FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5854, 488 aa 1>>>pF1KB5854 488 - 488 aa - 488 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2669+/-0.000535; mu= 13.8070+/- 0.033 mean_var=195.0436+/-40.706, 0's: 0 Z-trim(113.2): 469 B-trim: 652 in 3/53 Lambda= 0.091835 statistics sampled from 21899 (22494) to 21899 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.264), width: 16 Scan time: 8.230 The best scores are: opt bits E(85289) NP_000495 (OMIM: 227600,613872) coagulation factor ( 488) 3369 460.0 6.8e-129 NP_001299603 (OMIM: 227600,613872) coagulation fac ( 444) 2229 308.9 1.9e-83 NP_001299604 (OMIM: 227600,613872) coagulation fac ( 332) 2002 278.7 1.8e-74 XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 1101 159.5 2e-38 XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 843 125.3 3.5e-28 NP_001300842 (OMIM: 122700,300746,300807,306900) c ( 423) 751 113.1 1.6e-24 NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 749 112.8 2.1e-24 XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 744 112.1 3.1e-24 NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 709 107.4 7.3e-23 XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 696 105.7 2.3e-22 XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 681 103.9 1.1e-21 NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 639 98.3 5e-20 XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 639 98.3 5.1e-20 XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 639 98.4 5.5e-20 NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 627 96.7 1.5e-19 NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 618 95.5 3.5e-19 XP_016876302 (OMIM: 176895,614024) PREDICTED: vita ( 334) 551 86.4 1.3e-16 NP_001243063 (OMIM: 176895,614024) vitamin K-depen ( 422) 551 86.6 1.5e-16 XP_016876301 (OMIM: 176895,614024) PREDICTED: vita ( 467) 551 86.6 1.6e-16 NP_940866 (OMIM: 615144) serine protease 55 isofor ( 352) 542 85.3 3.2e-16 NP_003882 (OMIM: 176895,614024) vitamin K-dependen ( 400) 541 85.2 3.7e-16 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 537 84.8 6.4e-16 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 537 84.9 6.6e-16 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 537 84.9 6.6e-16 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 532 84.3 1.2e-15 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 532 84.6 1.5e-15 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 532 84.6 1.5e-15 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 524 83.2 2.2e-15 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 521 82.6 2.5e-15 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 521 82.6 2.5e-15 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 521 82.8 3.1e-15 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 521 82.8 3.1e-15 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 521 82.8 3.1e-15 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 514 81.3 3.4e-15 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 521 83.0 3.5e-15 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 521 83.0 3.5e-15 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 510 81.2 6.9e-15 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 501 79.6 1.1e-14 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 501 79.6 1.2e-14 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 503 80.1 1.2e-14 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 502 79.9 1.2e-14 NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 501 79.7 1.3e-14 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 503 80.2 1.3e-14 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 503 80.3 1.4e-14 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 503 80.3 1.4e-14 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 503 80.3 1.4e-14 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 499 79.5 1.6e-14 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 499 79.7 1.9e-14 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 498 79.5 2e-14 NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 495 78.8 2e-14 >>NP_000495 (OMIM: 227600,613872) coagulation factor X i (488 aa) initn: 3369 init1: 3369 opt: 3369 Z-score: 2435.0 bits: 460.0 E(85289): 6.8e-129 Smith-Waterman score: 3369; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488) 10 20 30 40 50 60 pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE 430 440 450 460 470 480 pF1KB5 VITSSPLK :::::::: NP_000 VITSSPLK >>NP_001299603 (OMIM: 227600,613872) coagulation factor (444 aa) initn: 3022 init1: 2189 opt: 2229 Z-score: 1619.2 bits: 308.9 E(85289): 1.9e-83 Smith-Waterman score: 2938; 90.8% identity (91.0% similar) in 488 aa overlap (1-488:1-444) 10 20 30 40 50 60 pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR :::. :::::::::::: NP_001 CELW--------------------------------------------PYPCGKQTLERR 130 190 200 210 220 230 240 pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE 380 390 400 410 420 430 pF1KB5 VITSSPLK :::::::: NP_001 VITSSPLK 440 >>NP_001299604 (OMIM: 227600,613872) coagulation factor (332 aa) initn: 2002 init1: 2002 opt: 2002 Z-score: 1458.0 bits: 278.7 E(85289): 1.8e-74 Smith-Waterman score: 2002; 100.0% identity (100.0% similar) in 285 aa overlap (1-285:1-285) 10 20 30 40 50 60 pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE ::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKGTGTRSRRRAVRRCT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI NP_001 RWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA 310 320 330 >>XP_011535776 (OMIM: 227500,608446,613878) PREDICTED: c (495 aa) initn: 1252 init1: 459 opt: 1101 Z-score: 811.0 bits: 159.5 E(85289): 2e-38 Smith-Waterman score: 1154; 36.2% identity (61.7% similar) in 527 aa overlap (1-479:17-493) 10 20 30 40 pF1KB5 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSF ... :.:. : .: : : ..:. .:.:...: : :::.: XP_011 MGNVNRQGQHCRDFIMVSQALRLLCLLLGLQGCL---AAVFVTQEEAHGVLHRRRRANAF 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 LEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDG :::.. : ::::: :: ::.:::::.:.:...:. :: .:.::::: .::::: :.::: XP_011 LEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQ 60 70 80 90 100 110 110 120 130 pF1KB5 LGEYTCTCLEGFEGKNCEL---------FTRK-------------LCSL----------- : : : :: .:::.::: . :. ::: XP_011 LQSYICFCLPAFEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQ 120 130 140 150 160 170 140 150 160 170 180 pF1KB5 -----DNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSV .:: :.:.: .. .. : : .::.: .: .: :: ::::: ::.: XP_011 LICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR---- 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB5 AQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDG : ..:. : :::::. : : XP_011 ------------------------------------NASKPQ-G-----RIVGGKVCPKG 240 250 250 260 270 280 290 300 pF1KB5 ECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEA :::::.::. . . .::::... .....::::. . : .. . :... ...: : XP_011 ECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQ 260 270 280 290 300 310 310 320 330 340 350 360 pF1KB5 VHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIV ..: :: . .. : . :::.:::. :... .:.: ::::: ..: :: . ..: XP_011 SRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLV 320 330 340 350 360 370 370 380 390 400 410 pF1KB5 SGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQ ::.:. ..: . .: .:.:: . ..: :...: ::. ::::::. ..:.:. XP_011 SGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCK 380 390 400 410 420 430 420 430 440 450 460 470 pF1KB5 GDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKS :::::::.:... :...:::::::.::: :..:.::.:. ...:... :... : . XP_011 GDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLL 440 450 460 470 480 490 480 pF1KB5 HAPEVITSSPLK .:: XP_011 RAPFP >>XP_011535777 (OMIM: 227500,608446,613878) PREDICTED: c (433 aa) initn: 999 init1: 330 opt: 843 Z-score: 626.9 bits: 125.3 E(85289): 3.5e-28 Smith-Waterman score: 896; 34.4% identity (58.8% similar) in 442 aa overlap (86-479:37-431) 60 70 80 90 100 110 pF1KB5 ECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEG ::::: .::::: :.::: : : : :: . XP_011 QGQHCRDFIMVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA 10 20 30 40 50 60 120 130 pF1KB5 FEGKNCEL---------FTRK-------------LCSL----------------DNGDCD :::.::: . :. ::: .:: :. XP_011 FEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGCE 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 QFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPCGK-QTLERRKRSVAQATSSSGEAP :.: .. .. : : .::.: .: .: :: ::::: ::.: XP_011 QYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR--------------- 130 140 150 160 170 200 210 220 230 240 250 pF1KB5 DSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINE : ..:. : :::::. : ::::::.::. . XP_011 -------------------------NASKPQ-G-----RIVGGKVCPKGECPWQVLLLVN 180 190 200 260 270 280 290 300 310 pF1KB5 ENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV---GDRNTEQEEGGEAVHEVEVVIKHN . .::::... .....::::. . : .. . :... ...: : ..: :: . XP_011 GAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS 210 220 230 240 250 320 330 340 350 360 370 pF1KB5 RFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGR .. : . :::.:::. :... .:.: ::::: ..: :: . ..:::.:. ..: XP_011 TYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGA 260 270 280 290 300 310 380 390 400 410 420 pF1KB5 QSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRF . .: .:.:: . ..: :...: ::. ::::::. ..:.:.:::::::.:.. XP_011 TALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 KDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPL . :...:::::::.::: :..:.::.:. ...:... :... : . .:: XP_011 RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 380 390 400 410 420 430 pF1KB5 K >>NP_001300842 (OMIM: 122700,300746,300807,306900) coagu (423 aa) initn: 985 init1: 495 opt: 751 Z-score: 561.1 bits: 113.1 E(85289): 1.6e-24 Smith-Waterman score: 1095; 41.2% identity (66.2% similar) in 464 aa overlap (9-467:14-421) 10 20 30 40 50 pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL :.. : : :: .: ..:. .:.::.:: : : :: :::. .:.: NP_001 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL ::::::: ::.::::::::....:.:::..: : NP_001 ERECMEEKCSFEEAREVFENTERTTEFWKQYVD--------------------------- 70 80 90 120 130 140 150 160 170 pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEE-QNSVVCSCARGYTLADNGKACIPTGPYPC :.. :: :.:::.. .:.:::::..:: ::.: :.: :. :.:: NP_001 -------------VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC 100 110 120 130 140 180 190 200 210 220 230 pF1KB5 GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNL : . ::.: ::. .: : : :. .. :: .:: : :: .. :.. NP_001 G-------RVSVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDF 150 160 170 180 240 250 260 270 280 290 pF1KB5 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN ::.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..: NP_001 TRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHN 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB5 TEQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE :. : : ..: .: :. .. . :. :::.:.: :... :.: :. ..... NP_001 IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT- 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB5 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK . .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::. NP_001 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEG 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB5 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRG .:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. : NP_001 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 370 380 390 400 410 420 480 pF1KB5 LPKAKSHAPEVITSSPLK >>NP_000124 (OMIM: 122700,300746,300807,306900) coagulat (461 aa) initn: 1211 init1: 495 opt: 749 Z-score: 559.3 bits: 112.8 E(85289): 2.1e-24 Smith-Waterman score: 1365; 46.3% identity (72.6% similar) in 464 aa overlap (9-467:14-459) 10 20 30 40 50 pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL :.. : : :: .: ..:. .:.::.:: : : :: :::. .:.: NP_000 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL ::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : : NP_000 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEE-QNSVVCSCARGYTLADNGKACIPTGPYPC ::::::::: . :.. :: :.:::.. .:.:::::..:: ::.: :.: :. :.:: NP_000 FGFEGKNCELDV--TCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNL :. ::.: ::. .: : : :. .. :: .:: : :: .. :.. NP_000 GRV-------SVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDF 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN ::.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..: NP_000 TRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHN 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 TEQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE :. : : ..: .: :. .. . :. :::.:.: :... :.: :. ..... NP_000 IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT- 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK . .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::. NP_000 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEG 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB5 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRG .:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. : NP_000 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 410 420 430 440 450 460 480 pF1KB5 LPKAKSHAPEVITSSPLK >>XP_005262454 (OMIM: 122700,300746,300807,306900) PREDI (418 aa) initn: 1062 init1: 495 opt: 744 Z-score: 556.2 bits: 112.1 E(85289): 3.1e-24 Smith-Waterman score: 1126; 41.9% identity (65.4% similar) in 463 aa overlap (9-467:14-416) 10 20 30 40 50 pF1KB5 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL :.. : : :: .: ..:. .:.::.:: : : :: :::. .:.: XP_005 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL ::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : : XP_005 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 EGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCG ::::::::: :.::: XP_005 FGFEGKNCELV--------------------------------------------PFPCG 130 180 190 200 210 220 230 pF1KB5 KQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLT . ::.: ::. .: : : :. .. :: .:: : :: .. :..: XP_005 RV-------SVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDFT 140 150 160 170 180 240 250 260 270 280 290 pF1KB5 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNT :.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..: XP_005 RVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNI 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB5 EQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAES :. : : ..: .: :. .. . :. :::.:.: :... :.: :. ..... . XP_005 EETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-N 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB5 TLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQ .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::. XP_005 IFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGG 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB5 EDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGL .:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. : XP_005 RDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 370 380 390 400 410 480 pF1KB5 PKAKSHAPEVITSSPLK >>NP_001254483 (OMIM: 227500,608446,613878) coagulation (382 aa) initn: 999 init1: 330 opt: 709 Z-score: 531.5 bits: 107.4 E(85289): 7.3e-23 Smith-Waterman score: 964; 36.7% identity (63.3% similar) in 406 aa overlap (86-479:22-380) 60 70 80 90 100 110 pF1KB5 ECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEG ::::: .::::: :.::: : : : :: . NP_001 MVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA 10 20 30 40 50 120 130 140 150 160 170 pF1KB5 FEGKNCELFT--RKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTGPYPC :::.::: . .: .:: :.:.: .. .. : : .::.: .: .: :: ::: NP_001 FEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPC 60 70 80 90 100 110 180 190 200 210 220 230 pF1KB5 GK-QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNN :: ::.: : ..:. : NP_001 GKIPILEKR----------------------------------------NASKPQ-G--- 120 240 250 260 270 280 pF1KB5 LTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRV--- :::::. : ::::::.::. . . .::::... .....::::. . : .. . NP_001 --RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNLIAVL 130 140 150 160 170 180 290 300 310 320 330 340 pF1KB5 GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDW :... ...: : ..: :: . .. : . :::.:::. :... .:.: ::::: . NP_001 GEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTF 190 200 210 220 230 240 350 360 370 380 390 400 pF1KB5 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIITQNMF .: :: . ..:::.:. ..: . .: .:.:: . ..: :...: ::. :: NP_001 SERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMF 250 260 270 280 290 300 410 420 430 440 450 460 pF1KB5 CAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWID ::::. ..:.:.:::::::.:... :...:::::::.::: :..:.::.:. ...:.. NP_001 CAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQ 310 320 330 340 350 360 470 480 pF1KB5 RSMKTRGLPKAKSHAPEVITSSPLK . :... : . .:: NP_001 KLMRSEPRPGVLLRAPFP 370 380 >>XP_011535778 (OMIM: 227500,608446,613878) PREDICTED: c (364 aa) initn: 807 init1: 330 opt: 696 Z-score: 522.4 bits: 105.7 E(85289): 2.3e-22 Smith-Waterman score: 778; 32.4% identity (59.5% similar) in 410 aa overlap (81-479:12-362) 60 70 80 90 100 110 pF1KB5 GHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTC : . : .: .: . : : XP_011 MAQGPEESPASWRRLKREASCWSSGSRMPGD--------LC 10 20 30 120 130 140 150 160 pF1KB5 TCL-EGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSV-VCSCARGYTLADNGKACIPTG . : . :. .: .: .:: :.:.: .. .. : : .::.: .: .: :: XP_011 SALVPSSPDKDDQL----ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTV 40 50 60 70 80 170 180 190 200 210 220 pF1KB5 PYPCGK-QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPER ::::: ::.: : ..:. XP_011 EYPCGKIPILEKR----------------------------------------NASKPQ- 90 100 230 240 250 260 270 280 pF1KB5 GDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVR : :::::. : ::::::.::. . . .::::... .....::::. . : .. XP_011 G-----RIVGGKVCPKGECPWQVLLLVNGAQ-LCGGTLINTIWVVSAAHCFDKIKNWRNL 110 120 130 140 150 160 290 300 310 320 330 340 pF1KB5 V---GDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLP . :... ...: : ..: :: . .. : . :::.:::. :... .:.: ::: XP_011 IAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLP 170 180 190 200 210 220 350 360 370 380 390 pF1KB5 ERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC-----KLSSSFIIT :: ..: :: . ..:::.:. ..: . .: .:.:: . ..: :...: :: XP_011 ERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNIT 230 240 250 260 270 280 400 410 420 430 440 450 pF1KB5 QNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFL . ::::::. ..:.:.:::::::.:... :...:::::::.::: :..:.::.:. .. XP_011 EYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYI 290 300 310 320 330 340 460 470 480 pF1KB5 KWIDRSMKTRGLPKAKSHAPEVITSSPLK .:... :... : . .:: XP_011 EWLQKLMRSEPRPGVLLRAPFP 350 360 488 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:45:02 2016 done: Mon Nov 7 04:45:04 2016 Total Scan time: 8.230 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]