Result of FASTA (omim) for pF1KE0800
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0800, 1531 aa
  1>>>pF1KE0800 1531 - 1531 aa - 1531 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.8231+/-0.000619; mu= 1.7524+/- 0.038
 mean_var=251.5570+/-51.499, 0's: 0 Z-trim(112.2): 53  B-trim: 230 in 1/54
 Lambda= 0.080864
 statistics sampled from 20997 (21033) to 20997 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.582), E-opt: 0.2 (0.247), width:  16
 Scan time: 16.110

The best scores are:                                      opt bits E(85289)
NP_001058 (OMIM: 126430) DNA topoisomerase 2-alpha (1531) 10077 1191.0       0
XP_005257689 (OMIM: 126430) PREDICTED: DNA topoiso (1519) 9997 1181.7       0
XP_011523467 (OMIM: 126430) PREDICTED: DNA topoiso (1364) 9006 1066.0       0
XP_011532359 (OMIM: 126431) PREDICTED: DNA topoiso (1589) 6689 795.8       0
NP_001317629 (OMIM: 126431) DNA topoisomerase 2-be (1626) 6650 791.2       0
NP_001059 (OMIM: 126431) DNA topoisomerase 2-beta  (1621) 6648 791.0       0


>>NP_001058 (OMIM: 126430) DNA topoisomerase 2-alpha [Ho  (1531 aa)
 initn: 10077 init1: 10077 opt: 10077  Z-score: 6367.9  bits: 1191.0 E(85289):    0
Smith-Waterman score: 10077; 100.0% identity (100.0% similar) in 1531 aa overlap (1-1531:1-1531)

               10        20        30        40        50        60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KE0 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
             1450      1460      1470      1480      1490      1500

             1510      1520      1530 
pF1KE0 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
       :::::::::::::::::::::::::::::::
NP_001 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
             1510      1520      1530 

>>XP_005257689 (OMIM: 126430) PREDICTED: DNA topoisomera  (1519 aa)
 initn: 9997 init1: 9997 opt: 9997  Z-score: 6317.5  bits: 1181.7 E(85289):    0
Smith-Waterman score: 9997; 100.0% identity (100.0% similar) in 1519 aa overlap (13-1531:1-1519)

               10        20        30        40        50        60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
                   ::::::::::::::::::::::::::::::::::::::::::::::::
XP_005             MQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
                           10        20        30        40        

               70        80        90       100       110       120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
       50        60        70        80        90       100        

              130       140       150       160       170       180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
      110       120       130       140       150       160        

              190       200       210       220       230       240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
      170       180       190       200       210       220        

              250       260       270       280       290       300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
      230       240       250       260       270       280        

              310       320       330       340       350       360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
      290       300       310       320       330       340        

              370       380       390       400       410       420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
      350       360       370       380       390       400        

              430       440       450       460       470       480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
      410       420       430       440       450       460        

              490       500       510       520       530       540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
      470       480       490       500       510       520        

              550       560       570       580       590       600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
      530       540       550       560       570       580        

              610       620       630       640       650       660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
      590       600       610       620       630       640        

              670       680       690       700       710       720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
      650       660       670       680       690       700        

              730       740       750       760       770       780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
      710       720       730       740       750       760        

              790       800       810       820       830       840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
      770       780       790       800       810       820        

              850       860       870       880       890       900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
      830       840       850       860       870       880        

              910       920       930       940       950       960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
      890       900       910       920       930       940        

              970       980       990      1000      1010      1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
      950       960       970       980       990      1000        

             1030      1040      1050      1060      1070      1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
     1010      1020      1030      1040      1050      1060        

             1090      1100      1110      1120      1130      1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
     1070      1080      1090      1100      1110      1120        

             1150      1160      1170      1180      1190      1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
     1130      1140      1150      1160      1170      1180        

             1210      1220      1230      1240      1250      1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
     1190      1200      1210      1220      1230      1240        

             1270      1280      1290      1300      1310      1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
     1250      1260      1270      1280      1290      1300        

             1330      1340      1350      1360      1370      1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
     1310      1320      1330      1340      1350      1360        

             1390      1400      1410      1420      1430      1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
     1370      1380      1390      1400      1410      1420        

             1450      1460      1470      1480      1490      1500
pF1KE0 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
     1430      1440      1450      1460      1470      1480        

             1510      1520      1530 
pF1KE0 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
       :::::::::::::::::::::::::::::::
XP_005 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
     1490      1500      1510         

>>XP_011523467 (OMIM: 126430) PREDICTED: DNA topoisomera  (1364 aa)
 initn: 9006 init1: 9006 opt: 9006  Z-score: 5693.3  bits: 1066.0 E(85289):    0
Smith-Waterman score: 9006; 100.0% identity (100.0% similar) in 1363 aa overlap (1-1363:1-1363)

               10        20        30        40        50        60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
       :::::::::::::::::::::::::::::::::::::::::::                 
XP_011 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKP                
             1330      1340      1350      1360                    

             1390      1400      1410      1420      1430      1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG

>>XP_011532359 (OMIM: 126431) PREDICTED: DNA topoisomera  (1589 aa)
 initn: 6509 init1: 6179 opt: 6689  Z-score: 4231.5  bits: 795.8 E(85289):    0
Smith-Waterman score: 6978; 69.2% identity (84.5% similar) in 1570 aa overlap (14-1529:28-1580)

                             10        20               30         
pF1KE0               MEVSPLQPVNENMQVNKIKKNE-------DAKKRLSVERIYQKKTQ
                                  : :  ::.:       :..:.:::::.::::::
XP_011 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
               10        20        30        40        50        60

      40        50        60        70        80        90         
pF1KE0 LEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRD
       :::::::::::::::: .:: :::::::::.: :::::::::::::::::::::::::::
XP_011 LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
               70        80        90       100       110       120

     100       110       120       130       140       150         
pF1KE0 PKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT
        .:.::.:.::::.:.:::::::::::::::::::.::::::::::::::::::::::::
XP_011 KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
              130       140       150       160       170       180

     160       170       180       190       200       210         
pF1KE0 GGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITF
       ::::::::::::::::::::::: .:::. ::::::.:: ...: ..: :.:::::::::
XP_011 GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
              190       200       210       220       230       240

     220       230       240       250       260       270         
pF1KE0 QPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKL
       :::::::::..:::::::::.:::::.::: . :::..::.::::.:::::::.:.::::
XP_011 QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
              250       260       270       280       290       300

     280       290       300       310       320       330         
pF1KE0 DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD
       :::: .:::::: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..
XP_011 DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
              310       320       330       340       350       360

     340       350       360       370       380       390         
pF1KE0 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFI
       :::::::.::.::  :::::.:.:.: :::::::::::::::::::::::: :::::::.
XP_011 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
              370       380       390       400       410       420

     400       410       420       430       440       450         
pF1KE0 KAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLIL
       ::: .::::::::::::::::.:::::::.::...:::::::::::::::..: ::::::
XP_011 KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
              430       440       450       460       470       480

     460       470       480       490       500       510         
pF1KE0 TEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
       :::::::.::::::::.:::.:::::::::::::::::::::::::::::::::::::::
XP_011 TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
              490       500       510       520       530       540

     520       530       540       550       560       570         
pF1KE0 KNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVK
       :.:.: .:::::::::::::::::::::::::::::::::::::::.: :::::::::::
XP_011 KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
              550       560       570       580       590       600

     580       590       600       610       620       630         
pF1KE0 VSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFK
       .::::::..:::.:::.:::.   :.: ::.::::::::::.::::::::::.:::: :.
XP_011 ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
              610       620       630       640       650       660

     640       650       660       670       680       690         
pF1KE0 YSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFI
       :.::::::::.::::::.::::::::::::::::::.: ::::..::: .: .:::::::
XP_011 YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
              670       680       690       700       710       720

     700       710       720       730       740       750         
pF1KE0 NKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHH
       ::::::::::::::::::.:::.:::::::::::::::::::::::::::::::::.:::
XP_011 NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
              730       740       750       760       770       780

     760       770       780       790       800       810         
pF1KE0 GEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFP
       ::..:::::.:::::::::::.::::::::::::::::::.:::::::::::.:::::::
XP_011 GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
              790       800       810       820       830       840

     820       830       840       850       860       870         
pF1KE0 PKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRL
         ::. :::::::::::::::::::::::::::::::::::.::.::.:.::::::.::.
XP_011 AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
              850       860       870       880       890       900

     880       890       900       910       920       930         
pF1KE0 MDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQV
       .:: .: ::::.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::
XP_011 LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
              910       920       930       940       950       960

     940       950       960       970       980       990         
pF1KE0 LEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNS
       ::::::::.::: ::.::.::::::::::::::::::::.:: .::::::::::.:::::
XP_011 LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
              970       980       990      1000      1010      1020

    1000      1010      1020      1030      1040      1050         
pF1KE0 MVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKI
       ::::::.::::::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::
XP_011 MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
             1030      1040      1050      1060      1070      1080

    1060      1070      1080      1090      1100      1110         
pF1KE0 DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVT
       .::: :::. ::.::..:.::::.:::::::::::.:. .:.:   ..:...  .::: :
XP_011 QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDE---TQNQHDDSSSDSGT
             1090      1100      1110      1120         1130       

    1120      1130      1140      1150      1160      1170         
pF1KE0 DSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE
        ::: :::.:.: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::.
XP_011 PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELD
      1140      1150      1160      1170      1180      1190       

    1180      1190           1200      1210      1220      1230    
pF1KE0 AVEAKEKQDEQVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKK
        ::..:..:  .:. ::.     :: : :: :. :..::: :.:.::.::  :::.: ::
XP_011 KVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKK
      1200      1210      1220      1230      1240       1250      

         1240                  1250      1260             1270     
pF1KE0 NKKKIK------------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTK
         :: :            .:.  :.: : :.  :.:   .        :..:.::::...
XP_011 LLKKKKGDLDTAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVR
       1260      1270      1280       1290      1300      1310     

        1280       1290      1300        1310      1320       1330 
pF1KE0 KQTTLAFKP-IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDLD
       :  : . ::  :: ::::::::.::   ::  :..  : ::..  ::::. . :.:.:..
XP_011 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFS
        1320      1330      1340      1350      1360      1370     

            1340      1350      1360      1370       1380      1390
pF1KE0 SDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSD-LEADDVKGSVPL
        .:: .: :.  ::..    :    :.:.::  .. :   .. : :: :. :.   :   
XP_011 EEED-DDADDDDDDNN----DLEELKVKASPITNDGE---DEFVPSDGLDKDEYTFSPGK
         1380      1390          1400         1410      1420       

             1400        1410      1420      1430      1440        
pF1KE0 SSSPPATHFPDET--EITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALN
       :.. :   . :.   .. :     . . :.  .: .:.:     : . :::  :   :.:
XP_011 SKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDGKPSSDTV---PKPKRAPKQKKVVEAVN
      1430      1440      1450      1460         1470      1480    

           1450      1460        1470       1480      1490         
pF1KE0 S------GVSQKPDPAKTKNR--RKRKPSTSDD-SDSNFEKIVSKAVTSKKSKGES----
       :      :. .:    : :.:  .::: : :.. .: :  . .::. :::: :  :    
XP_011 SDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKT-TSKKPKKTSFDQD
         1490      1500      1510      1520      1530       1540   

           1500      1510      1520      1530        
pF1KE0 ---DDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF       
          : :  :: .      .. ::.: .::. ::::..         
XP_011 SDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
          1550      1560      1570      1580         

>>NP_001317629 (OMIM: 126431) DNA topoisomerase 2-beta i  (1626 aa)
 initn: 6509 init1: 6179 opt: 6650  Z-score: 4206.8  bits: 791.2 E(85289):    0
Smith-Waterman score: 6939; 69.3% identity (84.4% similar) in 1568 aa overlap (14-1503:28-1584)

                             10        20               30         
pF1KE0               MEVSPLQPVNENMQVNKIKKNE-------DAKKRLSVERIYQKKTQ
                                  : :  ::.:       :..:.:::::.::::::
NP_001 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
               10        20        30        40        50        60

      40        50        60        70        80        90         
pF1KE0 LEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRD
       :::::::::::::::: .:: :::::::::.: :::::::::::::::::::::::::::
NP_001 LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
               70        80        90       100       110       120

     100       110       120       130       140       150         
pF1KE0 PKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT
        .:.::.:.::::.:.:::::::::::::::::::.::::::::::::::::::::::::
NP_001 KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
              130       140       150       160       170       180

     160       170       180       190       200       210         
pF1KE0 GGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITF
       ::::::::::::::::::::::: .:::. ::::::.:: ...: ..: :.:::::::::
NP_001 GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
              190       200       210       220       230       240

     220       230       240       250       260       270         
pF1KE0 QPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKL
       :::::::::..:::::::::.:::::.::: . :::..::.::::.:::::::.:.::::
NP_001 QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
              250       260       270       280       290       300

     280       290       300       310       320       330         
pF1KE0 DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD
       :::: .:::::: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..
NP_001 DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
              310       320       330       340       350       360

     340       350       360       370       380       390         
pF1KE0 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFI
       :::::::.::.::  :::::.:.:.: :::::::::::::::::::::::: :::::::.
NP_001 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
              370       380       390       400       410       420

     400       410       420       430       440       450         
pF1KE0 KAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLIL
       ::: .::::::::::::::::.:::::::.::...:::::::::::::::..: ::::::
NP_001 KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
              430       440       450       460       470       480

     460       470       480       490       500       510         
pF1KE0 TEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
       :::::::.::::::::.:::.:::::::::::::::::::::::::::::::::::::::
NP_001 TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
              490       500       510       520       530       540

     520       530       540       550       560       570         
pF1KE0 KNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVK
       :.:.: .:::::::::::::::::::::::::::::::::::::::.: :::::::::::
NP_001 KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
              550       560       570       580       590       600

     580       590       600       610       620       630         
pF1KE0 VSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFK
       .::::::..:::.:::.:::.   :.: ::.::::::::::.::::::::::.:::: :.
NP_001 ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
              610       620       630       640       650       660

     640       650       660       670       680       690         
pF1KE0 YSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFI
       :.::::::::.::::::.::::::::::::::::::.: ::::..::: .: .:::::::
NP_001 YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
              670       680       690       700       710       720

     700       710       720       730       740       750         
pF1KE0 NKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHH
       ::::::::::::::::::.:::.:::::::::::::::::::::::::::::::::.:::
NP_001 NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
              730       740       750       760       770       780

     760       770       780       790       800       810         
pF1KE0 GEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFP
       ::..:::::.:::::::::::.::::::::::::::::::.:::::::::::.:::::::
NP_001 GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
              790       800       810       820       830       840

     820       830       840       850       860       870         
pF1KE0 PKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRL
         ::. :::::::::::::::::::::::::::::::::::.::.::.:.::::::.::.
NP_001 AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
              850       860       870       880       890       900

     880       890       900       910       920       930         
pF1KE0 MDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQV
       .:: .: ::::.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::
NP_001 LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
              910       920       930       940       950       960

     940       950       960       970       980       990         
pF1KE0 LEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNS
       ::::::::.::: ::.::.::::::::::::::::::::.:: .::::::::::.:::::
NP_001 LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
              970       980       990      1000      1010      1020

    1000      1010      1020      1030      1040      1050         
pF1KE0 MVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKI
       ::::::.::::::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::
NP_001 MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
             1030      1040      1050      1060      1070      1080

    1060      1070      1080      1090      1100      1110         
pF1KE0 DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVT
       .::: :::. ::.::..:.::::.:::::::::::.:. .:   .:..:...  .::: :
NP_001 QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEE---DETQNQHDDSSSDSGT
             1090      1100      1110      1120         1130       

    1120      1130      1140      1150      1160      1170         
pF1KE0 DSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE
        ::: :::.:.: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::.
NP_001 PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELD
      1140      1150      1160      1170      1180      1190       

    1180      1190           1200      1210      1220      1230    
pF1KE0 AVEAKEKQDEQVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKK
        ::..:..:  .:. ::.     :: : :: :. :..::: :.:.::.::  :::.: ::
NP_001 KVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKK
      1200      1210      1220      1230      1240       1250      

         1240                  1250      1260             1270     
pF1KE0 NKKKIK------------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTK
         :: :            .:.  :.: : :.  :.:   .        :..:.::::...
NP_001 LLKKKKGDLDTAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVR
       1260      1270      1280       1290      1300      1310     

        1280       1290      1300        1310      1320       1330 
pF1KE0 KQTTLAFKP-IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDL-
       :  : . ::  :: ::::::::.::   ::  :..  : ::..  ::::. . :.:.:. 
NP_001 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFS
        1320      1330      1340      1350      1360      1370     

                     1340               1350              1360     
pF1KE0 --------DSDEDFSDFDE--------KTDDED-FVPSDA--------SPPKTKTSPKLS
               :.:.: .:..:         .: :: :::::.        :: :.:..:. :
NP_001 EEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKS
        1380      1390      1400      1410      1420      1430     

        1370            1380      1390      1400        1410       
pF1KE0 NKELKPQK--SVVS----DLEADDVKGSVPLSSSPPATHFPDETEI--TNPVPKKNVTVK
        .. : :   .. :    . ...: ...   .    :. :     .  :. ::.:.:   
NP_001 LHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTV---
        1440      1450      1460      1470      1480      1490     

      1420      1430      1440            1450      1460           
pF1KE0 KTAAKSQSSTSTTGAKKRAAPKGTKRDPALNS------GVSQKPDPAKTKNR--RKRKPS
         :::. . .: :  : . :::  :   :.::      :. .:    : :.:  .::: :
NP_001 --AAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKAS
             1500      1510      1520      1530      1540      1550

    1470       1480      1490      1500      1510      1520        
pF1KE0 TSDD-SDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDED
        :.. .: :  . .::. :::: :  : :   : :                         
NP_001 GSENEGDYNPGRKTSKT-TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKY
             1560       1570      1580      1590      1600         

     1530               
pF1KE0 DLF              
                        
NP_001 FAESDEEEDDVDFAMFN
    1610      1620      

>>NP_001059 (OMIM: 126431) DNA topoisomerase 2-beta isof  (1621 aa)
 initn: 6509 init1: 6179 opt: 6648  Z-score: 4205.6  bits: 791.0 E(85289):    0
Smith-Waterman score: 6937; 69.6% identity (84.8% similar) in 1555 aa overlap (20-1503:37-1579)

                          10        20        30        40         
pF1KE0            MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDT
                                     :: :..:.:::::.::::::::::::::::
NP_001 CGAGAGVGGGNGALTWVNNAAKKEESETANKN-DSSKKLSVERVYQKKTQLEHILLRPDT
         10        20        30         40        50        60     

      50        60        70        80        90       100         
pF1KE0 YIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTI
       :::::: .:: :::::::::.: ::::::::::::::::::::::::::: .:.::.:.:
NP_001 YIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSI
          70        80        90       100       110       120     

     110       120       130       140       150       160         
pF1KE0 DPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKL
       :::.:.:::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_001 DPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKL
         130       140       150       160       170       180     

     170       180       190       200       210       220         
pF1KE0 CNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQ
       ::::::::::::: .:::. ::::::.:: ...: ..: :.::::::::::::::::::.
NP_001 CNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKME
         190       200       210       220       230       240     

     230       240       250       260       270       280         
pF1KE0 SLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVI
       .:::::::::.:::::.::: . :::..::.::::.:::::::.:.:::::::: .::::
NP_001 KLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVI
         250       260       270       280       290       300     

     290       300       310       320       330       340         
pF1KE0 HEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGV
       :: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..:::::::.::
NP_001 HELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGV
         310       320       330       340       350       360     

     350       360       370       380       390       400         
pF1KE0 AVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVE
       .::  :::::.:.:.: :::::::::::::::::::::::: :::::::.::: .:::::
NP_001 SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVE
         370       380       390       400       410       420     

     410       420       430       440       450       460         
pF1KE0 SILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLA
       :::::::::::.:::::::.::...:::::::::::::::..: :::::::::::::.::
NP_001 SILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLA
         430       440       450       460       470       480     

     470       480       490       500       510       520         
pF1KE0 VSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK
       ::::::.:::.::::::::::::::::::::::::::::::::::::::::.:.: .:::
NP_001 VSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLK
         490       500       510       520       530       540     

     530       540       550       560       570       580         
pF1KE0 TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAF
       ::::::::::::::::::::::::::::::::::::.: :::::::::::.::::::..:
NP_001 TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSF
         550       560       570       580       590       600     

     590       600       610       620       630       640         
pF1KE0 YSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAI
       ::.:::.:::.   :.: ::.::::::::::.::::::::::.:::: :.:.::::::::
NP_001 YSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAI
         610       620       630       640       650       660     

     650       660       670       680       690       700         
pF1KE0 SLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNS
       .::::::.::::::::::::::::::.: ::::..::: .: .:::::::::::::::::
NP_001 TLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNS
         670       680       690       700       710       720     

     710       720       730       740       750       760         
pF1KE0 DNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTII
       ::::::::.:::.:::::::::::::::::::::::::::::::::.:::::..:::::.
NP_001 DNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIV
         730       740       750       760       770       780     

     770       780       790       800       810       820         
pF1KE0 NLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL
       :::::::::::.::::::::::::::::::.:::::::::::.:::::::  ::. ::::
NP_001 NLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL
         790       800       810       820       830       840     

     830       840       850       860       870       880         
pF1KE0 YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPML
       :::::::::::::::::::::::::::::::.::.::.:.::::::.::..:: .: :::
NP_001 YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPML
         850       860       870       880       890       900     

     890       900       910       920       930       940         
pF1KE0 PSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEK
       :.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::::::::::.:
NP_001 PNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDK
         910       920       930       940       950       960     

     950       960       970       980       990      1000         
pF1KE0 TPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCL
       :: ::.::.::::::::::::::::::::.:: .::::::::::.:::::::::::.:::
NP_001 TPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCL
         970       980       990      1000      1010      1020     

    1010      1020      1030      1040      1050      1060         
pF1KE0 KKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKP
       :::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::.::: :::. 
NP_001 KKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRS
        1030      1040      1050      1060      1070      1080     

    1070      1080      1090      1100      1110      1120         
pF1KE0 KKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLL
       ::.::..:.::::.:::::::::::.:. .:.:   ..:...  .::: : ::: :::.:
NP_001 KKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDE---TQNQHDDSSSDSGTPSGPDFNYIL
        1090      1100      1110         1120      1130      1140  

    1130      1140      1150      1160      1170      1180         
pF1KE0 DMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE
       .: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::. ::..:..: 
NP_001 NMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDV
           1150      1160      1170      1180      1190      1200  

    1190           1200      1210      1220      1230      1240    
pF1KE0 QVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIK----
        .:. ::.     :: : :: :. :..::: :.:.::.::  :::.: ::  :: :    
NP_001 LAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKKLLKKKKGDLD
           1210      1220      1230      1240       1250      1260 

                     1250      1260             1270      1280     
pF1KE0 --------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTKKQTTLAFKP-
               .:.  :.: : :.  :.:   .        :..:.::::...:  : . :: 
NP_001 TAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS
            1270       1280      1290      1300      1310      1320

         1290      1300        1310      1320       1330           
pF1KE0 IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDL---------DS
        :: ::::::::.::   ::  :..  : ::..  ::::. . :.:.:.         :.
NP_001 AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD
             1330      1340      1350      1360      1370      1380

           1340               1350              1360      1370     
pF1KE0 DEDFSDFDE--------KTDDED-FVPSDA--------SPPKTKTSPKLSNKELKPQK--
       :.: .:..:         .: :: :::::.        :: :.:..:. : .. : :   
NP_001 DDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFG
             1390      1400      1410      1420      1430      1440

              1380      1390      1400        1410      1420       
pF1KE0 SVVS----DLEADDVKGSVPLSSSPPATHFPDETEI--TNPVPKKNVTVKKTAAKSQSST
       .. :    . ...: ...   .    :. :     .  :. ::.:.:     :::. . .
NP_001 NLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTV-----AAKKGKPS
             1450      1460      1470      1480           1490     

      1430      1440            1450      1460        1470         
pF1KE0 STTGAKKRAAPKGTKRDPALNS------GVSQKPDPAKTKNR--RKRKPSTSDD-SDSNF
       : :  : . :::  :   :.::      :. .:    : :.:  .::: : :.. .: : 
NP_001 SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
        1500      1510      1520      1530      1540      1550     

     1480      1490      1500      1510      1520      1530        
pF1KE0 EKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF       
        . .::. :::: :  : :   : :                                   
NP_001 GRKTSKT-TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDD
        1560       1570      1580      1590      1600      1610    




1531 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 10:39:27 2016 done: Sun Nov  6 10:39:29 2016
 Total Scan time: 16.110 Total Display time:  0.540

Function used was FASTA [36.3.4 Apr, 2011]
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