FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2062, 821 aa 1>>>pF1KE2062 821 - 821 aa - 821 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.1186+/-0.00146; mu= -2.6669+/- 0.083 mean_var=475.7568+/-108.081, 0's: 0 Z-trim(107.2): 452 B-trim: 0 in 0/52 Lambda= 0.058801 statistics sampled from 8924 (9414) to 8924 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.289), width: 16 Scan time: 2.480 The best scores are: opt bits E(32554) CCDS31298.1 FGFR2 gene_id:2263|Hs108|chr10 ( 821) 5549 487.2 4.8e-137 CCDS81515.1 FGFR2 gene_id:2263|Hs108|chr10 ( 819) 5525 485.1 2e-136 CCDS7620.2 FGFR2 gene_id:2263|Hs108|chr10 ( 822) 5372 472.2 1.6e-132 CCDS44489.1 FGFR2 gene_id:2263|Hs108|chr10 ( 769) 4981 439.0 1.5e-122 CCDS73210.1 FGFR2 gene_id:2263|Hs108|chr10 ( 732) 4722 417.0 6e-116 CCDS44485.1 FGFR2 gene_id:2263|Hs108|chr10 ( 704) 4521 399.9 7.9e-111 CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 ( 707) 4350 385.4 1.8e-106 CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 ( 680) 4154 368.7 1.8e-101 CCDS43732.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 4046 359.7 1.2e-98 CCDS55223.1 FGFR1 gene_id:2260|Hs108|chr8 ( 853) 4046 359.7 1.2e-98 CCDS6107.2 FGFR1 gene_id:2260|Hs108|chr8 ( 822) 4043 359.4 1.4e-98 CCDS55222.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 4019 357.4 5.7e-98 CCDS55221.1 FGFR1 gene_id:2260|Hs108|chr8 ( 812) 3970 353.2 1e-96 CCDS81514.1 FGFR2 gene_id:2263|Hs108|chr10 ( 593) 3858 343.5 6.1e-94 CCDS43731.1 FGFR1 gene_id:2260|Hs108|chr8 ( 731) 3757 335.1 2.6e-91 CCDS43730.1 FGFR1 gene_id:2260|Hs108|chr8 ( 733) 3754 334.8 3.1e-91 CCDS3353.1 FGFR3 gene_id:2261|Hs108|chr4 ( 806) 3401 305.0 3.4e-82 CCDS54706.1 FGFR3 gene_id:2261|Hs108|chr4 ( 808) 3285 295.1 3.1e-79 CCDS44486.1 FGFR2 gene_id:2263|Hs108|chr10 ( 709) 3156 284.1 5.7e-76 CCDS4410.1 FGFR4 gene_id:2264|Hs108|chr5 ( 802) 3035 273.9 7.6e-73 CCDS44487.1 FGFR2 gene_id:2263|Hs108|chr10 ( 705) 2690 244.6 4.5e-64 CCDS3354.1 FGFR3 gene_id:2261|Hs108|chr4 ( 694) 2174 200.8 6.7e-51 CCDS4411.1 FGFR4 gene_id:2264|Hs108|chr5 ( 762) 1808 169.8 1.6e-41 CCDS78096.1 FGFR4 gene_id:2264|Hs108|chr5 ( 734) 1662 157.4 8.3e-38 CCDS53525.1 RET gene_id:5979|Hs108|chr10 (1072) 1115 111.2 9.6e-24 CCDS7200.1 RET gene_id:5979|Hs108|chr10 (1114) 1115 111.2 9.9e-24 CCDS78389.1 TEK gene_id:7010|Hs108|chr9 ( 976) 832 87.1 1.5e-16 CCDS75825.1 TEK gene_id:7010|Hs108|chr9 (1081) 832 87.2 1.6e-16 CCDS6519.1 TEK gene_id:7010|Hs108|chr9 (1124) 832 87.2 1.7e-16 CCDS482.1 TIE1 gene_id:7075|Hs108|chr1 (1138) 830 87.1 1.9e-16 CCDS58399.1 NTRK3 gene_id:4916|Hs108|chr15 ( 817) 792 83.6 1.5e-15 CCDS10340.1 NTRK3 gene_id:4916|Hs108|chr15 ( 825) 776 82.3 3.7e-15 CCDS75874.1 MUSK gene_id:4593|Hs108|chr9 ( 783) 749 80.0 1.8e-14 CCDS48005.1 MUSK gene_id:4593|Hs108|chr9 ( 869) 749 80.0 1.9e-14 CCDS3497.1 KDR gene_id:3791|Hs108|chr4 (1356) 735 79.1 5.6e-14 CCDS5116.1 ROS1 gene_id:6098|Hs108|chr6 (2347) 737 79.6 6.9e-14 CCDS35050.1 NTRK2 gene_id:4915|Hs108|chr9 ( 822) 724 77.9 8e-14 CCDS6671.1 NTRK2 gene_id:4915|Hs108|chr9 ( 838) 720 77.5 1e-13 CCDS9330.1 FLT1 gene_id:2321|Hs108|chr13 (1338) 718 77.6 1.5e-13 CCDS30890.1 NTRK1 gene_id:4914|Hs108|chr1 ( 760) 698 75.6 3.5e-13 CCDS30891.1 NTRK1 gene_id:4914|Hs108|chr1 ( 790) 698 75.6 3.6e-13 CCDS47058.1 KIT gene_id:3815|Hs108|chr4 ( 972) 695 75.5 4.8e-13 CCDS3496.1 KIT gene_id:3815|Hs108|chr4 ( 976) 695 75.5 4.8e-13 CCDS1161.1 NTRK1 gene_id:4914|Hs108|chr1 ( 796) 685 74.5 7.7e-13 CCDS73785.1 IGF1R gene_id:3480|Hs108|chr15 (1366) 680 74.4 1.4e-12 CCDS10378.1 IGF1R gene_id:3480|Hs108|chr15 (1367) 680 74.4 1.4e-12 CCDS626.1 ROR1 gene_id:4919|Hs108|chr1 ( 937) 668 73.2 2.3e-12 CCDS6691.1 ROR2 gene_id:4920|Hs108|chr9 ( 943) 667 73.1 2.5e-12 CCDS42487.1 INSR gene_id:3643|Hs108|chr19 (1370) 666 73.2 3.3e-12 CCDS12176.1 INSR gene_id:3643|Hs108|chr19 (1382) 666 73.3 3.3e-12 >>CCDS31298.1 FGFR2 gene_id:2263|Hs108|chr10 (821 aa) initn: 5549 init1: 5549 opt: 5549 Z-score: 2573.8 bits: 487.2 E(32554): 4.8e-137 Smith-Waterman score: 5549; 100.0% identity (100.0% similar) in 821 aa overlap (1-821:1-821) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS 730 740 750 760 770 780 790 800 810 820 pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT ::::::::::::::::::::::::::::::::::::::::: CCDS31 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 790 800 810 820 >>CCDS81515.1 FGFR2 gene_id:2263|Hs108|chr10 (819 aa) initn: 2935 init1: 2906 opt: 5525 Z-score: 2562.8 bits: 485.1 E(32554): 2e-136 Smith-Waterman score: 5525; 99.8% identity (99.8% similar) in 821 aa overlap (1-821:1-819) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK :::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RIPLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK 430 440 450 460 470 490 500 510 520 530 540 pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS 720 730 740 750 760 770 790 800 810 820 pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT ::::::::::::::::::::::::::::::::::::::::: CCDS81 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 780 790 800 810 >>CCDS7620.2 FGFR2 gene_id:2263|Hs108|chr10 (822 aa) initn: 5263 init1: 3102 opt: 5372 Z-score: 2492.6 bits: 472.2 E(32554): 1.6e-132 Smith-Waterman score: 5372; 96.7% identity (98.2% similar) in 824 aa overlap (1-821:1-822) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL ::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .::::::: CCDS76 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL 310 320 330 340 350 370 380 390 400 410 pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK : :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS76 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 720 730 740 750 760 770 780 790 800 810 820 pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT :::::::::::::::::::::::::::::::::::::::::::: CCDS76 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 780 790 800 810 820 >>CCDS44489.1 FGFR2 gene_id:2263|Hs108|chr10 (769 aa) initn: 4872 init1: 2711 opt: 4981 Z-score: 2313.7 bits: 439.0 E(32554): 1.5e-122 Smith-Waterman score: 4981; 96.5% identity (98.1% similar) in 770 aa overlap (1-767:1-768) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL ::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .::::::: CCDS44 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL 310 320 330 340 350 370 380 390 400 410 pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK : :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 720 730 740 750 760 780 790 800 810 820 pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT >>CCDS73210.1 FGFR2 gene_id:2263|Hs108|chr10 (732 aa) initn: 4722 init1: 4722 opt: 4722 Z-score: 2195.2 bits: 417.0 E(32554): 6e-116 Smith-Waterman score: 4765; 89.2% identity (89.2% similar) in 821 aa overlap (1-821:1-732) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::: CCDS73 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------ 10 20 30 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF CCDS73 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF 460 470 480 490 500 510 610 620 630 640 650 660 pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT 520 530 540 550 560 570 670 680 690 700 710 720 pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS 640 650 660 670 680 690 790 800 810 820 pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT ::::::::::::::::::::::::::::::::::::::::: CCDS73 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 700 710 720 730 >>CCDS44485.1 FGFR2 gene_id:2263|Hs108|chr10 (704 aa) initn: 2878 init1: 2655 opt: 4521 Z-score: 2103.2 bits: 399.9 E(32554): 7.9e-111 Smith-Waterman score: 4521; 99.7% identity (99.7% similar) in 669 aa overlap (153-821:38-704) 130 140 150 160 170 180 pF1KE2 NVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAG :::::::::::::::::::::::::::::: CCDS44 ICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAG 10 20 30 40 50 60 190 200 210 220 230 240 pF1KE2 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINH 70 80 90 100 110 120 250 260 270 280 290 300 pF1KE2 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYG 130 140 150 160 170 180 310 320 330 340 350 360 pF1KE2 PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPA 190 200 210 220 230 240 370 380 390 400 410 420 pF1KE2 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 250 260 270 280 290 300 430 440 450 460 470 480 pF1KE2 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT :::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PLRRQV--SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 310 320 330 340 350 360 490 500 510 520 530 540 pF1KE2 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 370 380 390 400 410 420 550 560 570 580 590 600 pF1KE2 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 430 440 450 460 470 480 610 620 630 640 650 660 pF1KE2 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 490 500 510 520 530 540 670 680 690 700 710 720 pF1KE2 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 550 560 570 580 590 600 730 740 750 760 770 780 pF1KE2 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPS 610 620 630 640 650 660 790 800 810 820 pF1KE2 YPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT ::::::::::::::::::::::::::::::::::::::: CCDS44 YPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT 670 680 690 700 >>CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 (707 aa) initn: 4337 init1: 4337 opt: 4350 Z-score: 2024.8 bits: 385.4 E(32554): 1.8e-106 Smith-Waterman score: 4393; 86.3% identity (87.2% similar) in 790 aa overlap (1-790:1-701) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::: CCDS53 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------ 10 20 30 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF CCDS53 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE2 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE2 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE2 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 400 410 420 430 440 450 550 560 570 580 590 600 pF1KE2 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF 460 470 480 490 500 510 610 620 630 640 650 660 pF1KE2 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT 520 530 540 550 560 570 670 680 690 700 710 720 pF1KE2 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 580 590 600 610 620 630 730 740 750 760 770 780 pF1KE2 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS :::::::::::::::::::::::::::::::::::::::::::::::: .: .. .. CCDS53 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHK 640 650 660 670 680 690 790 800 810 820 pF1KE2 PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT : .. : CCDS53 PPCNPSHLPCVLAVDQ 700 >>CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 (680 aa) initn: 4045 init1: 2711 opt: 4154 Z-score: 1935.1 bits: 368.7 E(32554): 1.8e-101 Smith-Waterman score: 4197; 84.9% identity (86.5% similar) in 770 aa overlap (1-767:1-679) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV :::::::::::::::::::::::::::::::::::: CCDS44 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPE------------------------ 10 20 30 70 80 90 100 110 120 pF1KE2 RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF CCDS44 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE2 MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 -----DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE2 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE2 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE2 YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL ::::::::::::: .:.:... :. .:. ::: ::::: : ..: :: . .::::::: CCDS44 YGPDGLPYLKVLKHSGINSSNAEVLALF--NVTEADAGEYICKVSNYIGQANQSAWLTVL 220 230 240 250 260 370 380 390 400 410 pF1KE2 P---APGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK : :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHK 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE2 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFP 330 340 350 360 370 380 480 490 500 510 520 530 pF1KE2 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEM 390 400 410 420 430 440 540 550 560 570 580 590 pF1KE2 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 450 460 470 480 490 500 600 610 620 630 640 650 pF1KE2 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 510 520 530 540 550 560 660 670 680 690 700 710 pF1KE2 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 570 580 590 600 610 620 720 730 740 750 760 770 pF1KE2 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI 630 640 650 660 670 680 780 790 800 810 820 pF1KE2 QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT >>CCDS43732.1 FGFR1 gene_id:2260|Hs108|chr8 (820 aa) initn: 3880 init1: 2074 opt: 4046 Z-score: 1884.7 bits: 359.7 E(32554): 1.2e-98 Smith-Waterman score: 4046; 71.8% identity (88.6% similar) in 827 aa overlap (1-820:1-818) 10 20 30 40 50 60 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV : :: .. .:.. ::: :::: .: :.. .: :.. : ... ::. :.. CCDS43 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 10 20 30 40 50 70 80 90 100 110 pF1KE2 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY :: :.: . :.: .:::.:. .::: . :: .... ..: :::::::..: :.: : CCDS43 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK : :::.::. :..:.:: : . . .:..:.: :::::. :::::.:::::::.::: CCDS43 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE :.::..:.: ::.:::::::::: .::::::::: ::.::.::::::::::::.:::: CCDS43 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK ::::::::.:::::::::::::::::::: ....:..:::.:::::: ::::::.::.: CCDS43 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAW :::: :::.:::...::.:::::::::.:::..:::.::::::::::::::::.: :::: CCDS43 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 LTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVH :::: : .. . .:: :::: ::: :.:::.::: .::. .::. ::: :: :: ::: CCDS43 LTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 KLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF ::.: :::::::::::.::.::::.. ::: .::::.. ::::::::::::::::.::. CCDS43 KLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWEL 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE2 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME :::.:.::::::::::::::.:::.:.:::::.... :::::::.::::::::::.:::: CCDS43 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE ::::::::::::::::::::::::::::::::::::::::.::::::.:: :. .. ::: CCDS43 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY :.. ::::::.::.:::::::::.::::::::::::::::.::::::::::::::..::: CCDS43 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE2 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL ::::::::::::::::::::::.:::::::::::::.:::::::::::::.::::::::: CCDS43 YKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE2 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL :::::::::.::::::::::::::::::::::::::::::::::..::.:.::::::.:: CCDS43 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL 720 730 740 750 760 770 780 790 800 810 820 pF1KE2 EQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVKT .:::::.:::::: ::::.::::: .:.: :::::..: ::..: CCDS43 DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 780 790 800 810 820 >>CCDS55223.1 FGFR1 gene_id:2260|Hs108|chr8 (853 aa) initn: 3880 init1: 2074 opt: 4046 Z-score: 1884.5 bits: 359.7 E(32554): 1.2e-98 Smith-Waterman score: 4046; 71.8% identity (88.6% similar) in 827 aa overlap (1-820:34-851) 10 20 30 pF1KE2 MVSWGRFICLVVVTMATLSLARPSFSLVED : :: .. .:.. ::: :::: .: :. CCDS55 RVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQ 10 20 30 40 50 60 40 50 60 70 80 pF1KE2 TTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKD-AAVISWTKDGVHLGPNNRTVLIG . .: :.. : ... ::. :..:: :.: . :.: .:::.:. .::: . : CCDS55 A--QPWGAPVEV-----ESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITG 70 80 90 100 110 90 100 110 120 130 140 pF1KE2 EYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSN : .... ..: :::::::..: :.: :: :::.::. :..:.:: : . . .:..: CCDS55 EEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN 120 130 140 150 160 170 150 160 170 180 190 200 pF1KE2 NKR---APYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG .: :::::. :::::.:::::::.::::.::..:.: ::.:::::::::: .::::: CCDS55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGG 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE2 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA :::: ::.::.::::::::::::.::::::::::::.:::::::::::::::::::: CCDS55 YKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANK 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE2 STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEV ....:..:::.:::::: ::::::.::.: :::: :::.:::...::.:::::::::.:: CCDS55 TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE2 LYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVF :..:::.::::::::::::::::.: :::::::: : .. . .:: :::: ::: :.: CCDS55 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAF 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE2 LIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVR ::.::: .::. .::. ::: :: :: :::::.: :::::::::::.::.::::.. ::: CCDS55 LISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE2 ITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD .::::.. ::::::::::::::::.::.:::.:.::::::::::::::.:::.:.::: CCDS55 -PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE2 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY ::.... :::::::.::::::::::.:::::::::::::::::::::::::::::::::: CCDS55 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE2 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD ::::::::::.::::::.:: :. .. ::::.. ::::::.::.:::::::::.:::::: CCDS55 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE2 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV ::::::::::.::::::::::::::..:::::::::::::::::::::::::.::::::: CCDS55 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE2 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ ::::::.:::::::::::::.::::::::::::::::::.:::::::::::::::::::: CCDS55 WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ 720 730 740 750 760 770 750 760 770 780 790 800 pF1KE2 RPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPY ::::::::::::::..::.:.::::::.::.:::::.:::::: ::::.::::: .:.: CCDS55 RPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPE 780 790 800 810 820 830 810 820 pF1KE2 EPCLPQYPH--INGSVKT :::::..: ::..: CCDS55 EPCLPRHPAQLANGGLKRR 840 850 821 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:20:43 2016 done: Sun Nov 6 15:20:43 2016 Total Scan time: 2.480 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]