Result of FASTA (omim) for pF1KE3818
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3818, 1182 aa
  1>>>pF1KE3818     1182 - 1182 aa - 1182 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.5713+/-0.000529; mu= -4.2278+/- 0.033
 mean_var=655.6521+/-145.320, 0's: 0 Z-trim(120.9): 1515  B-trim: 2242 in 1/58
 Lambda= 0.050088
 statistics sampled from 36103 (38201) to 36103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.414), width:  16
 Scan time:  8.670

The best scores are:                                      opt bits E(92320)
NP_009298 (OMIM: 164690) tyrosine-protein kinase A (1182) 7914 588.8 7.3e-167
NP_005149 (OMIM: 164690) tyrosine-protein kinase A (1167) 7554 562.8 4.9e-159
XP_016856524 (OMIM: 164690) tyrosine-protein kinas (1182) 7409 552.3 7.1e-156
NP_001161708 (OMIM: 164690) tyrosine-protein kinas (1161) 7402 551.8  1e-155
XP_005245145 (OMIM: 164690) tyrosine-protein kinas (1146) 7401 551.7  1e-155
NP_001161709 (OMIM: 164690) tyrosine-protein kinas (1079) 4614 350.3 4.2e-95
NP_001129472 (OMIM: 164690) tyrosine-protein kinas (1064) 4254 324.2 2.9e-87
NP_001161710 (OMIM: 164690) tyrosine-protein kinas (1058) 4102 313.3 5.8e-84
NP_001161711 (OMIM: 164690) tyrosine-protein kinas (1043) 4101 313.2   6e-84
NP_005148 (OMIM: 189980,608232,617602) tyrosine-pr (1130) 3371 260.5 4.8e-68
NP_009297 (OMIM: 189980,608232,617602) tyrosine-pr (1149) 3371 260.5 4.8e-68
NP_001129473 (OMIM: 164690) tyrosine-protein kinas ( 542) 3213 248.6 8.5e-65
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 1275 108.6 1.2e-22
XP_016866142 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866139 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 1269 108.1 1.6e-22
NP_001357458 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866141 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
XP_016866140 (OMIM: 137025) tyrosine-protein kinas ( 537) 1269 108.1 1.6e-22
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 1259 107.4 2.7e-22
XP_024307011 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307013 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_016881449 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307014 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
XP_024307012 (OMIM: 164880) tyrosine-protein kinas ( 543) 1259 107.4 2.7e-22
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
XP_011539312 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1256 107.2 3.1e-22
XP_006710515 (OMIM: 164940) tyrosine-protein kinas ( 529) 1256 107.2 3.1e-22
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1251 106.8 4.1e-22
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1251 106.8 4.1e-22
XP_011527315 (OMIM: 114500,190090,616937) proto-on ( 536) 1251 106.8 4.1e-22
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 1230 105.3 1.1e-21
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 1230 105.3 1.1e-21
XP_024302815 (OMIM: 153390,615758) tyrosine-protei ( 567) 1229 105.3 1.3e-21
XP_024302814 (OMIM: 153390,615758) tyrosine-protei ( 567) 1229 105.3 1.3e-21
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 1218 104.4   2e-21
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 1218 104.4 2.1e-21
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 1216 104.3 2.3e-21
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 1216 104.3 2.3e-21
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 1216 104.3 2.3e-21
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 1216 104.3 2.3e-21
XP_011515831 (OMIM: 165120) tyrosine-protein kinas ( 682) 1208 103.9   4e-21
XP_016866134 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_011533956 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1196 102.8 6.2e-21
XP_011533957 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_005266938 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21
XP_011533955 (OMIM: 606573) tyrosine-protein kinas ( 505) 1196 102.8 6.2e-21


>>NP_009298 (OMIM: 164690) tyrosine-protein kinase ABL2   (1182 aa)
 initn: 7914 init1: 7914 opt: 7914  Z-score: 3117.3  bits: 588.8 E(92320): 7.3e-167
Smith-Waterman score: 7914; 100.0% identity (100.0% similar) in 1182 aa overlap (1-1182:1-1182)

               10        20        30        40        50        60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180  
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::::::::::::::::::::::::
NP_009 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
             1150      1160      1170      1180  

>>NP_005149 (OMIM: 164690) tyrosine-protein kinase ABL2   (1167 aa)
 initn: 7554 init1: 7554 opt: 7554  Z-score: 2976.7  bits: 562.8 E(92320): 4.9e-159
Smith-Waterman score: 7554; 100.0% identity (100.0% similar) in 1130 aa overlap (53-1182:38-1167)

             30        40        50        60        70        80  
pF1KE3 RGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGC
                                     ::::::::::::::::::::::::::::::
NP_005 LPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEALHRPYGC
        10        20        30        40        50        60       

             90       100       110       120       130       140  
pF1KE3 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
        70        80        90       100       110       120       

            150       160       170       180       190       200  
pF1KE3 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
       130       140       150       160       170       180       

            210       220       230       240       250       260  
pF1KE3 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
       190       200       210       220       230       240       

            270       280       290       300       310       320  
pF1KE3 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
       250       260       270       280       290       300       

            330       340       350       360       370       380  
pF1KE3 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
       310       320       330       340       350       360       

            390       400       410       420       430       440  
pF1KE3 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
       370       380       390       400       410       420       

            450       460       470       480       490       500  
pF1KE3 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
       430       440       450       460       470       480       

            510       520       530       540       550       560  
pF1KE3 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
       490       500       510       520       530       540       

            570       580       590       600       610       620  
pF1KE3 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
       550       560       570       580       590       600       

            630       640       650       660       670       680  
pF1KE3 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
       610       620       630       640       650       660       

            690       700       710       720       730       740  
pF1KE3 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
       670       680       690       700       710       720       

            750       760       770       780       790       800  
pF1KE3 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
       730       740       750       760       770       780       

            810       820       830       840       850       860  
pF1KE3 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
       790       800       810       820       830       840       

            870       880       890       900       910       920  
pF1KE3 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
       850       860       870       880       890       900       

            930       940       950       960       970       980  
pF1KE3 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
       910       920       930       940       950       960       

            990      1000      1010      1020      1030      1040  
pF1KE3 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
       970       980       990      1000      1010      1020       

           1050      1060      1070      1080      1090      1100  
pF1KE3 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
      1030      1040      1050      1060      1070      1080       

           1110      1120      1130      1140      1150      1160  
pF1KE3 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
      1090      1100      1110      1120      1130      1140       

           1170      1180  
pF1KE3 NPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::
NP_005 NPVLNNLLSCVQEISDVVQR
      1150      1160       

>>XP_016856524 (OMIM: 164690) tyrosine-protein kinase AB  (1182 aa)
 initn: 7407 init1: 7407 opt: 7409  Z-score: 2920.1  bits: 552.3 E(92320): 7.1e-156
Smith-Waterman score: 7409; 99.4% identity (99.6% similar) in 1118 aa overlap (65-1182:65-1182)

           40        50        60        70        80        90    
pF1KE3 RDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIR
                                     :..   .: :::::::::::::::::::::
XP_016 EMILKYLLIQIDRTASGRGPNKKKKKKEKNGESEELTSEEALHRPYGCDVEPQALNEAIR
           40        50        60        70        80        90    

          100       110       120       130       140       150    
pF1KE3 WSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ
          100       110       120       130       140       150    

          160       170       180       190       200       210    
pF1KE3 GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYE
          160       170       180       190       200       210    

          220       230       240       250       260       270    
pF1KE3 GRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGV
          220       230       240       250       260       270    

          280       290       300       310       320       330    
pF1KE3 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
          280       290       300       310       320       330    

          340       350       360       370       380       390    
pF1KE3 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS
          340       350       360       370       380       390    

          400       410       420       430       440       450    
pF1KE3 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
          400       410       420       430       440       450    

          460       470       480       490       500       510    
pF1KE3 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV
          460       470       480       490       500       510    

          520       530       540       550       560       570    
pF1KE3 YELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPI
          520       530       540       550       560       570    

          580       590       600       610       620       630    
pF1KE3 LPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSS
          580       590       600       610       620       630    

          640       650       660       670       680       690    
pF1KE3 LLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVAS
          640       650       660       670       680       690    

          700       710       720       730       740       750    
pF1KE3 LQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTP
          700       710       720       730       740       750    

          760       770       780       790       800       810    
pF1KE3 RLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLER
          760       770       780       790       800       810    

          820       830       840       850       860       870    
pF1KE3 TVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEK
          820       830       840       850       860       870    

          880       890       900       910       920       930    
pF1KE3 DPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVL
          880       890       900       910       920       930    

          940       950       960       970       980       990    
pF1KE3 ISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQ
          940       950       960       970       980       990    

         1000      1010      1020      1030      1040      1050    
pF1KE3 HPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSIS
         1000      1010      1020      1030      1040      1050    

         1060      1070      1080      1090      1100      1110    
pF1KE3 PAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGH
         1060      1070      1080      1090      1100      1110    

         1120      1130      1140      1150      1160      1170    
pF1KE3 QLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQ
         1120      1130      1140      1150      1160      1170    

         1180  
pF1KE3 EISDVVQR
       ::::::::
XP_016 EISDVVQR
         1180  

>>NP_001161708 (OMIM: 164690) tyrosine-protein kinase AB  (1161 aa)
 initn: 7401 init1: 7401 opt: 7402  Z-score: 2917.4  bits: 551.8 E(92320): 1e-155
Smith-Waterman score: 7709; 98.2% identity (98.2% similar) in 1182 aa overlap (1-1182:1-1161)

               10        20        30        40        50        60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH--------
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
                    :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
                          60        70        80        90         

              130       140       150       160       170       180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
     160       170       180       190       200       210         

              250       260       270       280       290       300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
     220       230       240       250       260       270         

              310       320       330       340       350       360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
     280       290       300       310       320       330         

              370       380       390       400       410       420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
     340       350       360       370       380       390         

              430       440       450       460       470       480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
     400       410       420       430       440       450         

              490       500       510       520       530       540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
     460       470       480       490       500       510         

              550       560       570       580       590       600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
     520       530       540       550       560       570         

              610       620       630       640       650       660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
     580       590       600       610       620       630         

              670       680       690       700       710       720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
     640       650       660       670       680       690         

              730       740       750       760       770       780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
     700       710       720       730       740       750         

              790       800       810       820       830       840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
     760       770       780       790       800       810         

              850       860       870       880       890       900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
     820       830       840       850       860       870         

              910       920       930       940       950       960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
     880       890       900       910       920       930         

              970       980       990      1000      1010      1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
     940       950       960       970       980       990         

             1030      1040      1050      1060      1070      1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
    1000      1010      1020      1030      1040      1050         

             1090      1100      1110      1120      1130      1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
    1060      1070      1080      1090      1100      1110         

             1150      1160      1170      1180  
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
    1120      1130      1140      1150      1160 

>>XP_005245145 (OMIM: 164690) tyrosine-protein kinase AB  (1146 aa)
 initn: 7401 init1: 7401 opt: 7401  Z-score: 2917.1  bits: 551.7 E(92320): 1e-155
Smith-Waterman score: 7401; 100.0% identity (100.0% similar) in 1109 aa overlap (74-1182:38-1146)

            50        60        70        80        90       100   
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLG
                                     ::::::::::::::::::::::::::::::
XP_005 LPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLLG
        10        20        30        40        50        60       

           110       120       130       140       150       160   
pF1KE3 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
        70        80        90       100       110       120       

           170       180       190       200       210       220   
pF1KE3 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
       130       140       150       160       170       180       

           230       240       250       260       270       280   
pF1KE3 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
       190       200       210       220       230       240       

           290       300       310       320       330       340   
pF1KE3 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
       250       260       270       280       290       300       

           350       360       370       380       390       400   
pF1KE3 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
       310       320       330       340       350       360       

           410       420       430       440       450       460   
pF1KE3 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
       370       380       390       400       410       420       

           470       480       490       500       510       520   
pF1KE3 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
       430       440       450       460       470       480       

           530       540       550       560       570       580   
pF1KE3 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
       490       500       510       520       530       540       

           590       600       610       620       630       640   
pF1KE3 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
       550       560       570       580       590       600       

           650       660       670       680       690       700   
pF1KE3 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
       610       620       630       640       650       660       

           710       720       730       740       750       760   
pF1KE3 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
       670       680       690       700       710       720       

           770       780       790       800       810       820   
pF1KE3 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
       730       740       750       760       770       780       

           830       840       850       860       870       880   
pF1KE3 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
       790       800       810       820       830       840       

           890       900       910       920       930       940   
pF1KE3 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
       850       860       870       880       890       900       

           950       960       970       980       990      1000   
pF1KE3 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
       910       920       930       940       950       960       

          1010      1020      1030      1040      1050      1060   
pF1KE3 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
       970       980       990      1000      1010      1020       

          1070      1080      1090      1100      1110      1120   
pF1KE3 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
      1030      1040      1050      1060      1070      1080       

          1130      1140      1150      1160      1170      1180  
pF1KE3 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
      1090      1100      1110      1120      1130      1140      

>>NP_001161709 (OMIM: 164690) tyrosine-protein kinase AB  (1079 aa)
 initn: 4653 init1: 4614 opt: 4614  Z-score: 1828.9  bits: 350.3 E(92320): 4.2e-95
Smith-Waterman score: 6990; 91.3% identity (91.3% similar) in 1182 aa overlap (1-1182:1-1079)

               10        20        30        40        50        60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
       :::::::::::::::::::::::::::                                 
NP_001 NAPTPPKRSSSFREMENQPHKKYELTG---------------------------------
              670       680                                        

              730       740       750       760       770       780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              790       800       810       820       830       840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
                 690       700       710       720       730       

              850       860       870       880       890       900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
       740       750       760       770       780       790       

              910       920       930       940       950       960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
       800       810       820       830       840       850       

              970       980       990      1000      1010      1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
       860       870       880       890       900       910       

             1030      1040      1050      1060      1070      1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
       920       930       940       950       960       970       

             1090      1100      1110      1120      1130      1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
       980       990      1000      1010      1020      1030       

             1150      1160      1170      1180  
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
      1040      1050      1060      1070         

>>NP_001129472 (OMIM: 164690) tyrosine-protein kinase AB  (1064 aa)
 initn: 4293 init1: 4254 opt: 4254  Z-score: 1688.4  bits: 324.2 E(92320): 2.9e-87
Smith-Waterman score: 6630; 90.9% identity (90.9% similar) in 1130 aa overlap (53-1182:38-1064)

             30        40        50        60        70        80  
pF1KE3 RGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGC
                                     ::::::::::::::::::::::::::::::
NP_001 LPPNSYGRDQDTSLCCLCTEASESALPDLTDHFASCVEDGFEGDKTGGSSPEALHRPYGC
        10        20        30        40        50        60       

             90       100       110       120       130       140  
pF1KE3 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
        70        80        90       100       110       120       

            150       160       170       180       190       200  
pF1KE3 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES
       130       140       150       160       170       180       

            210       220       230       240       250       260  
pF1KE3 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP
       190       200       210       220       230       240       

            270       280       290       300       310       320  
pF1KE3 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKED
       250       260       270       280       290       300       

            330       340       350       360       370       380  
pF1KE3 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVT
       310       320       330       340       350       360       

            390       400       410       420       430       440  
pF1KE3 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH
       370       380       390       400       410       420       

            450       460       470       480       490       500  
pF1KE3 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY
       430       440       450       460       470       480       

            510       520       530       540       550       560  
pF1KE3 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASS
       490       500       510       520       530       540       

            570       580       590       600       610       620  
pF1KE3 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPA
       550       560       570       580       590       600       

            630       640       650       660       670       680  
pF1KE3 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
       610       620       630       640       650       660       

            690       700       710       720       730       740  
pF1KE3 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAG
       :::::                                                       
NP_001 YELTG-------------------------------------------------------
       670                                                         

            750       760       770       780       790       800  
pF1KE3 GGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLP
                                                       ::::::::::::
NP_001 ------------------------------------------------LPEQDRMAMTLP
                                                            680    

            810       820       830       840       850       860  
pF1KE3 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPL
          690       700       710       720       730       740    

            870       880       890       900       910       920  
pF1KE3 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPV
          750       760       770       780       790       800    

            930       940       950       960       970       980  
pF1KE3 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKC
          810       820       830       840       850       860    

            990      1000      1010      1020      1030      1040  
pF1KE3 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMP
          870       880       890       900       910       920    

           1050      1060      1070      1080      1090      1100  
pF1KE3 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTE
          930       940       950       960       970       980    

           1110      1120      1130      1140      1150      1160  
pF1KE3 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGT
          990      1000      1010      1020      1030      1040    

           1170      1180  
pF1KE3 NPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::
NP_001 NPVLNNLLSCVQEISDVVQR
         1050      1060    

>>NP_001161710 (OMIM: 164690) tyrosine-protein kinase AB  (1058 aa)
 initn: 4140 init1: 4101 opt: 4102  Z-score: 1629.0  bits: 313.3 E(92320): 5.8e-84
Smith-Waterman score: 6785; 89.5% identity (89.5% similar) in 1182 aa overlap (1-1182:1-1058)

               10        20        30        40        50        60
pF1KE3 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
NP_001 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQH--------
               10        20        30        40        50          

               70        80        90       100       110       120
pF1KE3 DGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
                    :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVA
                          60        70        80        90         

              130       140       150       160       170       180
pF1KE3 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSR
     100       110       120       130       140       150         

              190       200       210       220       230       240
pF1KE3 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFST
     160       170       180       190       200       210         

              250       260       270       280       290       300
pF1KE3 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYG
     220       230       240       250       260       270         

              310       320       330       340       350       360
pF1KE3 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIV
     280       290       300       310       320       330         

              370       380       390       400       410       420
pF1KE3 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN
     340       350       360       370       380       390         

              430       440       450       460       470       480
pF1KE3 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIAT
     400       410       420       430       440       450         

              490       500       510       520       530       540
pF1KE3 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE
     460       470       480       490       500       510         

              550       560       570       580       590       600
pF1KE3 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATE
     520       530       540       550       560       570         

              610       620       630       640       650       660
pF1KE3 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKR
     580       590       600       610       620       630         

              670       680       690       700       710       720
pF1KE3 NAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGG
       :::::::::::::::::::::::::::                                 
NP_001 NAPTPPKRSSSFREMENQPHKKYELTG---------------------------------
     640       650       660                                       

              730       740       750       760       770       780
pF1KE3 SFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPR
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              790       800       810       820       830       840
pF1KE3 SNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEES
                  670       680       690       700       710      

              850       860       870       880       890       900
pF1KE3 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLG
        720       730       740       750       760       770      

              910       920       930       940       950       960
pF1KE3 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKL
        780       790       800       810       820       830      

              970       980       990      1000      1010      1020
pF1KE3 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQE
        840       850       860       870       880       890      

             1030      1040      1050      1060      1070      1080
pF1KE3 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKIS
        900       910       920       930       940       950      

             1090      1100      1110      1120      1130      1140
pF1KE3 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAV
        960       970       980       990      1000      1010      

             1150      1160      1170      1180  
pF1KE3 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       1020      1030      1040      1050        

>>NP_001161711 (OMIM: 164690) tyrosine-protein kinase AB  (1043 aa)
 initn: 4140 init1: 4101 opt: 4101  Z-score: 1628.7  bits: 313.2 E(92320): 6e-84
Smith-Waterman score: 6477; 90.7% identity (90.7% similar) in 1109 aa overlap (74-1182:38-1043)

            50        60        70        80        90       100   
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLG
                                     ::::::::::::::::::::::::::::::
NP_001 LPPNSYGRDQDTSLCCLCTEASESALPDLTEALHRPYGCDVEPQALNEAIRWSSKENLLG
        10        20        30        40        50        60       

           110       120       130       140       150       160   
pF1KE3 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYIT
        70        80        90       100       110       120       

           170       180       190       200       210       220   
pF1KE3 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN
       130       140       150       160       170       180       

           230       240       250       260       270       280   
pF1KE3 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM
       190       200       210       220       230       240       

           290       300       310       320       330       340   
pF1KE3 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN
       250       260       270       280       290       300       

           350       360       370       380       390       400   
pF1KE3 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK
       310       320       330       340       350       360       

           410       420       430       440       450       460   
pF1KE3 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS
       370       380       390       400       410       420       

           470       480       490       500       510       520   
pF1KE3 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK
       430       440       450       460       470       480       

           530       540       550       560       570       580   
pF1KE3 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLK
       490       500       510       520       530       540       

           590       600       610       620       630       640   
pF1KE3 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETC
       550       560       570       580       590       600       

           650       660       670       680       690       700   
pF1KE3 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSF
       ::::::::::::::::::::::::::::::::::::::::::::                
NP_001 FTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG----------------
       610       620       630       640       650                 

           710       720       730       740       750       760   
pF1KE3 TPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGL
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

           770       780       790       800       810       820   
pF1KE3 RAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
                                  :::::::::::::::::::::::::::::::::
NP_001 ---------------------------LPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPE
                                        660       670       680    

           830       840       850       860       870       880   
pF1KE3 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAG
          690       700       710       720       730       740    

           890       900       910       920       930       940   
pF1KE3 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTP
          750       760       770       780       790       800    

           950       960       970       980       990      1000   
pF1KE3 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPT
          810       820       830       840       850       860    

          1010      1020      1030      1040      1050      1060   
pF1KE3 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISPAKMANGTA
          870       880       890       900       910       920    

          1070      1080      1090      1100      1110      1120   
pF1KE3 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGY
          930       940       950       960       970       980    

          1130      1140      1150      1160      1170      1180  
pF1KE3 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR
          990      1000      1010      1020      1030      1040   

>>NP_005148 (OMIM: 189980,608232,617602) tyrosine-protei  (1130 aa)
 initn: 3269 init1: 2813 opt: 3371  Z-score: 1343.3  bits: 260.5 E(92320): 4.8e-68
Smith-Waterman score: 3643; 54.5% identity (72.5% similar) in 1162 aa overlap (74-1182:27-1130)

            50        60        70        80        90       100   
pF1KE3 TGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL-
                                     :::.:: . : :::.:.:: ::.:::::: 
NP_005     MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLA
                   10        20        30        40        50      

            110       120       130       140       150       160  
pF1KE3 GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI
       : .:.:::::::::::::::::::::::::::::::::.:::: :...::::::::::::
NP_005 GPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYI
         60        70        80        90       100       110      

            170       180       190       200       210       220  
pF1KE3 TPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI
       ::::::::::::::::::.:::::::: :::::::::::::::: :::::::::::::::
NP_005 TPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI
        120       130       140       150       160       170      

            230       240       250       260       270       280  
pF1KE3 NTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWE
       ::..:::.::..::::.::::::::::::::::.::::::::: :::::::::: .::::
NP_005 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE
        180       190       200       210       220       230      

            290       300       310       320       330       340  
pF1KE3 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP
       ::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_005 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP
        240       250       260       270       280       290      

            350       360       370       380       390       400  
pF1KE3 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK
       :::::::::: ::::::.::.: :::::::::::::.::.::::::::::::::::::::
NP_005 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK
        300       310       320       330       340       350      

            410       420       430       440       450       460  
pF1KE3 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF
       :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: :
NP_005 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF
        360       370       380       390       400       410      

            470       480       490       500       510       520  
pF1KE3 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACW
       :::::::::::::::::::::::::::::::::.:::: ::::.::::: ::::::::::
NP_005 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW
        420       430       440       450       460       470      

            530       540       550       560       570       580  
pF1KE3 KWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTL
       .:.:.::::::: ::::::::..::::.:: .:::. .  ..:   : . : ::.:::: 
NP_005 QWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLL-QAPELPTKTRTS
        480       490       500       510       520        530     

            590       600       610       620       630       640  
pF1KE3 KKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRDKSPSSLLEDAKET
       .. .:.... .  .    .. .   :      .  . :: ::::.:    ..: ::  : 
NP_005 RRAAEHRDTTDVPEMPHSKGQGESDPL----DHEPAVSPLLPRKERGPPEGGLNED--ER
         540       550       560           570       580           

            650       660         670       680       690       700
pF1KE3 CFTRDRKGGFFSSFMKKRN--APTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADG
        . .:.: ..::...::..  ::::::::::::::..::...     .  ....     .
NP_005 LLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISN----GA
     590       600       610       620       630       640         

              710       720       730       740       750       760
pF1KE3 FSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKKT
       ..::: .       ::  .:.           :  .:.   .::    .:: .:.: ::.
NP_005 LAFTPLDTADPAKSPKPSNGA-----------GVPNGALRESGG----SGFRSPHLWKKS
         650       660                  670           680       690

                   770       780       790       800       810     
pF1KE3 LGLRA-----GKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERT
         : .     :.  .. ..:: : :: :.: .  :  . .  ..::::. : .  :.. .
NP_005 STLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSS
              700       710       720       730       740       750

         820       830       840       850       860        870    
pF1KE3 VSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLR-TPSGDLAITE-
       .  . . :. .      ::.:    :. .:    .  . ::... : : . ... :  : 
NP_005 TFGGHKSEKPA------LPRKR---AGENR----SDQVTRGTVTPPPRLVKKNEEAADEV
              760                770           780       790       

                880       890       900       910       920        
pF1KE3 -KD----PPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHN
        ::     :: .  ...  :  .. . .   :.    : :.  .  .:: : :: ::.  
NP_005 FKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTS--
       800       810       820       830       840       850       

      930       940       950       960       970        980       
pF1KE3 HKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSG-DKDRPRRVKPKCAPPPP
        :.        .. ::.      .:.  . :    :.  : : :: .  :.::  :::::
NP_005 -KAGSGAPGGTSKGPAE------ESRVRRHK----HSSESPGRDKGKLSRLKP--APPPP
          860       870                 880       890         900  

       990      1000      1010                           1020      
pF1KE3 PVMRLLQHPSICSDPTEEPTALTAGQST---------------------SETQEGGKKAA
       :.    .  .  . :.. :.  .::...                     :.  :: :: .
NP_005 PAA---SAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPV
               910       920       930       940       950         

       1030         1040        1050       1060           1070     
pF1KE3 LGAVPISGKA---GRPVMPPPQVP--LPTSSISPA-KMANGTA-----GTKVALRKTKQA
       : :.:   .:   : :. : : ::  ::..: . :  . ..::     .:.:.::::.: 
NP_005 LPATPKPQSAKPSGTPISPAP-VPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQP
     960       970       980        990      1000      1010        

        1080      1090      1100          1110      1120      1130 
pF1KE3 AEKISADKISKEALLECADLLSSALT----EPVPNSQLVDTGHQLLDYCSGYVDCIPQTR
        :.:..  :.: ..:. .. :  :..    . . .: ....:..:  .: .::: : : :
NP_005 PERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMR
     1020      1030      1040      1050      1060      1070        

            1140      1150       1160      1170      1180  
pF1KE3 NKFAFREAVSKLELSLQELQVSSAAAGV-PGTNPVLNNLLSCVQEISDVVQR
       ::::::::..::: .:.:::.  :.::  :...  ...::: :.::::.:::
NP_005 NKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
     1080      1090      1100      1110      1120      1130




1182 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:49:50 2019 done: Thu Oct 24 21:49:52 2019
 Total Scan time:  8.670 Total Display time:  0.320

Function used was FASTA [36.3.4 Apr, 2011]
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