Result of FASTA (omim) for
pF1KA0596
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0596, 1514 aa
1>>>pF1KA0596 1514 - 1514 aa - 1514 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6879+/-0.000462; mu= -10.2426+/- 0.029
mean_var=444.8169+/-91.338, 0's: 0 Z-trim(121.1): 50 B-trim: 46 in 1/54
Lambda= 0.060811
statistics sampled from 37170 (37228) to 37170 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.436), width: 16
Scan time: 22.940
The best scores are: opt bits E(85289)
NP_001122080 (OMIM: 616786) mitogen-activated prot (1514) 10109 902.8 0
NP_055809 (OMIM: 616786) mitogen-activated protein (1508) 10049 897.5 0
XP_011519686 (OMIM: 616786) PREDICTED: mitogen-act (1412) 9469 846.6 0
NP_001252540 (OMIM: 616786) mitogen-activated prot (1231) 7493 673.2 3.5e-192
XP_011519685 (OMIM: 616786) PREDICTED: mitogen-act (1465) 7254 652.3 8.2e-186
XP_016877506 (OMIM: 616786) PREDICTED: mitogen-act (1465) 7254 652.3 8.2e-186
XP_006720501 (OMIM: 616786) PREDICTED: mitogen-act (1459) 7181 645.9 6.9e-184
XP_006720502 (OMIM: 616786) PREDICTED: mitogen-act ( 931) 6247 563.8 2.3e-159
XP_011525140 (OMIM: 604317,613583) PREDICTED: WD r (1440) 2334 220.7 7e-56
XP_005258866 (OMIM: 604317,613583) PREDICTED: WD r (1486) 2334 220.7 7.2e-56
NP_775907 (OMIM: 604317,613583) WD repeat-containi (1518) 2334 220.7 7.3e-56
XP_016882154 (OMIM: 604317,613583) PREDICTED: WD r (1523) 2334 220.7 7.3e-56
NP_001077430 (OMIM: 604317,613583) WD repeat-conta (1523) 2334 220.7 7.3e-56
XP_011525142 (OMIM: 604317,613583) PREDICTED: WD r (1187) 1721 166.8 9.3e-40
XP_011525143 (OMIM: 604317,613583) PREDICTED: WD r (1049) 1504 147.7 4.6e-34
XP_011525139 (OMIM: 604317,613583) PREDICTED: WD r (1518) 1360 135.2 3.9e-30
XP_011525144 (OMIM: 604317,613583) PREDICTED: WD r (1000) 1345 133.8 7e-30
XP_011525141 (OMIM: 604317,613583) PREDICTED: WD r (1406) 1204 121.5 4.8e-26
>>NP_001122080 (OMIM: 616786) mitogen-activated protein (1514 aa)
initn: 10109 init1: 10109 opt: 10109 Z-score: 4810.4 bits: 902.8 E(85289): 0
Smith-Waterman score: 10109; 99.9% identity (99.9% similar) in 1514 aa overlap (1-1514:1-1514)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
NP_001 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1450 1460 1470 1480 1490 1500
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
NP_001 LLLRAVERRMERKL
1510
>>NP_055809 (OMIM: 616786) mitogen-activated protein kin (1508 aa)
initn: 8271 init1: 8271 opt: 10049 Z-score: 4782.0 bits: 897.5 E(85289): 0
Smith-Waterman score: 10049; 99.5% identity (99.5% similar) in 1514 aa overlap (1-1514:1-1508)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_055 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELR------TTVAHCISVSQDYIFCGCADG
250 260 270 280 290
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
NP_055 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1440 1450 1460 1470 1480 1490
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
NP_055 LLLRAVERRMERKL
1500
>>XP_011519686 (OMIM: 616786) PREDICTED: mitogen-activat (1412 aa)
initn: 9659 init1: 9469 opt: 9469 Z-score: 4507.3 bits: 846.6 E(85289): 0
Smith-Waterman score: 9469; 99.9% identity (99.9% similar) in 1412 aa overlap (1-1412:1-1412)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_011 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
:::::::::::::::::::::::::::::: :
XP_011 GPENLQPPPPEKTPNPMECTKPGAALSQDSGP
1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
>>NP_001252540 (OMIM: 616786) mitogen-activated protein (1231 aa)
initn: 5715 init1: 5715 opt: 7493 Z-score: 3571.3 bits: 673.2 E(85289): 3.5e-192
Smith-Waterman score: 7576; 81.3% identity (81.3% similar) in 1514 aa overlap (1-1514:1-1231)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::: :::::::::::::::::::::
NP_001 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELR------TTVAHCISVSQDYIFCGCADG
250 260 270 280 290
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQAS-------
1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
NP_001 ------------------------------------------------------------
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
NP_001 ------------------------------------------------------------
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
NP_001 ------------------------------------------------------------
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
NP_001 ------------------------------------------------------------
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::
NP_001 ------------------------------EPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1130 1140 1150
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1160 1170 1180 1190 1200 1210
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
NP_001 LLLRAVERRMERKL
1220 1230
>>XP_011519685 (OMIM: 616786) PREDICTED: mitogen-activat (1465 aa)
initn: 9764 init1: 7129 opt: 7254 Z-score: 3456.9 bits: 652.3 E(85289): 8.2e-186
Smith-Waterman score: 9670; 96.7% identity (96.7% similar) in 1514 aa overlap (1-1514:1-1465)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::
XP_011 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE------------------------
370 380 390
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
:::::::::::::::::::::::::::::::::::
XP_011 -------------------------DLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
400 410 420 430
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
440 450 460 470 480 490
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
560 570 580 590 600 610
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
680 690 700 710 720 730
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
740 750 760 770 780 790
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
800 810 820 830 840 850
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
980 990 1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1040 1050 1060 1070 1080 1090
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1100 1110 1120 1130 1140 1150
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_011 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1160 1170 1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1340 1350 1360 1370 1380 1390
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1400 1410 1420 1430 1440 1450
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
XP_011 LLLRAVERRMERKL
1460
>>XP_016877506 (OMIM: 616786) PREDICTED: mitogen-activat (1465 aa)
initn: 9764 init1: 7129 opt: 7254 Z-score: 3456.9 bits: 652.3 E(85289): 8.2e-186
Smith-Waterman score: 9670; 96.7% identity (96.7% similar) in 1514 aa overlap (1-1514:1-1465)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::
XP_016 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE------------------------
370 380 390
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
:::::::::::::::::::::::::::::::::::
XP_016 -------------------------DLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
400 410 420 430
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
440 450 460 470 480 490
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
560 570 580 590 600 610
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
680 690 700 710 720 730
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
740 750 760 770 780 790
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
800 810 820 830 840 850
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
980 990 1000 1010 1020 1030
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1040 1050 1060 1070 1080 1090
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1100 1110 1120 1130 1140 1150
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_016 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1160 1170 1180 1190 1200 1210
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1280 1290 1300 1310 1320 1330
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1340 1350 1360 1370 1380 1390
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1400 1410 1420 1430 1440 1450
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
XP_016 LLLRAVERRMERKL
1460
>>XP_006720501 (OMIM: 616786) PREDICTED: mitogen-activat (1459 aa)
initn: 8917 init1: 7129 opt: 7181 Z-score: 3422.3 bits: 645.9 E(85289): 6.9e-184
Smith-Waterman score: 9610; 96.3% identity (96.3% similar) in 1514 aa overlap (1-1514:1-1459)
10 20 30 40 50 60
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADG
::::::::::::::::::::::::::::::::: :::::::::::::::::::::
XP_006 RGKKADSTFCITSSGLLCEFSDRRLLDKWVELR------TTVAHCISVSQDYIFCGCADG
250 260 270 280 290
310 320 330 340 350 360
pF1KA0 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA0 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSD
::::::::::::::::::::::::::::::::::::
XP_006 CVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVE------------------------
360 370 380 390
430 440 450 460 470 480
pF1KA0 NTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
:::::::::::::::::::::::::::::::::::
XP_006 -------------------------DLIKIIYVDGNTQALLDTELPGGDKADASLLDPRV
400 410 420
490 500 510 520 530 540
pF1KA0 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLA
430 440 450 460 470 480
550 560 570 580 590 600
pF1KA0 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQK
490 500 510 520 530 540
610 620 630 640 650 660
pF1KA0 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGE
550 560 570 580 590 600
670 680 690 700 710 720
pF1KA0 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLIS
610 620 630 640 650 660
730 740 750 760 770 780
pF1KA0 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPG
670 680 690 700 710 720
790 800 810 820 830 840
pF1KA0 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGF
730 740 750 760 770 780
850 860 870 880 890 900
pF1KA0 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKH
790 800 810 820 830 840
910 920 930 940 950 960
pF1KA0 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPS
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KA0 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSES
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KA0 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGA
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KA0 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGN
1030 1040 1050 1060 1070 1080
1150 1160 1170 1180 1190 1200
pF1KA0 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVH
1090 1100 1110 1120 1130 1140
1210 1220 1230 1240 1250 1260
pF1KA0 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISR
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_006 SLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISR
1150 1160 1170 1180 1190 1200
1270 1280 1290 1300 1310 1320
pF1KA0 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGR
1210 1220 1230 1240 1250 1260
1330 1340 1350 1360 1370 1380
pF1KA0 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQ
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KA0 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSV
1330 1340 1350 1360 1370 1380
1450 1460 1470 1480 1490 1500
pF1KA0 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
1390 1400 1410 1420 1430 1440
1510
pF1KA0 LLLRAVERRMERKL
::::::::::::::
XP_006 LLLRAVERRMERKL
1450
>>XP_006720502 (OMIM: 616786) PREDICTED: mitogen-activat (931 aa)
initn: 6247 init1: 6247 opt: 6247 Z-score: 2982.2 bits: 563.8 E(85289): 2.3e-159
Smith-Waterman score: 6247; 99.9% identity (99.9% similar) in 931 aa overlap (584-1514:1-931)
560 570 580 590 600 610
pF1KA0 GREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHV
::::::::::::::::::::::::::::::
XP_006 MISCGADKSIYFRTAQKSGDGVQFTRTHHV
10 20 30
620 630 640 650 660 670
pF1KA0 VRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSG
40 50 60 70 80 90
680 690 700 710 720 730
pF1KA0 IYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLS
100 110 120 130 140 150
740 750 760 770 780 790
pF1KA0 SEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGED
160 170 180 190 200 210
800 810 820 830 840 850
pF1KA0 EGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRR
220 230 240 250 260 270
860 870 880 890 900 910
pF1KA0 RGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQN
280 290 300 310 320 330
920 930 940 950 960 970
pF1KA0 EKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQ
340 350 360 370 380 390
980 990 1000 1010 1020 1030
pF1KA0 APARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDL
400 410 420 430 440 450
1040 1050 1060 1070 1080 1090
pF1KA0 EEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSE
460 470 480 490 500 510
1100 1110 1120 1130 1140 1150
pF1KA0 SRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEP
520 530 540 550 560 570
1160 1170 1180 1190 1200 1210
pF1KA0 SSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEASLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEASLQ
580 590 600 610 620 630
1220 1230 1240 1250 1260 1270
pF1KA0 APSPGALLSREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISRSISVGENLGLVAE
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_006 APSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLVAE
640 650 660 670 680 690
1280 1290 1300 1310 1320 1330
pF1KA0 PQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAEKPGFPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAEKPGFPVG
700 710 720 730 740 750
1340 1350 1360 1370 1380 1390
pF1KA0 LGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKT
760 770 780 790 800 810
1400 1410 1420 1430 1440 1450
pF1KA0 PNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRI
820 830 840 850 860 870
1460 1470 1480 1490 1500 1510
pF1KA0 AQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSELLLRAVERRMERK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSELLLRAVERRMERK
880 890 900 910 920 930
pF1KA0 L
:
XP_006 L
>>XP_011525140 (OMIM: 604317,613583) PREDICTED: WD repea (1440 aa)
initn: 2248 init1: 1159 opt: 2334 Z-score: 1124.2 bits: 220.7 E(85289): 7e-56
Smith-Waterman score: 3393; 40.8% identity (65.0% similar) in 1545 aa overlap (18-1509:37-1436)
10 20 30 40
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSK--AGNRREDLSSKVTLEKVL
.: : ::: . .: ....:.:::::
XP_011 GGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KA0 GITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYL
:::.... ::.::: .: ::: ::::::...:...::.::.:..::...::::::::::.
XP_011 GITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KA0 VTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAW
::::.:: ::::.::: :..::::. ::::::::::::. :.:::.::::::..::: :
XP_011 VTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDW
130 140 150 160 170 180
170 180 190 200 210 220
pF1KA0 KKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGL
::.::::::::: :: :.::::: :::::.::::..::.:. : .::..::::.::::.
XP_011 KKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGI
190 200 210 220 230 240
230 240 250 260 270 280
pF1KA0 LGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHC
::::.::.: ::::::. : ::::.. :::::.:...:.:.::..:. .... :
XP_011 LGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLK------VSLSSC
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 ISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYP
. :::. :::::.:: ::.:. .::.:..::.:: ::.:.:. : : :: :.: ::
XP_011 LCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 DTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSN
::.:::::: .:::::::.:::::.:::.: ..::::.: :.::: ::.:::::: .:.
XP_011 DTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQ-
370 380 390 400 410
410 420 430 440 450 460
pF1KA0 QACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLD-TE
.:::: .::.:::::::::.:: .:: : ..::.:. :.:..::... : : : ..
XP_011 RACLPSGSFLTCSSDNTIRFWNLDSS--PDSHWQKNIFSNTLLKVVYVENDIQHLQDMSH
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 LPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEI
.: . ... .: ..:.: . :::.::::::::: :.::.:::. ..:..::::::.:.
XP_011 FPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEV
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 LCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRM
::::::::.::: ::::::::::::::.. ..:.:.::::.:::::::.:::. . ...:
XP_011 LCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAG-NRDIQM
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 ISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFN
::::::::::::.::...::..:.:::::..::::::::.. . ::.:..:::::.:..:
XP_011 ISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYN
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 ISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSE
.::::: .:::::..:.:.::..:::: ..:::::::..:..:: ::::.: ::::::
XP_011 TVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSE
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 IVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQR
:.:.:::. ::.:::.::::::.:.:.:. :.: :.:.: :. .:: :: .. ..
XP_011 IITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQ----QQQHTNDKK
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 ASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPR
:: :.. ...: . : : : .. ::: .: .: .: : :
XP_011 RSGHPRQD--TYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTN
780 790 800 810 820 830
830 840 850 860 870
pF1KA0 S-LSHWEMSRAQESVGFLDPAPAANPGPRR----RGRWVQPGVELSVRSMLDLRQLETLA
. : : :.. .: : : . .: .:::.. . . ....:: ..:.
XP_011 GKLPLW----AKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYF
840 850 860 870 880
880 890 900 910 920 930
pF1KA0 PSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEG
.. : .. . :.. . :: :..:.: . ..: :. :.:.
XP_011 TPMKPESLENSILDSLEPQSLA------SLLSESESPQEAGRGHPSFLPQ------QKES
890 900 910 920 930
940 950 960 970 980 990
pF1KA0 VFAQDLEPAPIEDGIVYPEPSDNPTMDT-SEFQVQAPARGTLGRVYPGSRSSEKHSPDSA
:..: :.: .. . : :.. . : ::.... ::
XP_011 SEASEL--------ILYSLEAEVTVTGTDSQYCRKEVEAG------PGDQQG-----DSY
940 950 960 970
1000 1010 1020 1030 1040 1050
pF1KA0 CSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEG
:. .: .:: : : : : :: : : :
XP_011 LRVSSDSPKDQSP--PEE----------------LFPAALGDVEASEAE-----------
980 990 1000
1060 1070 1080 1090 1100 1110
pF1KA0 SPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFL--LQVQTRPLREPSPS
.:: . :. :::..:: :: .: . :
XP_011 ------------DHFFN-------------PR----LSISTQFLSSLQKASRFTHTFPPR
1010 1020 1030
1120 1130 1140 1150 1160 1170
pF1KA0 SSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPD
... . : ... . .: :::.. .: ::... :: .
XP_011 ATQCLVKSPEVKLMDRGGSQPRAG--------------TGYASPDRT-HVLAAGKAEETL
1040 1050 1060 1070 1080
1180 1190 1200 1210 1220 1230
pF1KA0 SSWAPKRVATASP-FSGLQKAQSVHSLVPQERHEAS-LQAPSPGALLSREIEAQDGLGSL
.: : : ...: . . :..: .:. . .::.:: :.. ..:
XP_011 EAWRPP-----PPCLTSLASCVPASSVLPTDRNLPTPTSAPTPG--LAQGVHA-------
1090 1100 1110 1120
1240 1250 1260 1270 1280 1290
pF1KA0 PPADGPPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLA-LPSR
:: ::.. :.:: :.::::::.:.. : .. :. : : ...:: : ..
XP_011 ------PST-CSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQE
1130 1140 1150 1160 1170 1180
1300 1310 1320 1330
pF1KA0 AHLVLDIPKPLPD----RPTLAAF-------------SPVTKGR-APGEAEKPGF--PVG
. . : : .:.: .. : . : : .:: :.
XP_011 LQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAV
1190 1200 1210 1220 1230 1240
1340 1350 1360 1370 1380 1390
pF1KA0 LGKAHSTTERWACLGEGTTPKPRTECQAHPG-PSSPCAQQLPVS--SLFQGPENLQPPPP
: : .:. : .:.. .: :: :. : ::: . .. : .: :
XP_011 SFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTS
1250 1260 1270 1280 1290 1300
1400 1410 1420 1430 1440
pF1KA0 EKTP----NPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMP
.: . ..: . . . : . ... .:. . ..:. ::. ... .
XP_011 GALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQV
1310 1320 1330 1340 1350 1360
1450 1460 1470 1480 1490
pF1KA0 SAEQSRIAQLLRDTFSSVRQELEA-------VAGA-VLSSPGS-SPGAV---GAEQTQAL
.. :.. : .:: ....::: :: : .: ::: :: .. .. . :::
XP_011 DTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQAL
1370 1380 1390 1400 1410 1420
1500 1510
pF1KA0 LEQYSELLLRAVERRMERKL
::.:::::..::.:.
XP_011 LEHYSELLVQAVRRKARGH
1430 1440
>>XP_005258866 (OMIM: 604317,613583) PREDICTED: WD repea (1486 aa)
initn: 2327 init1: 1159 opt: 2334 Z-score: 1124.0 bits: 220.7 E(85289): 7.2e-56
Smith-Waterman score: 3524; 41.3% identity (66.2% similar) in 1558 aa overlap (18-1509:37-1482)
10 20 30 40
pF1KA0 MAVEGSTITSRIKNLLRSPSIKLRRSK--AGNRREDLSSKVTLEKVL
.: : ::: . .: ....:.:::::
XP_005 GGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KA0 GITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYL
:::.... ::.::: .: ::: ::::::...:...::.::.:..::...::::::::::.
XP_005 GITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KA0 VTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAW
::::.:: ::::.::: :..::::. ::::::::::::. :.:::.::::::..::: :
XP_005 VTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDW
130 140 150 160 170 180
170 180 190 200 210 220
pF1KA0 KKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGL
::.::::::::: :: :.::::: :::::.::::..::.:. : .::..::::.::::.
XP_005 KKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGI
190 200 210 220 230 240
230 240 250 260 270 280
pF1KA0 LGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHC
::::.::.: ::::::. : ::::.. :::::.:...:.:.::..:. .... :
XP_005 LGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLK------VSLSSC
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 ISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYP
. :::. :::::.:: ::.:. .::.:..::.:: ::.:.:. : : :: :.: ::
XP_005 LCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 DTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSN
::.:::::: .:::::::.:::::.:::.: ..::::.: :.::: ::.:::::: .:.
XP_005 DTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQ-
370 380 390 400 410
410 420 430 440 450 460
pF1KA0 QACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLD-TE
.:::: .::.:::::::::.:: .:: : ..::.:. :.:..::... : : : ..
XP_005 RACLPSGSFLTCSSDNTIRFWNLDSS--PDSHWQKNIFSNTLLKVVYVENDIQHLQDMSH
420 430 440 450 460 470
470 480 490 500 510 520
pF1KA0 LPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEI
.: . ... .: ..:.: . :::.::::::::: :.::.:::. ..:..::::::.:.
XP_005 FPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEV
480 490 500 510 520 530
530 540 550 560 570 580
pF1KA0 LCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRM
::::::::.::: ::::::::::::::.. ..:.:.::::.:::::::.:::. . ...:
XP_005 LCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAG-NRDIQM
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 ISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFN
::::::::::::.::...::..:.:::::..::::::::.. . ::.:..:::::.:..:
XP_005 ISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYN
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 ISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSE
.::::: .:::::..:.:.::..:::: ..:::::::..:..:: ::::.: ::::::
XP_005 TVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSE
660 670 680 690 700 710
710 720 730 740 750 760
pF1KA0 IVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQR
:.:.:::. ::.:::.::::::.:.:.:. :.: :.:.: :. .:: :: .. ..
XP_005 IITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQ----QQQHTNDKK
720 730 740 750 760 770
770 780 790 800 810 820
pF1KA0 ASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPR
:: :.. ...: . : : : .. ::: .: .: .: : :
XP_005 RSGHPRQD--TYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTN
780 790 800 810 820 830
830 840 850 860 870
pF1KA0 S-LSHWEMSRAQESVGFLDPAPAANPGPRR----RGRWVQPGVELSVRSMLDLRQLETLA
. : : :.. .: : : . .: .:::.. . . ....:: ..:.
XP_005 GKLPLW----AKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYF
840 850 860 870 880
880 890 900 910 920 930
pF1KA0 PSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEG
.. : .. . :.. . :: :..:.: . ..: :. :.:.
XP_005 TPMKPESLENSILDSLEPQSLA------SLLSESESPQEAGRGHPSFLPQ------QKES
890 900 910 920 930
940 950 960 970 980 990
pF1KA0 VFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSAC
:..: :.: ..... . :: ::
XP_005 SEASEL--------ILYS------------LEAEVTVTGT----------------DS--
940 950
1000 1010 1020 1030 1040 1050
pF1KA0 SVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEEGGM--GPYGLQE
.: : . : :... : :.. : . : :: :.: .. :: .
XP_005 --QY---CRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEGCAGPTEDELSLPEGPSVPSS
960 970 980 990 1000 1010
1060 1070 1080 1090 1100
pF1KA0 GSPQTPDQEQFLKQHFETLASGAA----PGAPVQVPERSESR--------SISSRFL--L
. ::::.::.::..:::::. . :.: .: : ::.. :::..:: :
XP_005 SLPQTPEQEKFLRHHFETLTESPCRELFPAALGDV-EASEAEDHFFNPRLSISTQFLSSL
1020 1030 1040 1050 1060 1070
1110 1120 1130 1140 1150 1160
pF1KA0 QVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQA
: .: . : ... . : ... . .: :::.. .: ::...
XP_005 QKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAG--------------TGYASPDRT
1080 1090 1100 1110
1170 1180 1190 1200 1210 1220
pF1KA0 ASVLLPRCRLNPDSSWAPKRVATASP-FSGLQKAQSVHSLVPQERHEAS-LQAPSPGALL
:: . .: : : ...: . . :..: .:. . .::.:: :
XP_005 -HVLAAGKAEETLEAWRPP-----PPCLTSLASCVPASSVLPTDRNLPTPTSAPTPG--L
1120 1130 1140 1150 1160
1230 1240 1250 1260 1270 1280
pF1KA0 SREIEAQDGLGSLPPADGPPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIR
.. ..: :: ::.. :.:: :.::::::.:.. : .. :. :
XP_005 AQGVHA-------------PST-CSYMEATASSRARISRSISLGDSEGPIVATLAQPLRR
1170 1180 1190 1200 1210
1290 1300 1310 1320
pF1KA0 VSPLSKLA-LPSRAHLVLDIPKPLPD----RPTLAAF-------------SPVTKGR-AP
: ...:: : .. . . : : .:.: .. : . : :
XP_005 PSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQP
1220 1230 1240 1250 1260 1270
1330 1340 1350 1360 1370
pF1KA0 GEAEKPGF--PVGLGKAHSTTERWACLGEGTTPKPRTECQAHPG-PSSPCAQQLPVS--S
.:: :. : : .:. : .:.. .: :: :. : ::: . .
XP_005 PVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPG
1280 1290 1300 1310 1320 1330
1380 1390 1400 1410 1420 1430
pF1KA0 LFQGPENLQPPPPEKTP----NPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQA
. : .: : .: . ..: . . . : . ... .:. . ..:
XP_005 IPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEA
1340 1350 1360 1370 1380 1390
1440 1450 1460 1470 1480
pF1KA0 VRLYHSVAGCKMPSAEQSRIAQLLRDTFSSVRQELEA-------VAGA-VLSSPGS-SPG
. ::. ... . .. :.. : .:: ....::: :: : .: ::: ::
XP_005 LDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPP
1400 1410 1420 1430 1440 1450
1490 1500 1510
pF1KA0 AV---GAEQTQALLEQYSELLLRAVERRMERKL
.. .. . :::::.:::::..::.:.
XP_005 TLYPLASPDLQALLEHYSELLVQAVRRKARGH
1460 1470 1480
1514 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 00:48:28 2016 done: Fri Nov 4 00:48:32 2016
Total Scan time: 22.940 Total Display time: 1.080
Function used was FASTA [36.3.4 Apr, 2011]