Result of FASTA (omim) for
pF1KA0226
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0226, 927 aa
1>>>pF1KA0226 927 - 927 aa - 927 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7495+/-0.000387; mu= -0.4450+/- 0.024
mean_var=194.5056+/-39.519, 0's: 0 Z-trim(118.8): 44 B-trim: 76 in 1/52
Lambda= 0.091962
statistics sampled from 32017 (32063) to 32017 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.376), width: 16
Scan time: 11.880
The best scores are: opt bits E(85289)
NP_001139114 (OMIM: 613516,615705) run domain Becl ( 927) 6211 837.2 0
XP_005269431 (OMIM: 613516,615705) PREDICTED: run ( 987) 6211 837.2 0
XP_016863034 (OMIM: 613516,615705) PREDICTED: run ( 820) 5480 740.2 9.7e-213
XP_016863033 (OMIM: 613516,615705) PREDICTED: run ( 820) 5480 740.2 9.7e-213
NP_055502 (OMIM: 613516,615705) run domain Beclin- ( 972) 3773 513.8 1.7e-144
XP_006713892 (OMIM: 613516,615705) PREDICTED: run ( 952) 3622 493.7 1.8e-138
XP_006713890 (OMIM: 613516,615705) PREDICTED: run (1012) 3622 493.7 1.9e-138
XP_006713894 (OMIM: 613516,615705) PREDICTED: run ( 845) 2891 396.7 2.5e-109
XP_006713893 (OMIM: 613516,615705) PREDICTED: run ( 845) 2891 396.7 2.5e-109
XP_016863032 (OMIM: 613516,615705) PREDICTED: run ( 830) 2605 358.8 6.5e-98
XP_006713891 (OMIM: 613516,615705) PREDICTED: run ( 997) 2605 358.8 7.7e-98
XP_016880943 (OMIM: 611466,611497) PREDICTED: plec ( 531) 485 77.4 2e-13
XP_011523830 (OMIM: 611466,611497) PREDICTED: plec ( 535) 485 77.4 2.1e-13
XP_016880942 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 77.5 3.4e-13
XP_006722264 (OMIM: 611466,611497) PREDICTED: plec ( 926) 485 77.5 3.4e-13
XP_016880941 (OMIM: 611466,611497) PREDICTED: plec ( 967) 485 77.5 3.5e-13
XP_011523828 (OMIM: 611466,611497) PREDICTED: plec ( 989) 485 77.5 3.6e-13
XP_011523827 (OMIM: 611466,611497) PREDICTED: plec (1005) 485 77.5 3.6e-13
NP_055613 (OMIM: 611466,611497) pleckstrin homolog (1056) 485 77.5 3.8e-13
XP_016880940 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 77.5 3.8e-13
XP_011523826 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 77.5 3.8e-13
XP_011523825 (OMIM: 611466,611497) PREDICTED: plec (1056) 485 77.5 3.8e-13
>>NP_001139114 (OMIM: 613516,615705) run domain Beclin-1 (927 aa)
initn: 6211 init1: 6211 opt: 6211 Z-score: 4463.6 bits: 837.2 E(85289): 0
Smith-Waterman score: 6211; 100.0% identity (100.0% similar) in 927 aa overlap (1-927:1-927)
10 20 30 40 50 60
pF1KA0 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQ
850 860 870 880 890 900
910 920
pF1KA0 SLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::
NP_001 SLESYLSDYEEEPAEALALEAAVLEAT
910 920
>>XP_005269431 (OMIM: 613516,615705) PREDICTED: run doma (987 aa)
initn: 6211 init1: 6211 opt: 6211 Z-score: 4463.2 bits: 837.2 E(85289): 0
Smith-Waterman score: 6211; 100.0% identity (100.0% similar) in 927 aa overlap (1-927:61-987)
10 20 30
pF1KA0 MQSILYHGLIRDQACRRQTDYWQFVKDIRW
::::::::::::::::::::::::::::::
XP_005 NLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRW
40 50 60 70 80 90
40 50 60 70 80 90
pF1KA0 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
100 110 120 130 140 150
100 110 120 130 140 150
pF1KA0 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KA0 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
220 230 240 250 260 270
220 230 240 250 260 270
pF1KA0 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
280 290 300 310 320 330
280 290 300 310 320 330
pF1KA0 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
340 350 360 370 380 390
340 350 360 370 380 390
pF1KA0 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
400 410 420 430 440 450
400 410 420 430 440 450
pF1KA0 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
460 470 480 490 500 510
460 470 480 490 500 510
pF1KA0 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
520 530 540 550 560 570
520 530 540 550 560 570
pF1KA0 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
580 590 600 610 620 630
580 590 600 610 620 630
pF1KA0 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
640 650 660 670 680 690
640 650 660 670 680 690
pF1KA0 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
700 710 720 730 740 750
700 710 720 730 740 750
pF1KA0 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
760 770 780 790 800 810
760 770 780 790 800 810
pF1KA0 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
820 830 840 850 860 870
820 830 840 850 860 870
pF1KA0 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
880 890 900 910 920 930
880 890 900 910 920
pF1KA0 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
940 950 960 970 980
>>XP_016863034 (OMIM: 613516,615705) PREDICTED: run doma (820 aa)
initn: 5480 init1: 5480 opt: 5480 Z-score: 3940.3 bits: 740.2 E(85289): 9.7e-213
Smith-Waterman score: 5480; 100.0% identity (100.0% similar) in 820 aa overlap (108-927:1-820)
80 90 100 110 120 130
pF1KA0 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
140 150 160 170 180 190
pF1KA0 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KA0 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
260 270 280 290 300 310
pF1KA0 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KA0 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
380 390 400 410 420 430
pF1KA0 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KA0 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
500 510 520 530 540 550
pF1KA0 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
400 410 420 430 440 450
560 570 580 590 600 610
pF1KA0 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
460 470 480 490 500 510
620 630 640 650 660 670
pF1KA0 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
520 530 540 550 560 570
680 690 700 710 720 730
pF1KA0 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
580 590 600 610 620 630
740 750 760 770 780 790
pF1KA0 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
640 650 660 670 680 690
800 810 820 830 840 850
pF1KA0 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
700 710 720 730 740 750
860 870 880 890 900 910
pF1KA0 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
760 770 780 790 800 810
920
pF1KA0 ALEAAVLEAT
::::::::::
XP_016 ALEAAVLEAT
820
>>XP_016863033 (OMIM: 613516,615705) PREDICTED: run doma (820 aa)
initn: 5480 init1: 5480 opt: 5480 Z-score: 3940.3 bits: 740.2 E(85289): 9.7e-213
Smith-Waterman score: 5480; 100.0% identity (100.0% similar) in 820 aa overlap (108-927:1-820)
80 90 100 110 120 130
pF1KA0 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
140 150 160 170 180 190
pF1KA0 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KA0 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
260 270 280 290 300 310
pF1KA0 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KA0 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
380 390 400 410 420 430
pF1KA0 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KA0 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
500 510 520 530 540 550
pF1KA0 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRN
400 410 420 430 440 450
560 570 580 590 600 610
pF1KA0 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLL
460 470 480 490 500 510
620 630 640 650 660 670
pF1KA0 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCA
520 530 540 550 560 570
680 690 700 710 720 730
pF1KA0 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLI
580 590 600 610 620 630
740 750 760 770 780 790
pF1KA0 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGH
640 650 660 670 680 690
800 810 820 830 840 850
pF1KA0 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIF
700 710 720 730 740 750
860 870 880 890 900 910
pF1KA0 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEAL
760 770 780 790 800 810
920
pF1KA0 ALEAAVLEAT
::::::::::
XP_016 ALEAAVLEAT
820
>>NP_055502 (OMIM: 613516,615705) run domain Beclin-1-in (972 aa)
initn: 6098 init1: 3746 opt: 3773 Z-score: 2715.2 bits: 513.8 E(85289): 1.7e-144
Smith-Waterman score: 6072; 98.4% identity (98.4% similar) in 927 aa overlap (1-927:61-972)
10 20 30
pF1KA0 MQSILYHGLIRDQACRRQTDYWQFVKDIRW
::::::::::::::::::::::::::::::
NP_055 NLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRW
40 50 60 70 80 90
40 50 60 70 80 90
pF1KA0 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
100 110 120 130 140 150
100 110 120 130 140 150
pF1KA0 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KA0 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
220 230 240 250 260 270
220 230 240 250 260 270
pF1KA0 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
280 290 300 310 320 330
280 290 300 310 320 330
pF1KA0 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
340 350 360 370 380 390
340 350 360 370 380 390
pF1KA0 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
:::::::::::::::::::::::::::::: :::::::::::::::
NP_055 EGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ESCNDKAKLRGPLPY
400 410 420 430
400 410 420 430 440 450
pF1KA0 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA0 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA0 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQS
560 570 580 590 600 610
580 590 600 610 620 630
pF1KA0 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KA0 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKR
680 690 700 710 720 730
700 710 720 730 740 750
pF1KA0 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDI
740 750 760 770 780 790
760 770 780 790 800 810
pF1KA0 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDL
800 810 820 830 840 850
820 830 840 850 860 870
pF1KA0 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEEC
860 870 880 890 900 910
880 890 900 910 920
pF1KA0 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
920 930 940 950 960 970
>>XP_006713892 (OMIM: 613516,615705) PREDICTED: run doma (952 aa)
initn: 3622 init1: 3622 opt: 3622 Z-score: 2607.1 bits: 493.7 E(85289): 1.8e-138
Smith-Waterman score: 6151; 97.4% identity (97.4% similar) in 952 aa overlap (1-927:1-952)
10 20 30 40 50 60
pF1KA0 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGS
490 500 510 520 530 540
550 560 570
pF1KA0 ADEVDEFEIQD-------------------------ADIRRNTASSSKSFVSSQSFSHCF
::::::::::: ::::::::::::::::::::::::
XP_006 ADEVDEFEIQDGSEGSNLTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCF
550 560 570 580 590 600
580 590 600 610 620 630
pF1KA0 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADI
610 620 630 640 650 660
640 650 660 670 680 690
pF1KA0 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KA0 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALY
730 740 750 760 770 780
760 770 780 790 800 810
pF1KA0 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRK
790 800 810 820 830 840
820 830 840 850 860 870
pF1KA0 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYH
850 860 870 880 890 900
880 890 900 910 920
pF1KA0 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
910 920 930 940 950
>>XP_006713890 (OMIM: 613516,615705) PREDICTED: run doma (1012 aa)
initn: 3622 init1: 3622 opt: 3622 Z-score: 2606.6 bits: 493.7 E(85289): 1.9e-138
Smith-Waterman score: 6151; 97.4% identity (97.4% similar) in 952 aa overlap (1-927:61-1012)
10 20 30
pF1KA0 MQSILYHGLIRDQACRRQTDYWQFVKDIRW
::::::::::::::::::::::::::::::
XP_006 NLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRW
40 50 60 70 80 90
40 50 60 70 80 90
pF1KA0 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIR
100 110 120 130 140 150
100 110 120 130 140 150
pF1KA0 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTAL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KA0 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAED
220 230 240 250 260 270
220 230 240 250 260 270
pF1KA0 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNL
280 290 300 310 320 330
280 290 300 310 320 330
pF1KA0 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFS
340 350 360 370 380 390
340 350 360 370 380 390
pF1KA0 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPY
400 410 420 430 440 450
400 410 420 430 440 450
pF1KA0 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAH
460 470 480 490 500 510
460 470 480 490 500 510
pF1KA0 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMY
520 530 540 550 560 570
520 530 540 550
pF1KA0 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_006 QEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSNLTHISKNGLSVSL
580 590 600 610 620 630
560 570 580 590 600
pF1KA0 ------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEW
640 650 660 670 680 690
610 620 630 640 650 660
pF1KA0 LVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTR
700 710 720 730 740 750
670 680 690 700 710 720
pF1KA0 KIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSK
760 770 780 790 800 810
730 740 750 760 770 780
pF1KA0 YYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAK
820 830 840 850 860 870
790 800 810 820 830 840
pF1KA0 ELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFI
880 890 900 910 920 930
850 860 870 880 890 900
pF1KA0 CEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESY
940 950 960 970 980 990
910 920
pF1KA0 LSDYEEEPAEALALEAAVLEAT
::::::::::::::::::::::
XP_006 LSDYEEEPAEALALEAAVLEAT
1000 1010
>>XP_006713894 (OMIM: 613516,615705) PREDICTED: run doma (845 aa)
initn: 2891 init1: 2891 opt: 2891 Z-score: 2083.8 bits: 396.7 E(85289): 2.5e-109
Smith-Waterman score: 5420; 97.0% identity (97.0% similar) in 845 aa overlap (108-927:1-845)
80 90 100 110 120 130
pF1KA0 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
140 150 160 170 180 190
pF1KA0 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KA0 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
260 270 280 290 300 310
pF1KA0 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KA0 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
380 390 400 410 420 430
pF1KA0 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KA0 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
500 510 520 530 540 550
pF1KA0 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN
400 410 420 430 440 450
560 570 580 590
pF1KA0 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
:::::::::::::::::::::::::::::::::::::::::
XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
460 470 480 490 500 510
600 610 620 630 640 650
pF1KA0 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
520 530 540 550 560 570
660 670 680 690 700 710
pF1KA0 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
580 590 600 610 620 630
720 730 740 750 760 770
pF1KA0 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
640 650 660 670 680 690
780 790 800 810 820 830
pF1KA0 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
700 710 720 730 740 750
840 850 860 870 880 890
pF1KA0 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
760 770 780 790 800 810
900 910 920
pF1KA0 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::
XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
820 830 840
>>XP_006713893 (OMIM: 613516,615705) PREDICTED: run doma (845 aa)
initn: 2891 init1: 2891 opt: 2891 Z-score: 2083.8 bits: 396.7 E(85289): 2.5e-109
Smith-Waterman score: 5420; 97.0% identity (97.0% similar) in 845 aa overlap (108-927:1-845)
80 90 100 110 120 130
pF1KA0 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_006 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
140 150 160 170 180 190
pF1KA0 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KA0 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
260 270 280 290 300 310
pF1KA0 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KA0 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
220 230 240 250 260 270
380 390 400 410 420 430
pF1KA0 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KA0 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
340 350 360 370 380 390
500 510 520 530 540 550
pF1KA0 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN
400 410 420 430 440 450
560 570 580 590
pF1KA0 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
:::::::::::::::::::::::::::::::::::::::::
XP_006 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
460 470 480 490 500 510
600 610 620 630 640 650
pF1KA0 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
520 530 540 550 560 570
660 670 680 690 700 710
pF1KA0 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
580 590 600 610 620 630
720 730 740 750 760 770
pF1KA0 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
640 650 660 670 680 690
780 790 800 810 820 830
pF1KA0 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
700 710 720 730 740 750
840 850 860 870 880 890
pF1KA0 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
760 770 780 790 800 810
900 910 920
pF1KA0 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::
XP_006 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
820 830 840
>>XP_016863032 (OMIM: 613516,615705) PREDICTED: run doma (830 aa)
initn: 4226 init1: 2605 opt: 2605 Z-score: 1878.8 bits: 358.8 E(85289): 6.5e-98
Smith-Waterman score: 5281; 95.3% identity (95.3% similar) in 845 aa overlap (108-927:1-830)
80 90 100 110 120 130
pF1KA0 QLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHES
::::::::::::::::::::::::::::::
XP_016 MLQCLEAVEQNNPRLLAQIDASMFARKHES
10 20 30
140 150 160 170 180 190
pF1KA0 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRK
40 50 60 70 80 90
200 210 220 230 240 250
pF1KA0 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGD
100 110 120 130 140 150
260 270 280 290 300 310
pF1KA0 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGE
160 170 180 190 200 210
320 330 340 350 360 370
pF1KA0 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAES
::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 SQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP---------------ES
220 230 240 250
380 390 400 410 420 430
pF1KA0 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQD
260 270 280 290 300 310
440 450 460 470 480 490
pF1KA0 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLR
320 330 340 350 360 370
500 510 520 530 540 550
pF1KA0 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQD------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDGSEGSN
380 390 400 410 420 430
560 570 580 590
pF1KA0 -------------------ADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
:::::::::::::::::::::::::::::::::::::::::
XP_016 LTHISKNGLSVSLASMFSDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQF
440 450 460 470 480 490
600 610 620 630 640 650
pF1KA0 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPR
500 510 520 530 540 550
660 670 680 690 700 710
pF1KA0 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMA
560 570 580 590 600 610
720 730 740 750 760 770
pF1KA0 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLC
620 630 640 650 660 670
780 790 800 810 820 830
pF1KA0 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATH
680 690 700 710 720 730
840 850 860 870 880 890
pF1KA0 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQA
740 750 760 770 780 790
900 910 920
pF1KA0 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
:::::::::::::::::::::::::::::::::::
XP_016 RREALARQSLESYLSDYEEEPAEALALEAAVLEAT
800 810 820 830
927 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:22:34 2016 done: Wed Nov 2 18:22:35 2016
Total Scan time: 11.880 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]