Result of FASTA (omim) for
pF1KE0940
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0940, 459 aa
1>>>pF1KE0940 459 - 459 aa - 459 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6921+/-0.000419; mu= 11.3167+/- 0.026
mean_var=99.4894+/-20.426, 0's: 0 Z-trim(114.2): 407 B-trim: 975 in 2/51
Lambda= 0.128584
statistics sampled from 23489 (23905) to 23489 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.28), width: 16
Scan time: 6.050
The best scores are: opt bits E(85289)
NP_008845 (OMIM: 601972) nuclear receptor ROR-beta ( 459) 3088 583.5 4e-166
NP_599024 (OMIM: 600825) nuclear receptor ROR-alph ( 468) 1971 376.3 9.8e-104
XP_016877955 (OMIM: 600825) PREDICTED: nuclear rec ( 460) 1967 375.5 1.6e-103
NP_599022 (OMIM: 600825) nuclear receptor ROR-alph ( 556) 1967 375.6 1.9e-103
NP_002934 (OMIM: 600825) nuclear receptor ROR-alph ( 548) 1964 375.0 2.8e-103
XP_011520179 (OMIM: 600825) PREDICTED: nuclear rec ( 467) 1961 374.4 3.5e-103
XP_011520176 (OMIM: 600825) PREDICTED: nuclear rec ( 525) 1961 374.5 3.9e-103
XP_005254641 (OMIM: 600825) PREDICTED: nuclear rec ( 477) 1957 373.7 6e-103
XP_011520177 (OMIM: 600825) PREDICTED: nuclear rec ( 504) 1957 373.7 6.3e-103
NP_599023 (OMIM: 600825) nuclear receptor ROR-alph ( 523) 1957 373.7 6.5e-103
XP_016877956 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 1453 280.2 7e-75
XP_011520180 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 1453 280.2 7e-75
XP_011520181 (OMIM: 600825) PREDICTED: nuclear rec ( 376) 1387 267.9 3.3e-71
NP_001001523 (OMIM: 602943,616622) nuclear recepto ( 497) 877 173.4 1.3e-42
NP_005051 (OMIM: 602943,616622) nuclear receptor R ( 518) 877 173.4 1.3e-42
XP_006711547 (OMIM: 602943,616622) PREDICTED: nucl ( 651) 877 173.4 1.6e-42
NP_068370 (OMIM: 602408) nuclear receptor subfamil ( 614) 432 90.8 1.1e-17
XP_006713514 (OMIM: 602304) PREDICTED: nuclear rec ( 448) 426 89.7 1.8e-17
NP_001138897 (OMIM: 602304) nuclear receptor subfa ( 504) 426 89.7 2e-17
NP_005117 (OMIM: 602304) nuclear receptor subfamil ( 579) 426 89.7 2.2e-17
NP_001263393 (OMIM: 604453) nuclear receptor subfa ( 469) 415 87.6 7.6e-17
XP_005245119 (OMIM: 604453) PREDICTED: nuclear rec ( 469) 415 87.6 7.6e-17
XP_011507684 (OMIM: 604453) PREDICTED: nuclear rec ( 469) 415 87.6 7.6e-17
NP_003813 (OMIM: 604453) nuclear receptor subfamil ( 495) 415 87.6 8e-17
XP_011507683 (OMIM: 604453) PREDICTED: nuclear rec ( 501) 415 87.6 8.1e-17
XP_016856393 (OMIM: 604453) PREDICTED: nuclear rec ( 501) 415 87.6 8.1e-17
XP_011507686 (OMIM: 604453) PREDICTED: nuclear rec ( 501) 415 87.6 8.1e-17
XP_011507682 (OMIM: 604453) PREDICTED: nuclear rec ( 501) 415 87.6 8.1e-17
NP_995582 (OMIM: 604453) nuclear receptor subfamil ( 541) 415 87.7 8.6e-17
NP_001230659 (OMIM: 180190) retinoic acid receptor ( 382) 404 85.6 2.6e-16
NP_001036193 (OMIM: 180190) retinoic acid receptor ( 443) 404 85.6 3e-16
NP_000957 (OMIM: 180190) retinoic acid receptor ga ( 454) 404 85.6 3.1e-16
NP_001277195 (OMIM: 180220,615524) retinoic acid r ( 399) 400 84.8 4.6e-16
NP_001277206 (OMIM: 180220,615524) retinoic acid r ( 402) 400 84.8 4.6e-16
NP_001277229 (OMIM: 180220,615524) retinoic acid r ( 405) 400 84.8 4.6e-16
NP_000956 (OMIM: 180220,615524) retinoic acid rece ( 448) 400 84.8 5.1e-16
NP_001277145 (OMIM: 180220,615524) retinoic acid r ( 455) 400 84.8 5.1e-16
XP_011528541 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_006724332 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_011528543 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_011528545 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_011528544 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_006724333 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_005261712 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_005261713 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
XP_011528542 (OMIM: 170998) PREDICTED: peroxisome ( 468) 397 84.3 7.7e-16
NP_005027 (OMIM: 170998) peroxisome proliferator-a ( 468) 397 84.3 7.7e-16
NP_001001928 (OMIM: 170998) peroxisome proliferato ( 468) 397 84.3 7.7e-16
XP_011523398 (OMIM: 180240,612376) PREDICTED: reti ( 404) 396 84.1 7.7e-16
NP_001317544 (OMIM: 125853,601487,601665,604367,60 ( 250) 392 83.2 8.6e-16
>>NP_008845 (OMIM: 601972) nuclear receptor ROR-beta [Ho (459 aa)
initn: 3088 init1: 3088 opt: 3088 Z-score: 3103.4 bits: 583.5 E(85289): 4e-166
Smith-Waterman score: 3088; 100.0% identity (100.0% similar) in 459 aa overlap (1-459:1-459)
10 20 30 40 50 60
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 EPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 THTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 THTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 EVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVC
370 380 390 400 410 420
430 440 450
pF1KE0 NLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
:::::::::::::::::::::::::::::::::::::::
NP_008 NLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
430 440 450
>>NP_599024 (OMIM: 600825) nuclear receptor ROR-alpha is (468 aa)
initn: 1833 init1: 1137 opt: 1971 Z-score: 1983.4 bits: 376.3 E(85289): 9.8e-104
Smith-Waterman score: 1971; 63.9% identity (85.1% similar) in 457 aa overlap (1-453:9-459)
10 20 30 40 50
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNC
:.::::.::::::::::::::::::::::::::::::::.::.::::::.::
NP_599 MMYFVIAAMKAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ-QRLQEQRQQQ
:::::.::::::::::::::.:::::::::::::::::::::::::::. :. :...:::
NP_599 LIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQ
70 80 90 100 110 120
120 130 140 150 160
pF1KE0 SGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGY---YNVDSGQPSPDQS
:::: :. .:. : .:::..:... :. : .::. . :... . .: :::::::
NP_599 PGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSKADSAVSSFYLDI-QPSPDQS
130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQ
:::..::: ::: : : . ..: : ::.::. .: ..:.:....:::: ::::::::
NP_599 GLDINGIK---PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQ
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 YTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQ
: :::.:..::: :::. ::.:.::..:: :::.::.:::::::::::: :::::::
NP_599 YLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQ
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 NDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKN
::::.:::.: ::::..::::::. :::: :.:::.. ..::.:: .:... .:.:.:.
NP_599 NDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 LCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAK
:::..:::.::::::. ::.: ::.:: : :..:::.:: .:::::.:::: .: :.:
NP_599 LCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTK
360 370 380 390 400 410
410 420 430 440 450
pF1KE0 LIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
:: :. :. :.:. : :::..:: .:.:: :::::::::. .
NP_599 LICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
420 430 440 450 460
>>XP_016877955 (OMIM: 600825) PREDICTED: nuclear recepto (460 aa)
initn: 1829 init1: 1137 opt: 1967 Z-score: 1979.5 bits: 375.5 E(85289): 1.6e-103
Smith-Waterman score: 1967; 63.9% identity (84.9% similar) in 457 aa overlap (1-453:1-451)
10 20 30 40 50 60
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRN
: ::::.::::::::::::::::::::::::::::::::.::.::::::.:::::::.::
XP_016 MNAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRN
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ-QRLQEQRQQQSGEAEALA
::::::::::::.:::::::::::::::::::::::::::. :. :...::: :::: :.
XP_016 RCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 RVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGY---YNVDSGQPSPDQSGLDMTGIK
.:. : .:::..:... :. : .::. . :... . .: ::::::::::..:::
XP_016 PTYNIS-ANGLTELHDDLSN-YIDGHTPEGSKADSAVSSFYLDI-QPSPDQSGLDINGIK
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 QIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQ
::: : : . ..: : ::.::. .: ..:.:....:::: ::::::::: :::.:
XP_016 ---PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 LAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLK
..::: :::. ::.:.::..:: :::.::.:::::::::::: :::::::::::.:::
XP_016 ITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLK
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 SGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTE
.: ::::..::::::. :::: :.:::.. ..::.:: .:... .:.:.:.:::..:::
XP_016 AGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE0 EEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTI
.::::::. ::.: ::.:: : :..:::.:: .:::::.:::: .: :.::: :. :.
XP_016 DEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTL
360 370 380 390 400 410
420 430 440 450
pF1KE0 TAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
:.:. : :::..:: .:.:: :::::::::. .
XP_016 RALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
420 430 440 450 460
>>NP_599022 (OMIM: 600825) nuclear receptor ROR-alpha is (556 aa)
initn: 1829 init1: 1137 opt: 1967 Z-score: 1978.2 bits: 375.6 E(85289): 1.9e-103
Smith-Waterman score: 1967; 63.9% identity (84.9% similar) in 457 aa overlap (1-453:97-547)
10 20 30
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGC
: ::::.:::::::::::::::::::::::
NP_599 FVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGVITCEGC
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE0 KGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQR
:::::::::.::.::::::.:::::::.::::::::::::::.:::::::::::::::::
NP_599 KGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQR
130 140 150 160 170 180
100 110 120 130 140
pF1KE0 DSLYAEVQKHQ-QRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDL
::::::::::. :. :...::: :::: :. .:. : .:::..:... :. : .::. .
NP_599 DSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEG
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE0 PKSEGY---YNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPG
:... . .: ::::::::::..::: ::: : : . ..: : ::.::. .:
NP_599 SKADSAVSSFYLDI-QPSPDQSGLDINGIK---PEPICDYTPASGFFPYCSFTNGETSPT
250 260 270 280 290 300
210 220 230 240 250 260
pF1KE0 ITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQI
..:.:....:::: ::::::::: :::.:..::: :::. ::.:.::..:: :::.:
NP_599 VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI
310 320 330 340 350 360
270 280 290 300 310 320
pF1KE0 THAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGG
:.:::::::::::: :::::::::::.:::.: ::::..::::::. :::: :.:::..
NP_599 TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS
370 380 390 400 410 420
330 340 350 360 370 380
pF1KE0 MQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQE
..::.:: .:... .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.
NP_599 PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ
430 440 450 460 470 480
390 400 410 420 430 440
pF1KE0 KIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLY
:: .:::::.:::: .: :.::: :. :. :.:. : :::..:: .:.:: :::::
NP_599 KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY
490 500 510 520 530 540
450
pF1KE0 KELFNPDCATGCK
::::. .
NP_599 KELFTSEFEPAMQIDG
550
>>NP_002934 (OMIM: 600825) nuclear receptor ROR-alpha is (548 aa)
initn: 1826 init1: 1137 opt: 1964 Z-score: 1975.3 bits: 375.0 E(85289): 2.8e-103
Smith-Waterman score: 1964; 63.8% identity (85.1% similar) in 456 aa overlap (2-453:90-539)
10 20 30
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCK
.::::.::::::::::::::::::::::::
NP_002 QLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGIHYGVITCEGCK
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE0 GFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRD
::::::::.::.::::::.:::::::.::::::::::::::.::::::::::::::::::
NP_002 GFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRD
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE0 SLYAEVQKHQ-QRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLP
:::::::::. :. :...::: :::: :. .:. : .:::..:... :. : .::. .
NP_002 SLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGS
180 190 200 210 220 230
160 170 180 190 200
pF1KE0 KSEGY---YNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGI
:... . .: ::::::::::..::: ::: : : . ..: : ::.::. .: .
NP_002 KADSAVSSFYLDI-QPSPDQSGLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTV
240 250 260 270 280 290
210 220 230 240 250 260
pF1KE0 TMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQIT
.:.:....:::: ::::::::: :::.:..::: :::. ::.:.::..:: :::.::
NP_002 SMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKIT
300 310 320 330 340 350
270 280 290 300 310 320
pF1KE0 HAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGM
.:::::::::::: :::::::::::.:::.: ::::..::::::. :::: :.:::..
NP_002 EAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASP
360 370 380 390 400 410
330 340 350 360 370 380
pF1KE0 QMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEK
..::.:: .:... .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.:
NP_002 DVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK
420 430 440 450 460 470
390 400 410 420 430 440
pF1KE0 IYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYK
: .:::::.:::: .: :.::: :. :. :.:. : :::..:: .:.:: ::::::
NP_002 IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYK
480 490 500 510 520 530
450
pF1KE0 ELFNPDCATGCK
:::. .
NP_002 ELFTSEFEPAMQIDG
540
>>XP_011520179 (OMIM: 600825) PREDICTED: nuclear recepto (467 aa)
initn: 1823 init1: 1137 opt: 1961 Z-score: 1973.4 bits: 374.4 E(85289): 3.5e-103
Smith-Waterman score: 1961; 64.0% identity (85.1% similar) in 455 aa overlap (3-453:10-458)
10 20 30 40 50
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCL
::::.::::::::::::::::::::::::::::::::.::.::::::.:::
XP_011 MKFREGTAIAQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 IDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ-QRLQEQRQQQS
::::.::::::::::::::.:::::::::::::::::::::::::::. :. :...:::
XP_011 IDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQP
70 80 90 100 110 120
120 130 140 150 160
pF1KE0 GEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGY---YNVDSGQPSPDQSG
:::: :. .:. : .:::..:... :. : .::. . :... . .: ::::::::
XP_011 GEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSKADSAVSSFYLDI-QPSPDQSG
130 140 150 160 170
170 180 190 200 210 220
pF1KE0 LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
::..::: ::: : : . ..: : ::.::. .: ..:.:....:::: :::::::::
XP_011 LDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQY
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
:::.:..::: :::. ::.:.::..:: :::.::.:::::::::::: ::::::::
XP_011 LREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQN
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
:::.:::.: ::::..::::::. :::: :.:::.. ..::.:: .:... .:.:.:.:
XP_011 DQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
::..:::.::::::. ::.: ::.:: : :..:::.:: .:::::.:::: .: :.::
XP_011 CSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKL
360 370 380 390 400 410
410 420 430 440 450
pF1KE0 IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
: :. :. :.:. : :::..:: .:.:: :::::::::. .
XP_011 ICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
420 430 440 450 460
>>XP_011520176 (OMIM: 600825) PREDICTED: nuclear recepto (525 aa)
initn: 1823 init1: 1137 opt: 1961 Z-score: 1972.6 bits: 374.5 E(85289): 3.9e-103
Smith-Waterman score: 1961; 64.0% identity (85.1% similar) in 455 aa overlap (3-453:68-516)
10 20 30
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKG
::::.:::::::::::::::::::::::::
XP_011 RASCPTEWGQKVVRGAFRGALRAEKRPAATAQIEIIPCKICGDKSSGIHYGVITCEGCKG
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE0 FFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDS
:::::::.::.::::::.:::::::.::::::::::::::.:::::::::::::::::::
XP_011 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE0 LYAEVQKHQ-QRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPK
::::::::. :. :...::: :::: :. .:. : .:::..:... :. : .::. . :
XP_011 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSK
160 170 180 190 200 210
160 170 180 190 200
pF1KE0 SEGY---YNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGIT
... . .: ::::::::::..::: ::: : : . ..: : ::.::. .: ..
XP_011 ADSAVSSFYLDI-QPSPDQSGLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVS
220 230 240 250 260 270
210 220 230 240 250 260
pF1KE0 MTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITH
:.:....:::: ::::::::: :::.:..::: :::. ::.:.::..:: :::.::.
XP_011 MAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITE
280 290 300 310 320 330
270 280 290 300 310 320
pF1KE0 AIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQ
:::::::::::: :::::::::::.:::.: ::::..::::::. :::: :.:::.. .
XP_011 AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPD
340 350 360 370 380 390
330 340 350 360 370 380
pF1KE0 MFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKI
.::.:: .:... .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.::
XP_011 VFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI
400 410 420 430 440 450
390 400 410 420 430 440
pF1KE0 YFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKE
.:::::.:::: .: :.::: :. :. :.:. : :::..:: .:.:: :::::::
XP_011 QLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKE
460 470 480 490 500 510
450
pF1KE0 LFNPDCATGCK
::. .
XP_011 LFTSEFEPAMQIDG
520
>>XP_005254641 (OMIM: 600825) PREDICTED: nuclear recepto (477 aa)
initn: 1819 init1: 1137 opt: 1957 Z-score: 1969.2 bits: 373.7 E(85289): 6e-103
Smith-Waterman score: 1957; 63.7% identity (85.1% similar) in 455 aa overlap (3-453:20-468)
10 20 30 40
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNAS
.:::.::::::::::::::::::::::::::::::::.::.
XP_005 MLTGSQSTFGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 YSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQ-Q
::::::.:::::::.::::::::::::::.:::::::::::::::::::::::::::. :
XP_005 YSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQ
70 80 90 100 110 120
110 120 130 140 150
pF1KE0 RLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGY---YNVD
. :...::: :::: :. .:. : .:::..:... :. : .::. . :... . .:
XP_005 QQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSKADSAVSSFYLD
130 140 150 160 170
160 170 180 190 200 210
pF1KE0 SGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNI
::::::::::..::: ::: : : . ..: : ::.::. .: ..:.:....::::
XP_005 I-QPSPDQSGLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNI
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 IKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKR
::::::::: :::.:..::: :::. ::.:.::..:: :::.::.:::::::::::
XP_005 SKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKR
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 ITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLV
: :::::::::::.:::.: ::::..::::::. :::: :.:::.. ..::.:: .:..
XP_005 IDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFI
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 NEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKN
. .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.:: .:::::.:::
XP_005 SFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKN
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE0 HLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
: .: :.::: :. :. :.:. : :::..:: .:.:: :::::::::. .
XP_005 HREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQ
420 430 440 450 460 470
XP_005 IDG
>>XP_011520177 (OMIM: 600825) PREDICTED: nuclear recepto (504 aa)
initn: 1819 init1: 1137 opt: 1957 Z-score: 1968.8 bits: 373.7 E(85289): 6.3e-103
Smith-Waterman score: 1957; 63.7% identity (85.1% similar) in 455 aa overlap (3-453:47-495)
10 20 30
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKG
.:::.:::::::::::::::::::::::::
XP_011 TEAIRTTHAVLLKKPPGWKSGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE0 FFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDS
:::::::.::.::::::.:::::::.::::::::::::::.:::::::::::::::::::
XP_011 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE0 LYAEVQKHQ-QRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPK
::::::::. :. :...::: :::: :. .:. : .:::..:... :. : .::. . :
XP_011 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSK
140 150 160 170 180 190
160 170 180 190 200
pF1KE0 SEGY---YNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGIT
... . .: ::::::::::..::: ::: : : . ..: : ::.::. .: ..
XP_011 ADSAVSSFYLDI-QPSPDQSGLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE0 MTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITH
:.:....:::: ::::::::: :::.:..::: :::. ::.:.::..:: :::.::.
XP_011 MAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITE
260 270 280 290 300 310
270 280 290 300 310 320
pF1KE0 AIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQ
:::::::::::: :::::::::::.:::.: ::::..::::::. :::: :.:::.. .
XP_011 AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPD
320 330 340 350 360 370
330 340 350 360 370 380
pF1KE0 MFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKI
.::.:: .:... .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.::
XP_011 VFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI
380 390 400 410 420 430
390 400 410 420 430 440
pF1KE0 YFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKE
.:::::.:::: .: :.::: :. :. :.:. : :::..:: .:.:: :::::::
XP_011 QLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKE
440 450 460 470 480 490
450
pF1KE0 LFNPDCATGCK
::. .
XP_011 LFTSEFEPAMQIDG
500
>>NP_599023 (OMIM: 600825) nuclear receptor ROR-alpha is (523 aa)
initn: 1819 init1: 1137 opt: 1957 Z-score: 1968.6 bits: 373.7 E(85289): 6.5e-103
Smith-Waterman score: 1957; 63.7% identity (85.1% similar) in 455 aa overlap (3-453:66-514)
10 20 30
pF1KE0 MRAQIEVIPCKICGDKSSGIHYGVITCEGCKG
.:::.:::::::::::::::::::::::::
NP_599 ARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKG
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE0 FFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDS
:::::::.::.::::::.:::::::.::::::::::::::.:::::::::::::::::::
NP_599 FFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE0 LYAEVQKHQ-QRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPK
::::::::. :. :...::: :::: :. .:. : .:::..:... :. : .::. . :
NP_599 LYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNIS-ANGLTELHDDLSN-YIDGHTPEGSK
160 170 180 190 200 210
160 170 180 190 200
pF1KE0 SEGY---YNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGIT
... . .: ::::::::::..::: ::: : : . ..: : ::.::. .: ..
NP_599 ADSAVSSFYLDI-QPSPDQSGLDINGIKP---EPICDYTPASGFFPYCSFTNGETSPTVS
220 230 240 250 260
210 220 230 240 250 260
pF1KE0 MTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITH
:.:....:::: ::::::::: :::.:..::: :::. ::.:.::..:: :::.::.
NP_599 MAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITE
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE0 AIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQ
:::::::::::: :::::::::::.:::.: ::::..::::::. :::: :.:::.. .
NP_599 AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPD
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE0 MFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKI
.::.:: .:... .:.:.:.:::..:::.::::::. ::.: ::.:: : :..:::.::
NP_599 VFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE0 YFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKE
.:::::.:::: .: :.::: :. :. :.:. : :::..:: .:.:: :::::::
NP_599 QLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKE
450 460 470 480 490 500
450
pF1KE0 LFNPDCATGCK
::. .
NP_599 LFTSEFEPAMQIDG
510 520
459 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:36:06 2016 done: Tue Nov 8 17:36:07 2016
Total Scan time: 6.050 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]