Gene/Protein Characteristic Table for FXC02170

Species
human

Product ID
FXC02170

Corresponding
HaloTag Clone PID

ORF Sequence
DNA sequence (1266 bp)
Protein sequence (422 aa)

Linker Type
Flexi type
The extra Val codon is attached to the 3'-end of the ORF, because a Pme I site ...

Cloning Site
SgfI-PmeI

GenBank Accession
ORF sequence is derived from [AB463112]

Gene
KIBB5188

Symbol
MCHR1
Alias : GPR24, MCH-1R, MCH1R, SLC-1, SLC1

Description
melanin-concentrating hormone receptor 1

Original Clone ID
oc00040

Features of the cloned ORF sequence

Length: 1266 bp
Restriction map A Restriction map B
Genomic Structure
Features of the protein sequence

Length: 422 aa
Result of homology search against nr database ( FASTA output, Multiple alignment)
Entry Exp ID% Protein Source
XP_003814658 2.6e-168 100.0 melanin-concent...
Pan paniscus
AAP36321 2.6e-168 100.0 G protein-coupl...
synthetic construct
NP_001012440 6.1e-168 99.8 melanin-concent...
Pan troglodytes
XP_003264838 2.2e-166 99.1 melanin-concent...
Nomascus leucogenys
EHH62291 3e-164 97.4 hypothetical pr...
Macaca fascicularis

The numbers on the left and right sides of a black line in the graphical overview indicate the lengths (in amino acid residues) of the non-homologous N-terminal and C-terminal portions flanking the homologous region (indicated by the black line), respectively.
Result of motif / domain search (InterProScan and SOSUI)
[ zoom out (x2) ] PR01507 PR01783 PR00237 PR01507 PR01783 PR00237 PR01783 PR01507 PR01783 PR00237 PR01507 PR00237 PR01783 PR01507 PR01783 PR00237 PR01507 PR00237 PR01783 PR01507 PR00237 PR01507 PR01507 PF00001 PS50262

Result of InterProScan

Search method interpro_ID From To Entry Definition
FPrintScan IPR004047 96 110 PR01507 Melanin-concentrating hormone 1 receptor
IPR008361 107 117 PR01783 Melanin-concentrating hormone receptor
IPR000276 111 135 PR00237 Rhodopsin-like GPCR superfamily
IPR004047 132 146 PR01507 Melanin-concentrating hormone 1 receptor
IPR008361 145 154 PR01783 Melanin-concentrating hormone receptor
IPR000276 147 168 PR00237 Rhodopsin-like GPCR superfamily
IPR008361 161 172 PR01783 Melanin-concentrating hormone receptor
IPR004047 171 181 PR01507 Melanin-concentrating hormone 1 receptor
IPR008361 180 193 PR01783 Melanin-concentrating hormone receptor
IPR000276 192 214 PR00237 Rhodopsin-like GPCR superfamily
IPR004047 214 236 PR01507 Melanin-concentrating hormone 1 receptor
IPR000276 228 249 PR00237 Rhodopsin-like GPCR superfamily
IPR008361 246 259 PR01783 Melanin-concentrating hormone receptor
IPR004047 255 275 PR01507 Melanin-concentrating hormone 1 receptor
IPR008361 273 282 PR01783 Melanin-concentrating hormone receptor
IPR000276 278 301 PR00237 Rhodopsin-like GPCR superfamily
IPR004047 298 321 PR01507 Melanin-concentrating hormone 1 receptor
IPR000276 323 347 PR00237 Rhodopsin-like GPCR superfamily
IPR008361 343 356 PR01783 Melanin-concentrating hormone receptor
IPR004047 350 369 PR01507 Melanin-concentrating hormone 1 receptor
IPR000276 362 388 PR00237 Rhodopsin-like GPCR superfamily
IPR004047 384 403 PR01507 Melanin-concentrating hormone 1 receptor
IPR004047 403 422 PR01507 Melanin-concentrating hormone 1 receptor
HMMPfam IPR000276 126 380 PF00001 Rhodopsin-like GPCR superfamily
ProfileScan IPR000276 126 380 PS50262 Rhodopsin-like GPCR superfamily

Prediction of transmembrane (TM) segments
Method No. N terminal transmembrane region C terminal type length
SOSUI2 1 110 IIMPSVFGTICLLGIIGNSTVIF 132 PRIMARY 23
2 145 NVPDIFIINLSVVDLLFLLGMPF 167 PRIMARY 23
3 196 QFTSTYILTAMAIDRYLATVHPI 218 SECONDARY 23
4 235 LLWALSFISITPVWLYARLIPFP 257 PRIMARY 23
5 276 WFTLYQFFLAFALPFVVITAAYV 298 PRIMARY 23
6 328 IAICLVFFVCWAPYYVLQLTQLS 350 PRIMARY 23
7 352 SRPTLTFVYLYNAAISLGYANSC 374 SECONDARY 23

Result of homology search against disease genes in OMIM database
(FASTA output, Multiple alignment)
H_id H_len (aa) OMIM_No. ID (%) Q_ali/Q_len (%)
NP_005288 422 601751 100.0 100.0
NP_001041 369 182452 65.3 82.9
NP_001042 418 182453 62.1 80.1
NP_001044 364 102200,182455 65.8 81.5
NP_000902 372 165195 62.8 80.3
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