Result of FASTA (omim) for pF1KE3561
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3561, 926 aa
  1>>>pF1KE3561 926 - 926 aa - 926 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5396+/-0.0006; mu= 20.4807+/- 0.037
 mean_var=88.7932+/-17.598, 0's: 0 Z-trim(106.9): 125  B-trim: 0 in 0/51
 Lambda= 0.136108
 statistics sampled from 14877 (15009) to 14877 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.489), E-opt: 0.2 (0.176), width:  16
 Scan time:  7.600

The best scores are:                                      opt bits E(85289)
NP_683766 (OMIM: 613572) G-protein coupled recepto ( 926) 6163 1221.8       0
XP_016865964 (OMIM: 613572) PREDICTED: G-protein c ( 879) 5852 1160.7       0
XP_016865965 (OMIM: 613572) PREDICTED: G-protein c ( 558) 3728 743.5 6.9e-214
NP_001273283 (OMIM: 613572) G-protein coupled rece ( 751) 3233 646.4 1.6e-184
NP_001273284 (OMIM: 613572) G-protein coupled rece ( 855) 2932 587.3 1.1e-166
XP_005247894 (OMIM: 145980,239200,601198,601199,61 ( 917) 1023 212.5 7.9e-54
NP_000379 (OMIM: 145980,239200,601198,601199,61289 (1078)  737 156.4 7.2e-37
XP_016862813 (OMIM: 145980,239200,601198,601199,61 (1078)  737 156.4 7.2e-37
XP_006713852 (OMIM: 145980,239200,601198,601199,61 (1078)  737 156.4 7.2e-37
XP_016862814 (OMIM: 145980,239200,601198,601199,61 (1078)  737 156.4 7.2e-37
NP_001171536 (OMIM: 145980,239200,601198,601199,61 (1088)  737 156.4 7.3e-37
NP_803884 (OMIM: 606225) taste receptor type 1 mem ( 587)  727 154.2 1.8e-36
XP_016857892 (OMIM: 606225) PREDICTED: taste recep ( 589)  727 154.2 1.8e-36
NP_689414 (OMIM: 605865) taste receptor type 1 mem ( 852)  721 153.1 5.3e-36
XP_016857925 (OMIM: 605865) PREDICTED: taste recep ( 893)  721 153.2 5.5e-36
XP_016857924 (OMIM: 605865) PREDICTED: taste recep ( 894)  721 153.2 5.5e-36
NP_619642 (OMIM: 606225) taste receptor type 1 mem ( 841)  632 135.7 9.6e-31
NP_689418 (OMIM: 606226) taste receptor type 1 mem ( 839)  594 128.2 1.7e-28
XP_016866277 (OMIM: 604473,614831) PREDICTED: meta ( 785)  587 126.8 4.2e-28
XP_011531948 (OMIM: 604099) PREDICTED: metabotropi ( 494)  579 125.1 8.8e-28
XP_011531942 (OMIM: 604099) PREDICTED: metabotropi ( 678)  580 125.4 9.7e-28
XP_011531943 (OMIM: 604099) PREDICTED: metabotropi ( 678)  580 125.4 9.7e-28
XP_011531939 (OMIM: 604099) PREDICTED: metabotropi ( 678)  580 125.4 9.7e-28
XP_011531941 (OMIM: 604099) PREDICTED: metabotropi ( 678)  580 125.4 9.7e-28
XP_011531940 (OMIM: 604099) PREDICTED: metabotropi ( 678)  580 125.4 9.7e-28
XP_011531938 (OMIM: 604099) PREDICTED: metabotropi ( 690)  580 125.4 9.8e-28
XP_011540508 (OMIM: 606225) PREDICTED: taste recep ( 580)  575 124.3 1.7e-27
XP_016857891 (OMIM: 606225) PREDICTED: taste recep ( 843)  575 124.5 2.3e-27
NP_000835 (OMIM: 604101) metabotropic glutamate re ( 915)  574 124.3 2.8e-27
NP_870989 (OMIM: 604101) metabotropic glutamate re ( 922)  573 124.1 3.2e-27
XP_011540505 (OMIM: 606225) PREDICTED: taste recep ( 763)  570 123.5 4.1e-27
NP_000831 (OMIM: 601115) metabotropic glutamate re ( 879)  547 119.0 1.1e-25
XP_011531947 (OMIM: 604099) PREDICTED: metabotropi ( 403)  539 117.1 1.7e-25
XP_011531946 (OMIM: 604099) PREDICTED: metabotropi ( 403)  539 117.1 1.7e-25
XP_011531945 (OMIM: 604099) PREDICTED: metabotropi ( 440)  539 117.2 1.9e-25
XP_011531949 (OMIM: 604099) PREDICTED: metabotropi ( 459)  539 117.2 1.9e-25
XP_016867562 (OMIM: 601115) PREDICTED: metabotropi ( 479)  529 115.2 7.7e-25
XP_011514390 (OMIM: 601115) PREDICTED: metabotropi ( 537)  529 115.3 8.4e-25
XP_011531944 (OMIM: 604099) PREDICTED: metabotropi ( 470)  506 110.7 1.7e-23
XP_011531937 (OMIM: 604099) PREDICTED: metabotropi ( 840)  506 110.9 2.7e-23
NP_000830 (OMIM: 604099) metabotropic glutamate re ( 872)  506 110.9 2.8e-23
XP_016861760 (OMIM: 604099) PREDICTED: metabotropi ( 872)  506 110.9 2.8e-23
NP_000833 (OMIM: 604102) metabotropic glutamate re (1180)  493 108.5   2e-22
XP_016873116 (OMIM: 604102) PREDICTED: metabotropi (1180)  493 108.5   2e-22
NP_001137303 (OMIM: 604102) metabotropic glutamate (1212)  493 108.5 2.1e-22
XP_006718891 (OMIM: 604102) PREDICTED: metabotropi (1212)  493 108.5 2.1e-22
XP_011541094 (OMIM: 604102) PREDICTED: metabotropi (1212)  493 108.5 2.1e-22
XP_016867563 (OMIM: 601116) PREDICTED: metabotropi ( 908)  487 107.2 3.8e-22
XP_011514393 (OMIM: 601116) PREDICTED: metabotropi ( 908)  487 107.2 3.8e-22
XP_006716001 (OMIM: 601116) PREDICTED: metabotropi ( 908)  487 107.2 3.8e-22


>>NP_683766 (OMIM: 613572) G-protein coupled receptor fa  (926 aa)
 initn: 6163 init1: 6163 opt: 6163  Z-score: 6542.0  bits: 1221.8 E(85289):    0
Smith-Waterman score: 6163; 99.9% identity (99.9% similar) in 926 aa overlap (1-926:1-926)

               10        20        30        40        50        60
pF1KE3 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QECVGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTVAMAATLRFLSKF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_683 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE3 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE3 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE3 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE3 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE3 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
              850       860       870       880       890       900

              910       920      
pF1KE3 QAFAHICRENATSVSKTLPRKRMSSI
       ::::::::::::::::::::::::::
NP_683 QAFAHICRENATSVSKTLPRKRMSSI
              910       920      

>>XP_016865964 (OMIM: 613572) PREDICTED: G-protein coupl  (879 aa)
 initn: 5852 init1: 5852 opt: 5852  Z-score: 6212.3  bits: 1160.7 E(85289):    0
Smith-Waterman score: 5852; 99.9% identity (99.9% similar) in 879 aa overlap (48-926:1-879)

        20        30        40        50        60        70       
pF1KE3 SQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAM
                                     ::::::::::::::::::::::::::::::
XP_016                               MLSSEDSPRRPQIQECVGFEISVFLQTLAM
                                             10        20        30

        80        90       100       110       120       130       
pF1KE3 IHSIEMINNSTLLSGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYM
       ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYM
               40        50        60        70        80        90

       140       150       160       170       180       190       
pF1KE3 PRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIK
              100       110       120       130       140       150

       200       210       220       230       240       250       
pF1KE3 AMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVR
              160       170       180       190       200       210

       260       270       280       290       300       310       
pF1KE3 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNV
              220       230       240       250       260       270

       320       330       340       350       360       370       
pF1KE3 KKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIF
              280       290       300       310       320       330

       380       390       400       410       420       430       
pF1KE3 NHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQN
              340       350       360       370       380       390

       440       450       460       470       480       490       
pF1KE3 PNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQ
              400       410       420       430       440       450

       500       510       520       530       540       550       
pF1KE3 NDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQT
              460       470       480       490       500       510

       560       570       580       590       600       610       
pF1KE3 DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTR
              520       530       540       550       560       570

       620       630       640       650       660       670       
pF1KE3 NLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCI
              580       590       600       610       620       630

       680       690       700       710       720       730       
pF1KE3 LTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP
              640       650       660       670       680       690

       740       750       760       770       780       790       
pF1KE3 RVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWIT
              700       710       720       730       740       750

       800       810       820       830       840       850       
pF1KE3 FIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYS
              760       770       780       790       800       810

       860       870       880       890       900       910       
pF1KE3 SHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKT
              820       830       840       850       860       870

       920      
pF1KE3 LPRKRMSSI
       :::::::::
XP_016 LPRKRMSSI
                

>>XP_016865965 (OMIM: 613572) PREDICTED: G-protein coupl  (558 aa)
 initn: 3728 init1: 3728 opt: 3728  Z-score: 3960.9  bits: 743.5 E(85289): 6.9e-214
Smith-Waterman score: 3728; 99.8% identity (99.8% similar) in 557 aa overlap (1-557:1-557)

               10        20        30        40        50        60
pF1KE3 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QECVGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTVAMAATLRFLSKF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_016 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE3 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE3 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
       :::::::::::::::::                                           
XP_016 CCYECQNCPENHYTNQTG                                          
              550                                                  

>>NP_001273283 (OMIM: 613572) G-protein coupled receptor  (751 aa)
 initn: 3233 init1: 3233 opt: 3233  Z-score: 3433.8  bits: 646.4 E(85289): 1.6e-184
Smith-Waterman score: 4612; 81.0% identity (81.0% similar) in 926 aa overlap (1-926:1-751)

               10        20        30        40        50        60
pF1KE3 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QECVGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTVAMAATLRFLSKF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
       ::::::::::::::::::::::::::::::                              
NP_001 FKEVLPAFLSDNTIEVRINRTLKKIILEAQ------------------------------
              250       260       270                              

              310       320       330       340       350       360
pF1KE3 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              370       380       390       400       410       420
pF1KE3 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
                                                                   
NP_001 ------------------------------------------------------------
                                                                   

              430       440       450       460       470       480
pF1KE3 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
                                :::::::::::::::::::::::::::::::::::
NP_001 -------------------------LLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
                                       280       290       300     

              490       500       510       520       530       540
pF1KE3 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
         310       320       330       340       350       360     

              550       560       570       580       590       600
pF1KE3 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
         370       380       390       400       410       420     

              610       620       630       640       650       660
pF1KE3 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
         430       440       450       460       470       480     

              670       680       690       700       710       720
pF1KE3 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
         490       500       510       520       530       540     

              730       740       750       760       770       780
pF1KE3 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
         550       560       570       580       590       600     

              790       800       810       820       830       840
pF1KE3 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
         610       620       630       640       650       660     

              850       860       870       880       890       900
pF1KE3 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
         670       680       690       700       710       720     

              910       920      
pF1KE3 QAFAHICRENATSVSKTLPRKRMSSI
       ::::::::::::::::::::::::::
NP_001 QAFAHICRENATSVSKTLPRKRMSSI
         730       740       750 

>>NP_001273284 (OMIM: 613572) G-protein coupled receptor  (855 aa)
 initn: 2977 init1: 2932 opt: 2932  Z-score: 3113.7  bits: 587.3 E(85289): 1.1e-166
Smith-Waterman score: 5526; 92.2% identity (92.2% similar) in 926 aa overlap (1-926:1-855)

               10        20        30        40        50        60
pF1KE3 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QECVGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTVAMAATLRFLSKF
       :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE3 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE3 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE3 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
       :::::::::::::::::::::::::                                   
NP_001 ALGYAIRDLCQARDCQNPNAFQPWE-----------------------------------
              430       440                                        

              490       500       510       520       530       540
pF1KE3 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
                                           ::::::::::::::::::::::::
NP_001 ------------------------------------QIQSKCSKECSPGQMKKTTRSQHI
                                             450       460         

              550       560       570       580       590       600
pF1KE3 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
     470       480       490       500       510       520         

              610       620       630       640       650       660
pF1KE3 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
     530       540       550       560       570       580         

              670       680       690       700       710       720
pF1KE3 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
     590       600       610       620       630       640         

              730       740       750       760       770       780
pF1KE3 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
     650       660       670       680       690       700         

              790       800       810       820       830       840
pF1KE3 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
     710       720       730       740       750       760         

              850       860       870       880       890       900
pF1KE3 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
     770       780       790       800       810       820         

              910       920      
pF1KE3 QAFAHICRENATSVSKTLPRKRMSSI
       ::::::::::::::::::::::::::
NP_001 QAFAHICRENATSVSKTLPRKRMSSI
     830       840       850     

>>XP_005247894 (OMIM: 145980,239200,601198,601199,612899  (917 aa)
 initn: 1026 init1: 295 opt: 1023  Z-score: 1087.4  bits: 212.5 E(85289): 7.9e-54
Smith-Waterman score: 1483; 32.6% identity (64.3% similar) in 807 aa overlap (164-924:1-795)

           140       150       160       170       180       190   
pF1KE3 SSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDF
                                     : ::.: :....::.: .: :::::.:.: 
XP_005                               MYQVSYASSSRLLSNKNQFKSFLRTIPNDE
                                             10        20        30

           200       210       220       230       240       250   
pF1KE3 HQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNT
       ::  ::: .:.   :::.: :..:::::: ... :  .::  ..:: :.:..  . ... 
XP_005 HQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEE
               40        50        60        70        80        90

           260       270       280       290        300       310  
pF1KE3 IEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN-KMWIASDNWSTATKIT
       :.  .     ..: .. ..:::::     .  :... .. ::. :.:.::. :.... :.
XP_005 IQHVV-----EVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIA
                   100       110       120       130       140     

            320       330       340       350       360            
pF1KE3 TIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSAC--------
            . .: ..:::.. :.: .:. ::...:   :  . . .:.  .   :        
XP_005 MPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKG
         150       160       170       180       190       200     

               370       380       390       400       410         
pF1KE3 -----AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAV
            ....  . :   :..:  . :..   . ..:.   .    ::..  . ... :::
XP_005 PLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAV
         210       220         230       240       250       260   

     420         430              440       450       460          
pF1KE3 FALGYAIRDL--C-QAR------DCQNPNAFQPWELLGVLKNVTFTDGWN-SFHFDAHGD
       .....:..:.  :  .:      .: . .  . :..:  :....::.. . .  ::  ::
XP_005 YSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGD
           270       280       290       300       310       320   

     470       480         490           500       510        520  
pF1KE3 LNTGYDVVLWK--EINGHMTVTKMAEYDLQND----VFIIPDQETKNEFRNLKQIQ-SKC
       :  .:... :.    .: ..  ... :..       .::  ..   . :   ...  :.:
XP_005 LVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFS--REVPFSNC
           330       340       350       360       370         380 

            530       540       550       560       570       580  
pF1KE3 SKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEK
       :..:  :  :   ...  ::.:: .::...:...::   :  : .   :.    : :. :
XP_005 SRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDD-FWSNENHTSCIAK
             390       400       410       420        430       440

            590       600       610       620       630       640  
pF1KE3 EVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFL
       :.:.:.:.. ..: : ....:::...  :  .: .  :::.::...  .. :..:.  . 
XP_005 EIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNR-ELSYLLLFSLLC
              450       460       470       480        490         

            650       660       670       680         690       700
pF1KE3 NFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAF--SFDPKLQKFLKC
        :.:. ::::::::.::. ::  ::.::.:::::::.:. ..::.:  ..  ....    
XP_005 CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
     500       510       520       530       540       550         

              710       720       730        740       750         
pF1KE3 LYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP-RVIILECEEGSILAFGTMLGYI
       :   .:..: :: .:.:::..::  : :.   :  :  ..:.. :.:::..:.: ..:: 
XP_005 LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
     560       570       580       590       600       610         

     760       770         780       790       800       810       
pF1KE3 AILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIV
        .:: :::.::::..   ::.::::::::.:::.::.::.::: ::.:.::.: :::.:.
XP_005 CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
     620       630       640       650       660       670         

       820       830       840         850       860       870     
pF1KE3 ILISNYGILYCTFIPKCYVIICKQEINT--KSAFLKMIYSYSSHSVSSIALSPASLDSMS
       :: ...:.: : :. : :.:. :   ::  .       ....  . ...  : .:    :
XP_005 ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
     680       690       700       710       720       730         

           880         890           900       910       920       
pF1KE3 --GNVTMTNPSSS--GKSATW----QKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI 
         :. : ..::::  .:: .     :  .. : : .: . ...  .   :::... :   
XP_005 SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQEQQQQPLTLPQQQRSQQQ
     740       750       760       770        780       790        

XP_005 PRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCG
      800       810       820       830       840       850        

>>NP_000379 (OMIM: 145980,239200,601198,601199,612899) e  (1078 aa)
 initn: 1247 init1: 462 opt: 737  Z-score: 782.9  bits: 156.4 E(85289): 7.2e-37
Smith-Waterman score: 1777; 33.1% identity (64.6% similar) in 970 aa overlap (5-924:1-956)

               10        20          30        40        50        
pF1KE3 MAFLIILITCFVIILATSQPCQT--PDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRR
           . . .:  ..:: .   ..  ::.   : . : ::.:::: ::  . ... :   :
NP_000     MAFYSCCWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSR
                   10        20          30        40        50    

        60        70        80         90       100       110      
pF1KE3 PQIQECVGFEISVFLQTLAMIHSIEMINNS-TLLSGVKLGYEIYDTCTEVTVAMAATLRF
       :.  ::. ...  :    ::: .:: ::.: .:: .. :::.:.:::. :. :. ::: :
NP_000 PESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSF
           60        70        80        90       100       110    

        120       130       140       150       160       170      
pF1KE3 LSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEIL
       ... . .  ...  :. : ..: . ::.:.  : .. ::. .:.:  .:::.: :....:
NP_000 VAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLL
          120       130       140       150       160       170    

        180       190       200       210       220       230      
pF1KE3 SDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANN
       :.: .: :::::.:.: ::  ::: .:.   :::.: :..:::::: ... :  .::  .
NP_000 SNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
          180       190       200       210       220       230    

        240       250       260       270       280       290      
pF1KE3 VCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN
       .:: :.:..  . ::   : .:..... .: .. ..:::::     .  :... .. ::.
NP_000 ICIDFSELISQY-SD---EEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT
          240           250        260       270       280         

         300       310       320       330       340       350     
pF1KE3 -KMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH
        :.:.::. :.... :.     . .: ..:::.. :.: .:. ::...:   :  . . .
NP_000 GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAK
     290       300       310       320       330       340         

         360                    370       380       390       400  
pF1KE3 EYAMHLSAC-------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDF
       :.  .   :             ....  . :   :..:  . :..   . ..:.   .  
NP_000 EFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETP
     350       360       370       380         390       400       

            410       420         430              440       450   
pF1KE3 LWDYAEPGLIHSIQLAVFALGYAIRDL--C-QAR------DCQNPNAFQPWELLGVLKNV
         ::..  . ... :::.....:..:.  :  .:      .: . .  . :..:  :...
NP_000 YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHL
       410       420       430       440       450       460       

           460        470       480         490           500      
pF1KE3 TFTDGWN-SFHFDAHGDLNTGYDVVLWK--EINGHMTVTKMAEYDLQND----VFIIPDQ
       .::.. . .  ::  :::  .:... :.    .: ..  ... :..       .::  ..
NP_000 NFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK
       470       480       490       500       510       520       

        510        520       530       540       550       560     
pF1KE3 ETKNEFRNLKQIQ-SKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLC
          . :   ...  :.::..:  :  :   ...  ::.:: .::...:...::   :  :
NP_000 ILWSGFS--REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKC
       530         540       550       560       570       580     

         570       580       590       600       610       620     
pF1KE3 NNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVK
        .   :.    : :. ::.:.:.:.. ..: : ....:::...  :  .: .  :::.::
NP_000 PDD-FWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVK
          590       600       610       620       630       640    

         630       640       650       660       670       680     
pF1KE3 SSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKIL
       ...  .. :..:.  .  :.:. ::::::::.::. ::  ::.::.:::::::.:. ..:
NP_000 ATNR-ELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
           650       660       670       680       690       700   

           690       700       710       720       730        740  
pF1KE3 LAF--SFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP-RVIIL
       :.:  ..  ....    :   .:..: :: .:.:::..::  : :.   :  :  ..:..
NP_000 LVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFI
           710       720       730       740       750       760   

            750       760       770         780       790       800
pF1KE3 ECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIP
        :.:::..:.: ..::  .:: :::.::::..   ::.::::::::.:::.::.::.:::
NP_000 TCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIP
           770       780       790       800       810       820   

              810       820       830       840         850        
pF1KE3 IYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINT--KSAFLKMIYSYSS
        ::.:.::.: :::.:.:: ...:.: : :. : :.:. :   ::  .       .... 
NP_000 AYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV
           830       840       850       860       870       880   

      860       870         880         890           900       910
pF1KE3 HSVSSIALSPASLDSMS--GNVTMTNPSSS--GKSATW----QKSKDLQAQAFAHICREN
        . ...  : .:    :  :. : ..::::  .:: .     :  .. : : .: . ...
NP_000 AARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQE
           890       900       910       920       930        940  

              920                                                  
pF1KE3 ATSVSKTLPRKRMSSI                                            
         .   :::... :                                              
NP_000 QQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQK
            950       960       970       980       990      1000  

>>XP_016862813 (OMIM: 145980,239200,601198,601199,612899  (1078 aa)
 initn: 1247 init1: 462 opt: 737  Z-score: 782.9  bits: 156.4 E(85289): 7.2e-37
Smith-Waterman score: 1777; 33.1% identity (64.6% similar) in 970 aa overlap (5-924:1-956)

               10        20          30        40        50        
pF1KE3 MAFLIILITCFVIILATSQPCQT--PDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRR
           . . .:  ..:: .   ..  ::.   : . : ::.:::: ::  . ... :   :
XP_016     MAFYSCCWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSR
                   10        20          30        40        50    

        60        70        80         90       100       110      
pF1KE3 PQIQECVGFEISVFLQTLAMIHSIEMINNS-TLLSGVKLGYEIYDTCTEVTVAMAATLRF
       :.  ::. ...  :    ::: .:: ::.: .:: .. :::.:.:::. :. :. ::: :
XP_016 PESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSF
           60        70        80        90       100       110    

        120       130       140       150       160       170      
pF1KE3 LSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEIL
       ... . .  ...  :. : ..: . ::.:.  : .. ::. .:.:  .:::.: :....:
XP_016 VAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLL
          120       130       140       150       160       170    

        180       190       200       210       220       230      
pF1KE3 SDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANN
       :.: .: :::::.:.: ::  ::: .:.   :::.: :..:::::: ... :  .::  .
XP_016 SNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
          180       190       200       210       220       230    

        240       250       260       270       280       290      
pF1KE3 VCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN
       .:: :.:..  . ::   : .:..... .: .. ..:::::     .  :... .. ::.
XP_016 ICIDFSELISQY-SD---EEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT
          240           250        260       270       280         

         300       310       320       330       340       350     
pF1KE3 -KMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH
        :.:.::. :.... :.     . .: ..:::.. :.: .:. ::...:   :  . . .
XP_016 GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAK
     290       300       310       320       330       340         

         360                    370       380       390       400  
pF1KE3 EYAMHLSAC-------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDF
       :.  .   :             ....  . :   :..:  . :..   . ..:.   .  
XP_016 EFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETP
     350       360       370       380         390       400       

            410       420         430              440       450   
pF1KE3 LWDYAEPGLIHSIQLAVFALGYAIRDL--C-QAR------DCQNPNAFQPWELLGVLKNV
         ::..  . ... :::.....:..:.  :  .:      .: . .  . :..:  :...
XP_016 YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHL
       410       420       430       440       450       460       

           460        470       480         490           500      
pF1KE3 TFTDGWN-SFHFDAHGDLNTGYDVVLWK--EINGHMTVTKMAEYDLQND----VFIIPDQ
       .::.. . .  ::  :::  .:... :.    .: ..  ... :..       .::  ..
XP_016 NFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK
       470       480       490       500       510       520       

        510        520       530       540       550       560     
pF1KE3 ETKNEFRNLKQIQ-SKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLC
          . :   ...  :.::..:  :  :   ...  ::.:: .::...:...::   :  :
XP_016 ILWSGFS--REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKC
       530         540       550       560       570       580     

         570       580       590       600       610       620     
pF1KE3 NNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVK
        .   :.    : :. ::.:.:.:.. ..: : ....:::...  :  .: .  :::.::
XP_016 PDD-FWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVK
          590       600       610       620       630       640    

         630       640       650       660       670       680     
pF1KE3 SSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKIL
       ...  .. :..:.  .  :.:. ::::::::.::. ::  ::.::.:::::::.:. ..:
XP_016 ATNR-ELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
           650       660       670       680       690       700   

           690       700       710       720       730        740  
pF1KE3 LAF--SFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP-RVIIL
       :.:  ..  ....    :   .:..: :: .:.:::..::  : :.   :  :  ..:..
XP_016 LVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFI
           710       720       730       740       750       760   

            750       760       770         780       790       800
pF1KE3 ECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIP
        :.:::..:.: ..::  .:: :::.::::..   ::.::::::::.:::.::.::.:::
XP_016 TCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIP
           770       780       790       800       810       820   

              810       820       830       840         850        
pF1KE3 IYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINT--KSAFLKMIYSYSS
        ::.:.::.: :::.:.:: ...:.: : :. : :.:. :   ::  .       .... 
XP_016 AYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV
           830       840       850       860       870       880   

      860       870         880         890           900       910
pF1KE3 HSVSSIALSPASLDSMS--GNVTMTNPSSS--GKSATW----QKSKDLQAQAFAHICREN
        . ...  : .:    :  :. : ..::::  .:: .     :  .. : : .: . ...
XP_016 AARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQE
           890       900       910       920       930        940  

              920                                                  
pF1KE3 ATSVSKTLPRKRMSSI                                            
         .   :::... :                                              
XP_016 QQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQK
            950       960       970       980       990      1000  

>>XP_006713852 (OMIM: 145980,239200,601198,601199,612899  (1078 aa)
 initn: 1247 init1: 462 opt: 737  Z-score: 782.9  bits: 156.4 E(85289): 7.2e-37
Smith-Waterman score: 1777; 33.1% identity (64.6% similar) in 970 aa overlap (5-924:1-956)

               10        20          30        40        50        
pF1KE3 MAFLIILITCFVIILATSQPCQT--PDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRR
           . . .:  ..:: .   ..  ::.   : . : ::.:::: ::  . ... :   :
XP_006     MAFYSCCWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSR
                   10        20          30        40        50    

        60        70        80         90       100       110      
pF1KE3 PQIQECVGFEISVFLQTLAMIHSIEMINNS-TLLSGVKLGYEIYDTCTEVTVAMAATLRF
       :.  ::. ...  :    ::: .:: ::.: .:: .. :::.:.:::. :. :. ::: :
XP_006 PESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSF
           60        70        80        90       100       110    

        120       130       140       150       160       170      
pF1KE3 LSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEIL
       ... . .  ...  :. : ..: . ::.:.  : .. ::. .:.:  .:::.: :....:
XP_006 VAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLL
          120       130       140       150       160       170    

        180       190       200       210       220       230      
pF1KE3 SDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANN
       :.: .: :::::.:.: ::  ::: .:.   :::.: :..:::::: ... :  .::  .
XP_006 SNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
          180       190       200       210       220       230    

        240       250       260       270       280       290      
pF1KE3 VCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN
       .:: :.:..  . ::   : .:..... .: .. ..:::::     .  :... .. ::.
XP_006 ICIDFSELISQY-SD---EEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT
          240           250        260       270       280         

         300       310       320       330       340       350     
pF1KE3 -KMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH
        :.:.::. :.... :.     . .: ..:::.. :.: .:. ::...:   :  . . .
XP_006 GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAK
     290       300       310       320       330       340         

         360                    370       380       390       400  
pF1KE3 EYAMHLSAC-------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDF
       :.  .   :             ....  . :   :..:  . :..   . ..:.   .  
XP_006 EFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETP
     350       360       370       380         390       400       

            410       420         430              440       450   
pF1KE3 LWDYAEPGLIHSIQLAVFALGYAIRDL--C-QAR------DCQNPNAFQPWELLGVLKNV
         ::..  . ... :::.....:..:.  :  .:      .: . .  . :..:  :...
XP_006 YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHL
       410       420       430       440       450       460       

           460        470       480         490           500      
pF1KE3 TFTDGWN-SFHFDAHGDLNTGYDVVLWK--EINGHMTVTKMAEYDLQND----VFIIPDQ
       .::.. . .  ::  :::  .:... :.    .: ..  ... :..       .::  ..
XP_006 NFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK
       470       480       490       500       510       520       

        510        520       530       540       550       560     
pF1KE3 ETKNEFRNLKQIQ-SKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLC
          . :   ...  :.::..:  :  :   ...  ::.:: .::...:...::   :  :
XP_006 ILWSGFS--REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKC
       530         540       550       560       570       580     

         570       580       590       600       610       620     
pF1KE3 NNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVK
        .   :.    : :. ::.:.:.:.. ..: : ....:::...  :  .: .  :::.::
XP_006 PDD-FWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVK
          590       600       610       620       630       640    

         630       640       650       660       670       680     
pF1KE3 SSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKIL
       ...  .. :..:.  .  :.:. ::::::::.::. ::  ::.::.:::::::.:. ..:
XP_006 ATNR-ELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
           650       660       670       680       690       700   

           690       700       710       720       730        740  
pF1KE3 LAF--SFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP-RVIIL
       :.:  ..  ....    :   .:..: :: .:.:::..::  : :.   :  :  ..:..
XP_006 LVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFI
           710       720       730       740       750       760   

            750       760       770         780       790       800
pF1KE3 ECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIP
        :.:::..:.: ..::  .:: :::.::::..   ::.::::::::.:::.::.::.:::
XP_006 TCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIP
           770       780       790       800       810       820   

              810       820       830       840         850        
pF1KE3 IYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINT--KSAFLKMIYSYSS
        ::.:.::.: :::.:.:: ...:.: : :. : :.:. :   ::  .       .... 
XP_006 AYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV
           830       840       850       860       870       880   

      860       870         880         890           900       910
pF1KE3 HSVSSIALSPASLDSMS--GNVTMTNPSSS--GKSATW----QKSKDLQAQAFAHICREN
        . ...  : .:    :  :. : ..::::  .:: .     :  .. : : .: . ...
XP_006 AARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQE
           890       900       910       920       930        940  

              920                                                  
pF1KE3 ATSVSKTLPRKRMSSI                                            
         .   :::... :                                              
XP_006 QQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQK
            950       960       970       980       990      1000  

>>XP_016862814 (OMIM: 145980,239200,601198,601199,612899  (1078 aa)
 initn: 1247 init1: 462 opt: 737  Z-score: 782.9  bits: 156.4 E(85289): 7.2e-37
Smith-Waterman score: 1777; 33.1% identity (64.6% similar) in 970 aa overlap (5-924:1-956)

               10        20          30        40        50        
pF1KE3 MAFLIILITCFVIILATSQPCQT--PDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRR
           . . .:  ..:: .   ..  ::.   : . : ::.:::: ::  . ... :   :
XP_016     MAFYSCCWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSR
                   10        20          30        40        50    

        60        70        80         90       100       110      
pF1KE3 PQIQECVGFEISVFLQTLAMIHSIEMINNS-TLLSGVKLGYEIYDTCTEVTVAMAATLRF
       :.  ::. ...  :    ::: .:: ::.: .:: .. :::.:.:::. :. :. ::: :
XP_016 PESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSF
           60        70        80        90       100       110    

        120       130       140       150       160       170      
pF1KE3 LSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEIL
       ... . .  ...  :. : ..: . ::.:.  : .. ::. .:.:  .:::.: :....:
XP_016 VAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLL
          120       130       140       150       160       170    

        180       190       200       210       220       230      
pF1KE3 SDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANN
       :.: .: :::::.:.: ::  ::: .:.   :::.: :..:::::: ... :  .::  .
XP_016 SNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
          180       190       200       210       220       230    

        240       250       260       270       280       290      
pF1KE3 VCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN
       .:: :.:..  . ::   : .:..... .: .. ..:::::     .  :... .. ::.
XP_016 ICIDFSELISQY-SD---EEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNIT
          240           250        260       270       280         

         300       310       320       330       340       350     
pF1KE3 -KMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH
        :.:.::. :.... :.     . .: ..:::.. :.: .:. ::...:   :  . . .
XP_016 GKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAK
     290       300       310       320       330       340         

         360                    370       380       390       400  
pF1KE3 EYAMHLSAC-------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDF
       :.  .   :             ....  . :   :..:  . :..   . ..:.   .  
XP_016 EFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETP
     350       360       370       380         390       400       

            410       420         430              440       450   
pF1KE3 LWDYAEPGLIHSIQLAVFALGYAIRDL--C-QAR------DCQNPNAFQPWELLGVLKNV
         ::..  . ... :::.....:..:.  :  .:      .: . .  . :..:  :...
XP_016 YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHL
       410       420       430       440       450       460       

           460        470       480         490           500      
pF1KE3 TFTDGWN-SFHFDAHGDLNTGYDVVLWK--EINGHMTVTKMAEYDLQND----VFIIPDQ
       .::.. . .  ::  :::  .:... :.    .: ..  ... :..       .::  ..
XP_016 NFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK
       470       480       490       500       510       520       

        510        520       530       540       550       560     
pF1KE3 ETKNEFRNLKQIQ-SKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLC
          . :   ...  :.::..:  :  :   ...  ::.:: .::...:...::   :  :
XP_016 ILWSGFS--REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKC
       530         540       550       560       570       580     

         570       580       590       600       610       620     
pF1KE3 NNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVK
        .   :.    : :. ::.:.:.:.. ..: : ....:::...  :  .: .  :::.::
XP_016 PDD-FWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVK
          590       600       610       620       630       640    

         630       640       650       660       670       680     
pF1KE3 SSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKIL
       ...  .. :..:.  .  :.:. ::::::::.::. ::  ::.::.:::::::.:. ..:
XP_016 ATNR-ELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
           650       660       670       680       690       700   

           690       700       710       720       730        740  
pF1KE3 LAF--SFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLP-RVIIL
       :.:  ..  ....    :   .:..: :: .:.:::..::  : :.   :  :  ..:..
XP_016 LVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFI
           710       720       730       740       750       760   

            750       760       770         780       790       800
pF1KE3 ECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIP
        :.:::..:.: ..::  .:: :::.::::..   ::.::::::::.:::.::.::.:::
XP_016 TCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIP
           770       780       790       800       810       820   

              810       820       830       840         850        
pF1KE3 IYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINT--KSAFLKMIYSYSS
        ::.:.::.: :::.:.:: ...:.: : :. : :.:. :   ::  .       .... 
XP_016 AYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV
           830       840       850       860       870       880   

      860       870         880         890           900       910
pF1KE3 HSVSSIALSPASLDSMS--GNVTMTNPSSS--GKSATW----QKSKDLQAQAFAHICREN
        . ...  : .:    :  :. : ..::::  .:: .     :  .. : : .: . ...
XP_016 AARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQE
           890       900       910       920       930        940  

              920                                                  
pF1KE3 ATSVSKTLPRKRMSSI                                            
         .   :::... :                                              
XP_016 QQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQK
            950       960       970       980       990      1000  




926 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 19:38:45 2016 done: Mon Nov  7 19:38:46 2016
 Total Scan time:  7.600 Total Display time:  0.270

Function used was FASTA [36.3.4 Apr, 2011]
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