Result of FASTA (omim) for pF1KE2032
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE2032, 622 aa
  1>>>pF1KE2032 622 - 622 aa - 622 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5046+/-0.00039; mu= 18.5770+/- 0.024
 mean_var=84.8591+/-17.245, 0's: 0 Z-trim(113.7): 333  B-trim: 843 in 1/50
 Lambda= 0.139227
 statistics sampled from 22759 (23115) to 22759 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.271), width:  16
 Scan time: 10.630

The best scores are:                                      opt bits E(85289)
NP_000497 (OMIM: 176930,188050,601367,613679,61439 ( 622) 4354 885.0       0
NP_001298186 (OMIM: 176930,188050,601367,613679,61 ( 606) 4174 848.8       0
NP_005568 (OMIM: 152200) apolipoprotein(a) precurs (2040)  524 116.1 1.2e-24
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317)  499 110.4 9.6e-24
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317)  499 110.4 9.6e-24
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290)  478 106.2 1.7e-22
NP_958850 (OMIM: 120580,613783) complement C1s sub ( 688)  456 102.1 6.9e-21
XP_005253817 (OMIM: 120580,613783) PREDICTED: comp ( 688)  456 102.1 6.9e-21
NP_001725 (OMIM: 120580,613783) complement C1s sub ( 688)  456 102.1 6.9e-21
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314)  435 97.6   7e-20
XP_011528291 (OMIM: 206200,609862) PREDICTED: tran ( 680)  434 97.6 1.5e-19
NP_001275929 (OMIM: 206200,609862) transmembrane p ( 824)  434 97.7 1.7e-19
XP_016862361 (OMIM: 257920,600521) PREDICTED: mann ( 615)  431 97.0 2.1e-19
XP_016862358 (OMIM: 257920,600521) PREDICTED: mann ( 702)  431 97.0 2.3e-19
NP_624302 (OMIM: 257920,600521) mannan-binding lec ( 728)  431 97.1 2.3e-19
XP_011511291 (OMIM: 257920,600521) PREDICTED: mann ( 735)  431 97.1 2.4e-19
NP_006601 (OMIM: 605102,613791) mannan-binding lec ( 686)  427 96.2 3.9e-19
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343)  416 93.8 1.1e-18
XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188)  402 90.8 4.7e-18
NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188)  402 90.8 4.7e-18
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364)  395 89.6 2.1e-17
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382)  395 89.6 2.1e-17
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433)  395 89.7 2.4e-17
XP_016862359 (OMIM: 257920,600521) PREDICTED: mann ( 668)  397 90.2 2.5e-17
NP_001870 (OMIM: 257920,600521) mannan-binding lec ( 699)  397 90.2 2.6e-17
XP_011511292 (OMIM: 257920,600521) PREDICTED: mann ( 706)  397 90.2 2.6e-17
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417)  394 89.4 2.6e-17
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417)  394 89.4 2.6e-17
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417)  394 89.4 2.6e-17
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417)  394 89.4 2.6e-17
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417)  394 89.4 2.6e-17
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621)  396 90.0 2.7e-17
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634)  396 90.0 2.8e-17
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637)  396 90.0 2.8e-17
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752)  396 90.0 3.1e-17
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761)  396 90.0 3.2e-17
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850)  396 90.1 3.4e-17
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855)  396 90.1 3.5e-17
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393)  391 88.8 3.8e-17
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275)  386 87.7 5.8e-17
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275)  380 86.5 1.3e-16
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855)  378 86.5 4.2e-16
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312)  369 84.3 6.9e-16
XP_006713229 (OMIM: 142408) PREDICTED: hepatocyte  ( 680)  355 81.8 8.7e-15
XP_011524673 (OMIM: 604434) PREDICTED: kallikrein- ( 275)  348 80.1 1.2e-14
NP_001161077 (OMIM: 604434) kallikrein-11 isoform  ( 275)  348 80.1 1.2e-14
XP_011524674 (OMIM: 604434) PREDICTED: kallikrein- ( 275)  348 80.1 1.2e-14
XP_011524675 (OMIM: 604434) PREDICTED: kallikrein- ( 275)  348 80.1 1.2e-14
XP_011524672 (OMIM: 604434) PREDICTED: kallikrein- ( 275)  348 80.1 1.2e-14
XP_011524671 (OMIM: 604434) PREDICTED: kallikrein- ( 307)  348 80.1 1.3e-14


>>NP_000497 (OMIM: 176930,188050,601367,613679,614390) p  (622 aa)
 initn: 4354 init1: 4354 opt: 4354  Z-score: 4728.1  bits: 885.0 E(85289):    0
Smith-Waterman score: 4354; 100.0% identity (100.0% similar) in 622 aa overlap (1-622:1-622)

               10        20        30        40        50        60
pF1KE2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE2 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE2 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE2 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE2 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE2 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE2 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE2 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE2 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE2 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
              550       560       570       580       590       600

              610       620  
pF1KE2 GFYTHVFRLKKWIQKVIDQFGE
       ::::::::::::::::::::::
NP_000 GFYTHVFRLKKWIQKVIDQFGE
              610       620  

>>NP_001298186 (OMIM: 176930,188050,601367,613679,614390  (606 aa)
 initn: 4174 init1: 4174 opt: 4174  Z-score: 4532.8  bits: 848.8 E(85289):    0
Smith-Waterman score: 4201; 97.4% identity (97.4% similar) in 622 aa overlap (1-622:1-606)

               10        20        30        40        50        60
pF1KE2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
       ::::::::::                ::::::::::::::::::::::::::::::::::
NP_001 MAHVRGLQLP----------------VFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
               10                        20        30        40    

               70        80        90       100       110       120
pF1KE2 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
           50        60        70        80        90       100    

              130       140       150       160       170       180
pF1KE2 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
          110       120       130       140       150       160    

              190       200       210       220       230       240
pF1KE2 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
          170       180       190       200       210       220    

              250       260       270       280       290       300
pF1KE2 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
          230       240       250       260       270       280    

              310       320       330       340       350       360
pF1KE2 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
          290       300       310       320       330       340    

              370       380       390       400       410       420
pF1KE2 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
          350       360       370       380       390       400    

              430       440       450       460       470       480
pF1KE2 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
          410       420       430       440       450       460    

              490       500       510       520       530       540
pF1KE2 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
          470       480       490       500       510       520    

              550       560       570       580       590       600
pF1KE2 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
          530       540       550       560       570       580    

              610       620  
pF1KE2 GFYTHVFRLKKWIQKVIDQFGE
       ::::::::::::::::::::::
NP_001 GFYTHVFRLKKWIQKVIDQFGE
          590       600      

>>NP_005568 (OMIM: 152200) apolipoprotein(a) precursor [  (2040 aa)
 initn: 997 init1: 225 opt: 524  Z-score: 563.3  bits: 116.1 E(85289): 1.2e-24
Smith-Waterman score: 865; 32.0% identity (54.2% similar) in 566 aa overlap (60-617:1574-2037)

      30        40        50        60        70        80         
pF1KE2 APQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDV--FWAKY
                                     :    ::  :.  .::. :.. :  . :. 
NP_005 AGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETES-GVLETPTVVPVPSMEAHS
          1550      1560      1570      1580       1590      1600  

        90       100       110       120       130       140       
pF1KE2 TACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTH
        :  : .::  .   : .::     : .:::  . : .:  :: : :  ::. . .  ..
NP_005 EAAPTEQTPVVR--QCYHGN-----GQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENY
           1610        1620           1630      1640      1650     

       150       160       170       180       190       200       
pF1KE2 PGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLS
       :.  :  :.:::::..: ::::.: ::..: . :..  :.. . :: ..: .  .  .:.
NP_005 PNDGLTMNYCRNPDADT-GPWCFTMDPSIRWEYCNLTRCSDTEGTV-VAPPTVIQVPSLG
        1660      1670       1680      1690      1700       1710   

       210        220       230       240       250           260  
pF1KE2 PPLEQ-CVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDF----NSAVQLVENFC
       :: :: :.   :. :.:. :.:. : ::  ::   :.   .:. :    :. . : .:.:
NP_005 PPSEQDCMFGNGKGYRGKKATTVTGTPCQEWA---AQEPHRHSTFIPGTNKWAGLEKNYC
          1720      1730      1740         1750      1760      1770

            270       280       290       300       310       320  
pF1KE2 RNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQT
       :::::: .: :::. .    : :::.  :                        :.: .  
NP_005 RNPDGDINGPWCYTMNPRKLFDYCDIPLC------------------------ASSSF--
             1780      1790                              1800      

            330       340       350       360       370       380  
pF1KE2 FFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLF
                   ::: .:  : :.               : :: :  :.    :::: : 
NP_005 ------------DCG-KPQVEPKKCP-------------GSIVGGCVAHPHSWPWQVSL-
                      1810                   1820      1830        

            390       400       410       420       430       440  
pF1KE2 RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS
       :    . .::..::: .:::::::::      :.   ..  : .: :...  : ....: 
NP_005 RTRFGKHFCGGTLISPEWVLTAAHCL-----KKSSRPSSYKVILGAHQEVNLESHVQEIE
      1840      1850      1860           1870      1880      1890  

            450       460       470       480       490       500  
pF1KE2 MLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVT
       .  .....:        . ::::.::..:....: . :.:::. .    .. :  .  .:
NP_005 V-SRLFLEPT-------QADIALLKLSRPAVITDKVMPACLPSPDY---MVTARTECYIT
            1900             1910      1920      1930         1940 

            510       520       530       540       550       560  
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRG-
       :::. . :.    : :   .:. ..: ..:  ::.    :       ::    ..  :: 
NP_005 GWGETQGTF----GTG---LLKEAQLLVIENEVCNHYKYI-------CA----EHLARGT
            1950             1960      1970                 1980   

             570       580       590       600       610       620 
pF1KE2 DACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
       :.:.::::::.:     ....  .:..::: :: : .: : :..: :.  ::. ..    
NP_005 DSCQGDSGGPLVCFE--KDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN 
          1990        2000      2010      2020      2030      2040 

        
pF1KE2 E

>--
 initn: 321 init1: 170 opt: 449  Z-score: 481.9  bits: 101.0 E(85289): 4.2e-20
Smith-Waterman score: 449; 31.0% identity (53.5% similar) in 245 aa overlap (60-294:784-1020)

      30        40        50        60        70        80         
pF1KE2 APQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTA
                                     :    ::  :.  :.   :.: :   .  .
NP_005 AGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEG-TAVAPPTVTPVPSLEAPS
           760       770       780       790        800       810  

      90       100       110       120       130       140         
pF1KE2 CETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPG
        ..    :  .  : .::     : .:::  . : .:  :: : :  ::.   .   .:.
NP_005 EQAPTEQRPGVQECYHGN-----GQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPN
            820       830            840       850       860       

     150       160       170       180       190                   
pF1KE2 ADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPR----------S
       : :  :.:::::  ...:.::: ::.:: . :..  :.. . :..  :           :
NP_005 AGLIMNYCRNPDP-VAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPS
       870       880        890       900       910       920      

     200       210       220       230       240       250         
pF1KE2 EGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVE
       : . ..  : ...:    ::.:::   .:. :  : ::.:   .. :.   .   . :..
NP_005 EQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIK
        930       940       950       960       970       980      

     260       270       280       290       300       310         
pF1KE2 NFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSE
       :.:::::    . :::..     . ::.:. : .:                         
NP_005 NYCRNPD-PVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALT
        990       1000      1010      1020      1030      1040     

     320       330       340       350       360       370         
pF1KE2 YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQV
                                                                   
NP_005 EETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRN
        1050      1060      1070      1080      1090      1100     

>--
 initn: 1054 init1: 169 opt: 448  Z-score: 480.8  bits: 100.8 E(85289): 4.8e-20
Smith-Waterman score: 448; 34.2% identity (61.5% similar) in 187 aa overlap (107-291:1167-1351)

         80        90       100       110       120       130      
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
                                     .: .: : .:::  . : .:  :: : :  
NP_005 SVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMT
       1140      1150      1160      1170      1180      1190      

        140       150       160       170       180         190    
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCG--QDQVTVA
       ::  . ..  .:.. : .:.:::::.  . ::::: ::.:: . :..  :   ...: ..
NP_005 PHWHQRTTEYYPNGGLTRNYCRNPDAEIS-PWCYTMDPNVRWEYCNLTQCPVTESSVLAT
       1200      1210      1220       1230      1240      1250     

          200       210       220       230       240       250    
pF1KE2 MTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSA
        :  :: . .. :: ...:    ::.:.: ...:. :  : .:.:   .  ..  ..   
NP_005 STAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPN
        1260      1270      1280      1290      1300      1310     

          260       270       280       290       300       310    
pF1KE2 VQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGR
         :..:.:::::. :   :::.      . ::.:. :                       
NP_005 GGLTRNYCRNPDA-EIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPS
        1320       1330      1340      1350      1360      1370    

          320       330       340       350       360       370    
pF1KE2 TATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGM
                                                                   
NP_005 EEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTR
         1380      1390      1400      1410      1420      1430    

>--
 initn: 331 init1: 175 opt: 430  Z-score: 461.3  bits: 97.2 E(85289): 5.9e-19
Smith-Waterman score: 430; 33.2% identity (60.3% similar) in 199 aa overlap (107-294:27-222)

         80        90       100       110       120       130      
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
                                     .: .: : .:::  . : .:  :: : :  
NP_005     MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMT
                   10        20        30        40        50      

        140       150       160       170       180       190      
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMT
       ::. . .. ..:.: :  :.:::::. ...:.::: :: :: . :..  :.. . :..  
NP_005 PHQHNRTTENYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAP
         60        70        80         90       100       110     

                  200       210       220       230       240      
pF1KE2 PR----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALS
       :           :: . ..  : ...:    ::.:.:  ..:. :  : ::.:   .. :
NP_005 PTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS
         120       130       140       150       160       170     

        250       260       270       280        290       300     
pF1KE2 KHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDE
       .  ..   . :. :.:::::.   . .::.   ::  . ::.:. : .:           
NP_005 RTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVT
         180       190        200        210       220       230   

         310       320       330       340       350       360     
pF1KE2 DSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIV
                                                                   
NP_005 PVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPE
           240       250       260       270       280       290   

>--
 initn: 165 init1: 165 opt: 398  Z-score: 426.5  bits: 90.8 E(85289): 5.1e-17
Smith-Waterman score: 420; 33.3% identity (58.6% similar) in 198 aa overlap (108-294:484-678)

        80        90       100       110       120       130       
pF1KE2 TATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYP
                                     : .: : .:::  . : .:  :: : :  :
NP_005 AVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTP
           460       470       480       490       500       510   

       140       150       160       170       180       190       
pF1KE2 HKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTP
       :.   .   .:.: :  :.:::::. ...:.::: :: :: . :..  :.. . :..  :
NP_005 HSHSRTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP
           520       530        540       550       560       570  

                 200       210       220       230       240       
pF1KE2 R----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSK
                  :: . ..  : ...:    ::.:.:  ..:. :  : ::.:   .. :.
NP_005 TVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSR
            580       590       600       610       620       630  

       250       260       270       280        290       300      
pF1KE2 HQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDED
         ..   . :. :.:::::.   . .::.   ::  . ::.:. : .:            
NP_005 TPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVTP
            640       650        660        670       680       690

        310       320       330       340       350       360      
pF1KE2 SDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVE
                                                                   
NP_005 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
              700       710       720       730       740       750

>--
 initn: 329 init1: 150 opt: 266  Z-score: 283.2  bits: 64.3 E(85289): 4.9e-09
Smith-Waterman score: 266; 37.5% identity (59.8% similar) in 112 aa overlap (107-212:1053-1161)

         80        90       100       110       120       130      
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
                                     .:    : .:::  . : .:  :: : :  
NP_005 TAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMT
           1030      1040      1050      1060      1070      1080  

        140       150       160       170       180         190    
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVC--GQDQVTVA
       ::.   .  ..:.: : .:.:::::.    ::::: ::.:: . :..  :   ...: ..
NP_005 PHQHSRTPENYPNAGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNLTQCLVTESSVLAT
           1090      1100      1110       1120      1130      1140 

              200       210       220       230       240       250
pF1KE2 MT----PRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQD
       .:    : .:.:: .   : ::                                      
NP_005 LTVVPDPSTEASSEE--APTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHW
            1150        1160      1170      1180      1190         

>--
 initn: 918 init1: 180 opt: 253  Z-score: 269.1  bits: 61.7 E(85289): 3e-08
Smith-Waterman score: 394; 34.1% identity (57.0% similar) in 179 aa overlap (107-275:1387-1563)

         80        90       100       110       120       130      
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
                                     .: .: : .::: .. : .:  :: : :  
NP_005 TLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMT
       1360      1370      1380      1390      1400      1410      

        140       150       160       170       180       190      
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMT
       ::  .     .:.: : .:.:::::.    ::::: ::.:: . :..  :   . .:  :
NP_005 PHWHRRIPLYYPNAGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNLTRCPVTESSVLTT
       1420      1430      1440       1450      1460      1470     

                  200       210       220       230       240      
pF1KE2 PR----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALS
       :           :: .  . :: ...:    :..:.:  ..:. :  : .:.:   .  .
NP_005 PTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQ
        1480      1490      1500      1510      1520      1530     

        250       260       270       280       290       300      
pF1KE2 KHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDED
       .  .    . :.::.:::::. ..  :::                               
NP_005 RTPENYPNAGLTENYCRNPDSGKQP-WCYTTDPCVRWEYCNLTQCSETESGVLETPTVVP
        1540      1550      1560       1570      1580      1590    

>--
 initn: 425 init1: 165 opt: 202  Z-score: 213.8  bits: 51.4 E(85289): 3.6e-05
Smith-Waterman score: 420; 33.3% identity (58.6% similar) in 198 aa overlap (108-294:256-450)

        80        90       100       110       120       130       
pF1KE2 TATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYP
                                     : .: : .:::  . : .:  :: : :  :
NP_005 AVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTP
         230       240       250       260       270       280     

       140       150       160       170       180       190       
pF1KE2 HKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTP
       :.   .   .:.: :  :.:::::. ...:.::: :: :: . :..  :.. . :..  :
NP_005 HSHSRTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP
         290       300       310        320       330       340    

                 200       210       220       230       240       
pF1KE2 R----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSK
                  :: . ..  : ...:    ::.:.:  ..:. :  : ::.:   .. :.
NP_005 TVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSR
          350       360       370       380       390       400    

       250       260       270       280        290       300      
pF1KE2 HQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDED
         ..   . :. :.:::::.   . .::.   ::  . ::.:. : .:            
NP_005 TPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVTP
          410       420        430        440       450       460  

        310       320       330       340       350       360      
pF1KE2 SDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVE
                                                                   
NP_005 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
            470       480       490       500       510       520  

>>NP_071402 (OMIM: 609343) brain-specific serine proteas  (317 aa)
 initn: 393 init1: 145 opt: 499  Z-score: 547.3  bits: 110.4 E(85289): 9.6e-24
Smith-Waterman score: 499; 32.6% identity (62.8% similar) in 261 aa overlap (363-617:49-289)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     :.: : :.  .  :: : . ... ..  :.
NP_071 TSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHH--CA
       20        30        40        50        60        70        

            400       410       420        430       440       450 
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLL-VRIGKHSRTRYERNIEKISMLEKIYIHP
       .::...:::.:::::.       :...  :. : .:  .        .:...   .  ::
NP_071 GSLLTSRWVITAAHCF-----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVGV-AWVEPHP
         80        90            100       110       120        130

             460       470       480       490       500       510 
pF1KE2 RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETW
        :.:.:.   ::::..:.. . ::. . :.::::   :.  :  . .  ..:::....  
NP_071 VYSWKEGACADIALVRLERSIQFSERVLPICLPD---ASIHLPPNTHCWISGWGSIQD--
              140       150       160          170       180       

             520       530            540       550       560      
pF1KE2 TANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDEGKRGDACEG
         .:   .:..:: ...::..  ::     . . .  ::..:.::::   ::.: ::: :
NP_071 --GVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYL--EGER-DACLG
           190       200       210       220       230          240

        570       580       590       600       610       620      
pF1KE2 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE    
       :::::.. .   .. :   ::.:::::: . .. : :  .   ..:..:..         
NP_071 DSGGPLMCQ--VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRA
                250       260       270       280       290        

NP_071 QGGGALRAPSQGSGAAARS
      300       310       

>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific   (317 aa)
 initn: 393 init1: 145 opt: 499  Z-score: 547.3  bits: 110.4 E(85289): 9.6e-24
Smith-Waterman score: 499; 32.6% identity (62.8% similar) in 261 aa overlap (363-617:49-289)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     :.: : :.  .  :: : . ... ..  :.
XP_005 TSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHH--CA
       20        30        40        50        60        70        

            400       410       420        430       440       450 
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLL-VRIGKHSRTRYERNIEKISMLEKIYIHP
       .::...:::.:::::.       :...  :. : .:  .        .:...   .  ::
XP_005 GSLLTSRWVITAAHCF-----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVGV-AWVEPHP
         80        90            100       110       120        130

             460       470       480       490       500       510 
pF1KE2 RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETW
        :.:.:.   ::::..:.. . ::. . :.::::   :.  :  . .  ..:::....  
XP_005 VYSWKEGACADIALVRLERSIQFSERVLPICLPD---ASIHLPPNTHCWISGWGSIQD--
              140       150       160          170       180       

             520       530            540       550       560      
pF1KE2 TANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDEGKRGDACEG
         .:   .:..:: ...::..  ::     . . .  ::..:.::::   ::.: ::: :
XP_005 --GVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYL--EGER-DACLG
           190       200       210       220       230          240

        570       580       590       600       610       620      
pF1KE2 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE    
       :::::.. .   .. :   ::.:::::: . .. : :  .   ..:..:..         
XP_005 DSGGPLMCQ--VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRA
                250       260       270       280       290        

XP_005 QGGGALRAPSQGSGAAARS
      300       310       

>>NP_114154 (OMIM: 608018) serine protease 27 isoform 1   (290 aa)
 initn: 422 init1: 116 opt: 478  Z-score: 525.0  bits: 106.2 E(85289): 1.7e-22
Smith-Waterman score: 534; 35.9% identity (62.0% similar) in 276 aa overlap (363-620:34-279)

            340       350       360       370       380       390  
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
                                     :.: :.:.. :  :::: . :.. .  .::
NP_114 PAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSH--FCG
            10        20        30        40        50          60 

            400       410       420                430       440   
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDL---------LVRIGKHSRTRYERNIEKISM
       .:::...::::::::.      .: .:..:         ::. : :.     :..:.   
NP_114 GSLIAEQWVLTAAHCF------RNTSETSLYQVLLGARQLVQPGPHAMYARVRQVES---
              70              80        90       100       110     

           450       460       470       480       490       500   
pF1KE2 LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTG
             .: :.   . . :.::..:. :: :..:: ::::::    . ....:..  :::
NP_114 ------NPLYQGTAS-SADVALVELEAPVPFTNYILPVCLPD---PSVIFETGMNCWVTG
                  120        130       140          150       160  

           510       520       530            540           550    
pF1KE2 WGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTR----IRITDNMFCAGYK
       ::. .:         .: .:: . .::.. : :     ::.        : ..:.:::. 
NP_114 WGSPSEEDLLP----EPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGF-
            170           180       190       200       210        

          560       570       580       590       600       610    
pF1KE2 PDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
        .:::. :::.::::::.:     .. : : :..:::::: :... : : .:   ..::.
NP_114 -EEGKK-DACKGDSGGPLVCL--VGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIH
        220        230         240       250       260       270   

          620           
pF1KE2 KVIDQFGE         
       ..: ..           
NP_114 RIIPKLQFQPARLGGQK
           280       290

>>NP_958850 (OMIM: 120580,613783) complement C1s subcomp  (688 aa)
 initn: 377 init1: 114 opt: 456  Z-score: 496.0  bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)

           160       170       180        190       200       210  
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
                                     : ::.     . .  .:.. .. ..  :  
NP_958 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
      220       230       240       250       260       270        

            220        230       240       250       260           
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
              .:.:  .    .  :  .:  :.:: .     : ..::..   :   :: :  
NP_958 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
      280       290       300       310            320             

     270               280        290       300       310          
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
       ::          :   :: ..    :.   :  .. :   .:  :: . .. : .   . 
NP_958 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
      330       340       350         360       370       380      

     320       330                340       350       360       370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
        . ..  .. :.::  :.         : : . :      . :: .:     ::. ::::
NP_958 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
        390       400       410       420       430         440    

              380       390       400       410       420       430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
       .:   ::::  :  .:     :..::.. ::::::: .      ..  :  . :   . .
NP_958 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
          450            460       470             480       490   

              440       450               460       470       480  
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
        .:  ..  :.   :...:::  .:        : :.: ::::..:: :: ..  . :.:
NP_958 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
           500         510         520       530       540         

            490       500       510         520        530         
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
       ::   .  .:.. :  : ..:::  ..   :   :.   : . :.  .   ::.:.  :.
NP_958 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
     550       560        570       580       590       600        

     540       550       560        570       580        590       
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
           .: ::.:::     :..: :.:.::::: :....: .. ..:  :.::::  :   
NP_958 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
       610       620            630       640       650            

       600       610       620      
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE    
       : ::.::.:     ::.:....       
NP_958 GTYGLYTRVKNYVDWIMKTMQENSTPRED
     660       670       680        

>>XP_005253817 (OMIM: 120580,613783) PREDICTED: compleme  (688 aa)
 initn: 377 init1: 114 opt: 456  Z-score: 496.0  bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)

           160       170       180        190       200       210  
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
                                     : ::.     . .  .:.. .. ..  :  
XP_005 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
      220       230       240       250       260       270        

            220        230       240       250       260           
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
              .:.:  .    .  :  .:  :.:: .     : ..::..   :   :: :  
XP_005 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
      280       290       300       310            320             

     270               280        290       300       310          
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
       ::          :   :: ..    :.   :  .. :   .:  :: . .. : .   . 
XP_005 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
      330       340       350         360       370       380      

     320       330                340       350       360       370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
        . ..  .. :.::  :.         : : . :      . :: .:     ::. ::::
XP_005 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
        390       400       410       420       430         440    

              380       390       400       410       420       430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
       .:   ::::  :  .:     :..::.. ::::::: .      ..  :  . :   . .
XP_005 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
          450            460       470             480       490   

              440       450               460       470       480  
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
        .:  ..  :.   :...:::  .:        : :.: ::::..:: :: ..  . :.:
XP_005 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
           500         510         520       530       540         

            490       500       510         520        530         
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
       ::   .  .:.. :  : ..:::  ..   :   :.   : . :.  .   ::.:.  :.
XP_005 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
     550       560        570       580       590       600        

     540       550       560        570       580        590       
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
           .: ::.:::     :..: :.:.::::: :....: .. ..:  :.::::  :   
XP_005 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
       610       620            630       640       650            

       600       610       620      
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE    
       : ::.::.:     ::.:....       
XP_005 GTYGLYTRVKNYVDWIMKTMQENSTPRED
     660       670       680        

>>NP_001725 (OMIM: 120580,613783) complement C1s subcomp  (688 aa)
 initn: 377 init1: 114 opt: 456  Z-score: 496.0  bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)

           160       170       180        190       200       210  
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
                                     : ::.     . .  .:.. .. ..  :  
NP_001 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
      220       230       240       250       260       270        

            220        230       240       250       260           
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
              .:.:  .    .  :  .:  :.:: .     : ..::..   :   :: :  
NP_001 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
      280       290       300       310            320             

     270               280        290       300       310          
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
       ::          :   :: ..    :.   :  .. :   .:  :: . .. : .   . 
NP_001 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
      330       340       350         360       370       380      

     320       330                340       350       360       370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
        . ..  .. :.::  :.         : : . :      . :: .:     ::. ::::
NP_001 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
        390       400       410       420       430         440    

              380       390       400       410       420       430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
       .:   ::::  :  .:     :..::.. ::::::: .      ..  :  . :   . .
NP_001 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
          450            460       470             480       490   

              440       450               460       470       480  
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
        .:  ..  :.   :...:::  .:        : :.: ::::..:: :: ..  . :.:
NP_001 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
           500         510         520       530       540         

            490       500       510         520        530         
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
       ::   .  .:.. :  : ..:::  ..   :   :.   : . :.  .   ::.:.  :.
NP_001 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
     550       560        570       580       590       600        

     540       550       560        570       580        590       
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
           .: ::.:::     :..: :.:.::::: :....: .. ..:  :.::::  :   
NP_001 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
       610       620            630       640       650            

       600       610       620      
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE    
       : ::.::.:     ::.:....       
NP_001 GTYGLYTRVKNYVDWIMKTMQENSTPRED
     660       670       680        

>>NP_006790 (OMIM: 608159) testisin isoform 1 preproprot  (314 aa)
 initn: 518 init1: 162 opt: 435  Z-score: 477.9  bits: 97.6 E(85289): 7e-20
Smith-Waterman score: 516; 37.2% identity (60.9% similar) in 274 aa overlap (360-621:38-289)

     330       340       350       360       370       380         
pF1KE2 GSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQEL
                                     : .::: : :::.:  :::  :  .  .  
NP_006 LLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSL--RLWDSH
        10        20        30        40        50          60     

     390       400       410       420       430       440         
pF1KE2 LCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS---MLEK
       .::.::.: ::.::::::  .  ..     .  .:..:. .      ...      .. .
NP_006 VCGVSLLSHRWALTAAHC--FETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSN
          70        80          90       100       110       120   

        450       460       470       480       490       500      
pF1KE2 IYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGR----VT
       ::. :::    :   ::::.::. ::... .:.:.::      :: ..  ...:    ::
NP_006 IYLSPRY--LGNSPYDIALVKLSAPVTYTKHIQPICLQ-----ASTFE--FENRTDCWVT
           130         140       150            160         170    

            510       520       530            540       550       
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDE
       ::: .::    . .  .: .:: :.. :..  .:     : : :  :  .: ::: . . 
NP_006 GWGYIKE----DEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAG-NAQG
          180           190       200       210       220          

       560       570       580       590       600       610       
pF1KE2 GKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
       ::  ::: ::::::.. ..  :. :::.:.:::: :: : .. : ::.. .  .::::..
NP_006 GK--DACFGDSGGPLACNK--NGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM
     230         240         250       260       270       280     

       620                          
pF1KE2 DQFGE                        
        : :                         
NP_006 AQSGMSQPDPSWPLLFFPLLWALPLLGPV
         290       300       310    




622 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 09:42:20 2016 done: Sun Nov  6 09:42:22 2016
 Total Scan time: 10.630 Total Display time:  0.150

Function used was FASTA [36.3.4 Apr, 2011]
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