disintegrin and (1103) 580 108.0 2.8e-22
XP_011537605 (OMIM: 607506) PREDICTED: A disintegr ( 820) 578 107.5 2.8e-22
XP_011530724 (OMIM: 605011) PREDICTED: A disintegr (1177) 579 107.9 3.2e-22
XP_011530723 (OMIM: 605011) PREDICTED: A disintegr (1186) 579 107.9 3.2e-22
NP_055058 (OMIM: 605011) A disintegrin and metallo (1205) 579 107.9 3.3e-22
XP_011537602 (OMIM: 607506) PREDICTED: A disintegr (1056) 574 107.0 5.3e-22
XP_016865552 (OMIM: 225410,604539) PREDICTED: A di (1046) 572 106.7 6.6e-22
>>NP_055509 (OMIM: 231050,612277) ADAMTS-like protein 2 (951 aa)
initn: 6876 init1: 6876 opt: 6876 Z-score: 6129.8 bits: 1145.6 E(85289): 0
Smith-Waterman score: 6876; 99.8% identity (99.9% similar) in 951 aa overlap (1-951:1-951)
10 20 30 40 50 60
pF1KA0 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_055 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 MGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
850 860 870 880 890 900
910 920 930 940 950
pF1KA0 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
910 920 930 940 950
>>NP_001138792 (OMIM: 231050,612277) ADAMTS-like protein (951 aa)
initn: 6876 init1: 6876 opt: 6876 Z-score: 6129.8 bits: 1145.6 E(85289): 0
Smith-Waterman score: 6876; 99.8% identity (99.9% similar) in 951 aa overlap (1-951:1-951)
10 20 30 40 50 60
pF1KA0 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
NP_001 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 MGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
850 860 870 880 890 900
910 920 930 940 950
pF1KA0 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
910 920 930 940 950
>>XP_005272296 (OMIM: 231050,612277) PREDICTED: ADAMTS-l (951 aa)
initn: 6876 init1: 6876 opt: 6876 Z-score: 6129.8 bits: 1145.6 E(85289): 0
Smith-Waterman score: 6876; 99.8% identity (99.9% similar) in 951 aa overlap (1-951:1-951)
10 20 30 40 50 60
pF1KA0 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_005 MDGRWQCSCWAWFLLVLAVVAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGAR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 MGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGFVPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQME
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQ
850 860 870 880 890 900
910 920 930 940 950
pF1KA0 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
910 920 930 940 950
>>XP_005272294 (OMIM: 231050,612277) PREDICTED: ADAMTS-l (1060 aa)
initn: 6876 init1: 6876 opt: 6876 Z-score: 6129.2 bits: 1145.6 E(85289): 0
Smith-Waterman score: 6876; 99.8% identity (99.9% similar) in 951 aa overlap (1-951:110-1060)
10 20 30
pF1KA0 MDGRWQCSCWAWFLLVLAVVAGDTVSTGST
::::::::::::::::::::::::::::::
XP_005 GPRGLFPKRTLVIWKRIGAGLVVTVALLPRMDGRWQCSCWAWFLLVLAVVAGDTVSTGST
80 90 100 110 120 130
40 50 60 70 80 90
pF1KA0 DNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_005 DNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC
140 150 160 170 180 190
100 110 120 130 140 150
pF1KA0 TGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDL
200 210 220 230 240 250
160 170 180 190 200 210
pF1KA0 HCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDG
260 270 280 290 300 310
220 230 240 250 260 270
pF1KA0 SSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYK
320 330 340 350 360 370
280 290 300 310 320 330
pF1KA0 VDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL
380 390 400 410 420 430
340 350 360 370 380 390
pF1KA0 LQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQASSERLGLDNRLFGHPG
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_005 LQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGHPG
440 450 460 470 480 490
400 410 420 430 440 450
pF1KA0 LDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQ
500 510 520 530 540 550
460 470 480 490 500 510
pF1KA0 EFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLL
560 570 580 590 600 610
520 530 540 550 560 570
pF1KA0 NGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKL
620 630 640 650 660 670
580 590 600 610 620 630
pF1KA0 SSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSS
680 690 700 710 720 730
640 650 660 670 680 690
pF1KA0 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE
740 750 760 770 780 790
700 710 720 730 740 750
pF1KA0 MSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCS
800 810 820 830 840 850
760 770 780 790 800 810
pF1KA0 GSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTC
860 870 880 890 900 910
820 830 840 850 860 870
pF1KA0 GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCG
920 930 940 950 960 970
880 890 900 910 920 930
pF1KA0 VGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKV
980 990 1000 1010 1020 1030
940 950
pF1KA0 NLCGHWYYSKACCRSCRPPHS
:::::::::::::::::::::
XP_005 NLCGHWYYSKACCRSCRPPHS
1040 1050 1060
>>XP_011517544 (OMIM: 231050,612277) PREDICTED: ADAMTS-l (973 aa)
initn: 6321 init1: 6321 opt: 6327 Z-score: 5640.7 bits: 1055.1 E(85289): 0
Smith-Waterman score: 6327; 97.8% identity (98.4% similar) in 900 aa overlap (58-951:74-973)
30 40 50 60 70 80
pF1KA0 GSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCL------QQRRKS
: : ::. : . .. : : . ::::
XP_011 SARPFLWEDNLLTRSQDGWQMAMFLLGLVPAGSGSCSWGHSVNRVHALTPSLHLSARRKS
50 60 70 80 90 100
90 100 110 120 130 140
pF1KA0 VPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYV
110 120 130 140 150 160
150 160 170 180 190 200
pF1KA0 HISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLD
170 180 190 200 210 220
210 220 230 240 250 260
pF1KA0 KCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAG
230 240 250 260 270 280
270 280 290 300 310 320
pF1KA0 YYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKS
290 300 310 320 330 340
330 340 350 360 370 380
pF1KA0 PSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQASSERLGL
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_011 PSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGL
350 360 370 380 390 400
390 400 410 420 430 440
pF1KA0 DNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDE
410 420 430 440 450 460
450 460 470 480 490 500
pF1KA0 EVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEE
470 480 490 500 510 520
510 520 530 540 550 560
pF1KA0 NEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVS
530 540 550 560 570 580
570 580 590 600 610 620
pF1KA0 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE
590 600 610 620 630 640
630 640 650 660 670 680
pF1KA0 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR
650 660 670 680 690 700
690 700 710 720 730 740
pF1KA0 NPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQW
710 720 730 740 750 760
750 760 770 780 790 800
pF1KA0 TVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQ
770 780 790 800 810 820
810 820 830 840 850 860
pF1KA0 DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP
830 840 850 860 870 880
870 880 890 900 910 920
pF1KA0 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG
890 900 910 920 930 940
930 940 950
pF1KA0 TNCALAIKVNLCGHWYYSKACCRSCRPPHS
::::::::::::::::::::::::::::::
XP_011 TNCALAIKVNLCGHWYYSKACCRSCRPPHS
950 960 970
>>XP_005272295 (OMIM: 231050,612277) PREDICTED: ADAMTS-l (961 aa)
initn: 5512 init1: 5512 opt: 5539 Z-score: 4938.9 bits: 925.2 E(85289): 0
Smith-Waterman score: 5539; 88.6% identity (91.7% similar) in 902 aa overlap (58-951:74-961)
30 40 50 60 70 80
pF1KA0 GSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRRKSVPGPGN
: : ::. : . .. : . : ::.
XP_005 SARPFLWEDNLLTRSQDGWQMAMFLLGLVPAGSGSCSWGHSVNRVHGGSPSRAPGTGPAR
50 60 70 80 90 100
90 100 110 120 130 140
pF1KA0 RTCTGTSKRYQLCR-VQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSK
.:::. :: :.. : : : : . . .::: : . .:..
XP_005 ARPSGTSS--AECRSVRRT--GGASARSSASPSTPTCTTGGRTSG--SLC--TRMTMSTS
110 120 130 140 150
150 160 170 180 190
pF1KA0 PCD-LHCT----TVDGQRQLMVPARDGTSCKLTDLRGVCVSGKC--EPIGCDGVLFSTHT
: . . :: :..:. . :: . .:: : . : .:::::::::::::
XP_005 PANRVTCTVPPWTASGS-SWSPPATAHPASSLT-----CEGFACLENPIGCDGVLFSTHT
160 170 180 190 200
200 210 220 230 240 250
pF1KA0 LDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADE
210 220 230 240 250 260
260 270 280 290 300 310
pF1KA0 AGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNG
270 280 290 300 310 320
320 330 340 350 360 370
pF1KA0 KSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQASSERL
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
XP_005 KSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERL
330 340 350 360 370 380
380 390 400 410 420 430
pF1KA0 GLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKD
390 400 410 420 430 440
440 450 460 470 480 490
pF1KA0 DEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDY
450 460 470 480 490 500
500 510 520 530 540 550
pF1KA0 EENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQG
510 520 530 540 550 560
560 570 580 590 600 610
pF1KA0 VSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAG
570 580 590 600 610 620
620 630 640 650 660 670
pF1KA0 RECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT
630 640 650 660 670 680
680 690 700 710 720 730
pF1KA0 CRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDR
690 700 710 720 730 740
740 750 760 770 780 790
pF1KA0 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWL
750 760 770 780 790 800
800 810 820 830 840 850
pF1KA0 AQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYT
810 820 830 840 850 860
860 870 880 890 900 910
pF1KA0 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQ
870 880 890 900 910 920
920 930 940 950
pF1KA0 PGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
::::::::::::::::::::::::::::::::
XP_005 PGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
930 940 950 960
>>XP_011517543 (OMIM: 231050,612277) PREDICTED: ADAMTS-l (1021 aa)
initn: 5731 init1: 5512 opt: 5524 Z-score: 4925.2 bits: 922.8 E(85289): 0
Smith-Waterman score: 5704; 86.6% identity (89.7% similar) in 953 aa overlap (1-951:110-1021)
10 20 30
pF1KA0 MDGRWQCSCWAWFLLVLAVVAGDTVSTGST
::::::::::::::::::::::::::::::
XP_011 GPRGLFPKRTLVIWKRIGAGLVVTVALLPRMDGRWQCSCWAWFLLVLAVVAGDTVSTGST
80 90 100 110 120 130
40 50 60 70 80 90
pF1KA0 DNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC
. . : ::. . : :. .:. .:..: : : . :: . : . :.
XP_011 PSLRACIFLPGGSPSRA-------PGTGPARARPSGTSSAE--CRSVRRTG--GASARSS
140 150 160 170 180
100 110 120 130 140 150
pF1KA0 TGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDL
.. : . : ::. : :.. : . : : .
XP_011 ASPS-------TPTCTTGGRT-SGSLC-----------TRMTMSTSPANRV-----TCTV
190 200 210 220
160 170 180 190 200
pF1KA0 HCTTVDGQRQLMVPARDGTSCKLTDLRGVCVSGKC--EPIGCDGVLFSTHTLDKCGICQG
:..:. :: . .:: : . : .::::::::::::::::::::::
XP_011 PPWTASGSSW-SPPATAHPASSLT-----CEGFACLENPIGCDGVLFSTHTLDKCGICQG
230 240 250 260 270
210 220 230 240 250 260
pF1KA0 DGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGN
280 290 300 310 320 330
270 280 290 300 310 320
pF1KA0 YKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEY
340 350 360 370 380 390
330 340 350 360 370 380
pF1KA0 TLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQASSERLGLDNRLFGH
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_011 TLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGH
400 410 420 430 440 450
390 400 410 420 430 440
pF1KA0 PGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFA
460 470 480 490 500 510
450 460 470 480 490 500
pF1KA0 SQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPY
520 530 540 550 560 570
510 520 530 540 550 560
pF1KA0 LLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRW
580 590 600 610 620 630
570 580 590 600 610 620
pF1KA0 KLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWET
640 650 660 670 680 690
630 640 650 660 670 680
pF1KA0 SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ
700 710 720 730 740 750
690 700 710 720 730 740
pF1KA0 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP
760 770 780 790 800 810
750 760 770 780 790 800
pF1KA0 CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNT
820 830 840 850 860 870
810 820 830 840 850 860
pF1KA0 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKT
880 890 900 910 920 930
870 880 890 900 910 920
pF1KA0 CGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAI
940 950 960 970 980 990
930 940 950
pF1KA0 KVNLCGHWYYSKACCRSCRPPHS
:::::::::::::::::::::::
XP_011 KVNLCGHWYYSKACCRSCRPPHS
1000 1010 1020
>>XP_016875468 (OMIM: 611681) PREDICTED: A disintegrin a (1506 aa)
initn: 745 init1: 189 opt: 828 Z-score: 740.3 bits: 149.0 E(85289): 1.7e-34
Smith-Waterman score: 1148; 26.8% identity (52.0% similar) in 975 aa overlap (50-909:155-1072)
20 30 40 50 60 70
pF1KA0 VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRR
:: : ... ::.::::. : :.:
XP_016 ADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC----N
130 140 150 160 170 180
80 90 100 110 120 130
pF1KA0 KSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNS-HV-YNG--RTHQWKPL
. : :. :.: ... : .. :: ..:::.:: .::. :. .: . .: :
XP_016 RPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPR
190 200 210 220 230 240
140 150 160 170 180 190
pF1KA0 YPDDYVHISSKP-CDLHCTTVDGQRQLMVP--ARDGTSCKLTDLRGVCVSGKCEPIGCDG
: :..: : :.: .. . .. ..::: : :. . .::.:.: :::
XP_016 YSG----IGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDH
250 260 270 280 290
200 210 220 230 240 250
pF1KA0 VLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD
:: :. .::::.: ::.::: .:: . ...: ::..:..::::: ...: . . :..
XP_016 VLNSSAKIDKCGVCGGDNSSCKTITGVF--NSSHYGYNVVVKIPAGATNVDIRQYSYSGQ
300 310 320 330 340 350
260 270 280 290 300
pF1KA0 ----VLALADEAGYYFFNGNYKVD-SPKNFNIAGT--VVKYRRPMDVYETGIEYIVAQGP
:::.: : ..::::. .. : :..:. :: :..: .. .: : . .
XP_016 PDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNA----VERINSTNR
360 370 380 390 400
310 320 330 340 350
pF1KA0 TNQGLNVMVWN-QNGKSPSITFEYTLLQPPHESRPQPIY---YGFSESAES--QGLDGAG
.. : ..: : .:.. . ... : : : . . :: :. . :::. .
XP_016 QEKELILQVLCVGNLYNPDVHYSFNI---PLEERSDMFTWDPYGPWEGCTKMCQGLQRRN
410 420 430 440 450 460
360 370 380 390 400 410
pF1KA0 LMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPP
. . . :. .. ..: : . . . : :: . . . .. .. :
XP_016 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCEL------RWHVIGKSECSSQC----
470 480 490 500 510
420 430 440 450 460 470
pF1KA0 RGKGFRDRNVTGTPLTGDKDDE-EVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNE-T
:.:.: .. . . . .:: :. .... . ...: .. . . .: .
XP_016 -GQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQL---KPPTQELCHGNCVFTRWHYSEWS
520 530 540 550 560 570
480 490 500 510 520 530
pF1KA0 VNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVA-NSSSEAPFPNVST
: :. :: ::. .. . : : .. ::: ::. .. .: :. ..
XP_016 QCSRSCGGGERSR--ESYCMN-----NFGHRLADNECQELS--RVTRENCNEFSCPSWAA
580 590 600 610 620
540 550 560 570
pF1KA0 S----LLTSAGNRTHKART--------------RPKARKQGVSPADMYR---WKLSSHEP
: :.. :. :.. .. ... ...:: ... :... :
XP_016 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGP
630 640 650 660 670 680
580 590 600 610 620
pF1KA0 CSATCTTGVMSAYAMCVRYDGVEV-DDSYCDALTRPEPVHEFCAGRECQ----------P
:..:: : . . :: . : .:. : .:: .. :. :. :
XP_016 CTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFISKLETALLP
690 700 710 720 730 740
630 640 650 660 670
pF1KA0 --------RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE
.:. .::. :: .::.: : : : : :. : : : :. :: :
XP_016 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY----C--AHLPRPAE
750 760 770 780 790
680 690 700 710 720 730
pF1KA0 RKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE-----DEKLCDPNTRPVGEKN
: .: :: .:. ..:: :.:.::. .. ::.. : . ::. :::..::. :..
XP_016 IWDCFTP-CG-EWQAGDWSPCSASCGHGKT-TRQVLCMNYHQPIDENYCDPEVRPLMEQE
800 810 820 830 840 850
740 750
pF1KA0 CTGPPCD-----------------------------------------RQWTVSDWGPCS
:. : :: .. :: ::
XP_016 CSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCS
860 870 880 890 900 910
760 770 780 790 800 810
pF1KA0 GSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTC
.::. : : : :. .:. . : :. .:: .. :: :: .: .: .:. ::
XP_016 SSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTC
920 930 940 950 960 970
820 830 840 850 860
pF1KA0 GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTK
: :.:.:::.: .. :: : .: ...::: : . : .:. ::. :.
XP_016 GGGIKSRLVIC-QFPNG--QILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSA
980 990 1000 1010 1020
870 880 890 900 910 920
pF1KA0 TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNC
.:: : ..:.: : .: .:. . :: ..:: ::.
XP_016 SCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGS
1030 1040 1050 1060 1070 1080
930 940 950
pF1KA0 ALAIKVNLCGHWYYSKACCRSCRPPHS
XP_016 GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD
1090 1100 1110 1120 1130 1140
>--
initn: 249 init1: 149 opt: 342 Z-score: 307.4 bits: 68.9 E(85289): 2.2e-10
Smith-Waterman score: 342; 27.0% identity (53.6% similar) in 252 aa overlap (626-860:1073-1310)
600 610 620 630 640 650
pF1KA0 GVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSP
:...::.::: ::: : : : : : .. .
XP_016 QFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC-RLKGV
1050 1060 1070 1080 1090 1100
660 670 680 690 700 710
pF1KA0 GFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS-ECTAKCGERSVVTRDIRCS
: .: ..:. ...:: .. : . : . : . .:...: ::. . ..:.
XP_016 G---QVVEEMCD--QSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSC-ERKDSHQRMECT
1110 1120 1130 1140 1150
720 730 740 750 760
pF1KA0 ED------EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----
.. : . . .: . ::: .:::. ...: . :...:: . : .::
XP_016 DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIP
1160 1170 1180 1190 1200 1210
770 780 790 800 810
pF1KA0 ---KTSDGRVVPESQCQMETKPLA-IHPCGDKNCP--AHWLAQDWERCNTTCGRGVKKRL
: . :. : . . : . .. : . .: : : . : .:..::: :. ::
XP_016 STKKHKLHRLRPIVYQECPVVPSSQVYQCIN-SCLHLATWKVGKWSKCSVTCGIGIMKRQ
1220 1230 1240 1250 1260 1270
820 830 840 850 860 870
pF1KA0 VLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDV
: :. . :. : :: .. :. : : .:.
XP_016 VKCIT-----KHGLSSDLCLNHLKPGAQKKCYANDC-KSFTTCKEIQVKNHIRKDGDYYL
1280 1290 1300 1310 1320
880 890 900 910 920 930
pF1KA0 KCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYY
XP_016 NIKGRIIKIYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDN
1330 1340 1350 1360 1370 1380
>>NP_079279 (OMIM: 611681) A disintegrin and metalloprot (1910 aa)
initn: 745 init1: 189 opt: 828 Z-score: 739.0 bits: 149.1 E(85289): 2e-34
Smith-Waterman score: 1148; 26.8% identity (52.0% similar) in 975 aa overlap (50-909:559-1476)
20 30 40 50 60 70
pF1KA0 VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRR
:: : ... ::.::::. : :.:
NP_079 ADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC----N
530 540 550 560 570 580
80 90 100 110 120 130
pF1KA0 KSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNS-HV-YNG--RTHQWKPL
. : :. :.: ... : .. :: ..:::.:: .::. :. .: . .: :
NP_079 RPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPR
590 600 610 620 630 640
140 150 160 170 180 190
pF1KA0 YPDDYVHISSKP-CDLHCTTVDGQRQLMVP--ARDGTSCKLTDLRGVCVSGKCEPIGCDG
: :..: : :.: .. . .. ..::: : :. . .::.:.: :::
NP_079 YSG----IGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDH
650 660 670 680 690
200 210 220 230 240 250
pF1KA0 VLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD
:: :. .::::.: ::.::: .:: . ...: ::..:..::::: ...: . . :..
NP_079 VLNSSAKIDKCGVCGGDNSSCKTITGVF--NSSHYGYNVVVKIPAGATNVDIRQYSYSGQ
700 710 720 730 740 750
260 270 280 290 300
pF1KA0 ----VLALADEAGYYFFNGNYKVD-SPKNFNIAGT--VVKYRRPMDVYETGIEYIVAQGP
:::.: : ..::::. .. : :..:. :: :..: .. .: : . .
NP_079 PDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNA----VERINSTNR
760 770 780 790 800 810
310 320 330 340 350
pF1KA0 TNQGLNVMVWN-QNGKSPSITFEYTLLQPPHESRPQPIY---YGFSESAES--QGLDGAG
.. : ..: : .:.. . ... : : : . . :: :. . :::. .
NP_079 QEKELILQVLCVGNLYNPDVHYSFNI---PLEERSDMFTWDPYGPWEGCTKMCQGLQRRN
820 830 840 850 860 870
360 370 380 390 400 410
pF1KA0 LMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPP
. . . :. .. ..: : . . . : :: . . . .. .. :
NP_079 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCEL------RWHVIGKSECSSQC----
880 890 900 910 920
420 430 440 450 460 470
pF1KA0 RGKGFRDRNVTGTPLTGDKDDE-EVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNE-T
:.:.: .. . . . .:: :. .... . ...: .. . . .: .
NP_079 -GQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQL---KPPTQELCHGNCVFTRWHYSEWS
930 940 950 960 970
480 490 500 510 520 530
pF1KA0 VNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVA-NSSSEAPFPNVST
: :. :: ::. .. . : : .. ::: ::. .. .: :. ..
NP_079 QCSRSCGGGERSR--ESYCMN-----NFGHRLADNECQELS--RVTRENCNEFSCPSWAA
980 990 1000 1010 1020
540 550 560 570
pF1KA0 S----LLTSAGNRTHKART--------------RPKARKQGVSPADMYR---WKLSSHEP
: :.. :. :.. .. ... ...:: ... :... :
NP_079 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGP
1030 1040 1050 1060 1070 1080
580 590 600 610 620
pF1KA0 CSATCTTGVMSAYAMCVRYDGVEV-DDSYCDALTRPEPVHEFCAGRECQ----------P
:..:: : . . :: . : .:. : .:: .. :. :. :
NP_079 CTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFISKLETALLP
1090 1100 1110 1120 1130 1140
630 640 650 660 670
pF1KA0 --------RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE
.:. .::. :: .::.: : : : : :. : : : :. :: :
NP_079 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY----C--AHLPRPAE
1150 1160 1170 1180 1190 1200
680 690 700 710 720 730
pF1KA0 RKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE-----DEKLCDPNTRPVGEKN
: .: :: .:. ..:: :.:.::. .. ::.. : . ::. :::..::. :..
NP_079 IWDCFTP-CG-EWQAGDWSPCSASCGHGKT-TRQVLCMNYHQPIDENYCDPEVRPLMEQE
1210 1220 1230 1240 1250
740 750
pF1KA0 CTGPPCD-----------------------------------------RQWTVSDWGPCS
:. : :: .. :: ::
NP_079 CSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCS
1260 1270 1280 1290 1300 1310
760 770 780 790 800 810
pF1KA0 GSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTC
.::. : : : :. .:. . : :. .:: .. :: :: .: .: .:. ::
NP_079 SSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTC
1320 1330 1340 1350 1360 1370
820 830 840 850 860
pF1KA0 GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTK
: :.:.:::.: .. :: : .: ...::: : . : .:. ::. :.
NP_079 GGGIKSRLVIC-QFPNG--QILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSA
1380 1390 1400 1410 1420 1430
870 880 890 900 910 920
pF1KA0 TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNC
.:: : ..:.: : .: .:. . :: ..:: ::.
NP_079 SCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGS
1440 1450 1460 1470 1480 1490
930 940 950
pF1KA0 ALAIKVNLCGHWYYSKACCRSCRPPHS
NP_079 GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD
1500 1510 1520 1530 1540 1550
>--
initn: 249 init1: 149 opt: 342 Z-score: 306.1 bits: 69.0 E(85289): 2.6e-10
Smith-Waterman score: 342; 27.0% identity (53.6% similar) in 252 aa overlap (626-860:1477-1714)
600 610 620 630 640 650
pF1KA0 GVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSP
:...::.::: ::: : : : : : .. .
NP_079 QFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC-RLKGV
1450 1460 1470 1480 1490 1500
660 670 680 690 700 710
pF1KA0 GFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS-ECTAKCGERSVVTRDIRCS
: .: ..:. ...:: .. : . : . : . .:...: ::. . ..:.
NP_079 G---QVVEEMCD--QSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSC-ERKDSHQRMECT
1510 1520 1530 1540 1550
720 730 740 750 760
pF1KA0 ED------EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----
.. : . . .: . ::: .:::. ...: . :...:: . : .::
NP_079 DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIP
1560 1570 1580 1590 1600 1610
770 780 790 800 810
pF1KA0 ---KTSDGRVVPESQCQMETKPLA-IHPCGDKNCP--AHWLAQDWERCNTTCGRGVKKRL
: . :. : . . : . .. : . .: : : . : .:..::: :. ::
NP_079 STKKHKLHRLRPIVYQECPVVPSSQVYQCIN-SCLHLATWKVGKWSKCSVTCGIGIMKRQ
1620 1630 1640 1650 1660 1670
820 830 840 850 860 870
pF1KA0 VLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDV
: :. . :. : :: .. :. : : .:.
NP_079 VKCIT-----KHGLSSDLCLNHLKPGAQKKCYANDC-KSFTTCKEIQVKNHIRKDGDYYL
1680 1690 1700 1710 1720 1730
880 890 900 910 920 930
pF1KA0 KCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYY
NP_079 NIKGRIIKIYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDN
1740 1750 1760 1770 1780 1790
>>XP_011537056 (OMIM: 611681) PREDICTED: A disintegrin a (1911 aa)
initn: 727 init1: 189 opt: 828 Z-score: 739.0 bits: 149.1 E(85289): 2e-34
Smith-Waterman score: 1148; 26.8% identity (52.0% similar) in 975 aa overlap (50-909:560-1477)
20 30 40 50 60 70
pF1KA0 VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTAFSRSCGGGVTSQERHCLQQRR
:: : ... ::.::::. : :.:
XP_011 ADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC----N
530 540 550 560 570 580
80 90 100 110 120 130
pF1KA0 KSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNS-HV-YNG--RTHQWKPL
. : :. :.: ... : .. :: ..:::.:: .::. :. .: . .: :
XP_011 RPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPR
590 600 610 620 630 640
140 150 160 170 180 190
pF1KA0 YPDDYVHISSKP-CDLHCTTVDGQRQLMVP--ARDGTSCKLTDLRGVCVSGKCEPIGCDG
: :..: : :.: .. . .. ..::: : :. . .::.:.: :::
XP_011 YSG----IGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDH
650 660 670 680 690 700
200 210 220 230 240 250
pF1KA0 VLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSAD
:: :. .::::.: ::.::: .:: . ...: ::..:..::::: ...: . . :..
XP_011 VLNSSAKIDKCGVCGGDNSSCKTITGVF--NSSHYGYNVVVKIPAGATNVDIRQYSYSGQ
710 720 730 740 750
260 270 280 290 300
pF1KA0 ----VLALADEAGYYFFNGNYKVD-SPKNFNIAGT--VVKYRRPMDVYETGIEYIVAQGP
:::.: : ..::::. .. : :..:. :: :..: .. .: : . .
XP_011 PDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNA----VERINSTNR
760 770 780 790 800 810
310 320 330 340 350
pF1KA0 TNQGLNVMVWN-QNGKSPSITFEYTLLQPPHESRPQPIY---YGFSESAES--QGLDGAG
.. : ..: : .:.. . ... : : : . . :: :. . :::. .
XP_011 QEKELILQVLCVGNLYNPDVHYSFNI---PLEERSDMFTWDPYGPWEGCTKMCQGLQRRN
820 830 840 850 860 870
360 370 380 390 400 410
pF1KA0 LMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPP
. . . :. .. ..: : . . . : :: . . . .. .. :
XP_011 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCEL------RWHVIGKSECSSQC----
880 890 900 910 920
420 430 440 450 460 470
pF1KA0 RGKGFRDRNVTGTPLTGDKDDE-EVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNE-T
:.:.: .. . . . .:: :. .... . ...: .. . . .: .
XP_011 -GQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQL---KPPTQELCHGNCVFTRWHYSEWS
930 940 950 960 970
480 490 500 510 520 530
pF1KA0 VNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVA-NSSSEAPFPNVST
: :. :: ::. .. . : : .. ::: ::. .. .: :. ..
XP_011 QCSRSCGGGERSR--ESYCMN-----NFGHRLADNECQELS--RVTRENCNEFSCPSWAA
980 990 1000 1010 1020
540 550 560 570
pF1KA0 S----LLTSAGNRTHKART--------------RPKARKQGVSPADMYR---WKLSSHEP
: :.. :. :.. .. ... ...:: ... :... :
XP_011 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGP
1030 1040 1050 1060 1070 1080
580 590 600 610 620
pF1KA0 CSATCTTGVMSAYAMCVRYDGVEV-DDSYCDALTRPEPVHEFCAGRECQ----------P
:..:: : . . :: . : .:. : .:: .. :. :. :
XP_011 CTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFISKLETALLP
1090 1100 1110 1120 1130 1140
630 640 650 660 670
pF1KA0 --------RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE
.:. .::. :: .::.: : : : : :. : : : :. :: :
XP_011 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY----C--AHLPRPAE
1150 1160 1170 1180 1190 1200
680 690 700 710 720 730
pF1KA0 RKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE-----DEKLCDPNTRPVGEKN
: .: :: .:. ..:: :.:.::. .. ::.. : . ::. :::..::. :..
XP_011 IWDCFTP-CG-EWQAGDWSPCSASCGHGKT-TRQVLCMNYHQPIDENYCDPEVRPLMEQE
1210 1220 1230 1240 1250
740 750
pF1KA0 CTGPPCD-----------------------------------------RQWTVSDWGPCS
:. : :: .. :: ::
XP_011 CSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCS
1260 1270 1280 1290 1300 1310
760 770 780 790 800 810
pF1KA0 GSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTC
.::. : : : :. .:. . : :. .:: .. :: :: .: .: .:. ::
XP_011 SSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTC
1320 1330 1340 1350 1360 1370
820 830 840 850 860
pF1KA0 GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTK
: :.:.:::.: .. :: : .: ...::: : . : .:. ::. :.
XP_011 GGGIKSRLVIC-QFPNG--QILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSA
1380 1390 1400 1410 1420 1430
870 880 890 900 910 920
pF1KA0 TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNC
.:: : ..:.: : .: .:. . :: ..:: ::.
XP_011 SCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGS
1440 1450 1460 1470 1480 1490
930 940 950
pF1KA0 ALAIKVNLCGHWYYSKACCRSCRPPHS
XP_011 GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD
1500 1510 1520 1530 1540 1550
>--
initn: 249 init1: 149 opt: 342 Z-score: 306.1 bits: 69.0 E(85289): 2.6e-10
Smith-Waterman score: 342; 27.0% identity (53.6% similar) in 252 aa overlap (626-860:1478-1715)
600 610 620 630 640 650
pF1KA0 GVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSP
:...::.::: ::: : : : : : .. .
XP_011 QFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC-RLKGV
1450 1460 1470 1480 1490 1500
660 670 680 690 700 710
pF1KA0 GFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS-ECTAKCGERSVVTRDIRCS
: .: ..:. ...:: .. : . : . : . .:...: ::. . ..:.
XP_011 G---QVVEEMCD--QSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSC-ERKDSHQRMECT
1510 1520 1530 1540 1550 1560
720 730 740 750 760
pF1KA0 ED------EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----
.. : . . .: . ::: .:::. ...: . :...:: . : .::
XP_011 DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIP
1570 1580 1590 1600 1610 1620
770 780 790 800 810
pF1KA0 ---KTSDGRVVPESQCQMETKPLA-IHPCGDKNCP--AHWLAQDWERCNTTCGRGVKKRL
: . :. : . . : . .. : . .: : : . : .:..::: :. ::
XP_011 STKKHKLHRLRPIVYQECPVVPSSQVYQCIN-SCLHLATWKVGKWSKCSVTCGIGIMKRQ
1630 1640 1650 1660 1670
820 830 840 850 860 870
pF1KA0 VLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDV
: :. . :. : :: .. :. : : .:.
XP_011 VKCIT-----KHGLSSDLCLNHLKPGAQKKCYANDC-KSFTTCKEIQVKNHIRKDGDYYL
1680 1690 1700 1710 1720 1730
880 890 900 910 920 930
pF1KA0 KCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYY
XP_011 NIKGRIIKIYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDN
1740 1750 1760 1770 1780 1790
951 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 00:50:50 2016 done: Fri Nov 4 00:50:52 2016
Total Scan time: 10.090 Total Display time: 0.340
Function used was FASTA [36.3.4 Apr, 2011]