FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2430, 533 aa 1>>>pF1KE2430 533 - 533 aa - 533 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2201+/-0.000324; mu= 20.2816+/- 0.020 mean_var=83.1745+/-17.251, 0's: 0 Z-trim(118.8): 129 B-trim: 1394 in 2/50 Lambda= 0.140630 statistics sampled from 31907 (32051) to 31907 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.376), width: 16 Scan time: 7.270 The best scores are: opt bits E(85289) NP_000037 (OMIM: 253200,611542) arylsulfatase B is ( 533) 3754 771.2 0 XP_011541692 (OMIM: 253200,611542) PREDICTED: aryl ( 533) 3754 771.2 0 XP_016864960 (OMIM: 253200,611542) PREDICTED: aryl ( 451) 2825 582.7 8e-166 XP_011541693 (OMIM: 253200,611542) PREDICTED: aryl ( 442) 2819 581.5 1.8e-165 NP_942002 (OMIM: 253200,611542) arylsulfatase B is ( 413) 2797 577.0 3.9e-164 XP_011541694 (OMIM: 253200,611542) PREDICTED: aryl ( 405) 2796 576.8 4.4e-164 XP_011541695 (OMIM: 253200,611542) PREDICTED: aryl ( 382) 2631 543.3 5e-154 XP_005263269 (OMIM: 610010) PREDICTED: arylsulfata ( 596) 1750 364.7 4.5e-100 XP_016864081 (OMIM: 610010) PREDICTED: arylsulfata ( 599) 1750 364.7 4.5e-100 NP_078866 (OMIM: 610010) arylsulfatase J precursor ( 599) 1750 364.7 4.5e-100 NP_001012301 (OMIM: 610009) arylsulfatase I precur ( 569) 1729 360.4 8.3e-99 XP_016864085 (OMIM: 610010) PREDICTED: arylsulfata ( 480) 1462 306.2 1.5e-82 XP_016864083 (OMIM: 610010) PREDICTED: arylsulfata ( 483) 1462 306.2 1.5e-82 XP_016864082 (OMIM: 610010) PREDICTED: arylsulfata ( 483) 1462 306.2 1.5e-82 XP_011530541 (OMIM: 610010) PREDICTED: arylsulfata ( 483) 1462 306.2 1.5e-82 XP_016864084 (OMIM: 610010) PREDICTED: arylsulfata ( 483) 1462 306.2 1.5e-82 XP_011530540 (OMIM: 610010) PREDICTED: arylsulfata ( 492) 1462 306.2 1.5e-82 XP_016864089 (OMIM: 610010) PREDICTED: arylsulfata ( 427) 1262 265.6 2.2e-70 XP_016864088 (OMIM: 610010) PREDICTED: arylsulfata ( 427) 1262 265.6 2.2e-70 XP_016864086 (OMIM: 610010) PREDICTED: arylsulfata ( 427) 1262 265.6 2.2e-70 XP_016864087 (OMIM: 610010) PREDICTED: arylsulfata ( 427) 1262 265.6 2.2e-70 NP_000503 (OMIM: 253000,612222) N-acetylgalactosam ( 522) 539 118.9 3.7e-26 XP_005256358 (OMIM: 253000,612222) PREDICTED: N-ac ( 575) 539 119.0 4e-26 NP_001078896 (OMIM: 250100,607574) arylsulfatase A ( 509) 516 114.3 9.3e-25 NP_000478 (OMIM: 250100,607574) arylsulfatase A is ( 509) 516 114.3 9.3e-25 NP_001078895 (OMIM: 250100,607574) arylsulfatase A ( 509) 516 114.3 9.3e-25 NP_001078894 (OMIM: 250100,607574) arylsulfatase A ( 509) 516 114.3 9.3e-25 XP_016884289 (OMIM: 250100,607574) PREDICTED: aryl ( 547) 516 114.3 9.8e-25 XP_016878601 (OMIM: 253000,612222) PREDICTED: N-ac ( 508) 511 113.3 1.9e-24 XP_016878600 (OMIM: 253000,612222) PREDICTED: N-ac ( 511) 511 113.3 1.9e-24 NP_001310473 (OMIM: 253000,612222) N-acetylgalacto ( 528) 511 113.3 1.9e-24 XP_011521284 (OMIM: 253000,612222) PREDICTED: N-ac ( 581) 511 113.3 2.1e-24 XP_011528993 (OMIM: 250100,607574) PREDICTED: aryl ( 387) 502 111.3 5.4e-24 XP_016885017 (OMIM: 300003) PREDICTED: arylsulfata ( 297) 354 81.2 4.9e-15 XP_011543826 (OMIM: 300003) PREDICTED: arylsulfata ( 462) 354 81.4 6.8e-15 XP_016885016 (OMIM: 300003) PREDICTED: arylsulfata ( 561) 354 81.4 7.8e-15 XP_011543825 (OMIM: 300003) PREDICTED: arylsulfata ( 578) 354 81.4 8e-15 NP_001188467 (OMIM: 300003) arylsulfatase F precur ( 590) 354 81.5 8.1e-15 NP_001188468 (OMIM: 300003) arylsulfatase F precur ( 590) 354 81.5 8.1e-15 NP_004033 (OMIM: 300003) arylsulfatase F precursor ( 590) 354 81.5 8.1e-15 XP_011543824 (OMIM: 300003) PREDICTED: arylsulfata ( 607) 354 81.5 8.3e-15 XP_005274576 (OMIM: 300180,302950) PREDICTED: aryl ( 589) 349 80.4 1.6e-14 NP_000038 (OMIM: 300180,302950) arylsulfatase E is ( 589) 349 80.4 1.6e-14 XP_005274575 (OMIM: 300180,302950) PREDICTED: aryl ( 598) 349 80.4 1.6e-14 NP_001269557 (OMIM: 300180,302950) arylsulfatase E ( 614) 349 80.5 1.7e-14 XP_016885014 (OMIM: 300180,302950) PREDICTED: aryl ( 614) 349 80.5 1.7e-14 XP_006721842 (OMIM: 610008) PREDICTED: arylsulfata ( 329) 334 77.2 8.8e-14 XP_005257229 (OMIM: 610008) PREDICTED: arylsulfata ( 344) 334 77.2 9.1e-14 XP_016879857 (OMIM: 610008) PREDICTED: arylsulfata ( 413) 334 77.3 1e-13 XP_011522847 (OMIM: 610008) PREDICTED: arylsulfata ( 413) 334 77.3 1e-13 >>NP_000037 (OMIM: 253200,611542) arylsulfatase B isofor (533 aa) initn: 3754 init1: 3754 opt: 3754 Z-score: 4115.7 bits: 771.2 E(85289): 0 Smith-Waterman score: 3754; 99.8% identity (100.0% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: NP_000 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 490 500 510 520 530 >>XP_011541692 (OMIM: 253200,611542) PREDICTED: arylsulf (533 aa) initn: 3754 init1: 3754 opt: 3754 Z-score: 4115.7 bits: 771.2 E(85289): 0 Smith-Waterman score: 3754; 99.8% identity (100.0% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_011 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 490 500 510 520 530 >>XP_016864960 (OMIM: 253200,611542) PREDICTED: arylsulf (451 aa) initn: 2809 init1: 2809 opt: 2825 Z-score: 3098.0 bits: 582.7 E(85289): 8e-166 Smith-Waterman score: 2825; 99.0% identity (99.5% similar) in 413 aa overlap (1-413:1-412) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_016 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP ::::::::::::::::::::::::::::::::::::::::::::: .::::: XP_016 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCC-TSMAPASAQLMMR 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD XP_016 PQTEGKGRAGMHMARVAAREMPGSFKEQLFKT 420 430 440 450 >>XP_011541693 (OMIM: 253200,611542) PREDICTED: arylsulf (442 aa) initn: 2796 init1: 2796 opt: 2819 Z-score: 3091.5 bits: 581.5 E(85289): 1.8e-165 Smith-Waterman score: 2819; 96.9% identity (98.6% similar) in 421 aa overlap (1-420:1-421) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_011 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPC-PRNSMAPAKDDSSL :::::::::::::::::::::::::::::::::::::::::::: ::. . : ...:. XP_011 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPSLPRSLVLTAGEEGSV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE2 PEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDR : XP_011 PPPPSLKPLRQFPHLWSKEGIK 430 440 >>NP_942002 (OMIM: 253200,611542) arylsulfatase B isofor (413 aa) initn: 2796 init1: 2796 opt: 2797 Z-score: 3067.8 bits: 577.0 E(85289): 3.9e-164 Smith-Waterman score: 2797; 98.5% identity (99.3% similar) in 411 aa overlap (1-410:1-411) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_942 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: NP_942 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPC-PRNSMAPAKDDSSL :::::::::::::::::::::::::::::::::::::::::::: :. :. NP_942 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPYWPECSLLL 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 PEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDR >>XP_011541694 (OMIM: 253200,611542) PREDICTED: arylsulf (405 aa) initn: 2796 init1: 2796 opt: 2796 Z-score: 3066.8 bits: 576.8 E(85289): 4.4e-164 Smith-Waterman score: 2796; 99.8% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_011 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP :::::::::::::::::::::::::::::::::::::::::::: XP_011 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPW 370 380 390 400 430 440 450 460 470 480 pF1KE2 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD >>XP_011541695 (OMIM: 253200,611542) PREDICTED: arylsulf (382 aa) initn: 2631 init1: 2631 opt: 2631 Z-score: 2886.2 bits: 543.3 E(85289): 5e-154 Smith-Waterman score: 2631; 99.7% identity (100.0% similar) in 380 aa overlap (1-380:1-380) 10 20 30 40 50 60 pF1KE2 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_011 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP :::::::::::::::::::: XP_011 ARGHTNGTKPLDGFDVWKTIRC 370 380 >>XP_005263269 (OMIM: 610010) PREDICTED: arylsulfatase J (596 aa) initn: 1869 init1: 774 opt: 1750 Z-score: 1917.7 bits: 364.7 E(85289): 4.5e-100 Smith-Waterman score: 1858; 53.7% identity (77.2% similar) in 501 aa overlap (41-532:72-554) 20 30 40 50 60 70 pF1KE2 RGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTP .. :::.:.:::: :. :::.:::.:.:: XP_005 GYLSWGQALEEEEEGALLAQAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTP 50 60 70 80 90 100 80 90 100 110 120 130 pF1KE2 HLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLP :: ::: :: :.:::.::.:::::::..::.:::.:::::.:: : ::.:.:::. :: XP_005 TLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLP 110 120 130 140 150 160 140 150 160 170 180 190 pF1KE2 QLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVT : :::.::.::::::::::.:::::.::::::::.:: :::: :::.: .: :. .. XP_005 QKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGDYYTHYKC---DSPGM- 170 180 190 200 210 200 210 220 230 240 pF1KE2 RCALDFRDGEEVATGYKN-MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPE :. :. .....: : : .:::...:.:. ....: : ::.:::.: :.:: :::.: XP_005 -CGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPG 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE2 EYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGG .:.. : : . ::..::.:.: .:::..::: :::. :..::...:.:.::::: ::: XP_005 RYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGG 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE2 NNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKLARGHTNGTK .:::::: : . ::::.:.:::: :::::.::. .::.::.:: :::..::.:. . XP_005 SNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDI 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE2 PLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSV :::.:.:.::::: :::...:::::: .. ::. : :. .::.. XP_005 QLDGYDIWETISEGLRSPRVDILHNIDPIYTK-----------AKNGSWAAGYGIWNTAI 400 410 420 430 440 430 440 450 460 470 480 pF1KE2 HAAIRHGNWKLLTGYPGCGYWFPP-------PSQYNVSEIPSSDPPTKTLWLFDIDRDPE ..::: .:::::: :: . : :: :.... .: : :..:::.: :: XP_005 QSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTG--KSVWLFNITADPY 450 460 470 480 490 500 490 500 510 520 530 pF1KE2 ERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATG-VWGPWM :: ::: .:: :: ::: ::. ..: .::: .: .::: .:. .: ::::: XP_005 ERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKK 510 520 530 540 550 560 XP_005 PSKNQAEKKQKKSKKKKKKQQKAVSGKPANLAR 570 580 590 >>XP_016864081 (OMIM: 610010) PREDICTED: arylsulfatase J (599 aa) initn: 1869 init1: 774 opt: 1750 Z-score: 1917.6 bits: 364.7 E(85289): 4.5e-100 Smith-Waterman score: 1858; 53.7% identity (77.2% similar) in 501 aa overlap (41-532:72-554) 20 30 40 50 60 70 pF1KE2 RGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTP .. :::.:.:::: :. :::.:::.:.:: XP_016 GYLSWGQALEEEEEGALLAQAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTP 50 60 70 80 90 100 80 90 100 110 120 130 pF1KE2 HLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLP :: ::: :: :.:::.::.:::::::..::.:::.:::::.:: : ::.:.:::. :: XP_016 TLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLP 110 120 130 140 150 160 140 150 160 170 180 190 pF1KE2 QLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVT : :::.::.::::::::::.:::::.::::::::.:: :::: :::.: .: :. .. XP_016 QKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGDYYTHYKC---DSPGM- 170 180 190 200 210 200 210 220 230 240 pF1KE2 RCALDFRDGEEVATGYKN-MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPE :. :. .....: : : .:::...:.:. ....: : ::.:::.: :.:: :::.: XP_016 -CGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPG 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE2 EYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGG .:.. : : . ::..::.:.: .:::..::: :::. :..::...:.:.::::: ::: XP_016 RYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGG 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE2 NNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKLARGHTNGTK .:::::: : . ::::.:.:::: :::::.::. .::.::.:: :::..::.:. . XP_016 SNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDI 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE2 PLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSV :::.:.:.::::: :::...:::::: .. ::. : :. .::.. XP_016 QLDGYDIWETISEGLRSPRVDILHNIDPIYTK-----------AKNGSWAAGYGIWNTAI 400 410 420 430 440 430 440 450 460 470 480 pF1KE2 HAAIRHGNWKLLTGYPGCGYWFPP-------PSQYNVSEIPSSDPPTKTLWLFDIDRDPE ..::: .:::::: :: . : :: :.... .: : :..:::.: :: XP_016 QSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTG--KSVWLFNITADPY 450 460 470 480 490 500 490 500 510 520 530 pF1KE2 ERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATG-VWGPWM :: ::: .:: :: ::: ::. ..: .::: .: .::: .:. .: ::::: XP_016 ERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKK 510 520 530 540 550 560 XP_016 PSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG 570 580 590 >>NP_078866 (OMIM: 610010) arylsulfatase J precursor [Ho (599 aa) initn: 1869 init1: 774 opt: 1750 Z-score: 1917.6 bits: 364.7 E(85289): 4.5e-100 Smith-Waterman score: 1858; 53.7% identity (77.2% similar) in 501 aa overlap (41-532:72-554) 20 30 40 50 60 70 pF1KE2 RGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTP .. :::.:.:::: :. :::.:::.:.:: NP_078 GYLSWGQALEEEEEGALLAQAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTP 50 60 70 80 90 100 80 90 100 110 120 130 pF1KE2 HLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLP :: ::: :: :.:::.::.:::::::..::.:::.:::::.:: : ::.:.:::. :: NP_078 TLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLP 110 120 130 140 150 160 140 150 160 170 180 190 pF1KE2 QLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVT : :::.::.::::::::::.:::::.::::::::.:: :::: :::.: .: :. .. NP_078 QKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGDYYTHYKC---DSPGM- 170 180 190 200 210 200 210 220 230 240 pF1KE2 RCALDFRDGEEVATGYKN-MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPE :. :. .....: : : .:::...:.:. ....: : ::.:::.: :.:: :::.: NP_078 -CGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPG 220 230 240 250 260 270 250 260 270 280 290 300 pF1KE2 EYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGG .:.. : : . ::..::.:.: .:::..::: :::. :..::...:.:.::::: ::: NP_078 RYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGG 280 290 300 310 320 330 310 320 330 340 350 360 pF1KE2 NNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLMKLARGHTNGTK .:::::: : . ::::.:.:::: :::::.::. .::.::.:: :::..::.:. . NP_078 SNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDI 340 350 360 370 380 390 370 380 390 400 410 420 pF1KE2 PLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSV :::.:.:.::::: :::...:::::: .. ::. : :. .::.. NP_078 QLDGYDIWETISEGLRSPRVDILHNIDPIYTK-----------AKNGSWAAGYGIWNTAI 400 410 420 430 440 430 440 450 460 470 480 pF1KE2 HAAIRHGNWKLLTGYPGCGYWFPP-------PSQYNVSEIPSSDPPTKTLWLFDIDRDPE ..::: .:::::: :: . : :: :.... .: : :..:::.: :: NP_078 QSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTG--KSVWLFNITADPY 450 460 470 480 490 500 490 500 510 520 530 pF1KE2 ERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATG-VWGPWM :: ::: .:: :: ::: ::. ..: .::: .: .::: .:. .: ::::: NP_078 ERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKK 510 520 530 540 550 560 NP_078 PSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG 570 580 590 533 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 19:58:18 2016 done: Mon Nov 7 19:58:19 2016 Total Scan time: 7.270 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]