FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2689, 562 aa 1>>>pF1KE2689 562 - 562 aa - 562 aa Library: /omim/omim.rfq.tfa 62035967 residues in 87258 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0491+/-0.000285; mu= 15.3118+/- 0.018 mean_var=78.5742+/-15.337, 0's: 0 Z-trim(118.9): 45 B-trim: 33 in 1/53 Lambda= 0.144689 statistics sampled from 32619 (32664) to 32619 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.374), width: 16 Scan time: 9.640 The best scores are: opt bits E(87258) NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 3917 827.0 0 NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 2522 535.8 1.4e-151 XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 2510 533.3 7.7e-151 XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 2380 506.1 1.2e-142 XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 2368 503.6 6.8e-142 NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 1872 400.1 1e-110 NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 1761 376.9 9.5e-104 NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 1757 376.1 1.6e-103 NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 1727 369.9 1.5e-101 XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 1245 269.1 1.5e-71 NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 1019 222.0 3.8e-57 NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 1019 222.0 3.9e-57 NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 1019 222.0 3.9e-57 NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 753 166.5 1.9e-40 NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 583 131.0 1.1e-29 XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 479 109.3 2.9e-23 NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 273 66.3 3.4e-10 NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 251 61.8 8.4e-09 NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 251 61.8 8.7e-09 NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 251 61.8 9.1e-09 XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 210 53.2 3e-06 NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 208 52.8 4.1e-06 XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 208 52.8 4.1e-06 XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 208 52.8 4.1e-06 XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 208 52.8 4.2e-06 XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 165 43.8 0.0021 XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 165 43.8 0.0021 XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 165 43.8 0.0022 XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 165 43.8 0.0022 XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 165 43.8 0.0023 XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 165 43.8 0.0023 XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 165 43.8 0.0024 XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 165 43.8 0.0024 XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 165 43.8 0.0024 XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 165 43.8 0.0024 XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 165 43.8 0.0025 NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 165 43.8 0.0025 XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 165 43.8 0.0025 XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 165 43.8 0.0025 XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 165 43.8 0.0026 XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 165 43.8 0.0026 XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 165 43.8 0.0026 XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 165 43.8 0.0027 XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 165 43.9 0.0028 XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 165 43.9 0.0028 >>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1 (562 aa) initn: 3917 init1: 3917 opt: 3917 Z-score: 4416.1 bits: 827.0 E(87258): 0 Smith-Waterman score: 3917; 100.0% identity (100.0% similar) in 562 aa overlap (1-562:1-562) 10 20 30 40 50 60 pF1KE2 MPIQIFCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPIQIFCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 PMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PMDLVAFANSCTLHGTNHIFVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 TLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 FSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 LKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 PGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 MVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKAS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 AKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGAS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 ILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAG 490 500 510 520 530 540 550 560 pF1KE2 MTYAANILPHHPARGTFEDFTC :::::::::::::::::::::: NP_001 MTYAANILPHHPARGTFEDFTC 550 560 >>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is (528 aa) initn: 2814 init1: 2515 opt: 2522 Z-score: 2842.8 bits: 535.8 E(87258): 1.4e-151 Smith-Waterman score: 2794; 78.9% identity (88.7% similar) in 522 aa overlap (53-562:7-528) 30 40 50 60 70 80 pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE .: : .:... :::.: :::: ::: NP_001 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY 10 20 30 90 100 110 120 130 140 pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : NP_001 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN 40 50 60 70 80 90 150 160 170 180 190 pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR :.::.: :: . . .:.: .. . : . .: ..:. .:::... NP_001 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN ::.:. : ..:::: : ..: :. ..:.::::::::::::::::::::::::::::::: NP_001 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE2 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE2 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH 460 470 480 490 500 510 560 pF1KE2 HPARGTFEDFTC :::::::::::: NP_001 HPARGTFEDFTC 520 >>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io (529 aa) initn: 2018 init1: 1733 opt: 2510 Z-score: 2829.2 bits: 533.3 E(87258): 7.7e-151 Smith-Waterman score: 2782; 78.8% identity (88.5% similar) in 523 aa overlap (53-562:7-529) 30 40 50 60 70 80 pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE .: : .:... :::.: :::: ::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY 10 20 30 90 100 110 120 130 140 pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN 40 50 60 70 80 90 150 160 170 180 190 pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR :.::.: :: . . .:.: .. . : . .: ..:. .:::... XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN ::.:. : ..:::: : ..: :. ..:.::::::::::::::::::::::::::::::: XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ 220 230 240 250 260 270 320 330 340 350 360 pF1KE2 EQR-LIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAP ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAP 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 YCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFN 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 KSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFD 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 YAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILP 460 470 480 490 500 510 550 560 pF1KE2 HHPARGTFEDFTC ::::::::::::: XP_011 HHPARGTFEDFTC 520 >>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io (559 aa) initn: 2771 init1: 2377 opt: 2380 Z-score: 2682.2 bits: 506.1 E(87258): 1.2e-142 Smith-Waterman score: 2722; 74.5% identity (83.7% similar) in 553 aa overlap (53-562:7-559) 30 40 50 60 70 80 pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE .: : .:... :::.: :::: ::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY 10 20 30 90 100 110 120 130 140 pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN 40 50 60 70 80 90 150 160 170 180 190 pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR :.::.: :: . . .:.: .. . : . .: ..:. .:::... XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE 100 110 120 130 140 150 200 210 220 pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSV------------------------------ ::.:. : ..:::: : ..: :. ..:.: XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEK 160 170 180 190 200 210 230 240 250 260 270 pF1KE2 -VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KE2 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSY 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE2 SITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEM 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE2 PCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKA 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE2 YEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVA 460 470 480 490 500 510 520 530 540 550 560 pF1KE2 LSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC ::::::::::::::::::::::::::::::::::::::::::: XP_011 LSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 520 530 540 550 >>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io (560 aa) initn: 2127 init1: 1733 opt: 2368 Z-score: 2668.6 bits: 503.6 E(87258): 6.8e-142 Smith-Waterman score: 2710; 74.4% identity (83.6% similar) in 554 aa overlap (53-562:7-560) 30 40 50 60 70 80 pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE .: : .:... :::.: :::: ::: XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY 10 20 30 90 100 110 120 130 140 pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : XP_011 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN 40 50 60 70 80 90 150 160 170 180 190 pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR :.::.: :: . . .:.: .. . : . .: ..:. .:::... XP_011 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE 100 110 120 130 140 150 200 210 220 pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSV------------------------------ ::.:. : ..:::: : ..: :. ..:.: XP_011 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEK 160 170 180 190 200 210 230 240 250 260 270 pF1KE2 -VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KE2 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQR-LIYLPPPWGTCKAVTMDSDLDFFDS :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::: XP_011 KVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDS 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE2 YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCE 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE2 MPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKK 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE2 AYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGV 460 470 480 490 500 510 520 530 540 550 560 pF1KE2 ALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC :::::::::::::::::::::::::::::::::::::::::::: XP_011 ALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 520 530 540 550 560 >>NP_064423 (OMIM: 602866) acid-sensing ion channel 1 is (574 aa) initn: 2142 init1: 1857 opt: 1872 Z-score: 2108.9 bits: 400.1 E(87258): 1e-110 Smith-Waterman score: 2579; 71.8% identity (81.0% similar) in 554 aa overlap (53-548:7-560) 30 40 50 60 70 80 pF1KE2 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE .: : .:... :::.: :::: ::: NP_064 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY 10 20 30 90 100 110 120 130 140 pF1KE2 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN . ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: : NP_064 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN 40 50 60 70 80 90 150 160 170 180 190 pF1KE2 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR :.::.: :: . . .:.: .. . : . .: ..:. .:::... NP_064 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN ::.:. : ..:::: : ..: :. ..:.::::::::::::::::::::::::::::::: NP_064 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 340 350 360 370 380 390 440 450 460 pF1KE2 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLG----------------------- ::::::::::::::::::::::::::::::::::::: NP_064 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKA 400 410 420 430 440 450 470 480 490 500 pF1KE2 -----------------------DIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGK ::::::::::::::::::::::::::::::::::::: NP_064 GCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGK 460 470 480 490 500 510 510 520 530 540 550 560 pF1KE2 CQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC :::::::::::::::::::::::::::::::::::::::::::: NP_064 CQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC 520 530 540 550 560 570 >>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is (563 aa) initn: 1178 init1: 979 opt: 1761 Z-score: 1983.8 bits: 376.9 E(87258): 9.5e-104 Smith-Waterman score: 1964; 59.5% identity (76.6% similar) in 516 aa overlap (73-562:66-563) 50 60 70 80 90 pF1KE2 EEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFV----EGGPGPRQVLWAVAFVL ::: :. . :: :..::..:: NP_899 GQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCT 40 50 60 70 80 90 100 110 120 130 140 150 pF1KE2 ALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTNAVRLSQLSYPDLLYLA ..: .: ..:. :.::.: : ... . .: :::::.::.: .:. .:: :: : . NP_899 SFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAG 100 110 120 130 140 150 160 170 180 190 pF1KE2 PMLGLDESDDPGVPLAPPGPEAFSG-EP----------FNL-----H------RFYNRSC ::: . . ::. : . : :: : : : :..: NP_899 HWLGLLLPNRTARPLVS---ELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLG 160 170 180 190 200 210 200 210 220 230 240 250 pF1KE2 HRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIML :.:::::: :.:.: ::::::: :::.::::: ::::.::.: : :.:::::::::::: NP_899 HQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML 220 230 240 250 260 270 260 270 280 290 300 310 pF1KE2 DIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIY :::::::::.::::.::.::::.:::::::.:::::..:::::::::::::: ::::: : NP_899 DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY 280 290 300 310 320 330 320 330 340 350 360 370 pF1KE2 LPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQY :::::: :.. : :::: ::::::::::::::.::::::::::::::::.:::::. NP_899 LPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH 340 350 360 370 380 390 380 390 400 410 420 430 pF1KE2 KECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIG ::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: :::::::.::. NP_899 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE2 ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIK :::::::::::.:::::::::::::.:.:::::::::::::::::::.:::::: ::.:: NP_899 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE2 HKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGT .:: :: ..: :..:. :... .: .....:. : . . :: NP_899 EKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV-PLQTTLGT 520 530 540 550 560 pF1KE2 FEDFTC .:...: NP_899 LEEIAC 560 >>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is (512 aa) initn: 1291 init1: 979 opt: 1757 Z-score: 1979.9 bits: 376.1 E(87258): 1.6e-103 Smith-Waterman score: 2088; 60.6% identity (79.8% similar) in 525 aa overlap (51-562:3-512) 30 40 50 60 70 pF1KE2 LGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGH-SPMDLVAFANSCTLHGTNHI ... ::: .: .. :::. :::: :: NP_001 MDLKESPSEGSLQPSSIQIFANTSTLHGIRHI 10 20 30 80 90 100 110 120 130 pF1KE2 FVEGGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLC :: : :.:::::::: .:: .: . ..::.::.:: ::: ..::.. :.::::::: NP_001 FVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLC 40 50 60 70 80 90 140 150 160 170 180 pF1KE2 NTNAVRLSQLSYPDLLYLAPMLGLDESDD--PGVPLAPPGP-EA---------FSGEPFN : :. :.:.:. :: . . .:.: . . : :: :. :: .. . :. NP_001 NLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 LHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGG . .: .: : :.::.:::...: :: ..:..:::.::::: ::::.::.: : :.::: NP_001 MLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 TGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFV ::::::::::::::::::.::::.::.::::.:::::::.:::::..::::::::::::: NP_001 TGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 ACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGD : ::::: ::::::: :.. : :::: ::::::::::::::.:::::::::::::: NP_001 ATQEQRLTYLPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGD 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 APYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKK ::.:::::.::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: :: NP_001 APFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKK 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLEL :::::.::.:::::::::::.:::::::::::::.:.:::::::::::::::::::.::: NP_001 FNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILEL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 FDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANI ::: ::.::.:: :: ..: :..:. :... .: .....:. NP_001 FDYIYELIKEKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV 460 470 480 490 550 560 pF1KE2 LPHHPARGTFEDFTC : . . ::.:...: NP_001 -PLQTTLGTLEEIAC 500 510 >>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is (666 aa) initn: 1208 init1: 848 opt: 1727 Z-score: 1944.3 bits: 369.9 E(87258): 1.5e-101 Smith-Waterman score: 1727; 49.8% identity (72.5% similar) in 546 aa overlap (36-562:136-666) 10 20 30 40 50 60 pF1KE2 FCSMSFSSGEEAPGPLGDIWGPHHHQQQQDISESEEEEEEKEKEAVRKEA-----SEGHS :. .::. . ::::: ... . : . NP_061 PGLLAREGQGREALASPSSRGQMPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAA 110 120 130 140 150 160 70 80 90 100 110 pF1KE2 PMDLVAFANSCTLHGTNHIFVEGGPGP---RQVLWAVAFVLALGAFLCQVGDRVAYYLSY : ::..::.. :::: .. :::: :..:::.:.. .:.::: :.. . ::. NP_061 PRDLATFASTSTLHGLGRAC---GPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTR 170 180 190 200 210 220 120 130 140 150 160 170 pF1KE2 PHVTLLNEVATTELA-FPAVTLCNTNAVRLSQLSYPDLLYLAPMLGLDESDDPG---VPL ::.. .. .: . .: :::::::: : : : :: :...:: . :: .: : . : NP_061 PHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL 230 240 250 260 270 280 180 190 200 210 220 230 pF1KE2 APPGPEAFSGEPFNLHRFYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNS : :. . . ::. :.: ::: :...: :. :::::.::::::::::. NP_061 RYPEPDMVD--------ILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA 290 300 310 320 330 240 250 260 270 280 290 pF1KE2 GRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFID : : : . :: :.::::::::::.::::.: ::.::::::::.::::::.:::.: NP_061 --DPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIH 340 350 360 370 380 390 300 310 320 330 340 350 pF1KE2 QLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFFDSYSITACRIDCETR ::::::.:::::::.:::::: ::: :::.:.: . . .:. ...::..:::. :: . NP_061 QLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKE 400 410 420 430 440 450 360 370 380 390 400 410 pF1KE2 YLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELS ... :.::::::::. : :. : :::: .:: : . : : ::::::::::.: NP_061 AVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEIS 460 470 480 490 500 510 420 430 440 450 460 470 pF1KE2 MVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGG ::.::...::.:::.:.:..: :: ::.::::.:::.:. :..::. :: ...::::.:: NP_061 MVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGG 520 530 540 550 560 570 480 490 500 510 520 530 pF1KE2 QMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPC ::::::::::::.::..:: ::: .: : . : :.:. .:.:...:...:: NP_061 QMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPC 580 590 600 610 620 630 540 550 560 pF1KE2 ESLRGHPAGMTYAANILPHH-----PARGTFEDFTC : ::. : ....::.: : : ::::.: NP_061 PS-RGRVEG-GGVSSLLPNHHHPHGPPGGLFEDFAC 640 650 660 >>XP_016859928 (OMIM: 606715) PREDICTED: acid-sensing io (320 aa) initn: 1257 init1: 739 opt: 1245 Z-score: 1405.5 bits: 269.1 E(87258): 1.5e-71 Smith-Waterman score: 1245; 56.4% identity (79.1% similar) in 321 aa overlap (249-562:2-320) 220 230 240 250 260 270 pF1KE2 SVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAG :.::::::::::.::::.: ::.::::::: XP_016 MGSGLEIMLDIQQEEYLPIWRETNETSFEAG 10 20 30 280 290 300 310 320 330 pF1KE2 IKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFF :.::::::.:::.: ::::::.:::::::.:::::: ::: :::.:.: . . .:. . XP_016 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE2 DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV ..::..:::. :: . ... :.::::::::. : :. : :::: .:: : . : XP_016 SAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCF 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE2 CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ : ::::::::::.:::.::...::.:::.:.:..: :: ::.::::.:::.:. :..:: XP_016 CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQ 160 170 180 190 200 210 460 470 480 490 500 510 pF1KE2 KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADK . :: ...::::.::::::::::::::.::..:: ::: .: : . : :.:. XP_016 RAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGG 220 230 240 250 260 270 520 530 540 550 560 pF1KE2 GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH-----PARGTFEDFTC .:.:...:...:: : ::. : ....::.: : : ::::.: XP_016 ISTLGLQELKEQSPCPS-RGRVEGGG-VSSLLPNHHHPHGPPGGLFEDFAC 280 290 300 310 320 562 residues in 1 query sequences 62035967 residues in 87258 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jun 2 11:44:49 2017 done: Fri Jun 2 11:44:51 2017 Total Scan time: 9.640 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]