Result of FASTA (omim) for
pF1KA0580
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0580, 1704 aa
1>>>pF1KA0580 1704 - 1704 aa - 1704 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7708+/-0.000562; mu= 17.5330+/- 0.035
mean_var=157.8473+/-34.016, 0's: 0 Z-trim(109.9): 451 B-trim: 593 in 1/53
Lambda= 0.102084
statistics sampled from 17607 (18123) to 17607 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.556), E-opt: 0.2 (0.212), width: 16
Scan time: 16.830
The best scores are: opt bits E(85289)
XP_016863188 (OMIM: 606645) PREDICTED: arf-GAP wit (1704) 11202 1664.3 0
NP_056045 (OMIM: 606645) arf-GAP with Rho-GAP doma (1704) 11202 1664.3 0
XP_016863187 (OMIM: 606645) PREDICTED: arf-GAP wit (1710) 10397 1545.8 0
XP_016863190 (OMIM: 606645) PREDICTED: arf-GAP wit (1659) 10086 1499.9 0
XP_016863191 (OMIM: 606645) PREDICTED: arf-GAP wit (1636) 8527 1270.3 0
XP_016863189 (OMIM: 606645) PREDICTED: arf-GAP wit (1681) 8527 1270.3 0
NP_056057 (OMIM: 606646) arf-GAP with Rho-GAP doma (1205) 2749 419.2 1.1e-115
NP_001035207 (OMIM: 606646) arf-GAP with Rho-GAP d (1450) 2749 419.3 1.2e-115
NP_001128662 (OMIM: 606646) arf-GAP with Rho-GAP d (1133) 1831 284.0 5.2e-75
XP_011535979 (OMIM: 606647) PREDICTED: arf-GAP wit (1349) 1700 264.8 3.8e-69
XP_005268556 (OMIM: 606647) PREDICTED: arf-GAP wit (1466) 1700 264.8 4e-69
NP_071926 (OMIM: 606647) arf-GAP with Rho-GAP doma (1544) 1700 264.9 4.2e-69
XP_005268554 (OMIM: 606647) PREDICTED: arf-GAP wit (1531) 1688 263.1 1.4e-68
XP_005268557 (OMIM: 606647) PREDICTED: arf-GAP wit ( 934) 1231 195.6 1.8e-48
XP_006714855 (OMIM: 606647) PREDICTED: arf-GAP wit (1473) 1231 195.8 2.5e-48
XP_005268555 (OMIM: 606647) PREDICTED: arf-GAP wit (1524) 1231 195.8 2.6e-48
NP_055585 (OMIM: 605476) arf-GAP with GTPase, ANK ( 836) 340 64.3 5.4e-09
XP_005268683 (OMIM: 605476) PREDICTED: arf-GAP wit ( 856) 340 64.3 5.5e-09
XP_005268682 (OMIM: 605476) PREDICTED: arf-GAP wit (1172) 340 64.4 6.8e-09
XP_016874261 (OMIM: 605476) PREDICTED: arf-GAP wit (1192) 340 64.4 6.9e-09
NP_001116244 (OMIM: 605476) arf-GAP with GTPase, A (1192) 340 64.4 6.9e-09
NP_055729 (OMIM: 608651) arf-GAP with GTPase, ANK ( 804) 325 62.1 2.4e-08
XP_005246116 (OMIM: 608651) PREDICTED: arf-GAP wit ( 808) 325 62.1 2.4e-08
NP_001032208 (OMIM: 608651) arf-GAP with GTPase, A ( 857) 325 62.1 2.5e-08
XP_006712298 (OMIM: 608651) PREDICTED: arf-GAP wit ( 882) 325 62.1 2.6e-08
XP_006712297 (OMIM: 608651) PREDICTED: arf-GAP wit ( 886) 325 62.1 2.6e-08
XP_011508851 (OMIM: 608651) PREDICTED: arf-GAP wit (1073) 325 62.2 3e-08
XP_011508850 (OMIM: 608651) PREDICTED: arf-GAP wit (1098) 325 62.2 3e-08
XP_016858771 (OMIM: 608651) PREDICTED: arf-GAP wit (1106) 325 62.2 3e-08
XP_011508849 (OMIM: 608651) PREDICTED: arf-GAP wit (1126) 325 62.2 3.1e-08
XP_006712300 (OMIM: 608651) PREDICTED: arf-GAP wit (1147) 325 62.2 3.1e-08
XP_006712302 (OMIM: 608651) PREDICTED: arf-GAP wit (1151) 325 62.2 3.1e-08
XP_016867224 (OMIM: 616813) PREDICTED: arf-GAP wit ( 462) 307 59.2 1e-07
XP_016867222 (OMIM: 616813) PREDICTED: arf-GAP wit ( 527) 307 59.2 1.1e-07
XP_005250000 (OMIM: 616813) PREDICTED: arf-GAP wit ( 565) 307 59.3 1.2e-07
NP_001268229 (OMIM: 616813) arf-GAP with GTPase, A ( 580) 307 59.3 1.2e-07
XP_016867223 (OMIM: 616813) PREDICTED: arf-GAP wit ( 580) 307 59.3 1.2e-07
XP_016867221 (OMIM: 616813) PREDICTED: arf-GAP wit ( 630) 307 59.3 1.3e-07
XP_011514082 (OMIM: 616813) PREDICTED: arf-GAP wit ( 683) 307 59.3 1.4e-07
NP_114152 (OMIM: 616813) arf-GAP with GTPase, ANK ( 911) 307 59.5 1.7e-07
NP_008832 (OMIM: 604875) unconventional myosin-IXa (2548) 287 57.0 2.6e-06
XP_006720602 (OMIM: 604875) PREDICTED: unconventio (2619) 287 57.0 2.7e-06
XP_011519920 (OMIM: 604875) PREDICTED: unconventio (2620) 287 57.0 2.7e-06
XP_011510907 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 276 54.8 3.5e-06
XP_011510908 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 276 54.8 3.5e-06
XP_011510906 (OMIM: 607766) PREDICTED: arf-GAP wit ( 776) 276 54.8 3.5e-06
NP_036419 (OMIM: 607766) arf-GAP with coiled-coil, ( 778) 276 54.8 3.5e-06
XP_006713620 (OMIM: 607766) PREDICTED: arf-GAP wit ( 785) 276 54.8 3.5e-06
XP_016861538 (OMIM: 607766) PREDICTED: arf-GAP wit ( 806) 276 54.8 3.6e-06
XP_016861537 (OMIM: 607766) PREDICTED: arf-GAP wit ( 813) 276 54.9 3.6e-06
>>XP_016863188 (OMIM: 606645) PREDICTED: arf-GAP with Rh (1704 aa)
initn: 11202 init1: 11202 opt: 11202 Z-score: 8924.2 bits: 1664.3 E(85289): 0
Smith-Waterman score: 11202; 99.9% identity (100.0% similar) in 1704 aa overlap (1-1704:1-1704)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
1630 1640 1650 1660 1670 1680
1690 1700
pF1KA0 EELNVVLQRSRTLPKELQDEQILK
::::::::::::::::::::::::
XP_016 EELNVVLQRSRTLPKELQDEQILK
1690 1700
>>NP_056045 (OMIM: 606645) arf-GAP with Rho-GAP domain, (1704 aa)
initn: 11202 init1: 11202 opt: 11202 Z-score: 8924.2 bits: 1664.3 E(85289): 0
Smith-Waterman score: 11202; 99.9% identity (100.0% similar) in 1704 aa overlap (1-1704:1-1704)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_056 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KA0 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
1630 1640 1650 1660 1670 1680
1690 1700
pF1KA0 EELNVVLQRSRTLPKELQDEQILK
::::::::::::::::::::::::
NP_056 EELNVVLQRSRTLPKELQDEQILK
1690 1700
>>XP_016863187 (OMIM: 606645) PREDICTED: arf-GAP with Rh (1710 aa)
initn: 10397 init1: 10397 opt: 10397 Z-score: 8283.4 bits: 1545.8 E(85289): 0
Smith-Waterman score: 10397; 99.9% identity (100.0% similar) in 1581 aa overlap (1-1581:1-1581)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
:::::::::::::::::::::
XP_016 GLPLIPIQHEGNATLARKNIERDPCEHTSSHLEASGSHMVGAGMNWNLDRTSSKLPTTSI
1570 1580 1590 1600 1610 1620
>>XP_016863190 (OMIM: 606645) PREDICTED: arf-GAP with Rh (1659 aa)
initn: 10086 init1: 10086 opt: 10086 Z-score: 8036.0 bits: 1499.9 E(85289): 0
Smith-Waterman score: 10791; 97.3% identity (97.4% similar) in 1704 aa overlap (1-1704:1-1659)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::
XP_016 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQ------------------------
1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
:::::::::::::::::::::::::::::::::::::::
XP_016 ---------------------SARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
1540 1550 1560 1570
1630 1640 1650 1660 1670 1680
pF1KA0 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
1580 1590 1600 1610 1620 1630
1690 1700
pF1KA0 EELNVVLQRSRTLPKELQDEQILK
::::::::::::::::::::::::
XP_016 EELNVVLQRSRTLPKELQDEQILK
1640 1650
>>XP_016863191 (OMIM: 606645) PREDICTED: arf-GAP with Rh (1636 aa)
initn: 9314 init1: 8521 opt: 8527 Z-score: 6795.2 bits: 1270.3 E(85289): 0
Smith-Waterman score: 10582; 96.0% identity (96.0% similar) in 1704 aa overlap (1-1704:1-1636)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
:::::::::::::::::::::::::::::::::::::::
XP_016 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEV---------------------
1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --SQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1420 1430 1440 1450 1460 1470
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::
XP_016 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQ------------------------
1480 1490 1500 1510
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
:::::::::::::::::::::::::::::::::::::::
XP_016 ---------------------SARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
1520 1530 1540 1550
1630 1640 1650 1660 1670 1680
pF1KA0 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
1560 1570 1580 1590 1600 1610
1690 1700
pF1KA0 EELNVVLQRSRTLPKELQDEQILK
::::::::::::::::::::::::
XP_016 EELNVVLQRSRTLPKELQDEQILK
1620 1630
>>XP_016863189 (OMIM: 606645) PREDICTED: arf-GAP with Rh (1681 aa)
initn: 8521 init1: 8521 opt: 8527 Z-score: 6795.1 bits: 1270.3 E(85289): 0
Smith-Waterman score: 10993; 98.6% identity (98.7% similar) in 1704 aa overlap (1-1704:1-1681)
10 20 30 40 50 60
pF1KA0 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
:::::::::::::::::::::::::::::::::::::::
XP_016 AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEV---------------------
1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KA0 QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --SQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KA0 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KA0 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
1420 1430 1440 1450 1460 1470
1510 1520 1530 1540 1550 1560
pF1KA0 PTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_016 PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
1480 1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KA0 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KA0 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
1600 1610 1620 1630 1640 1650
1690 1700
pF1KA0 EELNVVLQRSRTLPKELQDEQILK
::::::::::::::::::::::::
XP_016 EELNVVLQRSRTLPKELQDEQILK
1660 1670 1680
>>NP_056057 (OMIM: 606646) arf-GAP with Rho-GAP domain, (1205 aa)
initn: 2581 init1: 1026 opt: 2749 Z-score: 2197.9 bits: 419.2 E(85289): 1.1e-115
Smith-Waterman score: 2904; 41.7% identity (70.6% similar) in 1143 aa overlap (484-1591:84-1203)
460 470 480 490 500 510
pF1KA0 SSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSIS
.:.::::: :::. ..:::::..: .
NP_056 SSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLR
60 70 80 90 100 110
520 530 540 550 560 570
pF1KA0 YYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNAL
:....:. ::: .: .. :: : . ::.::::.:..:::.::.:.. ::..:.. : .:.
NP_056 YFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM
120 130 140 150 160 170
580 590 600 610 620
pF1KA0 KSQSLTSQ-SQAVVT-------PEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGL
: .. :.: . :.. : :::::.: :..... :..: : :: .... :.
NP_056 AEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGI
180 190 200 210 220 230
630 640 650 660 670 680
pF1KA0 GITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY
:::.: :.:.:::.::: .::.. :::: :::.:..: ::..:.::.: .:::.::
NP_056 GITFIDMSVGNVKEVDR---RSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTS
240 250 260 270 280 290
690 700 710 720 730 740
pF1KA0 EVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDAS
::::.:: :: :::: ::.::::::::::::::.:::.::.:: ::::::::: .
NP_056 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK
300 310 320 330 340 350
750 760 770 780 790 800
pF1KA0 IWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLA
.:.. :::::. .:: .: :::.:. .: :. .: :. . ::.:::.:.
NP_056 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPL
360 370 380 390 400 410
810 820 830 840 850 860
pF1KA0 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEF
..:::.:::::::. :. ::.::: :: . : .::: :: ::..:::.:::::
NP_056 FGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEF
420 430 440 450 460 470
870 880 890 900 910 920
pF1KA0 LYHNKFSDFPQHDIHSEGVLSQESS---QSTFLCDFLYQAPSAASKLSSEKKLLEETNKK
: .:. .. :. : : : .. : .. :::.. ::. :: .... :: ...
NP_056 LRNNRTTEVPRLD--SMKPLEKHYSVVLPTVSHSGFLYKTASAG-KLLQDRRAREEFSRR
480 490 500 510 520
930 940 950 960 970 980
pF1KA0 WCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFL
:::: : :::.::....:::: : .:..:::. : . : ::.: .::..:
NP_056 WCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYL
530 540 550 560 570 580
990 1000 1010 1020 1030 1040
pF1KA0 FGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKS
:: :... ..:.. ::: ::: .::.: :.. .:.: :: .:.. ..:::... :
NP_056 FGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGS
590 600 610 620 630 640
1050 1060 1070 1080 1090 1100
pF1KA0 SLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTV
:. . . . ..::.::::.: :. . .::.:::. :::::.:. .:::
NP_056 ELRAVFPEGPCE-EPLQLRKLQELSI----QGDSENQVLVLVERRRTLYIQGERRLDFMG
650 660 670 680 690
1110 1120 1130 1140 1150 1160
pF1KA0 WHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISEL
: ::.:::.. :..:..:::. .:.:.:: :. ..:: :: . ::.: :. . ..:
NP_056 WLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRL
700 710 720 730 740 750
1170 1180 1190 1200 1210 1220
pF1KA0 LESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERI
:::...:::: .:. :.....::...:: :: :. :.:.:. :. : . .:..:..
NP_056 LESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKV
760 770 780 790 800 810
1230 1240 1250 1260 1270 1280
pF1KA0 KKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEE
..: .. :: :::::. :.: ::: :: :. :.::.::::.::. :::: :: .
NP_056 SRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKA
820 830 840 850 860 870
1290 1300 1310 1320 1330
pF1KA0 VNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWK----DTQVSQAGDLLIEVYVERKE
:.:::::.:: .: : :...... : . :.: . . ...:::.. ::.:.:.
NP_056 GRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKK
880 890 900 910 920 930
1340 1350 1360 1370 1380 1390
pF1KA0 PDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQ
. :.. : ::::: .:: .:. . : :. ::: : :: :::::. :.::
NP_056 AETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLP-
940 950 960 970 980 990
1400 1410 1420 1430 1440 1450
pF1KA0 VLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNK
.:. .:. ...::::. . ... : .:. :.:..:..:. : . : ..
NP_056 ILH--GLGT--DSHLVVKKHQAMEAML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGG
1000 1010 1020 1030 1040 1050
1460 1470 1480 1490 1500
pF1KA0 FQDRYFVLRDGFLFLYKDVKSSK---------H--DKMFSLSSMKFYRGVKKKMKPPTSW
:.::::.: .. : :::.:.:.. : .: . ..:.: : :::::..::: :
NP_056 FHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCW
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550
pF1KA0 GLTAY--SEKH---HWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKI
:.:. .::: .:.::::... ::.......::. .:: .. .:.. . ..
NP_056 GFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV-RL
1120 1130 1140 1150 1160 1170
1560 1570 1580 1590 1600 1610
pF1KA0 GGLPLIPIQHEGNATLARKNIESARAE-LERLRLSEKCDKESVDSSLKERASMVAHCLEH
:.. :::.. :. . :... . :. : ::
NP_056 GSVSLIPLR--GSENEMRRSVAAFTADPLSLLRNV
1180 1190 1200
1620 1630 1640 1650 1660 1670
pF1KA0 KDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSR
>>NP_001035207 (OMIM: 606646) arf-GAP with Rho-GAP domai (1450 aa)
initn: 2682 init1: 1026 opt: 2749 Z-score: 2196.9 bits: 419.3 E(85289): 1.2e-115
Smith-Waterman score: 2904; 41.7% identity (70.6% similar) in 1143 aa overlap (484-1591:329-1448)
460 470 480 490 500 510
pF1KA0 SSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSIS
.:.::::: :::. ..:::::..: .
NP_001 SSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLR
300 310 320 330 340 350
520 530 540 550 560 570
pF1KA0 YYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNAL
:....:. ::: .: .. :: : . ::.::::.:..:::.::.:.. ::..:.. : .:.
NP_001 YFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM
360 370 380 390 400 410
580 590 600 610 620
pF1KA0 KSQSLTSQ-SQAVVT-------PEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGL
: .. :.: . :.. : :::::.: :..... :..: : :: .... :.
NP_001 AEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGI
420 430 440 450 460 470
630 640 650 660 670 680
pF1KA0 GITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY
:::.: :.:.:::.::: .::.. :::: :::.:..: ::..:.::.: .:::.::
NP_001 GITFIDMSVGNVKEVDR---RSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTS
480 490 500 510 520 530
690 700 710 720 730 740
pF1KA0 EVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDAS
::::.:: :: :::: ::.::::::::::::::.:::.::.:: ::::::::: .
NP_001 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK
540 550 560 570 580 590
750 760 770 780 790 800
pF1KA0 IWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLA
.:.. :::::. .:: .: :::.:. .: :. .: :. . ::.:::.:.
NP_001 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPL
600 610 620 630 640 650
810 820 830 840 850 860
pF1KA0 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEF
..:::.:::::::. :. ::.::: :: . : .::: :: ::..:::.:::::
NP_001 FGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEF
660 670 680 690 700 710
870 880 890 900 910 920
pF1KA0 LYHNKFSDFPQHDIHSEGVLSQESS---QSTFLCDFLYQAPSAASKLSSEKKLLEETNKK
: .:. .. :. : : : .. : .. :::.. ::. :: .... :: ...
NP_001 LRNNRTTEVPRLD--SMKPLEKHYSVVLPTVSHSGFLYKTASAG-KLLQDRRAREEFSRR
720 730 740 750 760 770
930 940 950 960 970 980
pF1KA0 WCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFL
:::: : :::.::....:::: : .:..:::. : . : ::.: .::..:
NP_001 WCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYL
780 790 800 810 820
990 1000 1010 1020 1030 1040
pF1KA0 FGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKS
:: :... ..:.. ::: ::: .::.: :.. .:.: :: .:.. ..:::... :
NP_001 FGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGS
830 840 850 860 870 880
1050 1060 1070 1080 1090 1100
pF1KA0 SLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTV
:. . . . ..::.::::.: :. . .::.:::. :::::.:. .:::
NP_001 ELRAVFPEGPCE-EPLQLRKLQELSI----QGDSENQVLVLVERRRTLYIQGERRLDFMG
890 900 910 920 930 940
1110 1120 1130 1140 1150 1160
pF1KA0 WHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISEL
: ::.:::.. :..:..:::. .:.:.:: :. ..:: :: . ::.: :. . ..:
NP_001 WLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRL
950 960 970 980 990 1000
1170 1180 1190 1200 1210 1220
pF1KA0 LESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERI
:::...:::: .:. :.....::...:: :: :. :.:.:. :. : . .:..:..
NP_001 LESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKV
1010 1020 1030 1040 1050 1060
1230 1240 1250 1260 1270 1280
pF1KA0 KKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEE
..: .. :: :::::. :.: ::: :: :. :.::.::::.::. :::: :: .
NP_001 SRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKA
1070 1080 1090 1100 1110 1120
1290 1300 1310 1320 1330
pF1KA0 VNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWK----DTQVSQAGDLLIEVYVERKE
:.:::::.:: .: : :...... : . :.: . . ...:::.. ::.:.:.
NP_001 GRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKK
1130 1140 1150 1160 1170 1180
1340 1350 1360 1370 1380 1390
pF1KA0 PDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQ
. :.. : ::::: .:: .:. . : :. ::: : :: :::::. :.::
NP_001 AETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLP-
1190 1200 1210 1220 1230 1240
1400 1410 1420 1430 1440 1450
pF1KA0 VLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNK
.:. .:. ...::::. . ... : .:. :.:..:..:. : . : ..
NP_001 ILH--GLGT--DSHLVVKKHQAMEAML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGG
1250 1260 1270 1280 1290
1460 1470 1480 1490 1500
pF1KA0 FQDRYFVLRDGFLFLYKDVKSSK---------H--DKMFSLSSMKFYRGVKKKMKPPTSW
:.::::.: .. : :::.:.:.. : .: . ..:.: : :::::..::: :
NP_001 FHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCW
1300 1310 1320 1330 1340 1350
1510 1520 1530 1540 1550
pF1KA0 GLTAY--SEKH---HWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKI
:.:. .::: .:.::::... ::.......::. .:: .. .:.. . ..
NP_001 GFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV-RL
1360 1370 1380 1390 1400 1410
1560 1570 1580 1590 1600 1610
pF1KA0 GGLPLIPIQHEGNATLARKNIESARAE-LERLRLSEKCDKESVDSSLKERASMVAHCLEH
:.. :::.. :. . :... . :. : ::
NP_001 GSVSLIPLR--GSENEMRRSVAAFTADPLSLLRNV
1420 1430 1440 1450
1620 1630 1640 1650 1660 1670
pF1KA0 KDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSR
>>NP_001128662 (OMIM: 606646) arf-GAP with Rho-GAP domai (1133 aa)
initn: 2218 init1: 701 opt: 1831 Z-score: 1467.6 bits: 284.0 E(85289): 5.2e-75
Smith-Waterman score: 2663; 40.0% identity (67.7% similar) in 1132 aa overlap (484-1591:84-1131)
460 470 480 490 500 510
pF1KA0 SSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSIS
.:.::::: :::. ..:::::..: .
NP_001 SSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLR
60 70 80 90 100 110
520 530 540 550 560 570
pF1KA0 YYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNAL
:....:. ::: .: .. :: : . ::.::::.:..:::.::.:.. ::..:.. : .:.
NP_001 YFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM
120 130 140 150 160 170
580 590 600 610 620
pF1KA0 KSQSLTSQ-SQAVVT-------PEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGL
: .. :.: . :.. : :::::.: :..... :..: : :: .... :.
NP_001 AEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGI
180 190 200 210 220 230
630 640 650 660 670 680
pF1KA0 GITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY
:::.: :.:.:::.::: .::.. :::: :::.:..: ::..:.::.: .:::.::
NP_001 GITFIDMSVGNVKEVDR---RSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTS
240 250 260 270 280 290
690 700 710 720 730 740
pF1KA0 EVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDAS
::::.:: :: :::: ::.::::::::::::::.:::.::.:: ::::::::: .
NP_001 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK
300 310 320 330 340 350
750 760 770 780 790 800
pF1KA0 IWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLA
.:.. :::
NP_001 VWTETLIE----------------------------------------------------
810 820 830 840 850 860
pF1KA0 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEF
::::::. :. ::.::: :: . : .::: :: ::..:::.:::::
NP_001 ---------ALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEF
360 370 380 390 400
870 880 890 900 910 920
pF1KA0 LYHNKFSDFPQHDIHSEGVLSQESS---QSTFLCDFLYQAPSAASKLSSEKKLLEETNKK
: .:. .. :. : : : .. : .. :::.. ::. :: .... :: ...
NP_001 LRNNRTTEVPRLD--SMKPLEKHYSVVLPTVSHSGFLYKTASAG-KLLQDRRAREEFSRR
410 420 430 440 450 460
930 940 950 960 970 980
pF1KA0 WCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFL
:::: : :::.::....:::: : .:..:::. : . : ::.: .::..:
NP_001 WCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYL
470 480 490 500 510 520
990 1000 1010 1020 1030 1040
pF1KA0 FGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKS
:: :... ..:.. ::: ::: .::.: :.. .:.: :: .:.. ..:::... :
NP_001 FGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGS
530 540 550 560 570 580
1050 1060 1070 1080 1090 1100
pF1KA0 SLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTV
:. . . . ..::.::::.: :. . .::.:::. :::::.:. .:::
NP_001 ELRAVFPEGPCE-EPLQLRKLQELSI----QGDSENQVLVLVERRRTLYIQGERRLDFMG
590 600 610 620 630
1110 1120 1130 1140 1150 1160
pF1KA0 WHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISEL
: ::.:::.. :..:..:::. .:.:.:: :. ..:: :: . ::.: :. . ..:
NP_001 WLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRL
640 650 660 670 680 690
1170 1180 1190 1200 1210 1220
pF1KA0 LESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERI
:::...:::: .:. :.....::...:: :: :. :.:.:. :. : . .:..:..
NP_001 LESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKV
700 710 720 730 740 750
1230 1240 1250 1260 1270 1280
pF1KA0 KKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEE
..: .. :: :::::. :.: ::: :: :. :.::.::::.::. :::: :: .
NP_001 SRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKA
760 770 780 790 800 810
1290 1300 1310 1320 1330
pF1KA0 VNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWK----DTQVSQAGDLLIEVYVERKE
:.:::::.:: .: : :...... : . :.: . . ...:::.. ::.:.:.
NP_001 GRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKK
820 830 840 850 860 870
1340 1350 1360 1370 1380 1390
pF1KA0 PDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQ
. :.. : ::::: .:: .:. . : :. ::: : :: :::::. :.::
NP_001 AETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLP-
880 890 900 910 920 930
1400 1410 1420 1430 1440 1450
pF1KA0 VLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNK
.:. .:. ...::::. . ... : .:. :.:..:..:. : . : ..
NP_001 ILH--GLGT--DSHLVVKKHQAMEAML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGG
940 950 960 970 980 990
1460 1470 1480 1490 1500 1510
pF1KA0 FQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAY--SEKH
:.::::.: .. : :::.:.: . .: . ..:.: : :::::..::: ::.:. .:::
NP_001 FHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKH
1000 1010 1020 1030 1040 1050
1520 1530 1540 1550 1560 1570
pF1KA0 ---HWHLCCDSSQTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHE
.:.::::... ::.......::. .:: .. .:.. . ..:.. :::..
NP_001 EKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV-RLGSVSLIPLR--
1060 1070 1080 1090 1100
1580 1590 1600 1610 1620
pF1KA0 GNATLARKNIESARAE-LERLRLSEKCDKESVDSSLKERASMVAHCLEHKDDKLRNRPRK
:. . :... . :. : ::
NP_001 GSENEMRRSVAAFTADPLSLLRNV
1110 1120 1130
>>XP_011535979 (OMIM: 606647) PREDICTED: arf-GAP with Rh (1349 aa)
initn: 2707 init1: 1024 opt: 1700 Z-score: 1362.4 bits: 264.8 E(85289): 3.8e-69
Smith-Waterman score: 2864; 40.5% identity (67.0% similar) in 1226 aa overlap (452-1649:58-1248)
430 440 450 460 470
pF1KA0 FQSLRRKNSKASKSRTQKALILDSVNRHSYPLSST--SGNADSSAVSSQAISPYACFYGA
: .:: : . .. .:.. ::::: : .
XP_011 RGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFT
30 40 50 60 70 80
480 490 500 510 520 530
pF1KA0 SAK--KVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRV
. . . :::::::::::. .::.:.:.:.: :. :....:. . ::.:::.:: .:
XP_011 ADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRS
90 100 110 120 130 140
540 550 560 570 580 590
pF1KA0 QGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPE--KCGYLE
. ::::.:.: ::.::::.:.: .:. : : : . :: : : .. . :. . :.::
XP_011 SKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLE
150 160 170 180 190 200
600 610 620 630 640 650
pF1KA0 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR
:::.:::.:..:: . . : :.:: :. :.:: .: .. .:.. : ..::...::.:
XP_011 LRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRE---TKSRSFDLLTPHR
210 220 230 240 250 260
660 670 680 690 700 710
pF1KA0 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL
::::::. .:.: :.:....::::::::::::: :..::.:::: . ::::..::
XP_011 CFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNL
270 280 290 300 310 320
720 730 740 750 760 770
pF1KA0 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDE
:::::.::::::.:: :::.:::.:.:.::::...::::.:: ::: ::::.: :
XP_011 GVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGE
330 340 350 360 370 380
780 790 800 810 820 830
pF1KA0 ELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALL---
:: :. : .::..::. : ::: . .: .::::::..:..:..:. :
XP_011 GLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCV
390 400 410 420 430 440
840 850 860 870 880 890
pF1KA0 --FSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESS
: : . . : : : :: :: : : :: ..
XP_011 EAFEGEEPWFPPA-PDGSCPGLLP-----------------SD-P-----SPGVYNEVVV
450 460 470 480
900 910 920 930 940
pF1KA0 QSTFLCDFLYQAP-SAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININ
..:. ::: .: : . : .. . . :::: :. : .. ...: : . :. .
XP_011 RATY-SGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVL-GAALEMFASENSPEPLSLIQPQ
490 500 510 520 530
950 960 970 980 990 1000
pF1KA0 EVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAEN
...::.. . : ::. : . :. ::.. ... . :: :..: : :: ..
XP_011 DIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQ
540 550 560 570 580 590
1010 1020 1030 1040 1050 1060
pF1KA0 LTEADYDLIGQLFYKD-CH---ALDQWRKGWFAMDKSSLHFCLQM---QEVQGDRMHLRR
: .:.:. .. : : : .:. . . : .: . : .::::
XP_011 LLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRR
600 610 620 630 640 650
1070 1080 1090 1100 1110 1120
pF1KA0 LQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQ
:::... . ... .: . :.::: :::::..:. .::::.:..:: ::: :..::.::
XP_011 LQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQ
660 670 680 690 700 710
1130 1140 1150 1160 1170 1180
pF1KA0 LSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQL
.:..:.::::..::.::::.:: . .:.:.: . .:: :..:::: ::: :.: .
XP_011 MSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFV
720 730 740 750 760 770
1190 1200 1210 1220 1230 1240
pF1KA0 EDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAA
:::: .:: :. ..:: . . .: : : : . . ..:..:: : :: ::: :::.
XP_011 EDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLAT
780 790 800 810 820 830
1250 1260 1270 1280 1290 1300
pF1KA0 IIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKED
.: ::::::::. .:.: ..::::.:. .::: :. .:: :...::..:. .:.. :
XP_011 LIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSD
840 850 860 870 880 890
1310 1320 1330 1340 1350 1360
pF1KA0 QVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILA
:: :.:.: :.:: :::.:.::::::..:::.:.. :: . ...::.. ::::::..:
XP_011 QVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLE
900 910 920 930 940 950
1370 1380 1390 1400 1410 1420
pF1KA0 IKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTAD
... . :.:.:::. :. ::::::: ::.::::.:.: .: :: :: :..:. :.
XP_011 MRGTA-AGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQ
960 970 980 990 1000 1010
1430 1440 1450 1460 1470 1480
pF1KA0 TIKHCSDRSTLG-SIKEGILKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDK
. : . : . :.:. .::: ..: :..::.:.:.:: :.: :. :::: ..
XP_011 A--GCLFTGIRRESPRVGLLRCREEPPRLL-GSRFQERFFLLRGRCLLLLKEKKSSKPER
1020 1030 1040 1050 1060 1070
1490 1500 1510 1520 1530 1540
pF1KA0 MFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKHHWHLCCDSSQTQTEWMTSIFIAQHEYDI
. : . : : :..::.:::: ::.: :: : .: : . . . .: :::. :::. :
XP_011 EWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSILKAQHD-DQ
1080 1090 1100 1110 1120 1130
1550 1560 1570 1580 1590 1600
pF1KA0 WPPAGKERKRSITKNPKIGGLPLIPIQ-HEGNATLARKNIESARAELERLRLSEKCDKES
: . .... : :.: .::.::. ...::: : .. : .: :: .:
XP_011 QPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSAN-QTLRRLHNRRTLSMFFPMKS
1140 1150 1160 1170 1180 1190
1610 1620 1630 1640 1650
pF1KA0 VDSSLKERASMVAHCLEHK-DDKLRNRPR----KHRSFNCLED--TEPEAPLGQPKGHKG
..:..:. . :. ... :. ::. .. ..:: :: . :
XP_011 SQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLTSQKSLDQ
1200 1210 1220 1230 1240 1250
1660 1670 1680 1690 1700
pF1KA0 LKTLRKTEDRNSKATLDSDHKLPSRVIEELNVVLQRSRTLPKELQDEQILK
XP_011 PFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPS
1260 1270 1280 1290 1300 1310
1704 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:46:43 2016 done: Thu Nov 3 09:46:46 2016
Total Scan time: 16.830 Total Display time: 1.190
Function used was FASTA [36.3.4 Apr, 2011]