Result of FASTA (omim) for
pF1KA0151
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0151, 716 aa
1>>>pF1KA0151 716 - 716 aa - 716 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3464+/-0.000624; mu= 3.1930+/- 0.038
mean_var=761.8380+/-174.276, 0's: 0 Z-trim(115.4): 706 B-trim: 0 in 0/56
Lambda= 0.046467
statistics sampled from 25025 (25871) to 25025 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.303), width: 16
Scan time: 10.390
The best scores are: opt bits E(85289)
XP_005273413 (OMIM: 605048) PREDICTED: inhibitor o ( 716) 4690 331.6 6.6e-90
NP_054721 (OMIM: 605048) inhibitor of nuclear fact ( 716) 4690 331.6 6.6e-90
NP_001180251 (OMIM: 605048) inhibitor of nuclear f ( 657) 4207 299.1 3.6e-80
NP_001180250 (OMIM: 605048) inhibitor of nuclear f ( 631) 4154 295.6 4.1e-79
XP_016858357 (OMIM: 605048) PREDICTED: inhibitor o ( 594) 3911 279.2 3.2e-74
XP_005268867 (OMIM: 604834,616439) PREDICTED: seri ( 729) 1981 150.0 3.1e-35
XP_005268866 (OMIM: 604834,616439) PREDICTED: seri ( 729) 1981 150.0 3.1e-35
NP_037386 (OMIM: 604834,616439) serine/threonine-p ( 729) 1981 150.0 3.1e-35
XP_016871101 (OMIM: 600664,613630) PREDICTED: inhi ( 598) 388 43.1 0.004
NP_001307857 (OMIM: 600664,613630) inhibitor of nu ( 719) 388 43.2 0.0043
NP_001269 (OMIM: 600664,613630) inhibitor of nucle ( 745) 388 43.2 0.0044
XP_016871100 (OMIM: 600664,613630) PREDICTED: inhi ( 814) 388 43.3 0.0046
XP_011537101 (OMIM: 603168) PREDICTED: serine/thre (1044) 375 42.6 0.0093
NP_003556 (OMIM: 603168) serine/threonine-protein (1050) 375 42.6 0.0094
XP_011537100 (OMIM: 603168) PREDICTED: serine/thre (1073) 375 42.7 0.0094
NP_001136082 (OMIM: 608650) serine/threonine-prote (1036) 374 42.6 0.0097
NP_055498 (OMIM: 608650) serine/threonine-protein (1036) 374 42.6 0.0097
>>XP_005273413 (OMIM: 605048) PREDICTED: inhibitor of nu (716 aa)
initn: 4690 init1: 4690 opt: 4690 Z-score: 1735.1 bits: 331.6 E(85289): 6.6e-90
Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 716 aa overlap (1-716:1-716)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
610 620 630 640 650 660
670 680 690 700 710
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
670 680 690 700 710
>>NP_054721 (OMIM: 605048) inhibitor of nuclear factor k (716 aa)
initn: 4690 init1: 4690 opt: 4690 Z-score: 1735.1 bits: 331.6 E(85289): 6.6e-90
Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 716 aa overlap (1-716:1-716)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
610 620 630 640 650 660
670 680 690 700 710
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
670 680 690 700 710
>>NP_001180251 (OMIM: 605048) inhibitor of nuclear facto (657 aa)
initn: 4207 init1: 4207 opt: 4207 Z-score: 1560.4 bits: 299.1 E(85289): 3.6e-80
Smith-Waterman score: 4207; 100.0% identity (100.0% similar) in 644 aa overlap (1-644:1-644)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
::::::::::::::::::::::::::::::::::::::::::::
NP_001 QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKHARALRGDEAAGI
610 620 630 640 650
670 680 690 700 710
pF1KA0 AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV
>>NP_001180250 (OMIM: 605048) inhibitor of nuclear facto (631 aa)
initn: 4154 init1: 4154 opt: 4154 Z-score: 1541.3 bits: 295.6 E(85289): 4.1e-79
Smith-Waterman score: 4154; 100.0% identity (100.0% similar) in 631 aa overlap (86-716:1-631)
60 70 80 90 100 110
pF1KA0 FEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVV
::::::::::::::::::::::::::::::
NP_001 MEYCSSGSLLSVLESPENAFGLPEDEFLVV
10 20 30
120 130 140 150 160 170
pF1KA0 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYG
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMY
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGF
160 170 180 190 200 210
300 310 320 330 340 350
pF1KA0 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFE
220 230 240 250 260 270
360 370 380 390 400 410
pF1KA0 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTA
280 290 300 310 320 330
420 430 440 450 460 470
pF1KA0 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTE
340 350 360 370 380 390
480 490 500 510 520 530
pF1KA0 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVH
400 410 420 430 440 450
540 550 560 570 580 590
pF1KA0 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEE
460 470 480 490 500 510
600 610 620 630 640 650
pF1KA0 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQ
520 530 540 550 560 570
660 670 680 690 700 710
pF1KA0 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPD
580 590 600 610 620 630
pF1KA0 V
:
NP_001 V
>>XP_016858357 (OMIM: 605048) PREDICTED: inhibitor of nu (594 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 1453.5 bits: 279.2 E(85289): 3.2e-74
Smith-Waterman score: 3911; 100.0% identity (100.0% similar) in 594 aa overlap (123-716:1-594)
100 110 120 130 140 150
pF1KA0 SLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSI
::::::::::::::::::::::::::::::
XP_016 MNHLRENGIVHRDIKPGNIMRLVGEEGQSI
10 20 30
160 170 180 190 200 210
pF1KA0 YKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLY
40 50 60 70 80 90
220 230 240 250 260 270
pF1KA0 HAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLG
100 110 120 130 140 150
280 290 300 310 320 330
pF1KA0 LQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQSQLVPILANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KA0 AIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAF
220 230 240 250 260 270
400 410 420 430 440 450
pF1KA0 RDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQA
280 290 300 310 320 330
460 470 480 490 500 510
pF1KA0 TCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQN
340 350 360 370 380 390
520 530 540 550 560 570
pF1KA0 ITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQ
400 410 420 430 440 450
580 590 600 610 620 630
pF1KA0 IHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACN
460 470 480 490 500 510
640 650 660 670 680 690
pF1KA0 TEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKL
520 530 540 550 560 570
700 710
pF1KA0 LASDLLDNNRIIERLNRVPAPPDV
::::::::::::::::::::::::
XP_016 LASDLLDNNRIIERLNRVPAPPDV
580 590
>>XP_005268867 (OMIM: 604834,616439) PREDICTED: serine/t (729 aa)
initn: 2148 init1: 1951 opt: 1981 Z-score: 753.5 bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::.:.:: .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
XP_005 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::.:::::::.:: .:.:::.::.: ::: .::: : ::.::::.:::.::: ::
XP_005 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
.::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
XP_005 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
:::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: :
XP_005 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::.:::.:.:. ::::..:: .:..:.:: ::: :.:.::::::..: ::::::::::
XP_005 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::.:.:.:::::.: . :.::::..:: .::.: :.:::.. .:: ..::. :
XP_005 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
:::. :::. .:: .:. . : . ... ...:: :. ::..: . ::.. :
XP_005 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
370 380 390 400 410 420
430 440 450 460 470
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
. : :.: .:: :::: .:..:..:... : .. ::. : . . . :
XP_005 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
430 440 450 460 470 480
480 490 500 510 520
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
:.. .. . : :: ......: :. . .. . . :: :: ..
XP_005 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
490 500 510 520 530
530 540 550 560 570 580
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
.. .::.....: :. :. :: ::::.. . :.::::::::.:: .. . : . .
XP_005 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
: .:::.::.: : . .: . . :..: . . . :.. :: ..: : :
XP_005 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
.... ..: . . :: : : : .. : :..: : :. ....: .::.:.::.
XP_005 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
660 670 680 690 700 710
710
pF1KA0 VPAPPDV
XP_005 LTMDGGLRNVDCL
720
>>XP_005268866 (OMIM: 604834,616439) PREDICTED: serine/t (729 aa)
initn: 2148 init1: 1951 opt: 1981 Z-score: 753.5 bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::.:.:: .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
XP_005 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::.:::::::.:: .:.:::.::.: ::: .::: : ::.::::.:::.::: ::
XP_005 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
.::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
XP_005 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
:::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: :
XP_005 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::.:::.:.:. ::::..:: .:..:.:: ::: :.:.::::::..: ::::::::::
XP_005 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::.:.:.:::::.: . :.::::..:: .::.: :.:::.. .:: ..::. :
XP_005 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
:::. :::. .:: .:. . : . ... ...:: :. ::..: . ::.. :
XP_005 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
370 380 390 400 410 420
430 440 450 460 470
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
. : :.: .:: :::: .:..:..:... : .. ::. : . . . :
XP_005 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
430 440 450 460 470 480
480 490 500 510 520
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
:.. .. . : :: ......: :. . .. . . :: :: ..
XP_005 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
490 500 510 520 530
530 540 550 560 570 580
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
.. .::.....: :. :. :: ::::.. . :.::::::::.:: .. . : . .
XP_005 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
: .:::.::.: : . .: . . :..: . . . :.. :: ..: : :
XP_005 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
.... ..: . . :: : : : .. : :..: : :. ....: .::.:.::.
XP_005 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
660 670 680 690 700 710
710
pF1KA0 VPAPPDV
XP_005 LTMDGGLRNVDCL
720
>>NP_037386 (OMIM: 604834,616439) serine/threonine-prote (729 aa)
initn: 2148 init1: 1951 opt: 1981 Z-score: 753.5 bits: 150.0 E(85289): 3.1e-35
Smith-Waterman score: 2222; 49.3% identity (74.9% similar) in 718 aa overlap (1-707:1-714)
10 20 30 40 50 60
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
::::.:.:: .:.:::::::.:...:.::.:.: :.::::. :.::: .::.::::::.
NP_037 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
::::.:::::::.:: .:.:::.::.: ::: .::: : ::.::::.:::.::: ::
NP_037 KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
.::::::::::::::::::::::..::.:::.::::::::::::.:::.:::.:::::::
NP_037 GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
:::::::::::: .:: .:.::::::::::.:::::::::: :: :::::::.::.: :
NP_037 HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
::.:::.:.:. ::::..:: .:..:.:: ::: :.:.::::::..: ::::::::::
NP_037 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
::::::.:.:.:::::.: . :.::::..:: .::.: :.:::.. .:: ..::. :
NP_037 ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
:::. :::. .:: .:. . : . ... ...:: :. ::..: . ::.. :
NP_037 LEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITG
370 380 390 400 410 420
430 440 450 460 470
pF1KA0 AGYQALRLARALLDGQELMFRGLHWVMEVLQ----ATCRRTLEVARTSLLYLSSSLGT--
. : :.: .:: :::: .:..:..:... : .. ::. : . . . :
NP_037 VVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVK
430 440 450 460 470 480
480 490 500 510 520
pF1KA0 --ERFSSVAGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLS---SLNRELVK
:.. .. . : :: ......: :. . .. . . :: :: ..
NP_037 VYEKLMKI--NLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAH
490 500 510 520 530
530 540 550 560 570 580
pF1KA0 SRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLL
.. .::.....: :. :. :: ::::.. . :.::::::::.:: .. . : . .
NP_037 QEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAM
540 550 560 570 580 590
590 600 610 620 630 640
pF1KA0 QVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEEL
: .:::.::.: : . .: . . :..: . . . :.. :: ..: : :
NP_037 THFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETL
600 610 620 630 640 650
650 660 670 680 690 700
pF1KA0 SHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNR
.... ..: . . :: : : : .. : :..: : :. ....: .::.:.::.
NP_037 PQKMFTA-SSGIKHTMTPIYP-SSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGS
660 670 680 690 700 710
710
pF1KA0 VPAPPDV
NP_037 LTMDGGLRNVDCL
720
>>XP_016871101 (OMIM: 600664,613630) PREDICTED: inhibito (598 aa)
initn: 313 init1: 195 opt: 388 Z-score: 177.1 bits: 43.1 E(85289): 0.004
Smith-Waterman score: 474; 25.7% identity (53.3% similar) in 604 aa overlap (9-572:15-585)
10 20 30 40 50
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR
:. . :: :. ..: .... .:.: . :: .
XP_016 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 EFEVLRKLNHQNIVKLFAV-EETGGSRQKV--LVMEYCSSGSLLSVLESPENAFGLPEDE
:.....:::: :.:: : :: . . : :.:::::.:.: ..:..::: :: :..
XP_016 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 FLVVLRCVVAGMNHLRENGIVHRDIKPGNI-MRLVGEEGQSIYKLTDFGAARELDDDEKF
.: .: . .:. .:.:: :.:::.:: :: .. :: :. :.:. :.: :...:.
XP_016 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLC
130 140 150 160 170
180 190 200 210 220 230
pF1KA0 VSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN
.: :: .:: :...: :: . .::: ::.:. ... .: ::. :
XP_016 TSFVGTLQYLAPELFEN----KP----YTATVDYWSFGTMVFECIAGYRPFLHHLQPFTW
180 190 200 210 220 230
240 250 260 270 280
pF1KA0 KEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPIT---CQLSLGLQSQLVPILANI---
.: .: . : .: . .: ...: :: :.: . . . . .. :
XP_016 HE---KIKKKDPKCIFACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQ
240 250 260 270 280
290 300 310 320 330
pF1KA0 -------LEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQE
: ..: .: :. . ::. .::......: . . . ... .:
XP_016 QRGGPVDLTLKQPRC------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQS
290 300 310 320 330
340 350 360 370 380 390
pF1KA0 AVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIA----HTTASSPLTLF--STAIPKG-L
....:.. :: : : . :.: :.. . . : . :: : .. .: .
XP_016 RIERETGINTGSQELLSETGIS-LDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPF
340 350 360 370 380 390
400 410 420 430 440 450
pF1KA0 AFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVL
: :. . : .: .: . : . .:.. . .: . .:.: . .: :
XP_016 ASRSLSDCVNYIVQDSKIQLPIIQLRKVWA---EAVHYVSGLKEDYSRLFQGQRAAMLSL
400 410 420 430 440 450
460 470 480 490
pF1KA0 Q------ATCRRTLEVARTSL------LYLSSSLGTERFSS--VAGTPEIQELKAAAELR
. . :: : .: .. : .: ::.: . : . ::: :..
XP_016 LRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEME
460 470 480 490 500 510
500 510 520 530 540 550
pF1KA0 SRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQ
. ::: : .... ::. :... . . . :. . .. .. .:::
XP_016 EKAIHYAEV-----GVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ
520 530 540 550 560 570
560 570 580 590 600 610
pF1KA0 FKKSRMRPGLGY--NEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVV
.:. ::.. . : ::
XP_016 LKH---RPSVEHLLNTEQGLLERVLDGESEA
580 590
>>NP_001307857 (OMIM: 600664,613630) inhibitor of nuclea (719 aa)
initn: 313 init1: 195 opt: 388 Z-score: 176.4 bits: 43.2 E(85289): 0.0043
Smith-Waterman score: 469; 25.6% identity (53.2% similar) in 594 aa overlap (9-564:15-575)
10 20 30 40 50
pF1KA0 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVR
:. . :: :. ..: .... .:.: . :: .
NP_001 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA0 EFEVLRKLNHQNIVKLFAV-EETGGSRQKV--LVMEYCSSGSLLSVLESPENAFGLPEDE
:.....:::: :.:: : :: . . : :.:::::.:.: ..:..::: :: :..
NP_001 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA0 FLVVLRCVVAGMNHLRENGIVHRDIKPGNI-MRLVGEEGQSIYKLTDFGAARELDDDEKF
.: .: . .:. .:.:: :.:::.:: :: .. :: :. :.:. :.: :...:.
NP_001 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLC
130 140 150 160 170
180 190 200 210 220 230
pF1KA0 VSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRN
.: :: .:: :...: :: . .::: ::.:. ... .: ::. :
NP_001 TSFVGTLQYLAPELFE----NKP----YTATVDYWSFGTMVFECIAGYRPFLHHLQPFTW
180 190 200 210 220 230
240 250 260 270 280
pF1KA0 KEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPIT---CQLSLGLQSQLVPILANI---
.: .: . : .: . .: ...: :: :.: . . . . .. :
NP_001 HE---KIKKKDPKCIFACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQ
240 250 260 270 280
290 300 310 320 330
pF1KA0 -------LEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQE
: ..: .: :. . ::. .::......: . . . ... .:
NP_001 QRGGPVDLTLKQPRC------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQS
290 300 310 320 330
340 350 360 370 380 390
pF1KA0 AVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIA----HTTASSPLTLF--STAIPKG-L
....:.. :: : : . :.: :.. . . : . :: : .. .: .
NP_001 RIERETGINTGSQELLSETGIS-LDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPF
340 350 360 370 380 390
400 410 420 430 440 450
pF1KA0 AFRDPALDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVL
: :. . : .: .: . : . .:.. . .: . .:.: . .: :
NP_001 ASRSLSDCVNYIVQDSKIQLPIIQLRKVWA---EAVHYVSGLKEDYSRLFQGQRAAMLSL
400 410 420 430 440 450
460 470 480 490
pF1KA0 Q------ATCRRTLEVARTSL------LYLSSSLGTERFSS--VAGTPEIQELKAAAELR
. . :: : .: .. : .: ::.: . : . ::: :..
NP_001 LRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEME
460 470 480 490 500 510
500 510 520 530 540 550
pF1KA0 SRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQ
. ::: : .... ::. :... . . . :. . .. .. .:::
NP_001 EKAIHYAEV-----GVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ
520 530 540 550 560 570
560 570 580 590 600 610
pF1KA0 FKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHE
.:. ::
NP_001 LKH---RPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEV
580 590 600 610 620
716 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:16:26 2016 done: Wed Nov 2 18:16:28 2016
Total Scan time: 10.390 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]